Response to comment on "Cathepsin-l influences the expression of extracellular matrix in lymphoid organs and plays a role in the regulation of thymic output and of peripheral T cel...

Autores
Lombardi, María Gabriela; Burzyn, Dalia; Mundiñano, Juliana; Berguer, Paula MercedeS; Costa, Hector Luis; Goldman, Alejandra; Piazzon, Margarita Isabel; Nepomnaschy, Irene
Año de publicación
2006
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In our article published in The Journal of Immunology in June 1, 2005 (1), we reported that lymph nodes from nackt mice (CTSLnkt/CTSLnkt) are hypertrophied, showing a normal absolute number of CD4+ T cells and a marked increase in the number of CD8+ T lymphocytes. Correlatively, extracellular matrix (ECM) components were found to be increased. Contrarily, in nackt thymus, laminin, fibronectin, and collagen I and IV are markedly decreased, with an augmented output of CD8+ cells.
Fil: Lombardi, María Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Burzyn, Dalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Mundiñano, Juliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Berguer, Paula MercedeS. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Costa, Hector Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Goldman, Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Piazzon, Margarita Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Nepomnaschy, Irene. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Materia
Cathepsin L
Cysteine Endopeptidases
Gene Expression Regulation
Lymphoid Tissue
T-Lymphocytes
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/45015
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/45015
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Response to comment on "Cathepsin-l influences the expression of extracellular matrix in lymphoid organs and plays a role in the regulation of thymic output and of peripheral T cell number"Lombardi, María GabrielaBurzyn, DaliaMundiñano, JulianaBerguer, Paula MercedeSCosta, Hector LuisGoldman, AlejandraPiazzon, Margarita IsabelNepomnaschy, IreneCathepsin LCysteine EndopeptidasesGene Expression RegulationLymphoid TissueT-Lymphocyteshttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3In our article published in The Journal of Immunology in June 1, 2005 (1), we reported that lymph nodes from nackt mice (CTSLnkt/CTSLnkt) are hypertrophied, showing a normal absolute number of CD4+ T cells and a marked increase in the number of CD8+ T lymphocytes. Correlatively, extracellular matrix (ECM) components were found to be increased. Contrarily, in nackt thymus, laminin, fibronectin, and collagen I and IV are markedly decreased, with an augmented output of CD8+ cells.Fil: Lombardi, María Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Burzyn, Dalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Mundiñano, Juliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Berguer, Paula MercedeS. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Costa, Hector Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Goldman, Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Piazzon, Margarita Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Nepomnaschy, Irene. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaAmerican Association of Immunologists2006-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/45015Lombardi, María Gabriela; Burzyn, Dalia; Mundiñano, Juliana; Berguer, Paula MercedeS; Costa, Hector Luis; et al.; Response to comment on "Cathepsin-l influences the expression of extracellular matrix in lymphoid organs and plays a role in the regulation of thymic output and of peripheral T cell number"; American Association of Immunologists; Journal of Immunology; 176; 9; 12-2006; 5135-51360022-17671550-6606CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.4049/jimmunol.176.9.5135info:eu-repo/semantics/altIdentifier/url/http://www.jimmunol.org/content/176/9/5135info:eu-repo/semantics/altIdentifier/pmid/16621972info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:53:40Zoai:ri.conicet.gov.ar:11336/45015instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:53:41.168CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Response to comment on "Cathepsin-l influences the expression of extracellular matrix in lymphoid organs and plays a role in the regulation of thymic output and of peripheral T cell number"
title Response to comment on "Cathepsin-l influences the expression of extracellular matrix in lymphoid organs and plays a role in the regulation of thymic output and of peripheral T cell number"
spellingShingle Response to comment on "Cathepsin-l influences the expression of extracellular matrix in lymphoid organs and plays a role in the regulation of thymic output and of peripheral T cell number"
Lombardi, María Gabriela
Cathepsin L
Cysteine Endopeptidases
Gene Expression Regulation
Lymphoid Tissue
