Thieno[2,3-b]pyridine derivatives: a new class of antiviral drugs against Mayaro virus

Autores
Amorim, Raquel; Meneses, Marcelo Damião Ferreira de; Borges, Julio Cesar; Pinheiro, Luiz Carlos da Silva; Caldas, Lucio Ayres; Cirne Santos, Claudio Cesar; Mello, Marcos Vinícius Palmeira de; Souza, Alessandra Mendonça Teles de; Castro, Helena Carla; Paixão, Izabel Christina Nunes de Palmer; Campos, Renata de Mendonça; Bergmann, Ingrid Evelyn; Malirat, Viviana; Bernardino, Alice Maria Rolim; Rebello, Moacyr Alcoforado; Fernandes Ferreira, Davis
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Mayaro virus (MAYV) is an arthropod-borne virus and a member of the family Togaviridae, genus Alphavirus. Its infection leads to an acute illness accompanied by long-lasting arthralgia. To date, there are no antiviral drugs or vaccines against infection with MAYV and resources for the prevention or treatment of other alphaviruses are very limited. MAYV has served as a model to study the antiviral potential of several substances on alphavirus replication. In this work we evaluated the antiviral effect of seven new derivatives of thieno[2,3-b]pyridine against MAYV replication in a mammalian cell line. All derivatives were able to reduce viral production effectively at concentrations that were non-toxic for Vero cells. Molecular modeling assays predicted low toxicity risk and good oral bioavailability of the substances in humans. One of the molecules, selected for further study, demonstrated a strong anti-MAYV effect at early stages of replication, as it protected pre-treated cells and also during the late stages, affecting virus morphogenesis. This study is the first to demonstrate the antiviral effect of thienopyridine derivatives on MAYV replication in vitro, suggesting the potential application of these substances as antiviral molecules against alphaviruses. Additional in vivo research will be needed to expand the putative therapeutic applications.
Fil: Amorim, Raquel. Universidade Federal do Rio de Janeiro; Brasil
Fil: Meneses, Marcelo Damião Ferreira de. Universidade Federal do Rio de Janeiro; Brasil
Fil: Borges, Julio Cesar. Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro; Brasil
Fil: Pinheiro, Luiz Carlos da Silva. Universidade Federal do Rio de Janeiro; Brasil
Fil: Caldas, Lucio Ayres. Universidade Federal do Rio de Janeiro; Brasil
Fil: Cirne Santos, Claudio Cesar. Universidade Federal do Rio de Janeiro; Brasil
Fil: Mello, Marcos Vinícius Palmeira de. Universidade Federal Fluminense; Brasil
Fil: Souza, Alessandra Mendonça Teles de. Universidade Federal do Rio de Janeiro; Brasil
Fil: Castro, Helena Carla. Universidade Federal Fluminense; Brasil
Fil: Paixão, Izabel Christina Nunes de Palmer. Universidade Federal Fluminense; Brasil
Fil: Campos, Renata de Mendonça. Universidade Federal do Rio de Janeiro; Brasil
Fil: Bergmann, Ingrid Evelyn. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología "Dr. César Milstein". Fundación Pablo Cassará. Instituto de Ciencia y Tecnología ; Argentina
Fil: Malirat, Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología "Dr. César Milstein". Fundación Pablo Cassará. Instituto de Ciencia y Tecnología ; Argentina
Fil: Bernardino, Alice Maria Rolim. Universidade Federal Fluminense; Brasil
Fil: Rebello, Moacyr Alcoforado. Universidade Federal do Rio de Janeiro; Brasil
Fil: Fernandes Ferreira, Davis. Universidade Federal do Rio de Janeiro; Brasil
Materia
Antivirales
Virus Mayaro
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/43583
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/43583
