Metastatic deaths in retinoblastoma patients treated with intraarterial chemotherapy (ophthalmic artery chemosurgery) worldwide

Autores
Abramson, David H.; Shields, Carol L.; Jabbour, Pascal; Teixeira, Luiz Fernando; Falco Fonseca, José Roberto; Marques, Marcio Chaves Pedro; Munier, Francis L.; Puccinelli, Francesco; Hadjistilianou, Theodora; Bracco, Sandra; Chantada, Guillermo Luis; Ceciliano, Alejandro; Gobin, Y. Pierre
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Ophthalmic artery chemosurgery [OAC, intra-arterial chemotherapy (IAC)] was introduced in 2006 as treatment modality for intraocular retinoblastoma. The purpose of this commentary is to retrospectively review the incidence of metastatic deaths in retinoblastoma patients treated with OAC worldwide over a 10 year period. Retrospective data regarding metastatic deaths was collected from six international retinoblastoma centers (New York City USA, Philadelphia USA, Sao Paulo Brazil, Siena Italy, Lausanne Switzerland and Buenos Aires Argentina). All retinoblastoma patients from these centers (naive and recurrent, unilateral and bilateral) treated with OAC/IAC since 2006 have been included in this study. Data regarding number of patients, number of OAC/IAC infusions, number unilateral and bilateral, number treated for naive disease or salvage and number of metastatic deaths have been assessed. Over a 10-year period of time 1139 patients received OAC/IAC for 4396 infusions. At last follow-up there were only three metastatic deaths (all treated in Buenos Aires). Conclusion: The current survey assessed the recorded risk of metastatic deaths in six retinoblastoma centers worldwide in children with retinoblastoma (unilateral or bilateral) treated with OAC/IAC as primary or secondary therapy. Overall, the observed risk for metastatic deaths from retinoblastoma was < 1% in OAC/IAC treated children.
Fil: Abramson, David H.. Weill Graduate School Of Medical Sciences; Estados Unidos. Memorial Sloan-kettering Cancer Center; Estados Unidos
Fil: Shields, Carol L.. Thomas Jefferson University; Estados Unidos
Fil: Jabbour, Pascal. Thomas Jefferson University; Estados Unidos
Fil: Teixeira, Luiz Fernando. Universidade Federal de Sao Paulo; Brasil
Fil: Falco Fonseca, José Roberto. Universidade Federal de Sao Paulo; Brasil
Fil: Marques, Marcio Chaves Pedro. Hospital Santa Marcelina; Brasil
Fil: Munier, Francis L.. Universite de Lausanne; Suiza
Fil: Puccinelli, Francesco. Centre Hospitalier Universitatire Vaudois; Suiza
Fil: Hadjistilianou, Theodora. Università degli Studi di Siena; Italia
Fil: Bracco, Sandra. Azienda Universitaria Ospedaliera Sense; Italia
Fil: Chantada, Guillermo Luis. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ceciliano, Alejandro. Universidad Austral. Hospital Universitario Austral; Argentina
Fil: Gobin, Y. Pierre. New York Presbyterian Hospital; Estados Unidos
Materia
INTRA-ARTERIAL (INTRARTERIAL) CHEMOTHERAPY (IAC)
MELPHALAN
METASTATIC DEATH
OPHTHALMIC ARTERY CHEMOSURGERY (OAC)
RETINOBLASTOMA (RB)
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/177592
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/177592
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Metastatic deaths in retinoblastoma patients treated with intraarterial chemotherapy (ophthalmic artery chemosurgery) worldwideAbramson, David H.Shields, Carol L.Jabbour, PascalTeixeira, Luiz FernandoFalco Fonseca, José RobertoMarques, Marcio Chaves PedroMunier, Francis L.Puccinelli, FrancescoHadjistilianou, TheodoraBracco, SandraChantada, Guillermo LuisCeciliano, AlejandroGobin, Y. PierreINTRA-ARTERIAL (INTRARTERIAL) CHEMOTHERAPY (IAC)MELPHALANMETASTATIC DEATHOPHTHALMIC ARTERY CHEMOSURGERY (OAC)RETINOBLASTOMA (RB)https://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Background: Ophthalmic artery chemosurgery [OAC, intra-arterial chemotherapy (IAC)] was introduced in 2006 as treatment modality for intraocular retinoblastoma. The purpose of this commentary is to retrospectively review the incidence of metastatic deaths in retinoblastoma patients treated with OAC worldwide over a 10 year period. Retrospective data regarding metastatic deaths was collected from six international retinoblastoma centers (New York City USA, Philadelphia USA, Sao Paulo Brazil, Siena Italy, Lausanne Switzerland and Buenos Aires Argentina). All retinoblastoma patients from these centers (naive and recurrent, unilateral and bilateral) treated with OAC/IAC since 2006 have