High TSH and low T4 as prognostic markers in older patients
- Autores
- Mingote, Evelin; Meroño, Tomás; Rujelman, Rocío; Marquez, Alejandra; Fossati, Pia; Gurfinkiel, Mirta; Schnitman, Marta; Brites, Fernando Daniel; Faingold, Cristina; Brenta, Gabriela
- Año de publicación
- 2012
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- OBJECTIVE: To examine the association between thyroid profile and morbidity/mortality (MM) in hospitalized older patients. DESIGN: This is a retrospective study of patients over the age of 60yr admitted to the Dr. Cesar Milstein Hospital between 2009 and 2010 and who had thyroid function tests (TFT). The patients were grouped as per their thyroid tests and their clinical characteristics and MM was associated with their TFT. High MM was defined as mortality, intensive care unit (ICU) requirement or prolonged hospital stay (>18 days, 75thpercentile), and mortality assessed during an 18-month follow-up period after their hospital discharge. RESULTS: Out of 2599 older patients admitted to our hospital, 7% had TFT performed for various reasons. The patients who had TFT were mostly women and presented in a more serious clinical condition compared to the rest of the patients. The patients were grouped as per their thyroid values as follows: 61% of them had a non-thyroidal illness, 25% were euthyroid, 7% had overt hyperthyroidism, 5% overt hypothyroidism and 1% had subclinical hyper- or hypothyroidism. The hypothyroid patients had a worse clinical outcome compared to the others. Patients with increased MM exhibited higher TSH and lower TT4 (p<0.005). Short-term MM (OR=2.0,95%CI=1.1-3.6, p<0.01) was associated with the decrease of TT4 adjusted by age, sex, T3 and TSH, while for long-term MM the increase in TSH (OR=1.6,95%CI 1.1-2.3, p<0.05) was also significant. CONCLUSION: Among hospitalized older patients who had TFT tests, low TT4 and high TSH were associated with a worse prognosis. We propose that TFT be used as an additional tool in assessing MM in elderly hospitalized patients.
Fil: Mingote, Evelin. Hospital "Dr. César Milstein"; Argentina
Fil: Meroño, Tomás. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rujelman, Rocío. Hospital "Dr. César Milstein"; Argentina
Fil: Marquez, Alejandra. Hospital "Dr. César Milstein"; Argentina
Fil: Fossati, Pia. Hospital "Dr. César Milstein"; Argentina
Fil: Gurfinkiel, Mirta. Hospital "Dr. César Milstein"; Argentina
Fil: Schnitman, Marta. Hospital "Dr. César Milstein"; Argentina
Fil: Brites, Fernando Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Faingold, Cristina. Hospital "Dr. César Milstein"; Argentina
Fil: Brenta, Gabriela. Hospital "Dr. César Milstein"; Argentina - Materia
-
Elderly patients
Hypothyroidism
Hospitalization
Non-thyroidal illness
Thyroid hormones - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/12867
Ver los metadatos del registro completo
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High TSH and low T4 as prognostic markers in older patientsMingote, EvelinMeroño, TomásRujelman, RocíoMarquez, AlejandraFossati, PiaGurfinkiel, MirtaSchnitman, MartaBrites, Fernando DanielFaingold, CristinaBrenta, GabrielaElderly patientsHypothyroidismHospitalizationNon-thyroidal illnessThyroid hormoneshttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3OBJECTIVE: To examine the association between thyroid profile and morbidity/mortality (MM) in hospitalized older patients. DESIGN: This is a retrospective study of patients over the age of 60yr admitted to the Dr. Cesar Milstein Hospital between 2009 and 2010 and who had thyroid function tests (TFT). The patients were grouped as per their thyroid tests and their clinical characteristics and MM was associated with their TFT. High MM was defined as mortality, intensive care unit (ICU) requirement or prolonged hospital stay (>18 days, 75thpercentile), and mortality assessed during an 18-month follow-up period after their hospital discharge. RESULTS: Out of 2599 older patients admitted to our hospital, 7% had TFT performed for various reasons. The patients who had TFT were mostly women and presented in a more serious clinical condition compared to the rest of the patients. The patients were grouped as per their thyroid values as follows: 61% of them had a non-thyroidal illness, 25% were euthyroid, 7% had overt