Dynamical structure-function correlations provide robust and generalizable signatures of consciousness in humans

Autores
Castro, Pablo; Luppi, Andrea; Tagliazucchi, Enzo Rodolfo; Sanz Perl Hernandez, Yonatan; Naci, Lorina; Owen, Adrian M.; Sitt, Jacobo Diego; Destexhe, Alain; Cofré, Rodrigo
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Resting-state functional magnetic resonance imaging evolves through a repertoire of functional connectivity patterns which might reflect ongoing cognition, as well as the contents of conscious awareness. We investigated whether the dynamic exploration of these states can provide robust and generalizable markers for the state of consciousness in human participants, across loss of consciousness induced by general anaesthesia or slow wave sleep. By clustering transient states of functional connectivity, we demonstrated that brain activity during unconsciousness is dominated by a recurrent pattern primarily mediated by structural connectivity and with a reduced capacity to transition to other patterns. Our results provide evidence supporting the pronounced differences between conscious and unconscious brain states in terms of whole-brain dynamics; in particular, the maintenance of rich brain dynamics measured by entropy is a critical aspect of conscious awareness. Collectively, our results may have significant implications for our understanding of consciousness and the neural basis of human awareness, as well as for the discovery of robust signatures of consciousness that are generalizable among different brain conditions.
Fil: Castro, Pablo. Universite Paris-saclay (universite Paris-saclay);
Fil: Luppi, Andrea. University of Cambridge; Reino Unido. McGill University; Canadá
Fil: Tagliazucchi, Enzo Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina. Universidad Adolfo Ibañez; Chile
Fil: Sanz Perl Hernandez, Yonatan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina. Universidad de San Andrés; Argentina. Universitat Pompeu Fabra; España. Paris Brain Institute; Francia
Fil: Naci, Lorina. Trinity College Dublin; Irlanda
Fil: Owen, Adrian M.. Western University; Canadá
Fil: Sitt, Jacobo Diego. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Paris Brain Institute; Francia
Fil: Destexhe, Alain. Universite Paris-saclay (universite Paris-saclay);
Fil: Cofré, Rodrigo. Universite Paris-saclay (universite Paris-saclay);
Materia
Neuroimaging
Brain dynamical metastates
Clustering
State of consciousness
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/251987
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Dynamical structure-function correlations provide robust and generalizable signatures of consciousness in humansCastro, PabloLuppi, AndreaTagliazucchi, Enzo RodolfoSanz Perl Hernandez, YonatanNaci, LorinaOwen, Adrian M.Sitt, Jacobo DiegoDestexhe, AlainCofré, RodrigoNeuroimagingBrain dynamical metastatesClusteringState of consciousnesshttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1Resting-state functional magnetic resonance imaging evolves through a repertoire of functional connectivity patterns which might reflect ongoing cognition, as well as the contents of conscious awareness. We investigated whether the dynamic exploration of these states can provide robust and generalizable markers for the state of consciousness in human participants, across loss of consciousness induced by general anaesthesia or slow wave sleep. By clustering transient states of functional connectivity, we demonstrated that brain activity during unconsciousness is dominated by a recurrent pattern primarily mediated by structural connectivity and with a reduced capacity to transition to other patterns. Our results provide evidence supporting the pronounced differences between conscious and unconscious brain states in terms of whole-brain dynamics; in particular, the maintenance of rich brain dynamics measured by entropy is a critical aspect of conscious awareness. Collectively, our results may have significant implications for our understanding of consciousness and the neural basis of human awareness, as well as for the discovery of robust signatures of consciousness that are generalizable among different brain conditions.Fil: Castro, Pablo. Universite Paris-saclay (universite Paris-saclay);Fil: Luppi, Andrea. University of Cambridge; Reino Unido. McGill University; CanadáFil: Tagliazucchi, Enzo Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina. Universidad Adolfo Ibañez; ChileFil: Sanz Perl Hernandez, Yonatan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina. Universidad de San Andrés; Argentina. Universitat Pompeu Fabra; España. Paris Brain Institute; FranciaFil: Naci, Lorina. Trinity College Dublin; IrlandaFil: Owen, Adrian M.. Western University; CanadáFil: Sitt, Jacobo Diego. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Paris Brain Institute; FranciaFil: Destexhe, Alain. Universite Paris-saclay (universite Paris-saclay);Fil: Cofré, Rodrigo. Universite Paris-saclay (universite Paris-saclay);Nature2024-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/251987Castro, Pablo; Luppi, Andrea; Tagliazucchi, Enzo Rodolfo; Sanz Perl Hernandez, Yonatan; Naci, Lorina; et al.; Dynamical structure-function correlations provide robust and generalizable signatures of consciousness in humans; Nature; Communications Biology; 7; 1; 9-2024; 1-122399-3642CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s42003-024-06858-3info:eu-repo/semantics/altIdentifier/doi/10.1038/s42003-024-06858-3info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:36:29Zoai:ri.conicet.gov.ar:11336/251987instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:36:30.214CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Dynamical structure-function correlations provide robust and generalizable signatures of consciousness in humans
title Dynamical structure-function correlations provide robust and generalizable signatures of consciousness in humans
spellingShingle Dynamical structure-function correlations provide robust and generalizable signatures of consciousness in humans
Castro, Pablo
Neuroimaging
Brain dynamical metastates
Clustering
State of consciousness
title_short Dynamical structure-function correlations provide robust and generalizable signatures of consciousness in humans
title_full Dynamical structure-function correlations provide robust and generalizable signatures of consciousness in humans
title_fullStr Dynamical structure-function correlations provide robust and generalizable signatures of consciousness in humans
title_full_unstemmed Dynamical structure-function correlations provide robust and generalizable signatures of consciousness in humans
title_sort Dynamical structure-function correlations provide robust and generalizable signatures of consciousness in humans
dc.creator.none.fl_str_mv Castro, Pablo
Luppi, Andrea
Tagliazucchi, Enzo Rodolfo
Sanz Perl Hernandez, Yonatan
Naci, Lorina
Owen, Adrian M.
