A systematic review and meta-analysis of the potential non-human animal reservoirs and arthropod vectors of the Mayaro virus

• Autores: Celone, Michael; Okech, Bernard; Han, Barbara A.; Forshey, Brett M.; Anyamba, Assaf; Dunford, James; Rutherford, George; Mita-Mendoza, Neida Karen; Estallo, Elizabet Lilia; Khouri, Ricardo; de Siqueira, Isadora Cristina; Pollett, Simon
• Año de publicación: 2021
• Idioma: inglés
• Tipo de recurso: artículo
• Materia: METAANALISIS; MAYARO; VIRUS
• Institución: Consejo Nacional de Investigaciones Científicas y Técnicas

Improving our understanding of Mayaro virus (MAYV) ecology is critical to guide surveillance and risk assessment. We conducted a PRISMA-adherent systematic review of the published and grey literature to identify potential arthropod vectors and non-human animal reservoirs of MAYV. We searched PubMed/MEDLINE, Embase, Web of Science, SciELO and grey-literature sources including PAHO databases and dissertation repositories. Studies were included if they assessed MAYV virological/immunological measured occurrence in field-caught, domestic, or sentinel animals or in field-caught arthropods. We conducted an animal seroprevalence meta-analysis using a random effects model. We compiled gran-ular georeferenced maps of non-human MAYV occurrence and graded the quality of the studies using a customized framework. Overall, 57 studies were eligible out of 1523 screened, published between the years 1961 and 2020. Seventeen studies reported MAYV positivity in wild mammals, birds, or reptiles and five studies reported MAYV positivity in domestic animals. MAYV positivity was reported in 12 orders of wild-caught vertebrates, most frequently in the orders Charadriiformes and Primate. Sixteen studies detected MAYV in wild-caught mosquito genera including Haemagogus, Aedes, Culex, Psorophora, Coquil-lettidia, and Sabethes. Vertebrate animals or arthropods with MAYV were detected in Brazil, Panama, Peru, French Guiana, Colombia, Trinidad, Venezuela, Argentina, and Paraguay. Among non-human vertebrates, the Primate order had the highest pooled seroprevalence at 13.1% (95% CI: 4.3–25.1%). From the three most studied primate genera we found the highest seroprevalence was in Alouatta (32.2%, 95% CI: 0.0–79.2%), followed by Callithrix (17.8%, 95% CI: 8.6–28.5%), and Cebus/Sapajus (3.7%, 95% CI: 0.0–11.1%). We further found that MAYV occurs in a wide range of vectors beyond Haemagogus spp. The quality of evidence behind these findings was variable and prompts calls for standardization of reporting of arbovirus occurrence. These findings support further risk emergence prediction, guide field surveillance efforts, and prompt further in-vivo studies to better define the ecological drivers of MAYV maintenance and potential for emergence.
Fil: Celone, Michael. Edward Hébert School of Medicine; Estados Unidos
Fil: Okech, Bernard. Edward Hébert School of Medicine; Estados Unidos
Fil: Han, Barbara A.. Cary Institute of Ecosystem Studies; Estados Unidos
Fil: Forshey, Brett M.. Armed Forces Health Surveillance Division; Estados Unidos
Fil: Anyamba, Assaf. University Space Research Association & NASA/Goddard Space Flight Center; Estados Unidos
Fil: Dunford, James. Edward Hébert School of Medicine; Estados Unidos
Fil: Rutherford, George. University of California; Estados Unidos
Fil: Mita-Mendoza, Neida Karen. Wadsworth Center. State of New York Department of Health; Estados Unidos
Fil: Estallo, Elizabet Lilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina
Fil: Khouri, Ricardo. Fundación Oswaldo Cruz; Brasil
Fil: de Siqueira, Isadora Cristina. Fundación Oswaldo Cruz; Brasil
Fil: Pollett, Simon. Uniformed Services University of the Health Sciences; Estados Unidos. Henry M. Jackson Foundation for the Advancement of Military Medicine; Estados Unidos