hyperthyroidism, 5% overt hypothyroidism and 1% had subclinical hyper- or hypothyroidism. The hypothyroid patients had a worse clinical outcome compared to the others. Patients with increased MM exhibited higher TSH and lower TT4 (p<0.005). Short-term MM (OR=2.0,95%CI=1.1-3.6, p<0.01) was associated with the decrease of TT4 adjusted by age, sex, T3 and TSH, while for long-term MM the increase in TSH (OR=1.6,95%CI 1.1-2.3, p<0.05) was also significant. CONCLUSION: Among hospitalized older patients who had TFT tests, low TT4 and high TSH were associated with a worse prognosis. We propose that TFT be used as an additional tool in assessing MM in elderly hospitalized patients.Fil: Mingote, Evelin. Hospital "Dr. César Milstein"; ArgentinaFil: Meroño, Tomás. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Rujelman, Rocío. Hospital "Dr. César Milstein"; ArgentinaFil: Marquez, Alejandra. Hospital "Dr. César Milstein"; ArgentinaFil: Fossati, Pia. Hospital "Dr. César Milstein"; ArgentinaFil: Gurfinkiel, Mirta. Hospital "Dr. César Milstein"; ArgentinaFil: Schnitman, Marta. Hospital "Dr. César Milstein"; ArgentinaFil: Brites, Fernando Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Faingold, Cristina. Hospital "Dr. César Milstein"; ArgentinaFil: Brenta, Gabriela. Hospital "Dr. César Milstein"; ArgentinaHellenic Endocrine Society2012-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/12867Mingote, Evelin; Meroño, Tomás; Rujelman, Rocío; Marquez, Alejandra; Fossati, Pia; et al.; High TSH and low T4 as prognostic markers in older patients; Hellenic Endocrine Society; Hormone; 11; 3; 7-2012; 350-3551109-3099enginfo:eu-repo/semantics/altIdentifier/url/http://www.hormones.gr/814/article/article.htmlinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:39:15Zoai:ri.conicet.gov.ar:11336/12867instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:39:15.79CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
High TSH and low T4 as prognostic markers in older patients |
title |
High TSH and low T4 as prognostic markers in older patients |
spellingShingle |
High TSH and low T4 as prognostic markers in older patients Mingote, Evelin Elderly patients Hypothyroidism Hospitalization Non-thyroidal illness Thyroid hormones |
title_short |
High TSH and low T4 as prognostic markers in older patients |
title_full |
High TSH and low T4 as prognostic markers in older patients |
title_fullStr |
High TSH and low T4 as prognostic markers in older patients |
title_full_unstemmed |
High TSH and low T4 as prognostic markers in older patients |
title_sort |
High TSH and low T4 as prognostic markers in older patients |
dc.creator.none.fl_str_mv |
Mingote, Evelin Meroño, Tomás Rujelman, Rocío Marquez, Alejandra Fossati, Pia Gurfinkiel, Mirta Schnitman, Marta Brites, Fernando Daniel Faingold, Cristina Brenta, Gabriela |
author |
Mingote, Evelin |
author_facet |
Mingote, Evelin Meroño, Tomás Rujelman, Rocío Marquez, Alejandra Fossati, Pia Gurfinkiel, Mirta Schnitman, Marta Brites, Fernando Daniel Faingold, Cristina Brenta, Gabriela |
author_role |
author |
author2 |
Meroño, Tomás Rujelman, Rocío Marquez, Alejandra Fossati, Pia Gurfinkiel, Mirta Schnitman, Marta Brites, Fernando Daniel Faingold, Cristina Brenta, Gabriela |
author2_role |
author author author author author author author author author |
dc.subject.none.fl_str_mv |
Elderly patients Hypothyroidism Hospitalization Non-thyroidal illness Thyroid hormones |
topic |
Elderly patients Hypothyroidism Hospitalization Non-thyroidal illness Thyroid hormones |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
OBJECTIVE: To examine the association between thyroid profile and morbidity/mortality (MM) in hospitalized older patients. DESIGN: This is a retrospective study of patients over the age of 60yr admitted to the Dr. Cesar Milstein Hospital between 2009 and 2010 and who had thyroid function tests (TFT). The patients were grouped as per their thyroid tests and their clinical characteristics and MM was associated with their TFT. High MM was defined as mortality, intensive care unit (ICU) requirement or prolonged hospital stay (>18 days, 75thpercentile), and mortality assessed during an 18-month follow-up period after their hospital discharge. RESULTS: Out of 2599 older patients admitted to our hospital, 7% had TFT performed for