Ketoprofen Solubility in Organic Solvents and Aqueous Co-solvent Systems: Interactions and Thermodynamic Parameters of Solvation

Autores
Filippa, Mauricio Andres; Melo, Gisela Mabel; Gasull, Estela Isabel
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Ketoprofen (KET) solubility was determined in fifteen pure solvents and aqueous-cosolvent mixtures systems. The results obtained and the parameterized values solvents allowed us to observe the influence of the latter on the solubility of KET. The experimental data obtained indicates that the * parameter, which accounts for the polarity/polarizability of the solvent, and the Hildebrand's solubility parameter, which depicts the cohesive forces of the solvent ,has the greatest influence on the solubility of KET. In all the analyzed cosolvent mixtures, the solute was preferentially solvated by the organic cosolvent. This indicates that with a decreasing polarity of the solvent, solvent-solvent interactions decrease, favoring the solute-solvent interactions. For aqueous binary mixtures of ethanol, ethylene glycol and propylene glycol, the apparent enthalpy, entropy and Gibbs free energy changes involved in the solvation process were determined.
Fil: Filippa, Mauricio Andres. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química; Argentina
Fil: Melo, Gisela Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Gasull, Estela Isabel. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química; Argentina
Materia
KETOPROFEN
CO-SOLVENTS
SOLUBILITY
INTERACTIONS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/154257
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/154257
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Ketoprofen Solubility in Organic Solvents and Aqueous Co-solvent Systems: Interactions and Thermodynamic Parameters of SolvationFilippa, Mauricio AndresMelo, Gisela MabelGasull, Estela IsabelKETOPROFENCO-SOLVENTSSOLUBILITYINTERACTIONShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Ketoprofen (KET) solubility was determined in fifteen pure solvents and aqueous-cosolvent mixtures systems. The results obtained and the parameterized values solvents allowed us to observe the influence of the latter on the solubility of KET. The experimental data obtained indicates that the * parameter, which accounts for the polarity/polarizability of the solvent, and the Hildebrand's solubility parameter, which depicts the cohesive forces of the solvent ,has the greatest influence on the solubility of KET. In all the analyzed cosolvent mixtures, the solute was preferentially solvated by the organic cosolvent. This indicates that with a decreasing polarity of the solvent, solvent-solvent interactions decrease, favoring the solute-solvent interactions. For aqueous binary mixtures of ethanol, ethylene glycol and propylene glycol, the apparent enthalpy, entropy and Gibbs free energy changes involved in the solvation process were determined.Fil: Filippa, Mauricio Andres. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química; ArgentinaFil: Melo, Gisela Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Gasull, Estela Isabel. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química; ArgentinaScience and the Information Society2016-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/154257Filippa, Mauricio Andres; Melo, Gisela Mabel; Gasull, Estela Isabel; Ketoprofen Solubility in Organic Solvents and Aqueous Co-solvent Systems: Interactions and Thermodynamic Parameters of Solvation; Science and the Information Society; Journal of Pharmaceutical, Chemical and Biological Sciences; 3; 4; 2-2016; 440-4532348-76582348-7658CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://jpcbs.info/2015_3_4_02_Estela.pdfinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:03:21Zoai:ri.conicet.gov.ar:11336/154257instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:03:21.331CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Ketoprofen Solubility in Organic Solvents and Aqueous Co-solvent Systems: Interactions and Thermodynamic Parameters of Solvation
title Ketoprofen Solubility in Organic Solvents and Aqueous Co-solvent Systems: Interactions and Thermodynamic Parameters of Solvation
spellingShingle Ketoprofen Solubility in Organic Solvents and Aqueous Co-solvent Systems: Interactions and Thermodynamic Parameters of Solvation
Filippa, Mauricio Andres
KETOPROFEN
CO-SOLVENTS
SOLUBILITY
INTERACTIONS