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Thieno[2,3-b]pyridine derivatives: a new class of antiviral drugs against Mayaro virusAmorim, RaquelMeneses, Marcelo Damião Ferreira deBorges, Julio CesarPinheiro, Luiz Carlos da SilvaCaldas, Lucio AyresCirne Santos, Claudio CesarMello, Marcos Vinícius Palmeira deSouza, Alessandra Mendonça Teles deCastro, Helena CarlaPaixão, Izabel Christina Nunes de PalmerCampos, Renata de MendonçaBergmann, Ingrid EvelynMalirat, VivianaBernardino, Alice Maria RolimRebello, Moacyr AlcoforadoFernandes Ferreira, DavisAntiviralesVirus Mayarohttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Mayaro virus (MAYV) is an arthropod-borne virus and a member of the family Togaviridae, genus Alphavirus. Its infection leads to an acute illness accompanied by long-lasting arthralgia. To date, there are no antiviral drugs or vaccines against infection with MAYV and resources for the prevention or treatment of other alphaviruses are very limited. MAYV has served as a model to study the antiviral potential of several substances on alphavirus replication. In this work we evaluated the antiviral effect of seven new derivatives of thieno[2,3-b]pyridine against MAYV replication in a mammalian cell line. All derivatives were able to reduce viral production effectively at concentrations that were non-toxic for Vero cells. Molecular modeling assays predicted low toxicity risk and good oral bioavailability of the substances in humans. One of the molecules, selected for further study, demonstrated a strong anti-MAYV effect at early stages of replication, as it protected pre-treated cells and also during the late stages, affecting virus morphogenesis. This study is the first to demonstrate the antiviral effect of thienopyridine derivatives on MAYV replication in vitro, suggesting the potential application of these substances as antiviral molecules against alphaviruses. Additional in vivo research will be needed to expand the putative therapeutic applications.Fil: Amorim, Raquel. Universidade Federal do Rio de Janeiro; BrasilFil: Meneses, Marcelo Damião Ferreira de. Universidade Federal do Rio de Janeiro; BrasilFil: Borges, Julio Cesar. Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro; BrasilFil: Pinheiro, Luiz Carlos da Silva. Universidade Federal do Rio de Janeiro; BrasilFil: Caldas, Lucio Ayres. Universidade Federal do Rio de Janeiro; BrasilFil: Cirne Santos, Claudio Cesar. Universidade Federal do Rio de Janeiro; BrasilFil: Mello, Marcos Vinícius Palmeira de. Universidade Federal Fluminense; BrasilFil: Souza, Alessandra Mendonça Teles de. Universidade Federal do Rio de Janeiro; BrasilFil: Castro, Helena Carla. Universidade Federal Fluminense; BrasilFil: Paixão, Izabel Christina Nunes de Palmer. Universidade Federal Fluminense; BrasilFil: Campos, Renata de Mendonça. Universidade Federal do Rio de Janeiro; BrasilFil: Bergmann, Ingrid Evelyn. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología "Dr. César Milstein". Fundación Pablo Cassará. Instituto de Ciencia y Tecnología ; ArgentinaFil: Malirat, Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología "Dr. César Milstein". Fundación Pablo Cassará. Instituto de Ciencia y Tecnología ; ArgentinaFil: Bernardino, Alice Maria Rolim. Universidade Federal Fluminense; BrasilFil: Rebello, Moacyr Alcoforado. Universidade Federal do Rio de Janeiro; BrasilFil: Fernandes Ferreira, Davis. Universidade Federal do Rio de Janeiro; BrasilSpringer Wien2017-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/43583Amorim, Raquel; Meneses, Marcelo Damião Ferreira de ; Borges, Julio Cesar; Pinheiro, Luiz Carlos da Silva ; Caldas, Lucio Ayres; et al.; Thieno[2,3-b]pyridine derivatives: a new class of antiviral drugs against Mayaro virus; Springer Wien; Archives of Virology; 162; 6; 2-2017; 1577-15870304-86081432-8798CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1007/s00705-017-3261-0info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00705-017-3261-0info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:47:30Zoai:ri.conicet.gov.ar:11336/43583instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:47:30.714CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Thieno[2,3-b]pyridine derivatives: a new class of antiviral drugs against Mayaro virus