various reasons. The patients who had TFT were mostly women and presented in a more serious clinical condition compared to the rest of the patients. The patients were grouped as per their thyroid values as follows: 61% of them had a non-thyroidal illness, 25% were euthyroid, 7% had overt hyperthyroidism, 5% overt hypothyroidism and 1% had subclinical hyper- or hypothyroidism. The hypothyroid patients had a worse clinical outcome compared to the others. Patients with increased MM exhibited higher TSH and lower TT4 (p<0.005). Short-term MM (OR=2.0,95%CI=1.1-3.6, p<0.01) was associated with the decrease of TT4 adjusted by age, sex, T3 and TSH, while for long-term MM the increase in TSH (OR=1.6,95%CI 1.1-2.3, p<0.05) was also significant. CONCLUSION: Among hospitalized older patients who had TFT tests, low TT4 and high TSH were associated with a worse prognosis. We propose that TFT be used as an additional tool in assessing MM in elderly hospitalized patients. Fil: Mingote, Evelin. Hospital "Dr. César Milstein"; Argentina Fil: Meroño, Tomás. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Rujelman, Rocío. Hospital "Dr. César Milstein"; Argentina Fil: Marquez, Alejandra. Hospital "Dr. César Milstein"; Argentina Fil: Fossati, Pia. Hospital "Dr. César Milstein"; Argentina Fil: Gurfinkiel, Mirta. Hospital "Dr. César Milstein"; Argentina Fil: Schnitman, Marta. Hospital "Dr. César Milstein"; Argentina Fil: Brites, Fernando Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Faingold, Cristina. Hospital "Dr. César Milstein"; Argentina Fil: Brenta, Gabriela. Hospital "Dr. César Milstein"; Argentina |
description |
OBJECTIVE: To examine the association between thyroid profile and morbidity/mortality (MM) in hospitalized older patients. DESIGN: This is a retrospective study of patients over the age of 60yr admitted to the Dr. Cesar Milstein Hospital between 2009 and 2010 and who had thyroid function tests (TFT). The patients were grouped as per their thyroid tests and their clinical characteristics and MM was associated with their TFT. High MM was defined as mortality, intensive care unit (ICU) requirement or prolonged hospital stay (>18 days, 75thpercentile), and mortality assessed during an 18-month follow-up period after their hospital discharge. RESULTS: Out of 2599 older patients admitted to our hospital, 7% had TFT performed for various reasons. The patients who had TFT were mostly women and presented in a more serious clinical condition compared to the rest of the patients. The patients were grouped as per their thyroid values as follows: 61% of them had a non-thyroidal illness, 25% were euthyroid, 7% had overt hyperthyroidism, 5% overt hypothyroidism and 1% had subclinical hyper- or hypothyroidism. The hypothyroid patients had a worse clinical outcome compared to the others. Patients with increased MM exhibited higher TSH and lower TT4 (p<0.005). Short-term MM (OR=2.0,95%CI=1.1-3.6, p<0.01) was associated with the decrease of TT4 adjusted by age, sex, T3 and TSH, while for long-term MM the increase in TSH (OR=1.6,95%CI 1.1-2.3, p<0.05) was also significant. CONCLUSION: Among hospitalized older patients who had TFT tests, low TT4 and high TSH were associated with a worse prognosis. We propose that TFT be used as an additional tool in assessing MM in elderly hospitalized patients. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-07 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/12867 Mingote, Evelin; Meroño, Tomás; Rujelman, Rocío; Marquez, Alejandra; Fossati, Pia; et al.; High TSH and low T4 as prognostic markers in older patients; Hellenic Endocrine Society; Hormone; 11; 3; 7-2012; 350-355 1109-3099 |
url |
http://hdl.handle.net/11336/12867 |
identifier_str_mv |
Mingote, Evelin; Meroño, Tomás; Rujelman, Rocío; Marquez, Alejandra; Fossati, Pia; et al.; High TSH and low T4 as prognostic markers in older patients; Hellenic Endocrine Society; Hormone; 11; 3; 7-2012; 350-355 1109-3099 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://www.hormones.gr/814/article/article.html |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Hellenic Endocrine Society |
publisher.none.fl_str_mv |
Hellenic Endocrine Society |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614417354850304 |
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13.070432 |