Ketoprofen Solubility in Organic Solvents and Aqueous Co-solvent Systems: Interactions and Thermodynamic Parameters of Solvation
- Autores
- Filippa, Mauricio Andres; Melo, Gisela Mabel; Gasull, Estela Isabel
- Año de publicación
- 2016
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Ketoprofen (KET) solubility was determined in fifteen pure solvents and aqueous-cosolvent mixtures systems. The results obtained and the parameterized values solvents allowed us to observe the influence of the latter on the solubility of KET. The experimental data obtained indicates that the * parameter, which accounts for the polarity/polarizability of the solvent, and the Hildebrand's solubility parameter, which depicts the cohesive forces of the solvent ,has the greatest influence on the solubility of KET. In all the analyzed cosolvent mixtures, the solute was preferentially solvated by the organic cosolvent. This indicates that with a decreasing polarity of the solvent, solvent-solvent interactions decrease, favoring the solute-solvent interactions. For aqueous binary mixtures of ethanol, ethylene glycol and propylene glycol, the apparent enthalpy, entropy and Gibbs free energy changes involved in the solvation process were determined.
Fil: Filippa, Mauricio Andres. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química; Argentina
Fil: Melo, Gisela Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Gasull, Estela Isabel. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química; Argentina - Materia
-
KETOPROFEN
CO-SOLVENTS
SOLUBILITY
INTERACTIONS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/154257
Ver los metadatos del registro completo
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spelling |
Ketoprofen Solubility in Organic Solvents and Aqueous Co-solvent Systems: Interactions and Thermodynamic Parameters of SolvationFilippa, Mauricio AndresMelo, Gisela MabelGasull, Estela IsabelKETOPROFENCO-SOLVENTSSOLUBILITYINTERACTIONShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Ketoprofen (KET) solubility was determined in fifteen pure solvents and aqueous-cosolvent mixtures systems. The results obtained and the parameterized values solvents allowed us to observe the influence of the latter on the solubility of KET. The experimental data obtained indicates that the * parameter, which accounts for the polarity/polarizability of the solvent, and the Hildebrand's solubility parameter, which depicts the cohesive forces of the solvent ,has the greatest influence on the solubility of KET. In all the analyzed cosolvent mixtures, the solute was preferentially solvated by the organic cosolvent. This indicates that with a decreasing polarity of the solvent, solvent-solvent interactions decrease, favoring the solute-solvent interactions. For aqueous binary mixtures of ethanol, ethylene glycol and propylene glycol, the apparent enthalpy, entropy and Gibbs free energy changes involved in the solvation process were determined.Fil: Filippa, Mauricio Andres. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química; ArgentinaFil: Melo, Gisela Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Gasull, Estela Isabel. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química; ArgentinaScience and the Information Society2016-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/154257Filippa, Mauricio Andres; Melo, Gisela Mabel; Gasull, Estela Isabel; Ketoprofen Solubility in Organic Solvents and Aqueous Co-solvent Systems: Interactions and Thermodynamic Parameters of Solvation; Science and the Information Society; Journal of Pharmaceutical, Chemical and Biological Sciences; 3; 4; 2-2016; 440-4532348-76582348-7658CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://jpcbs.info/2015_3_4_02_Estela.pdfinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:06:28Zoai:ri.conicet.gov.ar:11336/154257instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:06:28.615CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Ketoprofen Solubility in Organic Solvents and Aqueous Co-solvent Systems: Interactions and Thermodynamic Parameters of Solvation |
title |
Ketoprofen Solubility in Organic Solvents and Aqueous Co-solvent Systems: Interactions and Thermodynamic Parameters of Solvation |
spellingShingle |
Ketoprofen Solubility in Organic Solvents and Aqueous Co-solvent Systems: Interactions and Thermodynamic Parameters of Solvation Filippa, Mauricio Andres KETOPROFEN CO-SOLVENTS SOLUBILITY INTERACTIONS |
title_short |
Ketoprofen Solubility in Organic Solvents and Aqueous Co-solvent Systems: Interactions and Thermodynamic Parameters of Solvation |
