Serotonin-transporter promoter polymorphism modulates the ability to control food intake: Effect on total weight loss

Autores
Bonnet, Gemma; Gómez Abellán, Purificación; Vera, Beatriz; Sánchez Romera, Juan Francisco; Hernández Martínez, Antonio M.; Sookoian, Silvia Cristina; Pirola, Carlos José; Garaulet, Marta
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
SCOPE:The biggest challenge for losing weight is the ability to control the amount of food eaten; the tendency to overeat is called disinhibition. Our aims were to determine whether a) the SLC6A4-promoter variant (5-HTTLPR) relates to disinhibition; b) this association could affect total weight-loss during a behavioral/dietary treatment for obesity.METHODS AND RESULTS:2961 subjects attended voluntarily five weight-loss clinics; a subsample (n = 624) was recruited for SLC6A4 genotyping. Total weight-loss, Emotional-Eating-Score and Disinhibition-Score were examined. We observed that: a) the reduced ability to control food intake (disinhibition) is implicated in the impairment to lose weight; b) SLC6A4-promoter variant is implicated in disinhibition. S carriers (low-expressing) of the SLC6A4-promoter variant had a lower inhibition capacity and showed more failure (1.6 times) to control the amount of food eaten than LL (P<0.05); other factors such as eating while bored, overeating after work at night, or craving for specific foods were associated to the SLC6A4 genotype (P<0.05); c) The combination of disinhibition (high disinhibition) and genetics (S carrier) had a higher impact on total weight loss than each factor separately.CONCLUSIONS:SLC6A4-promoter variant is associated with the ability to control food intake and interacts with emotional eating to modulate total weight loss
Fil: Bonnet, Gemma. Universidad de Murcia; España
Fil: Gómez Abellán, Purificación. Universidad de Murcia; España
Fil: Vera, Beatriz. Universidad de Murcia; España
Fil: Sánchez Romera, Juan Francisco. Universidad de Murcia; España
Fil: Hernández Martínez, Antonio M.. Universidad de Murcia; España
Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Pirola, Carlos José. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Garaulet, Marta. Universidad de Murcia; España
Materia
Serotonin Transporter
Slc6a4
Obesity
Weight Loss
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/47279
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/47279
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Serotonin-transporter promoter polymorphism modulates the ability to control food intake: Effect on total weight lossBonnet, GemmaGómez Abellán, PurificaciónVera, BeatrizSánchez Romera, Juan FranciscoHernández Martínez, Antonio M.Sookoian, Silvia CristinaPirola, Carlos JoséGaraulet, MartaSerotonin TransporterSlc6a4ObesityWeight Losshttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3SCOPE:The biggest challenge for losing weight is the ability to control the amount of food eaten; the tendency to overeat is called disinhibition. Our aims were to determine whether a) the SLC6A4-promoter variant (5-HTTLPR) relates to disinhibition; b) this association could affect total weight-loss during a behavioral/dietary treatment for obesity.METHODS AND RESULTS:2961 subjects attended voluntarily five weight-loss clinics; a subsample (n = 624) was recruited for SLC6A4 genotyping. Total weight-loss, Emotional-Eating-Score and Disinhibition-Score were examined. We observed that: a) the reduced ability to control food intake (disinhibition) is implicated in the impairment to lose weight; b) SLC6A4-promoter variant is implicated in disinhibition. S carriers (low-expressing) of the SLC6A4-promoter variant had a lower inhibition capacity and showed more failure (1.6 times) to control the amount of food eaten than LL (P<0.05); other factors such as eating while bored, overeating after work at night, or craving for specific foods were associated to the SLC6A4 genotype (P<0.05); c) The combination of disinhibition (high disinhibition) and genetics (S carrier) had a higher impact on total weight loss than each factor separately.CONCLUSIONS:SLC6A4-promoter variant is associated with the ability to control food intake and interacts with emotional eating to modulate total weight lossFil: Bonnet, Gemma. Universidad de Murcia; EspañaFil: Gómez Abellán, Purificación. Universidad de Murcia; EspañaFil: Vera, Beatriz. Universidad de Murcia; EspañaFil: Sánchez Romera, Juan Francisco. Universidad de Murcia; EspañaFil: Hernández Martínez, Antonio M.. Universidad de Murcia; EspañaFil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Pirola, Carlos José. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Garaulet, Marta. Universidad de Murcia; EspañaWiley VCH Verlag2017-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/47279Bonnet, Gemma; Gómez Abellán, Purificación; Vera, Beatriz; Sánchez Romera, Juan Francisco; Hernández Martínez, Antonio M.; et al.; Serotonin-transporter promoter polymorphism modulates the ability to control food intake: Effect on total weight loss; Wiley VCH Verlag; Molecular Nutrition & Food Research; 61; 11; 11-2017; 1-371613-4125CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/mnfr.201700494info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.201700494info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-01-08T12:45:56Zoai:ri.conicet.gov.ar:11336/47279instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-01-08 12:45:56.916CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Serotonin-transporter promoter polymorphism modulates the ability to control food intake: Effect on total weight loss
title Serotonin-transporter promoter polymorphism modulates the ability to control food intake: Effect on total weight loss
spellingShingle Serotonin-transporter promoter polymorphism modulates the ability to control food intake: Effect on total weight loss
Bonnet, Gemma
Serotonin Transporter
Slc6a4
Obesity
Weight Loss
title_short Serotonin-transporter promoter polymorphism modulates the ability to control food intake: Effect on total weight loss
title_full Serotonin-transporter promoter polymorphism modulates the ability to control food intake: Effect on total weight loss
title_fullStr Serotonin-transporter promoter polymorphism modulates the ability to control food intake: Effect on total weight loss
title_full_unstemmed Serotonin-transporter promoter polymorphism modulates the ability to control food intake: Effect on total weight loss
title_sort Serotonin-transporter promoter polymorphism modulates the ability to control food intake: Effect on total weight loss
dc.creator.none.fl_str_mv Bonnet, Gemma
Gómez Abellán, Purificación
Vera, Beatriz
Sánchez Romera, Juan Francisco
Hernández Martínez, Antonio M.