Sitt, Jacobo Diego
Destexhe, Alain
Cofré, Rodrigo
author Castro, Pablo
author_facet Castro, Pablo
Luppi, Andrea
Tagliazucchi, Enzo Rodolfo
Sanz Perl Hernandez, Yonatan
Naci, Lorina
Owen, Adrian M.
Sitt, Jacobo Diego
Destexhe, Alain
Cofré, Rodrigo
author_role author
author2 Luppi, Andrea
Tagliazucchi, Enzo Rodolfo
Sanz Perl Hernandez, Yonatan
Naci, Lorina
Owen, Adrian M.
Sitt, Jacobo Diego
Destexhe, Alain
Cofré, Rodrigo
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Neuroimaging
Brain dynamical metastates
Clustering
State of consciousness
topic Neuroimaging
Brain dynamical metastates
Clustering
State of consciousness
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Resting-state functional magnetic resonance imaging evolves through a repertoire of functional connectivity patterns which might reflect ongoing cognition, as well as the contents of conscious awareness. We investigated whether the dynamic exploration of these states can provide robust and generalizable markers for the state of consciousness in human participants, across loss of consciousness induced by general anaesthesia or slow wave sleep. By clustering transient states of functional connectivity, we demonstrated that brain activity during unconsciousness is dominated by a recurrent pattern primarily mediated by structural connectivity and with a reduced capacity to transition to other patterns. Our results provide evidence supporting the pronounced differences between conscious and unconscious brain states in terms of whole-brain dynamics; in particular, the maintenance of rich brain dynamics measured by entropy is a critical aspect of conscious awareness. Collectively, our results may have significant implications for our understanding of consciousness and the neural basis of human awareness, as well as for the discovery of robust signatures of consciousness that are generalizable among different brain conditions.
Fil: Castro, Pablo. Universite Paris-saclay (universite Paris-saclay);
Fil: Luppi, Andrea. University of Cambridge; Reino Unido. McGill University; Canadá
Fil: Tagliazucchi, Enzo Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina. Universidad Adolfo Ibañez; Chile
Fil: Sanz Perl Hernandez, Yonatan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina. Universidad de San Andrés; Argentina. Universitat Pompeu Fabra; España. Paris Brain Institute; Francia
Fil: Naci, Lorina. Trinity College Dublin; Irlanda
Fil: Owen, Adrian M.. Western University; Canadá
Fil: Sitt, Jacobo Diego. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Paris Brain Institute; Francia
Fil: Destexhe, Alain. Universite Paris-saclay (universite Paris-saclay);
Fil: Cofré, Rodrigo. Universite Paris-saclay (universite Paris-saclay);
description Resting-state functional magnetic resonance imaging evolves through a repertoire of functional connectivity patterns which might reflect ongoing cognition, as well as the contents of conscious awareness. We investigated whether the dynamic exploration of these states can provide robust and generalizable markers for the state of consciousness in human participants, across loss of consciousness induced by general anaesthesia or slow wave sleep. By clustering transient states of functional connectivity, we demonstrated that brain activity during unconsciousness is dominated by a recurrent pattern primarily mediated by structural connectivity and with a reduced capacity to transition to other patterns. Our results provide evidence supporting the pronounced differences between conscious and unconscious brain states in terms of whole-brain dynamics; in particular, the maintenance of rich brain dynamics measured by entropy is a critical aspect of conscious awareness. Collectively, our results may have significant implications for our understanding of consciousness and the neural basis of human awareness, as well as for the discovery of robust signatures of consciousness that are generalizable among different brain conditions.
publishDate 2024
dc.date.none.fl_str_mv 2024-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/251987
Castro, Pablo; Luppi, Andrea; Tagliazucchi, Enzo Rodolfo; Sanz Perl Hernandez, Yonatan; Naci, Lorina; et al.; Dynamical structure-function correlations provide robust and generalizable signatures of consciousness in humans; Nature; Communications Biology; 7; 1; 9-2024; 1-12
2399-3642
CONICET Digital
CONICET
url http://hdl.handle.net/11336/251987
identifier_str_mv Castro, Pablo; Luppi, Andrea; Tagliazucchi, Enzo Rodolfo; Sanz Perl Hernandez, Yonatan; Naci, Lorina; et al.; Dynamical structure-function correlations provide robust and generalizable signatures of consciousness in humans; Nature; Communications Biology; 7; 1; 9-2024; 1-12
2399-3642
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s42003-024-06858-3
info:eu-repo/semantics/altIdentifier/doi/10.1038/s42003-024-06858-3
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature
publisher.none.fl_str_mv Nature
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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