Real World Evidence: Treatment of Patients with Non- Metastatic Colon Cancer in a Community Hospital in Argentina: A Retrospective Cohort Study

Autores
Straminsky, Samanta; Itkin, Boris; De Ronato, Gabriela; Bibbó, Florencia; Lewi, Daniel; García, Gabriela; Bardach, Ariel Esteban
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: The addition of adjuvant chemotherapy (ACT) to the surgical treatment of locally advanced colon cancer (CC) was shown to reduce relapses in stage III disease, although it remains controversial in stage II. However, an underutilization of ACT in stage III patients was reported. Data on use of ACT in stage II and in older patients in the ?real world? in developing countries are limited. We aimed to describe management and outcome of non-metastatic colon cancer patients in a community hospital in Argentina.Methods: We retrospectively reviewed clinical charts of 99 patients with non-metastatic CC admitted in our Department between 2007 and 2016 extracting data on surgical treatment and chemotherapy use.Results: Emergency surgery was performed in 36.2% of cases. Near 72% of patients had 12 or more lymph nodes examined. Adjuvant chemotherapy was delivered to 93.1% of patients with stage III, to 38.1% of patients with stage II disease, and to 94.1% of stage III patients older than 70 years. Ninety six percent of patients with stage III disease received oxaliplatin-based chemotherapy. Similar proportions (near 50%) of patients <70 and > 70 years completed chemotherapy. After the median follow up of 2.1 years, (Interquartile range, 1.4 to 4.4 years), 16.2% of patients had a relapse.Conclusion: A guideline-compliant lymphadenectomy and ACT were performed in the majority of patients with CC in the routine practice in a developing country. The proportion of emergency surgical interventions is high. High proportion of older patients received ACT, and its completion rate in this subgroup is similar to younger patients.
Fil: Straminsky, Samanta. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
Fil: Itkin, Boris. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
Fil: De Ronato, Gabriela. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
Fil: Bibbó, Florencia. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
Fil: Lewi, Daniel. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
Fil: García, Gabriela. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
Fil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Materia
NON-METASTATIC COLON CANCER
ADJUVANT CHEMOTHERAPY
ELDERLY PATIENTS
REAL-WORLD EVIDENCE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/96639
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/96639
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Real World Evidence: Treatment of Patients with Non- Metastatic Colon Cancer in a Community Hospital in Argentina: A Retrospective Cohort StudyStraminsky, SamantaItkin, BorisDe Ronato, GabrielaBibbó, FlorenciaLewi, DanielGarcía, GabrielaBardach, Ariel EstebanNON-METASTATIC COLON CANCERADJUVANT CHEMOTHERAPYELDERLY PATIENTSREAL-WORLD EVIDENCEhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Background: The addition of adjuvant chemotherapy (ACT) to the surgical treatment of locally advanced colon cancer (CC) was shown to reduce relapses in stage III disease, although it remains controversial in stage II. However, an underutilization of ACT in stage III patients was reported. Data on use of ACT in stage II and in older patients in the ?real world? in developing countries are limited. We aimed to describe management and outcome of non-metastatic colon cancer patients in a community hospital in Argentina.Methods: We retrospectively reviewed clinical charts of 99 patients with non-metastatic CC admitted in our Department between 2007 and 2016 extracting data on surgical treatment and chemotherapy use.Results: Emergency surgery was performed in 36.2% of cases. Near 72% of patients had 12 or more lymph nodes examined. Adjuvant chemotherapy was delivered to 93.1% of patients with stage III, to 38.1% of patients with stage II disease, and to 94.1% of stage III patients older than 70 years. Ninety six percent of patients with stage III disease received oxaliplatin-based chemotherapy. Similar proportions (near 50%) of patients <70 and > 70 years completed chemotherapy. After the median follow up of 2.1 years, (Interquartile range, 1.4 to 4.4 years), 16.2% of patients had a relapse.Conclusion: A guideline-compliant lymphadenectomy and ACT were performed in the majority of patients with CC in the routine practice in a developing country. The proportion of emergency surgical interventions is high. High proportion of older patients received ACT, and its completion rate in this subgroup is similar to younger patients.Fil: Straminsky, Samanta. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; ArgentinaFil: Itkin, Boris. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; ArgentinaFil: De Ronato, Gabriela. