Complexity of Brain Dynamics as a Correlate of Consciousness in Anaesthetized Monkeys

Autores
Fuentes, Nicolás; Garcia, Alexis; Guevara, Ramón; Orofino, Roberto; Mateos, Diego Martín
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The use of anaesthesia is a fundamental tool in the investigation of consciousness. Anesthesia procedures allow to investigate different states of consciousness from sedation to deep anesthesia within controlled scenarios. In this study we use information quantifiers to measure the complexity of electrocorticogram recordings in monkeys. We apply these metrics to compare different stages of general anesthesia for evaluating consciousness in several anesthesia protocols. We find that the complexity of brain activity can be used as a correlate of consciousness. For two of the anaesthetics used, propofol and medetomidine, we find that the anaesthetised state is accompanied by a reduction in the complexity of brain activity. On the other hand we observe that use of ketamine produces an increase in complexity measurements. We relate this observation with increase activity within certain brain regions associated with the ketamine used doses. Our measurements indicate that complexity of brain activity is a good indicator for a general evaluation of different levels of consciousness awareness, both in anesthetized and non anesthetizes states.
Fil: Fuentes, Nicolás. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina
Fil: Garcia, Alexis. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina
Fil: Guevara, Ramón. Università di Padova; Italia
Fil: Orofino, Roberto. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina. Hospital Español de Buenos Aires;
Fil: Mateos, Diego Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Matemática Aplicada del Litoral. Universidad Nacional del Litoral. Instituto de Matemática Aplicada del Litoral; Argentina. Universidad Nacional de Entre Rios. Facultad de Ingeniería. Departamento de Bioingeniería; Argentina
Materia
ANAESTHETICS
BRAIN DYNAMICS
COMPLEXITY
CONSCIOUSNESS
ENTROPY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/187250
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Complexity of Brain Dynamics as a Correlate of Consciousness in Anaesthetized MonkeysFuentes, NicolásGarcia, AlexisGuevara, RamónOrofino, RobertoMateos, Diego MartínANAESTHETICSBRAIN DYNAMICSCOMPLEXITYCONSCIOUSNESSENTROPYhttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1The use of anaesthesia is a fundamental tool in the investigation of consciousness. Anesthesia procedures allow to investigate different states of consciousness from sedation to deep anesthesia within controlled scenarios. In this study we use information quantifiers to measure the complexity of electrocorticogram recordings in monkeys. We apply these metrics to compare different stages of general anesthesia for evaluating consciousness in several anesthesia protocols. We find that the complexity of brain activity can be used as a correlate of consciousness. For two of the anaesthetics used, propofol and medetomidine, we find that the anaesthetised state is accompanied by a reduction in the complexity of brain activity. On the other hand we observe that use of ketamine produces an increase in complexity measurements. We relate this observation with increase activity within certain brain regions associated with the ketamine used doses. Our measurements indicate that complexity of brain activity is a good indicator for a general evaluation of different levels of consciousness awareness, both in anesthetized and non anesthetizes states.Fil: Fuentes, Nicolás. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; ArgentinaFil: Garcia, Alexis. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; ArgentinaFil: Guevara, Ramón. Università di Padova; ItaliaFil: Orofino, Roberto. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina. Hospital Español de Buenos Aires;Fil: Mateos, Diego Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Matemática Aplicada del Litoral. Universidad Nacional del Litoral. Instituto de Matemática Aplicada del Litoral; Argentina. Universidad Nacional de Entre Rios. Facultad de Ingeniería. Departamento de Bioingeniería; ArgentinaHumana Press2022-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/187250Fuentes, Nicolás; Garcia, Alexis; Guevara, Ramón; Orofino, Roberto; Mateos, Diego Martín; Complexity of Brain Dynamics as a Correlate of Consciousness in Anaesthetized Monkeys; Humana Press; Neuroinformatics; 20; 4; 10-2022; 1041-10541539-2791CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s12021-022-09586-3info:eu-repo/semantics/altIdentifier/doi/10.1007/s12021-022-09586-3info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:02:11Zoai:ri.conicet.gov.ar:11336/187250instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:02:11.475CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Complexity of Brain Dynamics as a Correlate of Consciousness in Anaesthetized Monkeys
title Complexity of Brain Dynamics as a Correlate of Consciousness in Anaesthetized Monkeys
spellingShingle Complexity of Brain Dynamics as a Correlate of Consciousness in Anaesthetized Monkeys