title_full |
Ketoprofen Solubility in Organic Solvents and Aqueous Co-solvent Systems: Interactions and Thermodynamic Parameters of Solvation |
title_fullStr |
Ketoprofen Solubility in Organic Solvents and Aqueous Co-solvent Systems: Interactions and Thermodynamic Parameters of Solvation |
title_full_unstemmed |
Ketoprofen Solubility in Organic Solvents and Aqueous Co-solvent Systems: Interactions and Thermodynamic Parameters of Solvation |
title_sort |
Ketoprofen Solubility in Organic Solvents and Aqueous Co-solvent Systems: Interactions and Thermodynamic Parameters of Solvation |
dc.creator.none.fl_str_mv |
Filippa, Mauricio Andres Melo, Gisela Mabel Gasull, Estela Isabel |
author |
Filippa, Mauricio Andres |
author_facet |
Filippa, Mauricio Andres Melo, Gisela Mabel Gasull, Estela Isabel |
author_role |
author |
author2 |
Melo, Gisela Mabel Gasull, Estela Isabel |
author2_role |
author author |
dc.subject.none.fl_str_mv |
KETOPROFEN CO-SOLVENTS SOLUBILITY INTERACTIONS |
topic |
KETOPROFEN CO-SOLVENTS SOLUBILITY INTERACTIONS |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Ketoprofen (KET) solubility was determined in fifteen pure solvents and aqueous-cosolvent mixtures systems. The results obtained and the parameterized values solvents allowed us to observe the influence of the latter on the solubility of KET. The experimental data obtained indicates that the * parameter, which accounts for the polarity/polarizability of the solvent, and the Hildebrand's solubility parameter, which depicts the cohesive forces of the solvent ,has the greatest influence on the solubility of KET. In all the analyzed cosolvent mixtures, the solute was preferentially solvated by the organic cosolvent. This indicates that with a decreasing polarity of the solvent, solvent-solvent interactions decrease, favoring the solute-solvent interactions. For aqueous binary mixtures of ethanol, ethylene glycol and propylene glycol, the apparent enthalpy, entropy and Gibbs free energy changes involved in the solvation process were determined. Fil: Filippa, Mauricio Andres. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química; Argentina Fil: Melo, Gisela Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina Fil: Gasull, Estela Isabel. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química; Argentina |
description |
Ketoprofen (KET) solubility was determined in fifteen pure solvents and aqueous-cosolvent mixtures systems. The results obtained and the parameterized values solvents allowed us to observe the influence of the latter on the solubility of KET. The experimental data obtained indicates that the * parameter, which accounts for the polarity/polarizability of the solvent, and the Hildebrand's solubility parameter, which depicts the cohesive forces of the solvent ,has the greatest influence on the solubility of KET. In all the analyzed cosolvent mixtures, the solute was preferentially solvated by the organic cosolvent. This indicates that with a decreasing polarity of the solvent, solvent-solvent interactions decrease, favoring the solute-solvent interactions. For aqueous binary mixtures of ethanol, ethylene glycol and propylene glycol, the apparent enthalpy, entropy and Gibbs free energy changes involved in the solvation process were determined. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-02 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/154257 Filippa, Mauricio Andres; Melo, Gisela Mabel; Gasull, Estela Isabel; Ketoprofen Solubility in Organic Solvents and Aqueous Co-solvent Systems: Interactions and Thermodynamic Parameters of Solvation; Science and the Information Society; Journal of Pharmaceutical, Chemical and Biological Sciences; 3; 4; 2-2016; 440-453 2348-7658 2348-7658 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/154257 |
identifier_str_mv |
Filippa, Mauricio Andres; Melo, Gisela Mabel; Gasull, Estela Isabel; Ketoprofen Solubility in Organic Solvents and Aqueous Co-solvent Systems: Interactions and Thermodynamic Parameters of Solvation; Science and the Information Society; Journal of Pharmaceutical, Chemical and Biological Sciences; 3; 4; 2-2016; 440-453 2348-7658 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://jpcbs.info/2015_3_4_02_Estela.pdf |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Science and the Information Society |
publisher.none.fl_str_mv |
Science and the Information Society |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613913854869504 |
score |
13.070432 |