Antimicrobial Resistance of Uropathogenic Escherichia coli from Elderly Patients at a General Hospital, Argentina

Autores
Delpech, Gastón; Garcia Allende, Natalia; Lissarrague, Sabina; Sparo, Mónica Delfina
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background:Urinary Tract Infection (UTI) is a common cause of morbidity and mortality in older adults.Objective:To investigate antimicrobial resistance of uropathogenic Escherichia coli from elderly patients in a General Hospital, Argentina.Method:During the period July 2011-July 2015, patients over 70 years old with urinary tract infections, without urinary catheters and with noantimicrobial therapy the previous week before sampling, were included. Phenotypic characterization was carried out. In vitroqualitative and quantitative antimicrobial resistances were investigated. Antimicrobials assayed: ampicillin, amoxicillin-clavulanate,cefazolin, cefuroxime, cefoxitin, cefotaxime, ceftazidime, cefepime, imipenem, ertapenem, gentamicin, nalidixic acid, ciprofloxacin,trimethoprim-sulfamethoxazole (TMS) and nitrofurantoin. Patients? medical records were produced, and risk factors were analyzedby multivariate analysis.Results:768 bacterial isolates were identified as E. coli. Resistances to ampicillin (80.5%), nalidixic acid (61.7%), ciprofloxacin (42.8%),TMS (37.6%), amoxicillin-clavulanate (28.6%), cefazolin (21.6%), cefuroxime (20.7%), gentamicin (13.8%), cefotaxime (9.7%),ceftazidime (9.7%), cefepime (8.4%), cefoxitin (3.1%) and nitrofurantoin (2.3%) were observed. Resistance to carbapenems was notexpressed. Production of extended spectrum β-lactamases was detected (7.6%) in community acquired (96%) and healthcareassociated (4%) isolates. The independent risk factors for urinary infections produced by multi-resistant E. coli were: diabetesmellitus, recurrent infections, hospitalization during the last year and exposure to β-lactams in the last 3 months. Conclusion:A high prevalence of resistance to β-lactams and to other antimicrobials was observed. Detection of antimicrobial multi-resistantisolates highlights the need of antimicrobial resistance surveillance in elderly patients with urinary tract infections.
Fil: Delpech, Gastón. Universidad Nacional del Centro de la Provincia de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Garcia Allende, Natalia. Hospital Alemán; Argentina
Fil: Lissarrague, Sabina. Hospital Ramon Santamarina de Tandil; Argentina
Fil: Sparo, Mónica Delfina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Materia
BETA LACTAMASES
ELDERLY PATIENTS
ESCHERICHIA COLI
INFECTION
RESISTANCE
URINARY TRACT
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/92653
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/92653
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Antimicrobial Resistance of Uropathogenic Escherichia coli from Elderly Patients at a General Hospital, ArgentinaDelpech, GastónGarcia Allende, NataliaLissarrague, SabinaSparo, Mónica DelfinaBETA LACTAMASESELDERLY PATIENTSESCHERICHIA COLIINFECTIONRESISTANCEURINARY TRACThttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background:Urinary Tract Infection (UTI) is a common cause of morbidity and mortality in older adults.Objective:To investigate antimicrobial resistance of uropathogenic Escherichia coli from elderly patients in a General Hospital, Argentina.Method:During the period July 2011-July 2015, patients over 70 years old with urinary tract infections, without urinary catheters and with noantimicrobial therapy the previous week before sampling, were included. Phenotypic characterization was carried out. In vitroqualitative and quantitative antimicrobial resistances were investigated. Antimicrobials assayed: ampicillin, amoxicillin-clavulanate,cefazolin, cefuroxime, cefoxitin, cefotaxime, ceftazidime, cefepime, imipenem, ertapenem, gentamicin, nalidixic acid, ciprofloxacin,trimethoprim-sulfamethoxazole (TMS) and nitrofurantoin. Patients? medical records were produced, and risk factors were analyzedby multivariate analysis.Results:768 bacterial isolates were identified as E. coli. Resistances to ampicillin (80.5%), nalidixic acid (61.7%), ciprofloxacin (42.8%),TMS (37.6%), amoxicillin-clavulanate (28.6%), cefazolin (21.6%), cefuroxime (20.7%), gentamicin (13.8%), cefotaxime (9.7%),ceftazidime (9.7%), cefepime (8.4%), cefoxitin (3.1%) and nitrofurantoin (2.3%) were observed. Resistance to carbapenems was notexpressed. Production of extended spectrum β-lactamases was detected (7.6%) in community acquired (96%) and healthcareassociated (4%) isolates. The independent risk factors for urinary infections produced by multi-resistant E. coli were: diabetesmellitus, recurrent infections, hospitalization during the last year and exposure to β-lactams in the last 3 months. Conclusion:A high prevalence of resistance to β-lactams and to other antimicrobials was