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; ArgentinaFil: Bibbó, Florencia. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; ArgentinaFil: Lewi, Daniel. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; ArgentinaFil: García, Gabriela. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; ArgentinaFil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; ArgentinaMedwin Publishers2018-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/96639Straminsky, Samanta; Itkin, Boris; De Ronato, Gabriela; Bibbó, Florencia; Lewi, Daniel; et al.; Real World Evidence: Treatment of Patients with Non- Metastatic Colon Cancer in a Community Hospital in Argentina: A Retrospective Cohort Study; Medwin Publishers; Open Access Journal of Cancer & Oncology; 2; 4; 11-2018; 134-1372578-4625CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://medwinpublishers.com/OAJCO/OAJCO16000134.pdfinfo:eu-repo/semantics/altIdentifier/doi/10.23880/oajco-16000134info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:56:43Zoai:ri.conicet.gov.ar:11336/96639instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:56:43.417CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Real World Evidence: Treatment of Patients with Non- Metastatic Colon Cancer in a Community Hospital in Argentina: A Retrospective Cohort Study
title Real World Evidence: Treatment of Patients with Non- Metastatic Colon Cancer in a Community Hospital in Argentina: A Retrospective Cohort Study
spellingShingle Real World Evidence: Treatment of Patients with Non- Metastatic Colon Cancer in a Community Hospital in Argentina: A Retrospective Cohort Study
Straminsky, Samanta
NON-METASTATIC COLON CANCER
ADJUVANT CHEMOTHERAPY
ELDERLY PATIENTS
REAL-WORLD EVIDENCE
title_short Real World Evidence: Treatment of Patients with Non- Metastatic Colon Cancer in a Community Hospital in Argentina: A Retrospective Cohort Study
title_full Real World Evidence: Treatment of Patients with Non- Metastatic Colon Cancer in a Community Hospital in Argentina: A Retrospective Cohort Study
title_fullStr Real World Evidence: Treatment of Patients with Non- Metastatic Colon Cancer in a Community Hospital in Argentina: A Retrospective Cohort Study
title_full_unstemmed Real World Evidence: Treatment of Patients with Non- Metastatic Colon Cancer in a Community Hospital in Argentina: A Retrospective Cohort Study
title_sort Real World Evidence: Treatment of Patients with Non- Metastatic Colon Cancer in a Community Hospital in Argentina: A Retrospective Cohort Study
dc.creator.none.fl_str_mv Straminsky, Samanta
Itkin, Boris
De Ronato, Gabriela
Bibbó, Florencia
Lewi, Daniel
García, Gabriela
Bardach, Ariel Esteban
author Straminsky, Samanta
author_facet Straminsky, Samanta
Itkin, Boris
De Ronato, Gabriela
Bibbó, Florencia
Lewi, Daniel
García, Gabriela
Bardach, Ariel Esteban
author_role author
author2 Itkin, Boris
De Ronato, Gabriela
Bibbó, Florencia
Lewi, Daniel
García, Gabriela
Bardach, Ariel Esteban
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv NON-METASTATIC COLON CANCER
ADJUVANT CHEMOTHERAPY
ELDERLY PATIENTS
REAL-WORLD EVIDENCE
topic NON-METASTATIC COLON CANCER
ADJUVANT CHEMOTHERAPY
ELDERLY PATIENTS
REAL-WORLD EVIDENCE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: The addition of adjuvant chemotherapy (ACT) to the surgical treatment of locally advanced colon cancer (CC) was shown to reduce relapses in stage III disease, although it remains controversial in stage II. However, an underutilization of ACT in stage III patients was reported. Data on use of ACT in stage II and in older patients in the ?real world? in developing countries are limited. We aimed to describe management and outcome of non-metastatic colon cancer patients in a community hospital in Argentina.Methods: We retrospectively reviewed clinical charts of 99 patients with non-metastatic CC admitted in our Department between 2007 and 2016 extracting data on surgical treatment and chemotherapy use.Results: Emergency surgery was performed in 36.2% of cases. Near 72% of patients had 12 or more lymph nodes examined. Adjuvant chemotherapy was delivered to 93.1% of patients with stage III, to 38.1% of patients with stage II disease, and to 94.1% of stage III patients older than 70 years. Ninety six percent of patients with stage III disease received oxaliplatin-based chemotherapy. Similar proportions (near 50%) of patients <70 and > 70 years completed chemotherapy. After the median follow up of 2.1 years, (Interquartile range, 1.4 to 4.4 years), 16.2% of patients had a relapse.Conclusion: A guideline-compliant lymphadenectomy and ACT were performed in the majority of patients with CC in the routine practice in a developing country. The proportion of emergency surgical interventions is high. High proportion of older patients received ACT, and its completion rate in this subgroup is similar to younger patients.
