Behavioral and neurochemical long-term consequences of intranasal chlorpyrifos formulation administration in mice
- Autores
- Gallegos, Cristina Eugenia; Gumilar, Fernanda Andrea; Bartos, Mariana; Tisera, Gianina Rafaela; Baier, Carlos Javier
- Año de publicación
- 2023
- Idioma
- inglés
- Tipo de recurso
- documento de conferencia
- Estado
- versión publicada
- Descripción
- Environmental pollution negatively affects cognitive performance and accelerates its decline associated with age. Inhalation or intranasal (IN) administration of xenobiotics constitutes a feasible route for substance delivery to the brain. Recently, we described that CF-1 mice exposed to a commercial formulation of chlorpyrifos (fCPF) exhibited recognition memory and anxiety impairments, together with disturbances in both, the redox balance and cholinergic and glutamatergic enzymes activities. In the present work, we studied the long-term consequences of IN fCPF administration (10 mg/kg, every other day, for 15 to 30 days) in mice. After a 4 to 8 months fCPF-free washout period, fur appearance improved, and the number of body injuries decreased in fCPF treated mice. Scores in recognition memory and anxiety levels were similar between the control and fCPF-treated group. Notably, spatial learning and memory were improved in fCPF treated group. Neurochemical markers of oxidative stress and the activities of enzymes belonging to the cholinergic and glutamatergic pathways showed significant differences from the control group even after 8 months. Neurochemical disturbances in IN fCPF-treated mice were also modeled using the human neuroblastoma cell line SH-SY5Y treated with fCPF and CPF. The obtained results suggest that previous exposure to fCPF induces long-term modifications in the brain biochemistry that could be responsible for the phenotypic and behavioral observations.
Fil: Gallegos, Cristina Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina
Fil: Gumilar, Fernanda Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina
Fil: Bartos, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina
Fil: Tisera, Gianina Rafaela. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Baier, Carlos Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina
The 2nd International Electronic Conference on Biomedicines
Basilea
Suiza
Multidisciplinary Digital Publishing Institute
Biomedicines - Materia
-
CLORPYRIFOS
INTRANASAL ADMINISTRATION
MEMORY
ANXIETY
OXIDATIVE STRESS
GLUTAMATERGIC AND CHOLINERGIC SYSTEM - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/228486
Ver los metadatos del registro completo
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Behavioral and neurochemical long-term consequences of intranasal chlorpyrifos formulation administration in miceGallegos, Cristina EugeniaGumilar, Fernanda AndreaBartos, MarianaTisera, Gianina RafaelaBaier, Carlos JavierCLORPYRIFOSINTRANASAL ADMINISTRATIONMEMORYANXIETYOXIDATIVE STRESSGLUTAMATERGIC AND CHOLINERGIC SYSTEMhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Environmental pollution negatively affects cognitive performance and accelerates its decline associated with age. Inhalation or intranasal (IN) administration of xenobiotics constitutes a feasible route for substance delivery to the brain. Recently, we described that CF-1 mice exposed to a commercial formulation of chlorpyrifos (fCPF) exhibited recognition memory and anxiety impairments, together with disturbances in both, the redox balance and cholinergic and glutamatergic enzymes activities. In the present work, we studied the long-term consequences of IN fCPF administration (10 mg/kg, every other day, for 15 to 30 days) in mice. After a 4 to 8 months fCPF-free washout period, fur appearance improved, and the number of body injuries decreased in fCPF treated mice. Scores in recognition memory and anxiety levels were similar between the control and fCPF-treated group. Notably, spatial learning and memory were improved in fCPF treated group. Neurochemical markers of oxidative stress and the activities of enzymes belonging to the cholinergic and glutamatergic pathways showed significant differences from the control group even after 8 months. Neurochemical disturbances in IN fCPF-treated mice were also modeled using the human neuroblastoma cell line SH-SY5Y treated with fCPF and CPF. The obtained results suggest that previous exposure to fCPF induces long-term modifications in the brain biochemistry that could be responsible for the phenotypic and behavioral observations.Fil: Gallegos, Cristina Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; ArgentinaFil: Gumilar, Fernanda Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; ArgentinaFil: Bartos, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; ArgentinaFil: Tisera, Gianina Rafaela. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Baier, Carlos Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; ArgentinaThe 2nd International Electronic Conference on BiomedicinesBasileaSuizaMultidisciplinary Digital Publishing InstituteBiomedicinesMultidisciplinary Digital Publishing Institute2023info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/228486Behavioral and neurochemical long-term consequences of intranasal chlorpyrifos formulation administration in mice; The 2nd International Electronic Conference on Biomedicines; Basilea; Suiza; 2023; 1-12673-9992CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://ecb2023.sciforum.net/#session2624Internacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:38:38Zoai:ri.conicet.gov.ar:11336/228486instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:38:38.91CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Behavioral and neurochemical long-term consequences of intranasal chlorpyrifos formulation administration in mice |
title |
Behavioral and neurochemical long-term consequences of intranasal chlorpyrifos formulation administration in mice |
spellingShingle |
Behavioral and neurochemical long-term consequences of intranasal chlorpyrifos formulation administration in mice Gallegos, Cristina Eugenia CLORPYRIFOS INTRANASAL ADMINISTRATION MEMORY ANXIETY OXIDATIVE STRESS GLUTAMATERGIC AND CHOLINERGIC SYSTEM |
title_short |
Behavioral and neurochemical long-term consequences of intranasal chlorpyrifos formulation administration in mice |
title_full |