observed. Detection of antimicrobial multi-resistantisolates highlights the need of antimicrobial resistance surveillance in elderly patients with urinary tract infections.Fil: Delpech, Gastón. Universidad Nacional del Centro de la Provincia de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Garcia Allende, Natalia. Hospital Alemán; ArgentinaFil: Lissarrague, Sabina. Hospital Ramon Santamarina de Tandil; ArgentinaFil: Sparo, Mónica Delfina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaBentham Open2018-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/92653Delpech, Gastón; Garcia Allende, Natalia; Lissarrague, Sabina; Sparo, Mónica Delfina; Antimicrobial Resistance of Uropathogenic Escherichia coli from Elderly Patients at a General Hospital, Argentina; Bentham Open; The Open Infectious Diseases Journal; 10; 7-2018; 79-871874-2793CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://openinfectiousdiseasesjournal.com/VOLUME/10/PAGE/79/info:eu-repo/semantics/altIdentifier/doi/10.2174/1874279301810010079info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:04:25Zoai:ri.conicet.gov.ar:11336/92653instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:04:25.645CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Antimicrobial Resistance of Uropathogenic Escherichia coli from Elderly Patients at a General Hospital, Argentina
title Antimicrobial Resistance of Uropathogenic Escherichia coli from Elderly Patients at a General Hospital, Argentina
spellingShingle Antimicrobial Resistance of Uropathogenic Escherichia coli from Elderly Patients at a General Hospital, Argentina
Delpech, Gastón
BETA LACTAMASES
ELDERLY PATIENTS
ESCHERICHIA COLI
INFECTION
RESISTANCE
URINARY TRACT
title_short Antimicrobial Resistance of Uropathogenic Escherichia coli from Elderly Patients at a General Hospital, Argentina
title_full Antimicrobial Resistance of Uropathogenic Escherichia coli from Elderly Patients at a General Hospital, Argentina
title_fullStr Antimicrobial Resistance of Uropathogenic Escherichia coli from Elderly Patients at a General Hospital, Argentina
title_full_unstemmed Antimicrobial Resistance of Uropathogenic Escherichia coli from Elderly Patients at a General Hospital, Argentina
title_sort Antimicrobial Resistance of Uropathogenic Escherichia coli from Elderly Patients at a General Hospital, Argentina
dc.creator.none.fl_str_mv Delpech, Gastón
Garcia Allende, Natalia
Lissarrague, Sabina
Sparo, Mónica Delfina
author Delpech, Gastón
author_facet Delpech, Gastón
Garcia Allende, Natalia
Lissarrague, Sabina
Sparo, Mónica Delfina
author_role author
author2 Garcia Allende, Natalia
Lissarrague, Sabina
Sparo, Mónica Delfina
author2_role author
author
author
dc.subject.none.fl_str_mv BETA LACTAMASES
ELDERLY PATIENTS
ESCHERICHIA COLI
INFECTION
RESISTANCE
URINARY TRACT
topic BETA LACTAMASES
ELDERLY PATIENTS
ESCHERICHIA COLI
INFECTION
RESISTANCE
URINARY TRACT
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background:Urinary Tract Infection (UTI) is a common cause of morbidity and mortality in older adults.Objective:To investigate antimicrobial resistance of uropathogenic Escherichia coli from elderly patients in a General Hospital, Argentina.Method:During the period July 2011-July 2015, patients over 70 years old with urinary tract infections, without urinary catheters and with noantimicrobial therapy the previous week before sampling, were included. Phenotypic characterization was carried out. In vitroqualitative and quantitative antimicrobial resistances were investigated. Antimicrobials assayed: ampicillin, amoxicillin-clavulanate,cefazolin, cefuroxime, cefoxitin, cefotaxime, ceftazidime, cefepime, imipenem, ertapenem, gentamicin, nalidixic acid, ciprofloxacin,trimethoprim-sulfamethoxazole (TMS) and nitrofurantoin. Patients? medical records were produced, and risk factors were analyzedby multivariate analysis.Results:768 bacterial isolates were identified as E. coli. Resistances to ampicillin (80.5%), nalidixic acid (61.7%), ciprofloxacin (42.8%),TMS (37.6%), amoxicillin-clavulanate (28.6%), cefazolin (21.6%), cefuroxime (20.7%), gentamicin (13.8%), cefotaxime (9.7%),ceftazidime (9.7%), cefepime (8.4%), cefoxitin (3.1%) and nitrofurantoin (2.3%) were observed. Resistance to carbapenems was notexpressed. Production of extended spectrum β-lactamases was detected (7.6%) in community acquired (96%) and healthcareassociated (4%) isolates. The independent risk factors for urinary infections produced by multi-resistant E. coli were: diabetesmellitus, recurrent infections, hospitalization during the last year and exposure to β-lactams in the last 3 months. Conclusion:A high prevalence of resistance to β-lactams and to other antimicrobials was observed. Detection of antimicrobial multi-resistantisolates highlights the need of antimicrobial resistance surveillance in elderly patients with urinary tract infections.
