Wnt-regulated dynamics of positional information in zebrafish somitogenesis

Autores
Bajard, Lola; Morelli, Luis Guillermo; Ares, Saúl; Pécréaux, Jacques; Jülicher, Frank; Oates, Andrew C.
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
How signaling gradients supply positional information in a field of moving cells is an unsolved question in patterning and morphogenesis. Here, we ask how a Wnt signaling gradient regulates the dynamics of a wavefront of cellular change in a flow of cells during somitogenesis. Using time-controlled perturbations of Wnt signaling in the zebrafish embryo, we changed segment length without altering the rate of somite formation or embryonic elongation. This result implies specific Wnt regulation of the wavefront velocity. The observed Wnt signaling gradient dynamics and timing of downstream events support a model for wavefront regulation in which cell flow plays a dominant role in transporting positional information.
Fil: Bajard, Lola. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania
Fil: Morelli, Luis Guillermo. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania. Max Planck Institute for the Physics of Complex Systems; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ares, Saúl. Max Planck Institute for the Physics of Complex Systems; Alemania
Fil: Pécréaux, Jacques. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania
Fil: Jülicher, Frank. Max Planck Institute for the Physics of Complex Systems; Alemania
Fil: Oates, Andrew C.. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania
Materia
Wnt signaling
Fgf signaling
Signaling Gradients
Segmentation Clock
Embryonic Elongation
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/17990
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/17990
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Wnt-regulated dynamics of positional information in zebrafish somitogenesisBajard, LolaMorelli, Luis GuillermoAres, SaúlPécréaux, JacquesJülicher, FrankOates, Andrew C.Wnt signalingFgf signalingSignaling GradientsSegmentation ClockEmbryonic Elongationhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1How signaling gradients supply positional information in a field of moving cells is an unsolved question in patterning and morphogenesis. Here, we ask how a Wnt signaling gradient regulates the dynamics of a wavefront of cellular change in a flow of cells during somitogenesis. Using time-controlled perturbations of Wnt signaling in the zebrafish embryo, we changed segment length without altering the rate of somite formation or embryonic elongation. This result implies specific Wnt regulation of the wavefront velocity. The observed Wnt signaling gradient dynamics and timing of downstream events support a model for wavefront regulation in which cell flow plays a dominant role in transporting positional information.Fil: Bajard, Lola. Max Planck Institute of Molecular Cell Biology and Genetics; AlemaniaFil: Morelli, Luis Guillermo. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania. Max Planck Institute for the Physics of Complex Systems; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ares, Saúl. Max Planck Institute for the Physics of Complex Systems; AlemaniaFil: Pécréaux, Jacques. Max Planck Institute of Molecular Cell Biology and Genetics; AlemaniaFil: Jülicher, Frank. Max Planck Institute for the Physics of Complex Systems; AlemaniaFil: Oates, Andrew C.. Max Planck Institute of Molecular Cell Biology and Genetics; AlemaniaCompany Of Biologists2014-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/17990Bajard, Lola; Morelli, Luis Guillermo; Ares, Saúl; Pécréaux, Jacques; Jülicher, Frank; et al.; Wnt-regulated dynamics of positional information in zebrafish somitogenesis; Company Of Biologists; Development; 141; 3-2014; 1381-13910950-1991enginfo:eu-repo/semantics/altIdentifier/doi/10.1242/dev.093435info:eu-repo/semantics/altIdentifier/url/http://dev.biologists.org/content/141/6/1381info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:59:23Zoai:ri.conicet.gov.ar:11336/17990instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:59:24.346CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Wnt-regulated dynamics of positional information in zebrafish somitogenesis
title Wnt-regulated dynamics of positional information in zebrafish somitogenesis
spellingShingle Wnt-regulated dynamics of positional information in zebrafish somitogenesis
Bajard, Lola
Wnt signaling
Fgf signaling
Signaling Gradients
Segmentation Clock
Embryonic Elongation
title_short Wnt-regulated dynamics of positional information in zebrafish somitogenesis
title_full Wnt-regulated dynamics of positional information in zebrafish somitogenesis
title_fullStr Wnt-regulated dynamics of positional information in zebrafish somitogenesis
title_full_unstemmed Wnt-regulated dynamics of positional information in zebrafish somitogenesis
title_sort Wnt-regulated dynamics of positional information in zebrafish somitogenesis
dc.creator.none.fl_str_mv Bajard, Lola
Morelli, Luis Guillermo
Ares, Saúl
Pécréaux, Jacques
Jülicher, Frank
Oates, Andrew C.
author Bajard, Lola
author_facet Bajard, Lola
Morelli, Luis Guillermo
Ares, Saúl
Pécréaux, Jacques
Jülicher, Frank
Oates, Andrew C.
author_role author
author2 Morelli, Luis Guillermo
Ares, Saúl
Pécréaux, Jacques
Jülicher, Frank
Oates, Andrew C.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Wnt signaling
Fgf signaling
Signaling Gradients
Segmentation Clock
Embryonic Elongation
topic Wnt signaling
Fgf signaling
Signaling Gradients
Segmentation Clock
Embryonic Elongation
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv How signaling gradients supply positional information in a field of moving cells is an unsolved question in patterning and morphogenesis. Here, we ask how a Wnt signaling gradient regulates the dynamics of a wavefront of cellular change in a flow of cells during somitogenesis. Using time-controlled perturbations of Wnt signaling in the zebrafish embryo, we changed segment length without altering the rate of somite formation or embryonic elongation. This result implies specific Wnt regulation of the wavefront velocity. The observed Wnt signaling gradient dynamics and timing of downstream events support a model for wavefront regulation in which cell flow plays a dominant role in transporting positional information.
Fil: Bajard, Lola. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania
Fil: Morelli, Luis Guillermo. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania. Max Planck Institute for the Physics of Complex Systems; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ares, Saúl. Max Planck Institute for the Physics of Complex Systems; Alemania
Fil: Pécréaux, Jacques. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania
Fil: Jülicher, Frank. Max Planck Institute for the Physics of Complex Systems; Alemania
Fil: Oates, Andrew C.. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania
description How signaling gradients supply positional information in a field of moving cells is an unsolved question in patterning and morphogenesis. Here, we ask how a Wnt signaling gradient regulates the dynamics of a wavefront of cellular change in a flow of cells during somitogenesis. Using time-controlled perturbations of Wnt signaling in the zebrafish embryo, we changed segment length without altering the rate of somite formation or embryonic elongation. This result implies specific Wnt regulation of the wavefront velocity. The observed Wnt signaling gradient dynamics and timing of downstream events support a model for wavefront regulation in which cell flow plays a dominant role in transporting positional information.
publishDate 2014
dc.date.none.fl_str_mv 2014-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/17990
Bajard, Lola; Morelli, Luis Guillermo; Ares, Saúl; Pécréaux, Jacques; Jülicher, Frank; et al.; Wnt-regulated dynamics of positional information in zebrafish somitogenesis; Company Of Biologists; Development; 141; 3-2014; 1381-1391
0950-1991
url http://hdl.handle.net/11336/17990
identifier_str_mv Bajard, Lola; Morelli, Luis Guillermo; Ares, Saúl; Pécréaux, Jacques; Jülicher, Frank; et al.; Wnt-regulated dynamics of positional information in zebrafish somitogenesis; Company Of Biologists; Development; 141; 3-2014; 1381-1391
0950-1991
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1242/dev.093435
info:eu-repo/semantics/altIdentifier/url/http://dev.biologists.org/content/141/6/1381
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Company Of Biologists
publisher.none.fl_str_mv Company Of Biologists
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269578581770240
score 13.13397

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