IPSCs: A Minireview from bench to bed, including organoids and the crispr system

Autores
Orqueda, Andres Javier; Giménez, Carla Alejandra; Pereyra Bonnet, Federico Alberto
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
When Dolly the sheep was born, the first probe into an adult mammalian genome traveling back in time and generating a whole new animal appeared. Ten years later, the reprogramming process became a defined method of producing induced pluripotent stem cells (iPSCs) through the overexpression of four transcription factors. iPSCs are capable of originating virtually all types of cells and tissues, including a whole new animal. The reprogramming strategies based on patient-derived cells should make the development of clinical applications of cell based therapy much more straightforward. Here, we analyze the current state, opportunities, and challenges of iPSCs from bench to bed, including organoids and the CRISPR system.
Fil: Orqueda, Andres Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Italiano. Instituto Universitario - Escuela de Medicina; Argentina
Fil: Giménez, Carla Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Italiano. Instituto Universitario - Escuela de Medicina; Argentina
Fil: Pereyra Bonnet, Federico Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Italiano. Instituto Universitario - Escuela de Medicina; Argentina
Materia
Induced Pluripotent Stem Cells
Ransgenic Strategy
Clinical Trials
Reprogramming
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/74689
Acceder
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spelling IPSCs: A Minireview from bench to bed, including organoids and the crispr systemOrqueda, Andres JavierGiménez, Carla AlejandraPereyra Bonnet, Federico AlbertoInduced Pluripotent Stem CellsRansgenic StrategyClinical TrialsReprogramminghttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1When Dolly the sheep was born, the first probe into an adult mammalian genome traveling back in time and generating a whole new animal appeared. Ten years later, the reprogramming process became a defined method of producing induced pluripotent stem cells (iPSCs) through the overexpression of four transcription factors. iPSCs are capable of originating virtually all types of cells and tissues, including a whole new animal. The reprogramming strategies based on patient-derived cells should make the development of clinical applications of cell based therapy much more straightforward. Here, we analyze the current state, opportunities, and challenges of iPSCs from bench to bed, including organoids and the CRISPR system.Fil: Orqueda, Andres Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Italiano. Instituto Universitario - Escuela de Medicina; ArgentinaFil: Giménez, Carla Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Italiano. Instituto Universitario - Escuela de Medicina; ArgentinaFil: Pereyra Bonnet, Federico Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Italiano. Instituto Universitario - Escuela de Medicina; ArgentinaHindawi Publishing Corporation2016-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/74689Orqueda, Andres Javier; Giménez, Carla Alejandra; Pereyra Bonnet, Federico Alberto; IPSCs: A Minireview from bench to bed, including organoids and the crispr system; Hindawi Publishing Corporation; Stem Cells International; 2016; 1-2016; 1-91687-9678CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/sci/2016/5934782/info:eu-repo/semantics/altIdentifier/doi/10.1155/2016/5934782info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:29:05Zoai:ri.conicet.gov.ar:11336/74689instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:29:05.41CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv IPSCs: A Minireview from bench to bed, including organoids and the crispr system
title IPSCs: A Minireview from bench to bed, including organoids and the crispr system
spellingShingle IPSCs: A Minireview from bench to bed, including organoids and the crispr system
Orqueda, Andres Javier
Induced Pluripotent Stem Cells
Ransgenic Strategy
Clinical Trials
Reprogramming
title_short IPSCs: A Minireview from bench to bed, including organoids and the crispr system
title_full IPSCs: A Minireview from bench to bed, including organoids and the crispr system
title_fullStr IPSCs: A Minireview from bench to bed, including organoids and the crispr system
title_full_unstemmed IPSCs: A Minireview from bench to bed, including organoids and the crispr system
title_sort IPSCs: A Minireview from bench to bed, including organoids and the crispr system
dc.creator.none.fl_str_mv Orqueda, Andres Javier
Giménez, Carla Alejandra
Pereyra Bonnet, Federico Alberto
author Orqueda, Andres Javier
author_facet Orqueda, Andres Javier
Giménez, Carla Alejandra
Pereyra Bonnet, Federico Alberto
author_role author
author2 Giménez, Carla Alejandra
Pereyra Bonnet, Federico Alberto
author2_role author
author
dc.subject.none.fl_str_mv Induced Pluripotent Stem Cells
Ransgenic Strategy
Clinical Trials
Reprogramming
topic Induced Pluripotent Stem Cells
Ransgenic Strategy
Clinical Trials
Reprogramming
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv When Dolly the sheep was born, the first probe into an adult mammalian genome traveling back in time and generating a whole new animal appeared. Ten years later, the reprogramming process became a defined method of producing induced pluripotent stem cells (iPSCs) through the overexpression of four transcription factors. iPSCs are capable of originating virtually all types of cells and tissues, including a whole new animal. The reprogramming strategies based on patient-derived cells should make the development of clinical applications of cell based therapy much more straightforward. Here, we analyze the current state, opportunities, and challenges of iPSCs from bench to bed, including organoids and the CRISPR system.
Fil: Orqueda, Andres Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Italiano. Instituto Universitario - Escuela de Medicina; Argentina
Fil: Giménez, Carla Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Italiano. Instituto Universitario - Escuela de Medicina; Argentina
Fil: Pereyra Bonnet, Federico Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Italiano. Instituto Universitario - Escuela de Medicina; Argentina
description When Dolly the sheep was born, the first probe into an adult mammalian genome traveling back in time and generating a whole new animal appeared. Ten years later, the reprogramming process became a defined method of producing induced pluripotent stem cells (iPSCs) through the overexpression of four transcription factors. iPSCs are capable of originating virtually all types of cells and tissues, including a whole new animal. The reprogramming strategies based on patient-derived cells should make the development of clinical applications of cell based therapy much more straightforward. Here, we analyze the current state, opportunities, and challenges of iPSCs from bench to bed, including organoids and the CRISPR system.
publishDate 2016
dc.date.none.fl_str_mv 2016-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/74689
Orqueda, Andres Javier; Giménez, Carla Alejandra; Pereyra Bonnet, Federico Alberto; IPSCs: A Minireview from bench to bed, including organoids and the crispr system; Hindawi Publishing Corporation; Stem Cells International; 2016; 1-2016; 1-9
1687-9678
CONICET Digital
CONICET
url http://hdl.handle.net/11336/74689
identifier_str_mv Orqueda, Andres Javier; Giménez, Carla Alejandra; Pereyra Bonnet, Federico Alberto; IPSCs: A Minireview from bench to bed, including organoids and the crispr system; Hindawi Publishing Corporation; Stem Cells International; 2016; 1-2016; 1-9
1687-9678
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/sci/2016/5934782/
info:eu-repo/semantics/altIdentifier/doi/10.1155/2016/5934782
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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