title Thieno[2,3-b]pyridine derivatives: a new class of antiviral drugs against Mayaro virus
spellingShingle Thieno[2,3-b]pyridine derivatives: a new class of antiviral drugs against Mayaro virus
Amorim, Raquel
Antivirales
Virus Mayaro
title_short Thieno[2,3-b]pyridine derivatives: a new class of antiviral drugs against Mayaro virus
title_full Thieno[2,3-b]pyridine derivatives: a new class of antiviral drugs against Mayaro virus
title_fullStr Thieno[2,3-b]pyridine derivatives: a new class of antiviral drugs against Mayaro virus
title_full_unstemmed Thieno[2,3-b]pyridine derivatives: a new class of antiviral drugs against Mayaro virus
title_sort Thieno[2,3-b]pyridine derivatives: a new class of antiviral drugs against Mayaro virus
dc.creator.none.fl_str_mv Amorim, Raquel
Meneses, Marcelo Damião Ferreira de
Borges, Julio Cesar
Pinheiro, Luiz Carlos da Silva
Caldas, Lucio Ayres
Cirne Santos, Claudio Cesar
Mello, Marcos Vinícius Palmeira de
Souza, Alessandra Mendonça Teles de
Castro, Helena Carla
Paixão, Izabel Christina Nunes de Palmer
Campos, Renata de Mendonça
Bergmann, Ingrid Evelyn
Malirat, Viviana
Bernardino, Alice Maria Rolim
Rebello, Moacyr Alcoforado
Fernandes Ferreira, Davis
author Amorim, Raquel
author_facet Amorim, Raquel
Meneses, Marcelo Damião Ferreira de
Borges, Julio Cesar
Pinheiro, Luiz Carlos da Silva
Caldas, Lucio Ayres
Cirne Santos, Claudio Cesar
Mello, Marcos Vinícius Palmeira de
Souza, Alessandra Mendonça Teles de
Castro, Helena Carla
Paixão, Izabel Christina Nunes de Palmer
Campos, Renata de Mendonça
Bergmann, Ingrid Evelyn
Malirat, Viviana
Bernardino, Alice Maria Rolim
Rebello, Moacyr Alcoforado
Fernandes Ferreira, Davis
author_role author
author2 Meneses, Marcelo Damião Ferreira de
Borges, Julio Cesar
Pinheiro, Luiz Carlos da Silva
Caldas, Lucio Ayres
Cirne Santos, Claudio Cesar
Mello, Marcos Vinícius Palmeira de
Souza, Alessandra Mendonça Teles de
Castro, Helena Carla
Paixão, Izabel Christina Nunes de Palmer
Campos, Renata de Mendonça
Bergmann, Ingrid Evelyn
Malirat, Viviana
Bernardino, Alice Maria Rolim
Rebello, Moacyr Alcoforado
Fernandes Ferreira, Davis
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Antivirales
Virus Mayaro
topic Antivirales
Virus Mayaro
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Mayaro virus (MAYV) is an arthropod-borne virus and a member of the family Togaviridae, genus Alphavirus. Its infection leads to an acute illness accompanied by long-lasting arthralgia. To date, there are no antiviral drugs or vaccines against infection with MAYV and resources for the prevention or treatment of other alphaviruses are very limited. MAYV has served as a model to study the antiviral potential of several substances on alphavirus replication. In this work we evaluated the antiviral effect of seven new derivatives of thieno[2,3-b]pyridine against MAYV replication in a mammalian cell line. All derivatives were able to reduce viral production effectively at concentrations that were non-toxic for Vero cells. Molecular modeling assays predicted low toxicity risk and good oral bioavailability of the substances in humans. One of the molecules, selected for further study, demonstrated a strong anti-MAYV effect at early stages of replication, as it protected pre-treated cells and also during the late stages, affecting virus morphogenesis. This study is the first to demonstrate the antiviral effect of thienopyridine derivatives on MAYV replication in vitro, suggesting the potential application of these substances as antiviral molecules against alphaviruses. Additional in vivo research will be needed to expand the putative therapeutic applications.