Sookoian, Silvia Cristina
Pirola, Carlos José
Garaulet, Marta
author Bonnet, Gemma
author_facet Bonnet, Gemma
Gómez Abellán, Purificación
Vera, Beatriz
Sánchez Romera, Juan Francisco
Hernández Martínez, Antonio M.
Sookoian, Silvia Cristina
Pirola, Carlos José
Garaulet, Marta
author_role author
author2 Gómez Abellán, Purificación
Vera, Beatriz
Sánchez Romera, Juan Francisco
Hernández Martínez, Antonio M.
Sookoian, Silvia Cristina
Pirola, Carlos José
Garaulet, Marta
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Serotonin Transporter
Slc6a4
Obesity
Weight Loss
topic Serotonin Transporter
Slc6a4
Obesity
Weight Loss
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv SCOPE:The biggest challenge for losing weight is the ability to control the amount of food eaten; the tendency to overeat is called disinhibition. Our aims were to determine whether a) the SLC6A4-promoter variant (5-HTTLPR) relates to disinhibition; b) this association could affect total weight-loss during a behavioral/dietary treatment for obesity.METHODS AND RESULTS:2961 subjects attended voluntarily five weight-loss clinics; a subsample (n = 624) was recruited for SLC6A4 genotyping. Total weight-loss, Emotional-Eating-Score and Disinhibition-Score were examined. We observed that: a) the reduced ability to control food intake (disinhibition) is implicated in the impairment to lose weight; b) SLC6A4-promoter variant is implicated in disinhibition. S carriers (low-expressing) of the SLC6A4-promoter variant had a lower inhibition capacity and showed more failure (1.6 times) to control the amount of food eaten than LL (P<0.05); other factors such as eating while bored, overeating after work at night, or craving for specific foods were associated to the SLC6A4 genotype (P<0.05); c) The combination of disinhibition (high disinhibition) and genetics (S carrier) had a higher impact on total weight loss than each factor separately.CONCLUSIONS:SLC6A4-promoter variant is associated with the ability to control food intake and interacts with emotional eating to modulate total weight loss
Fil: Bonnet, Gemma. Universidad de Murcia; España
Fil: Gómez Abellán, Purificación. Universidad de Murcia; España
Fil: Vera, Beatriz. Universidad de Murcia; España
Fil: Sánchez Romera, Juan Francisco. Universidad de Murcia; España
Fil: Hernández Martínez, Antonio M.. Universidad de Murcia; España
Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Pirola, Carlos José. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Garaulet, Marta. Universidad de Murcia; España
description SCOPE:The biggest challenge for losing weight is the ability to control the amount of food eaten; the tendency to overeat is called disinhibition. Our aims were to determine whether a) the SLC6A4-promoter variant (5-HTTLPR) relates to disinhibition; b) this association could affect total weight-loss during a behavioral/dietary treatment for obesity.METHODS AND RESULTS:2961 subjects attended voluntarily five weight-loss clinics; a subsample (n = 624) was recruited for SLC6A4 genotyping. Total weight-loss, Emotional-Eating-Score and Disinhibition-Score were examined. We observed that: a) the reduced ability to control food intake (disinhibition) is implicated in the impairment to lose weight; b) SLC6A4-promoter variant is implicated in disinhibition. S carriers (low-expressing) of the SLC6A4-promoter variant had a lower inhibition capacity and showed more failure (1.6 times) to control the amount of food eaten than LL (P<0.05); other factors such as eating while bored, overeating after work at night, or craving for specific foods were associated to the SLC6A4 genotype (P<0.05); c) The combination of disinhibition (high disinhibition) and genetics (S carrier) had a higher impact on total weight loss than each factor separately.CONCLUSIONS:SLC6A4-promoter variant is associated with the ability to control food intake and interacts with emotional eating to modulate total weight loss
publishDate 2017
dc.date.none.fl_str_mv 2017-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/47279
Bonnet, Gemma; Gómez Abellán, Purificación; Vera, Beatriz; Sánchez Romera, Juan Francisco; Hernández Martínez, Antonio M.; et al.; Serotonin-transporter promoter polymorphism modulates the ability to control food intake: Effect on total weight loss; Wiley VCH Verlag; Molecular Nutrition & Food Research; 61; 11; 11-2017; 1-37
1613-4125
CONICET Digital
CONICET
url http://hdl.handle.net/11336/47279
identifier_str_mv Bonnet, Gemma; Gómez Abellán, Purificación; Vera, Beatriz; Sánchez Romera, Juan Francisco; Hernández Martínez, Antonio M.; et al.; Serotonin-transporter promoter polymorphism modulates the ability to control food intake: Effect on total weight loss; Wiley VCH Verlag; Molecular Nutrition & Food Research; 61; 11; 11-2017; 1-37
1613-4125
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1002/mnfr.201700494
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.201700494
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley VCH Verlag
publisher.none.fl_str_mv Wiley VCH Verlag
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.25844

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