title_short Ketoprofen Solubility in Organic Solvents and Aqueous Co-solvent Systems: Interactions and Thermodynamic Parameters of Solvation
title_full Ketoprofen Solubility in Organic Solvents and Aqueous Co-solvent Systems: Interactions and Thermodynamic Parameters of Solvation
title_fullStr Ketoprofen Solubility in Organic Solvents and Aqueous Co-solvent Systems: Interactions and Thermodynamic Parameters of Solvation
title_full_unstemmed Ketoprofen Solubility in Organic Solvents and Aqueous Co-solvent Systems: Interactions and Thermodynamic Parameters of Solvation
title_sort Ketoprofen Solubility in Organic Solvents and Aqueous Co-solvent Systems: Interactions and Thermodynamic Parameters of Solvation
dc.creator.none.fl_str_mv Filippa, Mauricio Andres
Melo, Gisela Mabel
Gasull, Estela Isabel
author Filippa, Mauricio Andres
author_facet Filippa, Mauricio Andres
Melo, Gisela Mabel
Gasull, Estela Isabel
author_role author
author2 Melo, Gisela Mabel
Gasull, Estela Isabel
author2_role author
author
dc.subject.none.fl_str_mv KETOPROFEN
CO-SOLVENTS
SOLUBILITY
INTERACTIONS
topic KETOPROFEN
CO-SOLVENTS
SOLUBILITY
INTERACTIONS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Ketoprofen (KET) solubility was determined in fifteen pure solvents and aqueous-cosolvent mixtures systems. The results obtained and the parameterized values solvents allowed us to observe the influence of the latter on the solubility of KET. The experimental data obtained indicates that the * parameter, which accounts for the polarity/polarizability of the solvent, and the Hildebrand's solubility parameter, which depicts the cohesive forces of the solvent ,has the greatest influence on the solubility of KET. In all the analyzed cosolvent mixtures, the solute was preferentially solvated by the organic cosolvent. This indicates that with a decreasing polarity of the solvent, solvent-solvent interactions decrease, favoring the solute-solvent interactions. For aqueous binary mixtures of ethanol, ethylene glycol and propylene glycol, the apparent enthalpy, entropy and Gibbs free energy changes involved in the solvation process were determined.
Fil: Filippa, Mauricio Andres. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química; Argentina
Fil: Melo, Gisela Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Gasull, Estela Isabel. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química; Argentina
description Ketoprofen (KET) solubility was determined in fifteen pure solvents and aqueous-cosolvent mixtures systems. The results obtained and the parameterized values solvents allowed us to observe the influence of the latter on the solubility of KET. The experimental data obtained indicates that the * parameter, which accounts for the polarity/polarizability of the solvent, and the Hildebrand's solubility parameter, which depicts the cohesive forces of the solvent ,has the greatest influence on the solubility of KET. In all the analyzed cosolvent mixtures, the solute was preferentially solvated by the organic cosolvent. This indicates that with a decreasing polarity of the solvent, solvent-solvent interactions decrease, favoring the solute-solvent interactions. For aqueous binary mixtures of ethanol, ethylene glycol and propylene glycol, the apparent enthalpy, entropy and Gibbs free energy changes involved in the solvation process were determined.
publishDate 2016
dc.date.none.fl_str_mv 2016-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/154257
Filippa, Mauricio Andres; Melo, Gisela Mabel; Gasull, Estela Isabel; Ketoprofen Solubility in Organic Solvents and Aqueous Co-solvent Systems: Interactions and Thermodynamic Parameters of Solvation; Science and the Information Society; Journal of Pharmaceutical, Chemical and Biological Sciences; 3; 4; 2-2016; 440-453
2348-7658
2348-7658
CONICET Digital
CONICET
url http://hdl.handle.net/11336/154257
identifier_str_mv Filippa, Mauricio Andres; Melo, Gisela Mabel; Gasull, Estela Isabel; Ketoprofen Solubility in Organic Solvents and Aqueous Co-solvent Systems: Interactions and Thermodynamic Parameters of Solvation; Science and the Information Society; Journal of Pharmaceutical, Chemical and Biological Sciences; 3; 4; 2-2016; 440-453
2348-7658
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://jpcbs.info/2015_3_4_02_Estela.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Science and the Information Society
publisher.none.fl_str_mv Science and the Information Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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