Innate lymphoid cells: Characterization and classification
- Autores
- Luci, Carmelo; Golub, Rachel; Jancic, Carolina Cristina
- Año de publicación
- 2023
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Innate lymphoid cells (ILCs) are lymphocytes lacking the rearranged antigen receptors and mainly localized at epithelial surfaces, where they maintain tissue homeostasis, and provide a rapid response to pathogen assaults. ILCs share similarities with conventional T cells and are divided into 5 subsets based on cell surface markers, transcription factor requirement and ability to produce type 1, type 2 and Th17 cell-associated cytokines: conventional Natural Killer (NK) cells, helper ILC1, ILC2, ILC3 and Lymphocytes Tissue-Inducers (LTi) cells. They are endowed with a plasticity that allows them to modify their phenotype and their functionality to adapt to the microenvironment in which they are located. ILCs are considered resident cells in different peripheral tissues but they can also be present in lymph and peripheral blood as it is the case for NK cells. The description of the ILCs are complex and discordant since distinctive markers are either not supported in few tissues or across species and after inflammatory conditions. Today, to better understand the origin and classification of ILCs as a whole, and its participation in the immune response, it is necessary to unify criteria and nomenclature after comparing human and mouse recent studies...
Fil: Luci, Carmelo. Inserm; Francia
Fil: Golub, Rachel. Inserm; Francia
Fil: Jancic, Carolina Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Cátedra de Microbiología, Parasitología e Inmunología; Argentina - Materia
-
INNATE LYMPHOID CELLS
CLASSIFICATION
CHARACTERIZATION - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/248428
Ver los metadatos del registro completo
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Innate lymphoid cells: Characterization and classificationLuci, CarmeloGolub, RachelJancic, Carolina CristinaINNATE LYMPHOID CELLSCLASSIFICATIONCHARACTERIZATIONhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Innate lymphoid cells (ILCs) are lymphocytes lacking the rearranged antigen receptors and mainly localized at epithelial surfaces, where they maintain tissue homeostasis, and provide a rapid response to pathogen assaults. ILCs share similarities with conventional T cells and are divided into 5 subsets based on cell surface markers, transcription factor requirement and ability to produce type 1, type 2 and Th17 cell-associated cytokines: conventional Natural Killer (NK) cells, helper ILC1, ILC2, ILC3 and Lymphocytes Tissue-Inducers (LTi) cells. They are endowed with a plasticity that allows them to modify their phenotype and their functionality to adapt to the microenvironment in which they are located. ILCs are considered resident cells in different peripheral tissues but they can also be present in lymph and peripheral blood as it is the case for NK cells. The description of the ILCs are complex and discordant since distinctive markers are either not supported in few tissues or across species and after inflammatory conditions. Today, to better understand the origin and classification of ILCs as a whole, and its participation in the immune response, it is necessary to unify criteria and nomenclature after comparing human and mouse recent studies...Fil: Luci, Carmelo. Inserm; FranciaFil: Golub, Rachel. Inserm; FranciaFil: Jancic, Carolina Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Cátedra de Microbiología, Parasitología e Inmunología; ArgentinaFrontiers Media2023-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/248428Luci, Carmelo; Golub, Rachel; Jancic, Carolina Cristina; Innate lymphoid cells: Characterization and classification; Frontiers Media; Frontiers in Immunology; 14; 1338463; 11-2023; 1-31664-3224CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2023.1338463info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1338463/fullinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:53:34Zoai:ri.conicet.gov.ar:11336/248428instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:53:34.838CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Innate lymphoid cells: Characterization and classification |
title |
Innate lymphoid cells: Characterization and classification |
spellingShingle |
Innate lymphoid cells: Characterization and classification Luci, Carmelo INNATE LYMPHOID CELLS CLASSIFICATION CHARACTERIZATION |
title_short |
Innate lymphoid cells: Characterization and classification |
title_full |
Innate lymphoid cells: Characterization and classification |
title_fullStr |
