Signature of consciousness in the dynamics of resting-state brain activity

Autores
Barttfeld, Pablo; Uhrig, Lynn; Sitt, Jacobo Diego; Sigman, Mariano; Jarraya, Béchir; Dehaene, Stanislas
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
At rest, the brain is traversed by spontaneous functional connectivity patterns. Two hypotheses have been proposed for their origins: they may reflect a continuous stream of ongoing cognitive processes as well as random fluctuations shaped by a fixed anatomical connectivity matrix. Here we show that both sources contribute to the shaping of resting-state networks, yet with distinct contributions during consciousness and anesthesia. We measured dynamical functional connectivity with functional MRI during the resting state in awake and anesthetized monkeys. Under anesthesia, the more frequent functional connectivity patterns inherit the structure of anatomical connectivity, exhibit fewer small-world properties, and lack negative correlations. Conversely, wakefulness is characterized by the sequential exploration of a richer repertoire of functional configurations, often dissimilar to anatomical structure, and comprising positive and negative correlations among brain regions. These results reconcile theories of consciousness with observations of long-range correlation in the anesthetized brain and show that a rich functional dynamics might constitute a signature of consciousness, with potential clinical implications for the detection of awareness in anesthesia and brain-lesioned patients.
Fil: Barttfeld, Pablo. Commissariat A Energie Atomique; Francia. Institut National de la Santé et de la Recherche Médicale; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Uhrig, Lynn. Commissariat A Energie Atomique; Francia. Institut National de la Santé et de la Recherche Médicale; Francia
Fil: Sitt, Jacobo Diego. Commissariat A Energie Atomique; Francia. Institut National de la Santé et de la Recherche Médicale; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sigman, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina. Universidad Torcuato Di Tella; Argentina
Fil: Jarraya, Béchir. Commissariat A Energie Atomique; Francia. Institut National de la Santé et de la Recherche Médicale; Francia
Fil: Dehaene, Stanislas. Commissariat A Energie Atomique; Francia. Institut National de la Santé et de la Recherche Médicale; Francia
Materia
Consciousness
Anesthesia
Brain States
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/20936
Acceder
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spelling Signature of consciousness in the dynamics of resting-state brain activityBarttfeld, PabloUhrig, LynnSitt, Jacobo DiegoSigman, MarianoJarraya, BéchirDehaene, StanislasConsciousnessAnesthesiaBrain Stateshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1At rest, the brain is traversed by spontaneous functional connectivity patterns. Two hypotheses have been proposed for their origins: they may reflect a continuous stream of ongoing cognitive processes as well as random fluctuations shaped by a fixed anatomical connectivity matrix. Here we show that both sources contribute to the shaping of resting-state networks, yet with distinct contributions during consciousness and anesthesia. We measured dynamical functional connectivity with functional MRI during the resting state in awake and anesthetized monkeys. Under anesthesia, the more frequent functional connectivity patterns inherit the structure of anatomical connectivity, exhibit fewer small-world properties, and lack negative correlations. Conversely, wakefulness is characterized by the sequential exploration of a richer repertoire of functional configurations, often dissimilar to anatomical structure, and comprising positive and negative correlations among brain regions. These results reconcile theories of consciousness with observations of long-range correlation in the anesthetized brain and show that a rich functional dynamics might constitute a signature of consciousness, with potential clinical implications for the detection of awareness in anesthesia and brain-lesioned patients.Fil: Barttfeld, Pablo. Commissariat A Energie Atomique; Francia. Institut National de la Santé et de la Recherche Médicale; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Uhrig, Lynn. Commissariat A Energie Atomique; Francia. Institut National de la Santé et de la Recherche Médicale; FranciaFil: Sitt, Jacobo Diego. Commissariat A Energie Atomique; Francia. Institut National de la Santé et de la Recherche Médicale; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sigman, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina. Universidad Torcuato Di Tella; ArgentinaFil: Jarraya, Béchir. Commissariat A Energie Atomique; Francia. Institut National de la Santé et de la Recherche Médicale; FranciaFil: Dehaene, Stanislas. Commissariat A Energie Atomique; Francia. Institut National de la Santé et de la Recherche Médicale; FranciaNational Academy Of Sciences2015-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/20936Barttfeld, Pablo; Uhrig, Lynn; Sitt, Jacobo Diego; Sigman, Mariano; Jarraya, Béchir; et al.; Signature of consciousness in the dynamics of resting-state brain activity; National Academy Of Sciences; Proceedings Of The National Academy Of Sciences Of The United States Of America; 112; 3; 1-2015; 887-8920027-8424CONICET DigitalCONICETenghttp://dx.doi.org/10.1073/pnas.1515029112info:eu-repo/semantics/altIdentifier/doi/10.1073/pnas.1418031112info:eu-repo/semantics/altIdentifier/url/http://www.pnas.org/content/112/3/887info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:07:20Zoai:ri.conicet.gov.ar:11336/20936instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:07:21.066CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Signature of consciousness in the dynamics of resting-state brain activity
title Signature of consciousness in the dynamics of resting-state brain activity
