Whole-brain models to explore altered states of consciousness from the bottom up

Autores
Cofré, Rodrigo; Herzog, Rubén; Mediano, Pedro A.M.; Piccinini, Juan Ignacio; Rosas, Fernando E.; Sanz Perl Hernandez, Yonatan; Tagliazucchi, Enzo Rodolfo
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The scope of human consciousness includes states departing from what most of us experience as ordinary wakefulness. These altered states of consciousness constitute a prime opportunity to study how global changes in brain activity relate to different varieties of subjective experience. We consider the problem of explaining how global signatures of altered consciousness arise from the interplay between large-scale connectivity and local dynamical rules that can be traced to known properties of neural tissue. For this purpose, we advocate a research program aimed at bridging the gap between bottom-up generative models of whole-brain activity and the top-down signatures proposed by theories of consciousness. Throughout this paper, we define altered states of consciousness, discuss relevant signatures of consciousness observed in brain activity, and introduce whole-brain models to explore the biophysics of altered consciousness from the bottom-up. We discuss the potential of our proposal in view of the current state of the art, give specific examples of how this research agenda might play out, and emphasize how a systematic investigation of altered states of consciousness via bottom-up modeling may help us better understand the biophysical, informational, and dynamical underpinnings of consciousness.
Fil: Cofré, Rodrigo. Universidad de Valparaíso; Chile
Fil: Herzog, Rubén. Universidad de Valparaíso; Chile
Fil: Mediano, Pedro A.M.. University of Cambridge; Estados Unidos
Fil: Piccinini, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Fil: Rosas, Fernando E.. Imperial College London; Reino Unido
Fil: Sanz Perl Hernandez, Yonatan. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Tagliazucchi, Enzo Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Materia
ALTERED STATES OF CONSCIOUSNESS
INTEGRATED INFORMATION THEORY
PSYCHEDELICS
SIGNATURES OF CONSCIOUSNESS
WHOLE-BRAIN MODELS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/146072
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Whole-brain models to explore altered states of consciousness from the bottom upCofré, RodrigoHerzog, RubénMediano, Pedro A.M.Piccinini, Juan IgnacioRosas, Fernando E.Sanz Perl Hernandez, YonatanTagliazucchi, Enzo RodolfoALTERED STATES OF CONSCIOUSNESSINTEGRATED INFORMATION THEORYPSYCHEDELICSSIGNATURES OF CONSCIOUSNESSWHOLE-BRAIN MODELShttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1The scope of human consciousness includes states departing from what most of us experience as ordinary wakefulness. These altered states of consciousness constitute a prime opportunity to study how global changes in brain activity relate to different varieties of subjective experience. We consider the problem of explaining how global signatures of altered consciousness arise from the interplay between large-scale connectivity and local dynamical rules that can be traced to known properties of neural tissue. For this purpose, we advocate a research program aimed at bridging the gap between bottom-up generative models of whole-brain activity and the top-down signatures proposed by theories of consciousness. Throughout this paper, we define altered states of consciousness, discuss relevant signatures of consciousness observed in brain activity, and introduce whole-brain models to explore the biophysics of altered consciousness from the bottom-up. We discuss the potential of our proposal in view of the current state of the art, give specific examples of how this research agenda might play out, and emphasize how a systematic investigation of altered states of consciousness via bottom-up modeling may help us better understand the biophysical, informational, and dynamical underpinnings of consciousness.Fil: Cofré, Rodrigo. Universidad de Valparaíso; ChileFil: Herzog, Rubén. Universidad de Valparaíso; ChileFil: Mediano, Pedro A.M.. University of Cambridge; Estados UnidosFil: Piccinini, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; ArgentinaFil: Rosas, Fernando E.. Imperial College London; Reino UnidoFil: Sanz Perl Hernandez, Yonatan. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Tagliazucchi, Enzo Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; ArgentinaMolecular Diversity Preservation International2020-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/146072Cofré, Rodrigo; Herzog, Rubén; Mediano, Pedro A.M.; Piccinini, Juan Ignacio; Rosas, Fernando E.; et al.; Whole-brain models to explore altered states of consciousness from the bottom up; Molecular Diversity Preservation International; Brain Sciences; 10; 9; 9-2020; 1-292076-3425CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3390/brainsci10090626info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:08:15Zoai:ri.conicet.gov.ar:11336/146072instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:08:16.024CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Whole-brain models to explore altered states of consciousness from the bottom up
title Whole-brain models to explore altered states of consciousness from the bottom up
spellingShingle Whole-brain models to explore altered states of consciousness from the bottom up
Cofré, Rodrigo
ALTERED STATES OF CONSCIOUSNESS
INTEGRATED INFORMATION THEORY
PSYCHEDELICS
SIGNATURES OF CONSCIOUSNESS
WHOLE-BRAIN MODELS
title_short Whole-brain models to explore altered states of consciousness from the bottom up
title_full Whole-brain models to explore altered states of consciousness from the bottom up
title_fullStr Whole-brain models to explore altered states of consciousness from the bottom up
title_full_unstemmed Whole-brain models to explore altered states of consciousness from the bottom up
title_sort Whole-brain models to explore altered states of consciousness from the bottom up
dc.creator.none.fl_str_mv Cofré, Rodrigo
Herzog, Rubén
Mediano, Pedro A.M.