Fil: Delpech, Gastón. Universidad Nacional del Centro de la Provincia de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Garcia Allende, Natalia. Hospital Alemán; Argentina
Fil: Lissarrague, Sabina. Hospital Ramon Santamarina de Tandil; Argentina
Fil: Sparo, Mónica Delfina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
description Background:Urinary Tract Infection (UTI) is a common cause of morbidity and mortality in older adults.Objective:To investigate antimicrobial resistance of uropathogenic Escherichia coli from elderly patients in a General Hospital, Argentina.Method:During the period July 2011-July 2015, patients over 70 years old with urinary tract infections, without urinary catheters and with noantimicrobial therapy the previous week before sampling, were included. Phenotypic characterization was carried out. In vitroqualitative and quantitative antimicrobial resistances were investigated. Antimicrobials assayed: ampicillin, amoxicillin-clavulanate,cefazolin, cefuroxime, cefoxitin, cefotaxime, ceftazidime, cefepime, imipenem, ertapenem, gentamicin, nalidixic acid, ciprofloxacin,trimethoprim-sulfamethoxazole (TMS) and nitrofurantoin. Patients? medical records were produced, and risk factors were analyzedby multivariate analysis.Results:768 bacterial isolates were identified as E. coli. Resistances to ampicillin (80.5%), nalidixic acid (61.7%), ciprofloxacin (42.8%),TMS (37.6%), amoxicillin-clavulanate (28.6%), cefazolin (21.6%), cefuroxime (20.7%), gentamicin (13.8%), cefotaxime (9.7%),ceftazidime (9.7%), cefepime (8.4%), cefoxitin (3.1%) and nitrofurantoin (2.3%) were observed. Resistance to carbapenems was notexpressed. Production of extended spectrum β-lactamases was detected (7.6%) in community acquired (96%) and healthcareassociated (4%) isolates. The independent risk factors for urinary infections produced by multi-resistant E. coli were: diabetesmellitus, recurrent infections, hospitalization during the last year and exposure to β-lactams in the last 3 months. Conclusion:A high prevalence of resistance to β-lactams and to other antimicrobials was observed. Detection of antimicrobial multi-resistantisolates highlights the need of antimicrobial resistance surveillance in elderly patients with urinary tract infections.
publishDate 2018
dc.date.none.fl_str_mv 2018-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/92653
Delpech, Gastón; Garcia Allende, Natalia; Lissarrague, Sabina; Sparo, Mónica Delfina; Antimicrobial Resistance of Uropathogenic Escherichia coli from Elderly Patients at a General Hospital, Argentina; Bentham Open; The Open Infectious Diseases Journal; 10; 7-2018; 79-87
1874-2793
CONICET Digital
CONICET
url http://hdl.handle.net/11336/92653
identifier_str_mv Delpech, Gastón; Garcia Allende, Natalia; Lissarrague, Sabina; Sparo, Mónica Delfina; Antimicrobial Resistance of Uropathogenic Escherichia coli from Elderly Patients at a General Hospital, Argentina; Bentham Open; The Open Infectious Diseases Journal; 10; 7-2018; 79-87
1874-2793
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://openinfectiousdiseasesjournal.com/VOLUME/10/PAGE/79/
info:eu-repo/semantics/altIdentifier/doi/10.2174/1874279301810010079
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Bentham Open
publisher.none.fl_str_mv Bentham Open
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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