Fil: Amorim, Raquel. Universidade Federal do Rio de Janeiro; Brasil
Fil: Meneses, Marcelo Damião Ferreira de. Universidade Federal do Rio de Janeiro; Brasil
Fil: Borges, Julio Cesar. Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro; Brasil
Fil: Pinheiro, Luiz Carlos da Silva. Universidade Federal do Rio de Janeiro; Brasil
Fil: Caldas, Lucio Ayres. Universidade Federal do Rio de Janeiro; Brasil
Fil: Cirne Santos, Claudio Cesar. Universidade Federal do Rio de Janeiro; Brasil
Fil: Mello, Marcos Vinícius Palmeira de. Universidade Federal Fluminense; Brasil
Fil: Souza, Alessandra Mendonça Teles de. Universidade Federal do Rio de Janeiro; Brasil
Fil: Castro, Helena Carla. Universidade Federal Fluminense; Brasil
Fil: Paixão, Izabel Christina Nunes de Palmer. Universidade Federal Fluminense; Brasil
Fil: Campos, Renata de Mendonça. Universidade Federal do Rio de Janeiro; Brasil
Fil: Bergmann, Ingrid Evelyn. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología "Dr. César Milstein". Fundación Pablo Cassará. Instituto de Ciencia y Tecnología ; Argentina
Fil: Malirat, Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología "Dr. César Milstein". Fundación Pablo Cassará. Instituto de Ciencia y Tecnología ; Argentina
Fil: Bernardino, Alice Maria Rolim. Universidade Federal Fluminense; Brasil
Fil: Rebello, Moacyr Alcoforado. Universidade Federal do Rio de Janeiro; Brasil
Fil: Fernandes Ferreira, Davis. Universidade Federal do Rio de Janeiro; Brasil
description Mayaro virus (MAYV) is an arthropod-borne virus and a member of the family Togaviridae, genus Alphavirus. Its infection leads to an acute illness accompanied by long-lasting arthralgia. To date, there are no antiviral drugs or vaccines against infection with MAYV and resources for the prevention or treatment of other alphaviruses are very limited. MAYV has served as a model to study the antiviral potential of several substances on alphavirus replication. In this work we evaluated the antiviral effect of seven new derivatives of thieno[2,3-b]pyridine against MAYV replication in a mammalian cell line. All derivatives were able to reduce viral production effectively at concentrations that were non-toxic for Vero cells. Molecular modeling assays predicted low toxicity risk and good oral bioavailability of the substances in humans. One of the molecules, selected for further study, demonstrated a strong anti-MAYV effect at early stages of replication, as it protected pre-treated cells and also during the late stages, affecting virus morphogenesis. This study is the first to demonstrate the antiviral effect of thienopyridine derivatives on MAYV replication in vitro, suggesting the potential application of these substances as antiviral molecules against alphaviruses. Additional in vivo research will be needed to expand the putative therapeutic applications.
publishDate 2017
dc.date.none.fl_str_mv 2017-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/43583
Amorim, Raquel; Meneses, Marcelo Damião Ferreira de ; Borges, Julio Cesar; Pinheiro, Luiz Carlos da Silva ; Caldas, Lucio Ayres; et al.; Thieno[2,3-b]pyridine derivatives: a new class of antiviral drugs against Mayaro virus; Springer Wien; Archives of Virology; 162; 6; 2-2017; 1577-1587
0304-8608
1432-8798
CONICET Digital
CONICET
url http://hdl.handle.net/11336/43583
identifier_str_mv Amorim, Raquel; Meneses, Marcelo Damião Ferreira de ; Borges, Julio Cesar; Pinheiro, Luiz Carlos da Silva ; Caldas, Lucio Ayres; et al.; Thieno[2,3-b]pyridine derivatives: a new class of antiviral drugs against Mayaro virus; Springer Wien; Archives of Virology; 162; 6; 2-2017; 1577-1587
0304-8608
1432-8798
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1007/s00705-017-3261-0
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00705-017-3261-0
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer Wien
publisher.none.fl_str_mv Springer Wien
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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