Serotonin and Serotonin Transporter Gene Variant in Rotating Shift Workers

Autores
Sookoian, Silvia Cristina; Gemma, Carolina; Fernández Gianotti, Tomás; Burgueño, Adriana Laura; Alvarez, Azucena; González, Claudio Daniel; Pirola, Carlos José
Año de publicación
2007
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Study Objectives: Because serotonin is a neurotransmitter associated with circadian rhythm regulation, we explored a possible relationship of serotonin (5-HT), serotonin metabolite, 5-hydroxyindolacetic acid (5-HIAA), and the functional polymorphism of the serotonin transporter gene (SLC6A4) promoter with rotating shift work. Design & Participants: 683 men were included in this study: 437 day-workers were compared with 246 rotating shift-workers. Results: Platelet 5-HT content differed significantly (p=0.002) between day-workers (41.28±1.99 pg/mg) and rotating shift-workers (37.91±4.16 pg/mg). Accordingly, 5-HIAA content was also significantly (p=0.00004) higher in day-workers (11.40±0.82 pg/mg) in comparison with rotating shift-workers (9.33±1.02 pg/mg). We looked for further differences in SLC6A4 promoter (5-HTTLPR, 44 bp insertion: long (L)/deletion: short (S) alleles). We found a significant (p< 0.008) difference in genotypes distribution between day-workers (LL: 126, LS: 202, and SS: 109 individuals) and rotating shift-workers (LL: 47, LS: 124 and SS: 75 individuals). Logistic regression analysis showed that rotating shift work was associated with S allele independently of work time exposure (Estimate±SE: 0.27±0.11, p<0.015). Besides, there was a significantly lower content of platelet 5-HIAA in S allele carriers in comparison with the other genotypes (SS: 9.2±1.0 pg/mg vs. SL/LL: 11.0±0.8 pg/mg, p<0.02). In conclusion, platelet 5-HT and 5-HIAA contents were significantly lower in rotating shift-workers in comparison with day-workers and there was a significant association between the S variant of SLC6A4 promoter and shift work. These findings may be important for targeting effective therapeutic strategies to ameliorate the associated co- morbidities and behavioral problems in rotating shift workers.
Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Gemma, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Fernández Gianotti, Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Burgueño, Adriana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Alvarez, Azucena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: González, Claudio Daniel. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Pirola, Carlos José. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Materia
ROTATING SHIFT WORK
SEROTONIN
5-HIAA
SLC6A4
GENTICS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/105947
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/105947
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Serotonin and Serotonin Transporter Gene Variant in Rotating Shift WorkersSookoian, Silvia CristinaGemma, CarolinaFernández Gianotti, TomásBurgueño, Adriana LauraAlvarez, AzucenaGonzález, Claudio DanielPirola, Carlos JoséROTATING SHIFT WORKSEROTONIN5-HIAASLC6A4GENTICShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Study Objectives: Because serotonin is a neurotransmitter associated with circadian rhythm regulation, we explored a possible relationship of serotonin (5-HT), serotonin metabolite, 5-hydroxyindolacetic acid (5-HIAA), and the functional polymorphism of the serotonin transporter gene (SLC6A4) promoter with rotating shift work. Design & Participants: 683 men were included in this study: 437 day-workers were compared with 246 rotating shift-workers. Results: Platelet 5-HT content differed significantly (p=0.002) between day-workers (41.28±1.99 pg/mg) and rotating shift-workers (37.91±4.16 pg/mg). Accordingly, 5-HIAA content was also significantly (p=0.00004) higher in day-workers (11.40±0.82 pg/mg) in comparison with rotating shift-workers (9.33±1.02 pg/mg). We looked for further differences in SLC6A4 promoter (5-HTTLPR, 44 bp insertion: long (L)/deletion: short (S) alleles). We found a significant (p< 0.008) difference in genotypes distribution between day-workers (LL: 126, LS: 202, and SS: 109 individuals) and rotating shift-workers (LL: 47, LS: 124 and SS: 75 individuals). Logistic regression analysis showed that rotating shift work was associated with S allele independently of work time exposure (Estimate±SE: 0.27±0.11, p<0.015). Besides, there was a significantly lower content of platelet 5-HIAA in S allele carriers in comparison with the other genotypes (SS: 9.2±1.0 pg/mg vs. SL/LL: 11.0±0.8 pg/mg, p<0.02). In conclusion, platelet 5-HT and 5-HIAA contents were significantly lower in rotating shift-workers in comparison with day-workers and there was a significant association between the S variant of SLC6A4 promoter and shift work. These findings may be important for targeting effective therapeutic strategies to ameliorate the associated co- morbidities and behavioral problems in rotating shift workers.Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Gemma, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Fernández Gianotti, Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Burgueño, Adriana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Alvarez, Azucena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: González, Claudio Daniel. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Pirola, Carlos José. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaOxford University Press2007-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/105947Sookoian, Silvia Cristina; Gemma, Carolina; Fernández Gianotti, Tomás; Burgueño, Adriana Laura; Alvarez, Azucena; et al.; Serotonin and Serotonin Transporter Gene Variant in Rotating Shift Workers; Oxford University Press; Sleep.; 30; 8; 8-2007; 1049-10530161-8105CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/sleep/article/30/8/1049/2696794info:eu-repo/semantics/altIdentifier/doi/10.1093/sleep/30.8.1049info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-01-08T13:06:55Zoai:ri.conicet.gov.ar:11336/105947instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-01-08 13:06:55.913CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Serotonin and Serotonin Transporter Gene Variant in Rotating Shift Workers
title Serotonin and Serotonin Transporter Gene Variant in Rotating Shift Workers
spellingShingle Serotonin and Serotonin Transporter Gene Variant in Rotating Shift Workers
Sookoian, Silvia Cristina
ROTATING SHIFT WORK
SEROTONIN
5-HIAA
SLC6A4
GENTICS
title_short Serotonin and Serotonin Transporter Gene Variant in Rotating Shift Workers
title_full Serotonin and Serotonin Transporter Gene Variant in Rotating Shift Workers
title_fullStr Serotonin and Serotonin Transporter Gene Variant in Rotating Shift Workers
title_full_unstemmed Serotonin and Serotonin Transporter Gene Variant in Rotating Shift Workers
title_sort Serotonin and Serotonin Transporter Gene Variant in Rotating Shift Workers
dc.creator.none.fl_str_mv Sookoian, Silvia Cristina
Gemma, Carolina
Fernández Gianotti, Tomás
Burgueño, Adriana Laura
Alvarez, Azucena
González, Claudio Daniel
Pirola, Carlos José
author Sookoian, Silvia Cristina
author_facet Sookoian, Silvia Cristina
Gemma, Carolina
Fernández Gianotti, Tomás
Burgueño, Adriana Laura
Alvarez, Azucena
González, Claudio Daniel
Pirola, Carlos José
author_role author
author2 Gemma, Carolina
Fernández Gianotti, Tomás
Burgueño, Adriana Laura
Alvarez, Azucena
González, Claudio Daniel
Pirola, Carlos José
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv ROTATING SHIFT WORK
SEROTONIN
5-HIAA
SLC6A4
GENTICS
topic ROTATING SHIFT WORK
SEROTONIN
5-HIAA
SLC6A4
GENTICS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Study Objectives: Because serotonin is a neurotransmitter associated with circadian rhythm regulation, we explored a possible relationship of serotonin (5-HT), serotonin metabolite, 5-hydroxyindolacetic acid (5-HIAA), and the functional polymorphism of the serotonin transporter gene (SLC6A4) promoter with rotating shift work. Design & Participants: 683 men were included in this study: 437 day-workers were compared with 246 rotating shift-workers. Results: Platelet 5-HT content differed significantly (p=0.002) between day-workers (41.28±1.99 pg/mg) and rotating shift-workers (37.91±4.16 pg/mg). Accordingly, 5-HIAA content was also significantly (p=0.00004) higher in day-workers (11.40±0.82 pg/mg) in comparison with rotating shift-workers (9.33±1.02 pg/mg). We looked for further differences in SLC6A4 promoter (5-HTTLPR, 44 bp insertion: long (L)/deletion: short (S) alleles). We found a significant (p< 0.008) difference in genotypes distribution between day-workers (LL: 126, LS: 202, and SS: 109 individuals) and rotating shift-workers (LL: 47, LS: 124 and SS: 75 individuals). Logistic regression analysis showed that rotating shift work was associated with S allele independently of work time exposure (Estimate±SE: 0.27±0.11, p<0.015). Besides, there was a significantly lower content of platelet 5-HIAA in S allele carriers in comparison with the other genotypes (SS: 9.2±1.0 pg/mg vs. SL/LL: 11.0±0.8 pg/mg, p<0.02). In conclusion, platelet 5-HT and 5-HIAA contents were significantly lower in rotating shift-workers in comparison with day-workers and there was a significant association between the S variant of SLC6A4 promoter and shift work. These findings may be important for targeting effective therapeutic strategies to ameliorate the associated co- morbidities and behavioral problems in rotating shift workers.
Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Gemma, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Fernández Gianotti, Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Burgueño, Adriana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Alvarez, Azucena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: González, Claudio Daniel. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Pirola, Carlos José. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
description Study Objectives: Because serotonin is a neurotransmitter associated with circadian rhythm regulation, we explored a possible relationship of serotonin (5-HT), serotonin metabolite, 5-hydroxyindolacetic acid (5-HIAA), and the functional polymorphism of the serotonin transporter gene (SLC6A4) promoter with rotating shift work. Design & Participants: 683 men were included in this study: 437 day-workers were compared with 246 rotating shift-workers. Results: Platelet 5-HT content differed significantly (p=0.002) between day-workers (41.28±1.99 pg/mg) and rotating shift-workers (37.91±4.16 pg/mg). Accordingly, 5-HIAA content was also significantly (p=0.00004) higher in day-workers (11.40±0.82 pg/mg) in comparison with rotating shift-workers (9.33±1.02 pg/mg). We looked for further differences in SLC6A4 promoter (5-HTTLPR, 44 bp insertion: long (L)/deletion: short (S) alleles). We found a significant (p< 0.008) difference in genotypes distribution between day-workers (LL: 126, LS: 202, and SS: 109 individuals) and rotating shift-workers (LL: 47, LS: 124 and SS: 75 individuals). Logistic regression analysis showed that rotating shift work was associated with S allele independently of work time exposure (Estimate±SE: 0.27±0.11, p<0.015). Besides, there was a significantly lower content of platelet 5-HIAA in S allele carriers in comparison with the other genotypes (SS: 9.2±1.0 pg/mg vs. SL/LL: 11.0±0.8 pg/mg, p<0.02). In conclusion, platelet 5-HT and 5-HIAA contents were significantly lower in rotating shift-workers in comparison with day-workers and there was a significant association between the S variant of SLC6A4 promoter and shift work. These findings may be important for targeting effective therapeutic strategies to ameliorate the associated co- morbidities and behavioral problems in rotating shift workers.
publishDate 2007
dc.date.none.fl_str_mv 2007-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/105947
Sookoian, Silvia Cristina; Gemma, Carolina; Fernández Gianotti, Tomás; Burgueño, Adriana Laura; Alvarez, Azucena; et al.; Serotonin and Serotonin Transporter Gene Variant in Rotating Shift Workers; Oxford University Press; Sleep.; 30; 8; 8-2007; 1049-1053
0161-8105
CONICET Digital
CONICET
url http://hdl.handle.net/11336/105947
identifier_str_mv Sookoian, Silvia Cristina; Gemma, Carolina; Fernández Gianotti, Tomás; Burgueño, Adriana Laura; Alvarez, Azucena; et al.; Serotonin and Serotonin Transporter Gene Variant in Rotating Shift Workers; Oxford University Press; Sleep.; 30; 8; 8-2007; 1049-1053
0161-8105
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/sleep/article/30/8/1049/2696794
info:eu-repo/semantics/altIdentifier/doi/10.1093/sleep/30.8.1049
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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