Piccinini, Juan Ignacio
Rosas, Fernando E.
Sanz Perl Hernandez, Yonatan
Tagliazucchi, Enzo Rodolfo
author Cofré, Rodrigo
author_facet Cofré, Rodrigo
Herzog, Rubén
Mediano, Pedro A.M.
Piccinini, Juan Ignacio
Rosas, Fernando E.
Sanz Perl Hernandez, Yonatan
Tagliazucchi, Enzo Rodolfo
author_role author
author2 Herzog, Rubén
Mediano, Pedro A.M.
Piccinini, Juan Ignacio
Rosas, Fernando E.
Sanz Perl Hernandez, Yonatan
Tagliazucchi, Enzo Rodolfo
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv ALTERED STATES OF CONSCIOUSNESS
INTEGRATED INFORMATION THEORY
PSYCHEDELICS
SIGNATURES OF CONSCIOUSNESS
WHOLE-BRAIN MODELS
topic ALTERED STATES OF CONSCIOUSNESS
INTEGRATED INFORMATION THEORY
PSYCHEDELICS
SIGNATURES OF CONSCIOUSNESS
WHOLE-BRAIN MODELS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The scope of human consciousness includes states departing from what most of us experience as ordinary wakefulness. These altered states of consciousness constitute a prime opportunity to study how global changes in brain activity relate to different varieties of subjective experience. We consider the problem of explaining how global signatures of altered consciousness arise from the interplay between large-scale connectivity and local dynamical rules that can be traced to known properties of neural tissue. For this purpose, we advocate a research program aimed at bridging the gap between bottom-up generative models of whole-brain activity and the top-down signatures proposed by theories of consciousness. Throughout this paper, we define altered states of consciousness, discuss relevant signatures of consciousness observed in brain activity, and introduce whole-brain models to explore the biophysics of altered consciousness from the bottom-up. We discuss the potential of our proposal in view of the current state of the art, give specific examples of how this research agenda might play out, and emphasize how a systematic investigation of altered states of consciousness via bottom-up modeling may help us better understand the biophysical, informational, and dynamical underpinnings of consciousness.
Fil: Cofré, Rodrigo. Universidad de Valparaíso; Chile
Fil: Herzog, Rubén. Universidad de Valparaíso; Chile
Fil: Mediano, Pedro A.M.. University of Cambridge; Estados Unidos
Fil: Piccinini, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Fil: Rosas, Fernando E.. Imperial College London; Reino Unido
Fil: Sanz Perl Hernandez, Yonatan. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Tagliazucchi, Enzo Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
description The scope of human consciousness includes states departing from what most of us experience as ordinary wakefulness. These altered states of consciousness constitute a prime opportunity to study how global changes in brain activity relate to different varieties of subjective experience. We consider the problem of explaining how global signatures of altered consciousness arise from the interplay between large-scale connectivity and local dynamical rules that can be traced to known properties of neural tissue. For this purpose, we advocate a research program aimed at bridging the gap between bottom-up generative models of whole-brain activity and the top-down signatures proposed by theories of consciousness. Throughout this paper, we define altered states of consciousness, discuss relevant signatures of consciousness observed in brain activity, and introduce whole-brain models to explore the biophysics of altered consciousness from the bottom-up. We discuss the potential of our proposal in view of the current state of the art, give specific examples of how this research agenda might play out, and emphasize how a systematic investigation of altered states of consciousness via bottom-up modeling may help us better understand the biophysical, informational, and dynamical underpinnings of consciousness.
publishDate 2020
dc.date.none.fl_str_mv 2020-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/146072
Cofré, Rodrigo; Herzog, Rubén; Mediano, Pedro A.M.; Piccinini, Juan Ignacio; Rosas, Fernando E.; et al.; Whole-brain models to explore altered states of consciousness from the bottom up; Molecular Diversity Preservation International; Brain Sciences; 10; 9; 9-2020; 1-29
2076-3425
CONICET Digital
CONICET
url http://hdl.handle.net/11336/146072
identifier_str_mv Cofré, Rodrigo; Herzog, Rubén; Mediano, Pedro A.M.; Piccinini, Juan Ignacio; Rosas, Fernando E.; et al.; Whole-brain models to explore altered states of consciousness from the bottom up; Molecular Diversity Preservation International; Brain Sciences; 10; 9; 9-2020; 1-29
2076-3425
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3390/brainsci10090626
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Molecular Diversity Preservation International
publisher.none.fl_str_mv Molecular Diversity Preservation International
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842270037646245888
score 13.13397

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