T-Lymphocytes
title_short Response to comment on "Cathepsin-l influences the expression of extracellular matrix in lymphoid organs and plays a role in the regulation of thymic output and of peripheral T cell number"
title_full Response to comment on "Cathepsin-l influences the expression of extracellular matrix in lymphoid organs and plays a role in the regulation of thymic output and of peripheral T cell number"
title_fullStr Response to comment on "Cathepsin-l influences the expression of extracellular matrix in lymphoid organs and plays a role in the regulation of thymic output and of peripheral T cell number"
title_full_unstemmed Response to comment on "Cathepsin-l influences the expression of extracellular matrix in lymphoid organs and plays a role in the regulation of thymic output and of peripheral T cell number"
title_sort Response to comment on "Cathepsin-l influences the expression of extracellular matrix in lymphoid organs and plays a role in the regulation of thymic output and of peripheral T cell number"
dc.creator.none.fl_str_mv Lombardi, María Gabriela
Burzyn, Dalia
Mundiñano, Juliana
Berguer, Paula MercedeS
Costa, Hector Luis
Goldman, Alejandra
Piazzon, Margarita Isabel
Nepomnaschy, Irene
author Lombardi, María Gabriela
author_facet Lombardi, María Gabriela
Burzyn, Dalia
Mundiñano, Juliana
Berguer, Paula MercedeS
Costa, Hector Luis
Goldman, Alejandra
Piazzon, Margarita Isabel
Nepomnaschy, Irene
author_role author
author2 Burzyn, Dalia
Mundiñano, Juliana
Berguer, Paula MercedeS
Costa, Hector Luis
Goldman, Alejandra
Piazzon, Margarita Isabel
Nepomnaschy, Irene
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cathepsin L
Cysteine Endopeptidases
Gene Expression Regulation
Lymphoid Tissue
T-Lymphocytes
topic Cathepsin L
Cysteine Endopeptidases
Gene Expression Regulation
Lymphoid Tissue
T-Lymphocytes
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv In our article published in The Journal of Immunology in June 1, 2005 (1), we reported that lymph nodes from nackt mice (CTSLnkt/CTSLnkt) are hypertrophied, showing a normal absolute number of CD4+ T cells and a marked increase in the number of CD8+ T lymphocytes. Correlatively, extracellular matrix (ECM) components were found to be increased. Contrarily, in nackt thymus, laminin, fibronectin, and collagen I and IV are markedly decreased, with an augmented output of CD8+ cells.
Fil: Lombardi, María Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Burzyn, Dalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Mundiñano, Juliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Berguer, Paula MercedeS. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Costa, Hector Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Goldman, Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Piazzon, Margarita Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Nepomnaschy, Irene. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
description In our article published in The Journal of Immunology in June 1, 2005 (1), we reported that lymph nodes from nackt mice (CTSLnkt/CTSLnkt) are hypertrophied, showing a normal absolute number of CD4+ T cells and a marked increase in the number of CD8+ T lymphocytes. Correlatively, extracellular matrix (ECM) components were found to be increased. Contrarily, in nackt thymus, laminin, fibronectin, and collagen I and IV are markedly decreased, with an augmented output of CD8+ cells.
publishDate 2006
dc.date.none.fl_str_mv 2006-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/45015
Lombardi, María Gabriela; Burzyn, Dalia; Mundiñano, Juliana; Berguer, Paula MercedeS; Costa, Hector Luis; et al.; Response to comment on "Cathepsin-l influences the expression of extracellular matrix in lymphoid organs and plays a role in the regulation of thymic output and of peripheral T cell number"; American Association of Immunologists; Journal of Immunology; 176; 9; 12-2006; 5135-5136
0022-1767
1550-6606
CONICET Digital
CONICET
url http://hdl.handle.net/11336/45015
identifier_str_mv Lombardi, María Gabriela; Burzyn, Dalia; Mundiñano, Juliana; Berguer, Paula MercedeS; Costa, Hector Luis; et al.; Response to comment on "Cathepsin-l influences the expression of extracellular matrix in lymphoid organs and plays a role in the regulation of thymic output and of peripheral T cell number"; American Association of Immunologists; Journal of Immunology; 176; 9; 12-2006; 5135-5136
0022-1767
1550-6606
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.4049/jimmunol.176.9.5135
info:eu-repo/semantics/altIdentifier/url/http://www.jimmunol.org/content/176/9/5135
info:eu-repo/semantics/altIdentifier/pmid/16621972
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Association of Immunologists
publisher.none.fl_str_mv American Association of Immunologists
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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