Fuentes, Nicolás
ANAESTHETICS
BRAIN DYNAMICS
COMPLEXITY
CONSCIOUSNESS
ENTROPY
title_short Complexity of Brain Dynamics as a Correlate of Consciousness in Anaesthetized Monkeys
title_full Complexity of Brain Dynamics as a Correlate of Consciousness in Anaesthetized Monkeys
title_fullStr Complexity of Brain Dynamics as a Correlate of Consciousness in Anaesthetized Monkeys
title_full_unstemmed Complexity of Brain Dynamics as a Correlate of Consciousness in Anaesthetized Monkeys
title_sort Complexity of Brain Dynamics as a Correlate of Consciousness in Anaesthetized Monkeys
dc.creator.none.fl_str_mv Fuentes, Nicolás
Garcia, Alexis
Guevara, Ramón
Orofino, Roberto
Mateos, Diego Martín
author Fuentes, Nicolás
author_facet Fuentes, Nicolás
Garcia, Alexis
Guevara, Ramón
Orofino, Roberto
Mateos, Diego Martín
author_role author
author2 Garcia, Alexis
Guevara, Ramón
Orofino, Roberto
Mateos, Diego Martín
author2_role author
author
author
author
dc.subject.none.fl_str_mv ANAESTHETICS
BRAIN DYNAMICS
COMPLEXITY
CONSCIOUSNESS
ENTROPY
topic ANAESTHETICS
BRAIN DYNAMICS
COMPLEXITY
CONSCIOUSNESS
ENTROPY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The use of anaesthesia is a fundamental tool in the investigation of consciousness. Anesthesia procedures allow to investigate different states of consciousness from sedation to deep anesthesia within controlled scenarios. In this study we use information quantifiers to measure the complexity of electrocorticogram recordings in monkeys. We apply these metrics to compare different stages of general anesthesia for evaluating consciousness in several anesthesia protocols. We find that the complexity of brain activity can be used as a correlate of consciousness. For two of the anaesthetics used, propofol and medetomidine, we find that the anaesthetised state is accompanied by a reduction in the complexity of brain activity. On the other hand we observe that use of ketamine produces an increase in complexity measurements. We relate this observation with increase activity within certain brain regions associated with the ketamine used doses. Our measurements indicate that complexity of brain activity is a good indicator for a general evaluation of different levels of consciousness awareness, both in anesthetized and non anesthetizes states.
Fil: Fuentes, Nicolás. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina
Fil: Garcia, Alexis. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina
Fil: Guevara, Ramón. Università di Padova; Italia
Fil: Orofino, Roberto. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina. Hospital Español de Buenos Aires;
Fil: Mateos, Diego Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Matemática Aplicada del Litoral. Universidad Nacional del Litoral. Instituto de Matemática Aplicada del Litoral; Argentina. Universidad Nacional de Entre Rios. Facultad de Ingeniería. Departamento de Bioingeniería; Argentina
description The use of anaesthesia is a fundamental tool in the investigation of consciousness. Anesthesia procedures allow to investigate different states of consciousness from sedation to deep anesthesia within controlled scenarios. In this study we use information quantifiers to measure the complexity of electrocorticogram recordings in monkeys. We apply these metrics to compare different stages of general anesthesia for evaluating consciousness in several anesthesia protocols. We find that the complexity of brain activity can be used as a correlate of consciousness. For two of the anaesthetics used, propofol and medetomidine, we find that the anaesthetised state is accompanied by a reduction in the complexity of brain activity. On the other hand we observe that use of ketamine produces an increase in complexity measurements. We relate this observation with increase activity within certain brain regions associated with the ketamine used doses. Our measurements indicate that complexity of brain activity is a good indicator for a general evaluation of different levels of consciousness awareness, both in anesthetized and non anesthetizes states.
publishDate 2022
dc.date.none.fl_str_mv 2022-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/187250
Fuentes, Nicolás; Garcia, Alexis; Guevara, Ramón; Orofino, Roberto; Mateos, Diego Martín; Complexity of Brain Dynamics as a Correlate of Consciousness in Anaesthetized Monkeys; Humana Press; Neuroinformatics; 20; 4; 10-2022; 1041-1054
1539-2791
CONICET Digital
CONICET
url http://hdl.handle.net/11336/187250
identifier_str_mv Fuentes, Nicolás; Garcia, Alexis; Guevara, Ramón; Orofino, Roberto; Mateos, Diego Martín; Complexity of Brain Dynamics as a Correlate of Consciousness in Anaesthetized Monkeys; Humana Press; Neuroinformatics; 20; 4; 10-2022; 1041-1054
1539-2791
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s12021-022-09586-3
info:eu-repo/semantics/altIdentifier/doi/10.1007/s12021-022-09586-3
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Humana Press
publisher.none.fl_str_mv Humana Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269742291746816
score 13.13397

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