Innate lymphoid cells: Characterization and classification

Autores
Luci, Carmelo; Golub, Rachel; Jancic, Carolina Cristina
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Innate lymphoid cells (ILCs) are lymphocytes lacking the rearranged antigen receptors and mainly localized at epithelial surfaces, where they maintain tissue homeostasis, and provide a rapid response to pathogen assaults. ILCs share similarities with conventional T cells and are divided into 5 subsets based on cell surface markers, transcription factor requirement and ability to produce type 1, type 2 and Th17 cell-associated cytokines: conventional Natural Killer (NK) cells, helper ILC1, ILC2, ILC3 and Lymphocytes Tissue-Inducers (LTi) cells. They are endowed with a plasticity that allows them to modify their phenotype and their functionality to adapt to the microenvironment in which they are located. ILCs are considered resident cells in different peripheral tissues but they can also be present in lymph and peripheral blood as it is the case for NK cells. The description of the ILCs are complex and discordant since distinctive markers are either not supported in few tissues or across species and after inflammatory conditions. Today, to better understand the origin and classification of ILCs as a whole, and its participation in the immune response, it is necessary to unify criteria and nomenclature after comparing human and mouse recent studies...
Fil: Luci, Carmelo. Inserm; Francia
Fil: Golub, Rachel. Inserm; Francia
Fil: Jancic, Carolina Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Cátedra de Microbiología, Parasitología e Inmunología; Argentina
Materia
INNATE LYMPHOID CELLS
CLASSIFICATION
CHARACTERIZATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/248428
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Innate lymphoid cells: Characterization and classificationLuci, CarmeloGolub, RachelJancic, Carolina CristinaINNATE LYMPHOID CELLSCLASSIFICATIONCHARACTERIZATIONhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Innate lymphoid cells (ILCs) are lymphocytes lacking the rearranged antigen receptors and mainly localized at epithelial surfaces, where they maintain tissue homeostasis, and provide a rapid response to pathogen assaults. ILCs share similarities with conventional T cells and are divided into 5 subsets based on cell surface markers, transcription factor requirement and ability to produce type 1, type 2 and Th17 cell-associated cytokines: conventional Natural Killer (NK) cells, helper ILC1, ILC2, ILC3 and Lymphocytes Tissue-Inducers (LTi) cells. They are endowed with a plasticity that allows them to modify their phenotype and their functionality to adapt to the microenvironment in which they are located. ILCs are considered resident cells in different peripheral tissues but they can also be present in lymph and peripheral blood as it is the case for NK cells. The description of the ILCs are complex and discordant since distinctive markers are either not supported in few tissues or across species and after inflammatory conditions. Today, to better understand the origin and classification of ILCs as a whole, and its participation in the immune response, it is necessary to unify criteria and nomenclature after comparing human and mouse recent studies...Fil: Luci, Carmelo. Inserm; FranciaFil: Golub, Rachel. Inserm; FranciaFil: Jancic, Carolina Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Cátedra de Microbiología, Parasitología e Inmunología; ArgentinaFrontiers Media2023-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/248428Luci, Carmelo; Golub, Rachel; Jancic, Carolina Cristina; Innate lymphoid cells: Characterization and classification; Frontiers Media; Frontiers in Immunology; 14; 1338463; 11-2023; 1-31664-3224CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2023.1338463info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1338463/fullinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:52:57Zoai:ri.conicet.gov.ar:11336/248428instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:52:57.508CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Innate lymphoid cells: Characterization and classification
title Innate lymphoid cells: Characterization and classification
spellingShingle Innate lymphoid cells: Characterization and classification
Luci, Carmelo
INNATE LYMPHOID CELLS
CLASSIFICATION
CHARACTERIZATION
title_short Innate lymphoid cells: Characterization and classification
title_full Innate lymphoid cells: Characterization and classification
title_fullStr Innate lymphoid cells: Characterization and classification
title_full_unstemmed Innate lymphoid cells: Characterization and classification
title_sort Innate lymphoid cells: Characterization and classification
dc.creator.none.fl_str_mv Luci, Carmelo
Golub, Rachel
Jancic, Carolina Cristina
author Luci, Carmelo
author_facet Luci, Carmelo
Golub, Rachel
Jancic, Carolina Cristina
author_role author
author2 Golub, Rachel
Jancic, Carolina Cristina
author2_role author
author
dc.subject.none.fl_str_mv INNATE LYMPHOID CELLS
CLASSIFICATION
CHARACTERIZATION
topic INNATE LYMPHOID CELLS
CLASSIFICATION
CHARACTERIZATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Innate lymphoid cells (ILCs) are lymphocytes lacking the rearranged antigen receptors and mainly localized at epithelial surfaces, where they maintain tissue homeostasis, and provide a rapid response to pathogen assaults. ILCs share similarities with conventional T cells and are divided into 5 subsets based on cell surface markers, transcription factor requirement and ability to produce type 1, type 2 and Th17 cell-associated cytokines: conventional Natural Killer (NK) cells, helper ILC1, ILC2, ILC3 and Lymphocytes Tissue-Inducers (LTi) cells. They are endowed with a plasticity that allows them to modify their phenotype and their functionality to adapt to the microenvironment in which they are located. ILCs are considered resident cells in different peripheral tissues but they can also be present in lymph and peripheral blood as it is the case for NK cells. The description of the ILCs are complex and discordant since distinctive markers are either not supported in few tissues or across species and after inflammatory conditions. Today, to better understand the origin and classification of ILCs as a whole, and its participation in the immune response, it is necessary to unify criteria and nomenclature after comparing human and mouse recent studies...
Fil: Luci, Carmelo. Inserm; Francia
Fil: Golub, Rachel. Inserm; Francia
Fil: Jancic, Carolina Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Cátedra de Microbiología, Parasitología e Inmunología; Argentina
description Innate lymphoid cells (ILCs) are lymphocytes lacking the rearranged antigen receptors and mainly localized at epithelial surfaces, where they maintain tissue homeostasis, and provide a rapid response to pathogen assaults. ILCs share similarities with conventional T cells and are divided into 5 subsets based on cell surface markers, transcription factor requirement and ability to produce type 1, type 2 and Th17 cell-associated cytokines: conventional Natural Killer (NK) cells, helper ILC1, ILC2, ILC3 and Lymphocytes Tissue-Inducers (LTi) cells. They are endowed with a plasticity that allows them to modify their phenotype and their functionality to adapt to the microenvironment in which they are located. ILCs are considered resident cells in different peripheral tissues but they can also be present in lymph and peripheral blood as it is the case for NK cells. The description of the ILCs are complex and discordant since distinctive markers are either not supported in few tissues or across species and after inflammatory conditions. Today, to better understand the origin and classification of ILCs as a whole, and its participation in the immune response, it is necessary to unify criteria and nomenclature after comparing human and mouse recent studies...
publishDate 2023
dc.date.none.fl_str_mv 2023-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/248428
Luci, Carmelo; Golub, Rachel; Jancic, Carolina Cristina; Innate lymphoid cells: Characterization and classification; Frontiers Media; Frontiers in Immunology; 14; 1338463; 11-2023; 1-3
1664-3224
CONICET Digital
CONICET
url http://hdl.handle.net/11336/248428
identifier_str_mv Luci, Carmelo; Golub, Rachel; Jancic, Carolina Cristina; Innate lymphoid cells: Characterization and classification; Frontiers Media; Frontiers in Immunology; 14; 1338463; 11-2023; 1-3
1664-3224
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2023.1338463
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1338463/full
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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