been included in this study. Data regarding number of patients, number of OAC/IAC infusions, number unilateral and bilateral, number treated for naive disease or salvage and number of metastatic deaths have been assessed. Over a 10-year period of time 1139 patients received OAC/IAC for 4396 infusions. At last follow-up there were only three metastatic deaths (all treated in Buenos Aires). Conclusion: The current survey assessed the recorded risk of metastatic deaths in six retinoblastoma centers worldwide in children with retinoblastoma (unilateral or bilateral) treated with OAC/IAC as primary or secondary therapy. Overall, the observed risk for metastatic deaths from retinoblastoma was < 1% in OAC/IAC treated children.Fil: Abramson, David H.. Weill Graduate School Of Medical Sciences; Estados Unidos. Memorial Sloan-kettering Cancer Center; Estados UnidosFil: Shields, Carol L.. Thomas Jefferson University; Estados UnidosFil: Jabbour, Pascal. Thomas Jefferson University; Estados UnidosFil: Teixeira, Luiz Fernando. Universidade Federal de Sao Paulo; BrasilFil: Falco Fonseca, José Roberto. Universidade Federal de Sao Paulo; BrasilFil: Marques, Marcio Chaves Pedro. Hospital Santa Marcelina; BrasilFil: Munier, Francis L.. Universite de Lausanne; SuizaFil: Puccinelli, Francesco. Centre Hospitalier Universitatire Vaudois; SuizaFil: Hadjistilianou, Theodora. Università degli Studi di Siena; ItaliaFil: Bracco, Sandra. Azienda Universitaria Ospedaliera Sense; ItaliaFil: Chantada, Guillermo Luis. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ceciliano, Alejandro. Universidad Austral. Hospital Universitario Austral; ArgentinaFil: Gobin, Y. Pierre. New York Presbyterian Hospital; Estados UnidosBioMed Central2018-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/177592Abramson, David H.; Shields, Carol L.; Jabbour, Pascal; Teixeira, Luiz Fernando; Falco Fonseca, José Roberto; et al.; Metastatic deaths in retinoblastoma patients treated with intraarterial chemotherapy (ophthalmic artery chemosurgery) worldwide; BioMed Central; International Journal of Retina and Vitreous; 3; 1; 10-2018; 1-42056-9920CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1186/s40942-017-0093-8info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:56:54Zoai:ri.conicet.gov.ar:11336/177592instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:56:54.674CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Metastatic deaths in retinoblastoma patients treated with intraarterial chemotherapy (ophthalmic artery chemosurgery) worldwide
title Metastatic deaths in retinoblastoma patients treated with intraarterial chemotherapy (ophthalmic artery chemosurgery) worldwide
spellingShingle Metastatic deaths in retinoblastoma patients treated with intraarterial chemotherapy (ophthalmic artery chemosurgery) worldwide
Abramson, David H.
INTRA-ARTERIAL (INTRARTERIAL) CHEMOTHERAPY (IAC)
MELPHALAN
METASTATIC DEATH
OPHTHALMIC ARTERY CHEMOSURGERY (OAC)
RETINOBLASTOMA (RB)
title_short Metastatic deaths in retinoblastoma patients treated with intraarterial chemotherapy (ophthalmic artery chemosurgery) worldwide
title_full Metastatic deaths in retinoblastoma patients treated with intraarterial chemotherapy (ophthalmic artery chemosurgery) worldwide
title_fullStr Metastatic deaths in retinoblastoma patients treated with intraarterial chemotherapy (ophthalmic artery chemosurgery) worldwide
title_full_unstemmed Metastatic deaths in retinoblastoma patients treated with intraarterial chemotherapy (ophthalmic artery chemosurgery) worldwide
title_sort Metastatic deaths in retinoblastoma patients treated with intraarterial chemotherapy (ophthalmic artery chemosurgery) worldwide
dc.creator.none.fl_str_mv Abramson, David H.
Shields, Carol L.
Jabbour, Pascal
Teixeira, Luiz Fernando
Falco Fonseca, José Roberto
Marques, Marcio Chaves Pedro
Munier, Francis L.
Puccinelli, Francesco
Hadjistilianou, Theodora
Bracco, Sandra
Chantada, Guillermo Luis
Ceciliano, Alejandro
Gobin, Y. Pierre
author Abramson, David H.
author_facet Abramson, David H.
Shields, Carol L.
Jabbour, Pascal
Teixeira, Luiz Fernando
Falco Fonseca, José Roberto
Marques, Marcio Chaves Pedro
Munier, Francis L.
Puccinelli, Francesco
Hadjistilianou, Theodora
Bracco, Sandra
Chantada, Guillermo Luis
Ceciliano, Alejandro
Gobin, Y. Pierre
author_role author
author2 Shields, Carol L.
Jabbour, Pascal
Teixeira, Luiz Fernando
Falco Fonseca, José Roberto
Marques, Marcio Chaves Pedro
Munier, Francis L.