Innate lymphoid cells: Characterization and classification |
title_full_unstemmed |
Innate lymphoid cells: Characterization and classification |
title_sort |
Innate lymphoid cells: Characterization and classification |
dc.creator.none.fl_str_mv |
Luci, Carmelo Golub, Rachel Jancic, Carolina Cristina |
author |
Luci, Carmelo |
author_facet |
Luci, Carmelo Golub, Rachel Jancic, Carolina Cristina |
author_role |
author |
author2 |
Golub, Rachel Jancic, Carolina Cristina |
author2_role |
author author |
dc.subject.none.fl_str_mv |
INNATE LYMPHOID CELLS CLASSIFICATION CHARACTERIZATION |
topic |
INNATE LYMPHOID CELLS CLASSIFICATION CHARACTERIZATION |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Innate lymphoid cells (ILCs) are lymphocytes lacking the rearranged antigen receptors and mainly localized at epithelial surfaces, where they maintain tissue homeostasis, and provide a rapid response to pathogen assaults. ILCs share similarities with conventional T cells and are divided into 5 subsets based on cell surface markers, transcription factor requirement and ability to produce type 1, type 2 and Th17 cell-associated cytokines: conventional Natural Killer (NK) cells, helper ILC1, ILC2, ILC3 and Lymphocytes Tissue-Inducers (LTi) cells. They are endowed with a plasticity that allows them to modify their phenotype and their functionality to adapt to the microenvironment in which they are located. ILCs are considered resident cells in different peripheral tissues but they can also be present in lymph and peripheral blood as it is the case for NK cells. The description of the ILCs are complex and discordant since distinctive markers are either not supported in few tissues or across species and after inflammatory conditions. Today, to better understand the origin and classification of ILCs as a whole, and its participation in the immune response, it is necessary to unify criteria and nomenclature after comparing human and mouse recent studies... Fil: Luci, Carmelo. Inserm; Francia Fil: Golub, Rachel. Inserm; Francia Fil: Jancic, Carolina Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Cátedra de Microbiología, Parasitología e Inmunología; Argentina |
description |
Innate lymphoid cells (ILCs) are lymphocytes lacking the rearranged antigen receptors and mainly localized at epithelial surfaces, where they maintain tissue homeostasis, and provide a rapid response to pathogen assaults. ILCs share similarities with conventional T cells and are divided into 5 subsets based on cell surface markers, transcription factor requirement and ability to produce type 1, type 2 and Th17 cell-associated cytokines: conventional Natural Killer (NK) cells, helper ILC1, ILC2, ILC3 and Lymphocytes Tissue-Inducers (LTi) cells. They are endowed with a plasticity that allows them to modify their phenotype and their functionality to adapt to the microenvironment in which they are located. ILCs are considered resident cells in different peripheral tissues but they can also be present in lymph and peripheral blood as it is the case for NK cells. The description of the ILCs are complex and discordant since distinctive markers are either not supported in few tissues or across species and after inflammatory conditions. Today, to better understand the origin and classification of ILCs as a whole, and its participation in the immune response, it is necessary to unify criteria and nomenclature after comparing human and mouse recent studies... |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-11 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/248428 Luci, Carmelo; Golub, Rachel; Jancic, Carolina Cristina; Innate lymphoid cells: Characterization and classification; Frontiers Media; Frontiers in Immunology; 14; 1338463; 11-2023; 1-3 1664-3224 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/248428 |
identifier_str_mv |
Luci, Carmelo; Golub, Rachel; Jancic, Carolina Cristina; Innate lymphoid cells: Characterization and classification; Frontiers Media; Frontiers in Immunology; 14; 1338463; 11-2023; 1-3 1664-3224 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2023.1338463 info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1338463/full |
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info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
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https://creativecommons.org/licenses/by/2.5/ar/ |
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application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers Media |
publisher.none.fl_str_mv |
Frontiers Media |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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