Behavioral and neurochemical long-term consequences of intranasal chlorpyrifos formulation administration in mice |
title_fullStr |
Behavioral and neurochemical long-term consequences of intranasal chlorpyrifos formulation administration in mice |
title_full_unstemmed |
Behavioral and neurochemical long-term consequences of intranasal chlorpyrifos formulation administration in mice |
title_sort |
Behavioral and neurochemical long-term consequences of intranasal chlorpyrifos formulation administration in mice |
dc.creator.none.fl_str_mv |
Gallegos, Cristina Eugenia Gumilar, Fernanda Andrea Bartos, Mariana Tisera, Gianina Rafaela Baier, Carlos Javier |
author |
Gallegos, Cristina Eugenia |
author_facet |
Gallegos, Cristina Eugenia Gumilar, Fernanda Andrea Bartos, Mariana Tisera, Gianina Rafaela Baier, Carlos Javier |
author_role |
author |
author2 |
Gumilar, Fernanda Andrea Bartos, Mariana Tisera, Gianina Rafaela Baier, Carlos Javier |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
CLORPYRIFOS INTRANASAL ADMINISTRATION MEMORY ANXIETY OXIDATIVE STRESS GLUTAMATERGIC AND CHOLINERGIC SYSTEM |
topic |
CLORPYRIFOS INTRANASAL ADMINISTRATION MEMORY ANXIETY OXIDATIVE STRESS GLUTAMATERGIC AND CHOLINERGIC SYSTEM |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Environmental pollution negatively affects cognitive performance and accelerates its decline associated with age. Inhalation or intranasal (IN) administration of xenobiotics constitutes a feasible route for substance delivery to the brain. Recently, we described that CF-1 mice exposed to a commercial formulation of chlorpyrifos (fCPF) exhibited recognition memory and anxiety impairments, together with disturbances in both, the redox balance and cholinergic and glutamatergic enzymes activities. In the present work, we studied the long-term consequences of IN fCPF administration (10 mg/kg, every other day, for 15 to 30 days) in mice. After a 4 to 8 months fCPF-free washout period, fur appearance improved, and the number of body injuries decreased in fCPF treated mice. Scores in recognition memory and anxiety levels were similar between the control and fCPF-treated group. Notably, spatial learning and memory were improved in fCPF treated group. Neurochemical markers of oxidative stress and the activities of enzymes belonging to the cholinergic and glutamatergic pathways showed significant differences from the control group even after 8 months. Neurochemical disturbances in IN fCPF-treated mice were also modeled using the human neuroblastoma cell line SH-SY5Y treated with fCPF and CPF. The obtained results suggest that previous exposure to fCPF induces long-term modifications in the brain biochemistry that could be responsible for the phenotypic and behavioral observations. Fil: Gallegos, Cristina Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina Fil: Gumilar, Fernanda Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina Fil: Bartos, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina Fil: Tisera, Gianina Rafaela. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina Fil: Baier, Carlos Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina The 2nd International Electronic Conference on Biomedicines Basilea Suiza Multidisciplinary Digital Publishing Institute Biomedicines |
description |
Environmental pollution negatively affects cognitive performance and accelerates its decline associated with age. Inhalation or intranasal (IN) administration of xenobiotics constitutes a feasible route for substance delivery to the brain. Recently, we described that CF-1 mice exposed to a commercial formulation of chlorpyrifos (fCPF) exhibited recognition memory and anxiety impairments, together with disturbances in both, the redox balance and cholinergic and glutamatergic enzymes activities. In the present work, we studied the long-term consequences of IN fCPF administration (10 mg/kg, every other day, for 15 to 30 days) in mice. After a 4 to 8 months fCPF-free washout period, fur appearance improved, and the number of body injuries decreased in fCPF treated mice. Scores in recognition memory and anxiety levels were similar between the control and fCPF-treated group. Notably, spatial learning and memory were improved in fCPF treated group. Neurochemical markers of oxidative stress and the activities of enzymes belonging to the cholinergic and glutamatergic pathways showed significant differences from the control group even after 8 months. Neurochemical disturbances in IN fCPF-treated mice were also modeled using the human neuroblastoma cell line SH-SY5Y treated with fCPF and CPF. The obtained results suggest that previous exposure to fCPF induces long-term modifications in the brain biochemistry that could be responsible for the phenotypic and behavioral observations. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/conferenceObject Congreso Journal http://purl.org/coar/resource_type/c_5794 info:ar-repo/semantics/documentoDeConferencia |
status_str |
publishedVersion |
format |
conferenceObject |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/228486 Behavioral and neurochemical long-term consequences of intranasal chlorpyrifos formulation administration in mice; The 2nd International Electronic Conference on Biomedicines; Basilea; Suiza; 2023; 1-1 2673-9992 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/228486 |
identifier_str_mv |
Behavioral and neurochemical long-term consequences of intranasal chlorpyrifos formulation administration in mice; The 2nd International Electronic Conference on Biomedicines; Basilea; Suiza; 2023; 1-1 2673-9992 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
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info:eu-repo/semantics/altIdentifier/url/https://ecb2023.sciforum.net/#session2624 |
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info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
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openAccess |
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https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
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Internacional |
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Multidisciplinary Digital Publishing Institute |
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Multidisciplinary Digital Publishing Institute |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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