Puccinelli, Francesco
Hadjistilianou, Theodora
Bracco, Sandra
Chantada, Guillermo Luis
Ceciliano, Alejandro
Gobin, Y. Pierre
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv INTRA-ARTERIAL (INTRARTERIAL) CHEMOTHERAPY (IAC)
MELPHALAN
METASTATIC DEATH
OPHTHALMIC ARTERY CHEMOSURGERY (OAC)
RETINOBLASTOMA (RB)
topic INTRA-ARTERIAL (INTRARTERIAL) CHEMOTHERAPY (IAC)
MELPHALAN
METASTATIC DEATH
OPHTHALMIC ARTERY CHEMOSURGERY (OAC)
RETINOBLASTOMA (RB)
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: Ophthalmic artery chemosurgery [OAC, intra-arterial chemotherapy (IAC)] was introduced in 2006 as treatment modality for intraocular retinoblastoma. The purpose of this commentary is to retrospectively review the incidence of metastatic deaths in retinoblastoma patients treated with OAC worldwide over a 10 year period. Retrospective data regarding metastatic deaths was collected from six international retinoblastoma centers (New York City USA, Philadelphia USA, Sao Paulo Brazil, Siena Italy, Lausanne Switzerland and Buenos Aires Argentina). All retinoblastoma patients from these centers (naive and recurrent, unilateral and bilateral) treated with OAC/IAC since 2006 have been included in this study. Data regarding number of patients, number of OAC/IAC infusions, number unilateral and bilateral, number treated for naive disease or salvage and number of metastatic deaths have been assessed. Over a 10-year period of time 1139 patients received OAC/IAC for 4396 infusions. At last follow-up there were only three metastatic deaths (all treated in Buenos Aires). Conclusion: The current survey assessed the recorded risk of metastatic deaths in six retinoblastoma centers worldwide in children with retinoblastoma (unilateral or bilateral) treated with OAC/IAC as primary or secondary therapy. Overall, the observed risk for metastatic deaths from retinoblastoma was < 1% in OAC/IAC treated children.
Fil: Abramson, David H.. Weill Graduate School Of Medical Sciences; Estados Unidos. Memorial Sloan-kettering Cancer Center; Estados Unidos
Fil: Shields, Carol L.. Thomas Jefferson University; Estados Unidos
Fil: Jabbour, Pascal. Thomas Jefferson University; Estados Unidos
Fil: Teixeira, Luiz Fernando. Universidade Federal de Sao Paulo; Brasil
Fil: Falco Fonseca, José Roberto. Universidade Federal de Sao Paulo; Brasil
Fil: Marques, Marcio Chaves Pedro. Hospital Santa Marcelina; Brasil
Fil: Munier, Francis L.. Universite de Lausanne; Suiza
Fil: Puccinelli, Francesco. Centre Hospitalier Universitatire Vaudois; Suiza
Fil: Hadjistilianou, Theodora. Università degli Studi di Siena; Italia
Fil: Bracco, Sandra. Azienda Universitaria Ospedaliera Sense; Italia
Fil: Chantada, Guillermo Luis. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ceciliano, Alejandro. Universidad Austral. Hospital Universitario Austral; Argentina
Fil: Gobin, Y. Pierre. New York Presbyterian Hospital; Estados Unidos
description Background: Ophthalmic artery chemosurgery [OAC, intra-arterial chemotherapy (IAC)] was introduced in 2006 as treatment modality for intraocular retinoblastoma. The purpose of this commentary is to retrospectively review the incidence of metastatic deaths in retinoblastoma patients treated with OAC worldwide over a 10 year period. Retrospective data regarding metastatic deaths was collected from six international retinoblastoma centers (New York City USA, Philadelphia USA, Sao Paulo Brazil, Siena Italy, Lausanne Switzerland and Buenos Aires Argentina). All retinoblastoma patients from these centers (naive and recurrent, unilateral and bilateral) treated with OAC/IAC since 2006 have been included in this study. Data regarding number of patients, number of OAC/IAC infusions, number unilateral and bilateral, number treated for naive disease or salvage and number of metastatic deaths have been assessed. Over a 10-year period of time 1139 patients received OAC/IAC for 4396 infusions. At last follow-up there were only three metastatic deaths (all treated in Buenos Aires). Conclusion: The current survey assessed the recorded risk of metastatic deaths in six retinoblastoma centers worldwide in children with retinoblastoma (unilateral or bilateral) treated with OAC/IAC as primary or secondary therapy. Overall, the observed risk for metastatic deaths from retinoblastoma was < 1% in OAC/IAC treated children.
publishDate 2018
dc.date.none.fl_str_mv 2018-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/177592
Abramson, David H.; Shields, Carol L.; Jabbour, Pascal; Teixeira, Luiz Fernando; Falco Fonseca, José Roberto; et al.; Metastatic deaths in retinoblastoma patients treated with intraarterial chemotherapy (ophthalmic artery chemosurgery) worldwide; BioMed Central; International Journal of Retina and Vitreous; 3; 1; 10-2018; 1-4
2056-9920
CONICET Digital
CONICET
url http://hdl.handle.net/11336/177592
identifier_str_mv Abramson, David H.; Shields, Carol L.; Jabbour, Pascal; Teixeira, Luiz Fernando; Falco Fonseca, José Roberto; et al.; Metastatic deaths in retinoblastoma patients treated with intraarterial chemotherapy (ophthalmic artery chemosurgery) worldwide; BioMed Central; International Journal of Retina and Vitreous; 3; 1; 10-2018; 1-4
2056-9920
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1186/s40942-017-0093-8
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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