Fil: Straminsky, Samanta. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
Fil: Itkin, Boris. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
Fil: De Ronato, Gabriela. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
Fil: Bibbó, Florencia. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
Fil: Lewi, Daniel. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
Fil: García, Gabriela. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
Fil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
description Background: The addition of adjuvant chemotherapy (ACT) to the surgical treatment of locally advanced colon cancer (CC) was shown to reduce relapses in stage III disease, although it remains controversial in stage II. However, an underutilization of ACT in stage III patients was reported. Data on use of ACT in stage II and in older patients in the ?real world? in developing countries are limited. We aimed to describe management and outcome of non-metastatic colon cancer patients in a community hospital in Argentina.Methods: We retrospectively reviewed clinical charts of 99 patients with non-metastatic CC admitted in our Department between 2007 and 2016 extracting data on surgical treatment and chemotherapy use.Results: Emergency surgery was performed in 36.2% of cases. Near 72% of patients had 12 or more lymph nodes examined. Adjuvant chemotherapy was delivered to 93.1% of patients with stage III, to 38.1% of patients with stage II disease, and to 94.1% of stage III patients older than 70 years. Ninety six percent of patients with stage III disease received oxaliplatin-based chemotherapy. Similar proportions (near 50%) of patients <70 and > 70 years completed chemotherapy. After the median follow up of 2.1 years, (Interquartile range, 1.4 to 4.4 years), 16.2% of patients had a relapse.Conclusion: A guideline-compliant lymphadenectomy and ACT were performed in the majority of patients with CC in the routine practice in a developing country. The proportion of emergency surgical interventions is high. High proportion of older patients received ACT, and its completion rate in this subgroup is similar to younger patients.
publishDate 2018
dc.date.none.fl_str_mv 2018-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/96639
Straminsky, Samanta; Itkin, Boris; De Ronato, Gabriela; Bibbó, Florencia; Lewi, Daniel; et al.; Real World Evidence: Treatment of Patients with Non- Metastatic Colon Cancer in a Community Hospital in Argentina: A Retrospective Cohort Study; Medwin Publishers; Open Access Journal of Cancer & Oncology; 2; 4; 11-2018; 134-137
2578-4625
CONICET Digital
CONICET
url http://hdl.handle.net/11336/96639
identifier_str_mv Straminsky, Samanta; Itkin, Boris; De Ronato, Gabriela; Bibbó, Florencia; Lewi, Daniel; et al.; Real World Evidence: Treatment of Patients with Non- Metastatic Colon Cancer in a Community Hospital in Argentina: A Retrospective Cohort Study; Medwin Publishers; Open Access Journal of Cancer & Oncology; 2; 4; 11-2018; 134-137
2578-4625
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://medwinpublishers.com/OAJCO/OAJCO16000134.pdf
info:eu-repo/semantics/altIdentifier/doi/10.23880/oajco-16000134
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Medwin Publishers
publisher.none.fl_str_mv Medwin Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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