spellingShingle Signature of consciousness in the dynamics of resting-state brain activity
Barttfeld, Pablo
Consciousness
Anesthesia
Brain States
title_short Signature of consciousness in the dynamics of resting-state brain activity
title_full Signature of consciousness in the dynamics of resting-state brain activity
title_fullStr Signature of consciousness in the dynamics of resting-state brain activity
title_full_unstemmed Signature of consciousness in the dynamics of resting-state brain activity
title_sort Signature of consciousness in the dynamics of resting-state brain activity
dc.creator.none.fl_str_mv Barttfeld, Pablo
Uhrig, Lynn
Sitt, Jacobo Diego
Sigman, Mariano
Jarraya, Béchir
Dehaene, Stanislas
author Barttfeld, Pablo
author_facet Barttfeld, Pablo
Uhrig, Lynn
Sitt, Jacobo Diego
Sigman, Mariano
Jarraya, Béchir
Dehaene, Stanislas
author_role author
author2 Uhrig, Lynn
Sitt, Jacobo Diego
Sigman, Mariano
Jarraya, Béchir
Dehaene, Stanislas
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Consciousness
Anesthesia
Brain States
topic Consciousness
Anesthesia
Brain States
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv At rest, the brain is traversed by spontaneous functional connectivity patterns. Two hypotheses have been proposed for their origins: they may reflect a continuous stream of ongoing cognitive processes as well as random fluctuations shaped by a fixed anatomical connectivity matrix. Here we show that both sources contribute to the shaping of resting-state networks, yet with distinct contributions during consciousness and anesthesia. We measured dynamical functional connectivity with functional MRI during the resting state in awake and anesthetized monkeys. Under anesthesia, the more frequent functional connectivity patterns inherit the structure of anatomical connectivity, exhibit fewer small-world properties, and lack negative correlations. Conversely, wakefulness is characterized by the sequential exploration of a richer repertoire of functional configurations, often dissimilar to anatomical structure, and comprising positive and negative correlations among brain regions. These results reconcile theories of consciousness with observations of long-range correlation in the anesthetized brain and show that a rich functional dynamics might constitute a signature of consciousness, with potential clinical implications for the detection of awareness in anesthesia and brain-lesioned patients.
Fil: Barttfeld, Pablo. Commissariat A Energie Atomique; Francia. Institut National de la Santé et de la Recherche Médicale; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Uhrig, Lynn. Commissariat A Energie Atomique; Francia. Institut National de la Santé et de la Recherche Médicale; Francia
Fil: Sitt, Jacobo Diego. Commissariat A Energie Atomique; Francia. Institut National de la Santé et de la Recherche Médicale; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sigman, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina. Universidad Torcuato Di Tella; Argentina
Fil: Jarraya, Béchir. Commissariat A Energie Atomique; Francia. Institut National de la Santé et de la Recherche Médicale; Francia
Fil: Dehaene, Stanislas. Commissariat A Energie Atomique; Francia. Institut National de la Santé et de la Recherche Médicale; Francia
description At rest, the brain is traversed by spontaneous functional connectivity patterns. Two hypotheses have been proposed for their origins: they may reflect a continuous stream of ongoing cognitive processes as well as random fluctuations shaped by a fixed anatomical connectivity matrix. Here we show that both sources contribute to the shaping of resting-state networks, yet with distinct contributions during consciousness and anesthesia. We measured dynamical functional connectivity with functional MRI during the resting state in awake and anesthetized monkeys. Under anesthesia, the more frequent functional connectivity patterns inherit the structure of anatomical connectivity, exhibit fewer small-world properties, and lack negative correlations. Conversely, wakefulness is characterized by the sequential exploration of a richer repertoire of functional configurations, often dissimilar to anatomical structure, and comprising positive and negative correlations among brain regions. These results reconcile theories of consciousness with observations of long-range correlation in the anesthetized brain and show that a rich functional dynamics might constitute a signature of consciousness, with potential clinical implications for the detection of awareness in anesthesia and brain-lesioned patients.
publishDate 2015
dc.date.none.fl_str_mv 2015-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/20936
Barttfeld, Pablo; Uhrig, Lynn; Sitt, Jacobo Diego; Sigman, Mariano; Jarraya, Béchir; et al.; Signature of consciousness in the dynamics of resting-state brain activity; National Academy Of Sciences; Proceedings Of The National Academy Of Sciences Of The United States Of America; 112; 3; 1-2015; 887-892
0027-8424
CONICET Digital
CONICET
url http://hdl.handle.net/11336/20936
identifier_str_mv Barttfeld, Pablo; Uhrig, Lynn; Sitt, Jacobo Diego; Sigman, Mariano; Jarraya, Béchir; et al.; Signature of consciousness in the dynamics of resting-state brain activity; National Academy Of Sciences; Proceedings Of The National Academy Of Sciences Of The United States Of America; 112; 3; 1-2015; 887-892
0027-8424
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv http://dx.doi.org/10.1073/pnas.1515029112
info:eu-repo/semantics/altIdentifier/doi/10.1073/pnas.1418031112
info:eu-repo/semantics/altIdentifier/url/http://www.pnas.org/content/112/3/887
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv National Academy Of Sciences
publisher.none.fl_str_mv National Academy Of Sciences
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842980325966217216
score 12.993085

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