A Public Health Response against Strongyloides stercoralis : Time to Look at Soil-Transmitted Helminthiasis in Full

Autores
Krolewiecki, Alejandro Javier; Lammie, Patrick; Jacobson, Julie; Gabrielli, Albis-Francesco; Levecke, Bruno; Socías, María Guillermina; Arias, Luis María; Sosa, Nicanor; Abraham, David; Cimino, Rubén Oscar; Echazú, Adriana; Crudo, Favio; Vercruysse, Josef; Albonico, Marco
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Strongyloides stercoralis infections have a worldwide distribution with a global burden in terms of prevalence and morbidity that is largely ignored. A public health response against soil-transmitted helminth (STH) infections should broaden the strategy to include S. stercoralis and overcome the epidemiological, diagnostic, and therapeutic challenges that this parasite poses in comparison to Ascaris lumbricoides, Trichuris trichiura, and hookworms. The relatively poor sensitivity of single stool evaluations, which is further lowered when quantitative techniques aimed at detecting eggs are used, also complicates morbidity evaluations and adequate drug efficacy measurements, since S. stercoralis is eliminated in stools in a larval stage. Specific stool techniques for the detection of larvae of S. stercoralis, like Baermann?s and Koga?s agar plate, despite superiority over direct techniques are still suboptimal. New serologies using recombinant antigens and molecular-based techniques offer new hopes in those areas. The use of ivermectin rather than benzimidazoles for its treatment and the need to have curative regimens rather than lowering the parasite burden are also unique for S. stercoralis in comparison to the other STH due to its life cycle, which allows reproduction and amplification of the worm burden within the human host. The potential impact on STH of the benzimidazoles/ivermectin combinations, already used for control/elimination of lymphatic filariasis, should be further evaluated in public health settings. While waiting for more effective single-dose drug regimens and new sensitive diagnostics, the evidence and the tools already available warrant the planning of a common platform for STH and S. stercoralis control.
Fil: Krolewiecki, Alejandro Javier. Universidad Nacional de Salta. Sede Regional Oran. Instituto de Investigación de Enfermedades Tropicales; Argentina;
Fil: Lammie, Patrick. Centers For Disease Control And Prevention. National Center For Infectious Diseases. Division Of Parasitic Diseases; Estados Unidos de América;
Fil: Jacobson, Julie. BILL & MELINDA GATES FOUNDATION;
Fil: Gabrielli, Albis-Francesco. WORLD HEALTH ORGANIZATION;
Fil: Levecke, Bruno. Ghent University. Faculty of Veterinary Medicine. Parasitology and Immunology. Department of Virology, Bélgica;
Fil: Socías, María Guillermina. Fundación Mundo Sano; Argentina;
Fil: Arias, Luis María. Ministerio de Salud Pública de la Provincia de Salta; Argentina;
Fil: Sosa, Nicanor. Ministerio de Salud Pública de la Provincia de Salta; Argentina;
Fil: Abraham, David. Thomas Jefferson University. Department of Microbiology and Immunology. Kimmel Cancer; Argentina;
Fil: Cimino, Rubén Oscar. Universidad Nacional de Salta. Sede Regional Oran. Instituto de Investigación de Enfermedades Tropicales; Argentina;
Fil: Echazú, Adriana. Universidad Nacional de Salta. Sede Regional Oran. Instituto de Investigación de Enfermedades Tropicales; Argentina;
Fil: Crudo, Favio. Municipio de Zárate. Subsecretaría de Salud; Argentina;
Fil: Vercruysse, Josef. Department of Control of Neglected Tropical Diseases; Italia;
Fil: Albonico, Marco. Ivo de Carneri Foundation; Italia;
Materia
STRONGYLOIDES STERCORALIS
SOIL TRANSMITTED HELMINTHS
ANTIHELMINTHICS
NEGLECTED TROPICAL DISEASES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/636

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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A Public Health Response against Strongyloides stercoralis : Time to Look at Soil-Transmitted Helminthiasis in FullKrolewiecki, Alejandro JavierLammie, PatrickJacobson, JulieGabrielli, Albis-FrancescoLevecke, BrunoSocías, María GuillerminaArias, Luis MaríaSosa, NicanorAbraham, DavidCimino, Rubén OscarEchazú, AdrianaCrudo, FavioVercruysse, JosefAlbonico, MarcoSTRONGYLOIDES STERCORALISSOIL TRANSMITTED HELMINTHSANTIHELMINTHICSNEGLECTED TROPICAL DISEASEShttps://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.3Strongyloides stercoralis infections have a worldwide distribution with a global burden in terms of prevalence and morbidity that is largely ignored. A public health response against soil-transmitted helminth (STH) infections should broaden the strategy to include S. stercoralis and overcome the epidemiological, diagnostic, and therapeutic challenges that this parasite poses in comparison to Ascaris lumbricoides, Trichuris trichiura, and hookworms. The relatively poor sensitivity of single stool evaluations, which is further lowered when quantitative techniques aimed at detecting eggs are used, also complicates morbidity evaluations and adequate drug efficacy measurements, since S. stercoralis is eliminated in stools in a larval stage. Specific stool techniques for the detection of larvae of S. stercoralis, like Baermann?s and Koga?s agar plate, despite superiority over direct techniques are still suboptimal. New serologies using recombinant antigens and molecular-based techniques offer new hopes in those areas. The use of ivermectin rather than benzimidazoles for its treatment and the need to have curative regimens rather than lowering the parasite burden are also unique for S. stercoralis in comparison to the other STH due to its life cycle, which allows reproduction and amplification of the worm burden within the human host. The potential impact on STH of the benzimidazoles/ivermectin combinations, already used for control/elimination of lymphatic filariasis, should be further evaluated in public health settings. While waiting for more effective single-dose drug regimens and new sensitive diagnostics, the evidence and the tools already available warrant the planning of a common platform for STH and S. stercoralis control.Fil: Krolewiecki, Alejandro Javier. Universidad Nacional de Salta. Sede Regional Oran. Instituto de Investigación de Enfermedades Tropicales; Argentina;Fil: Lammie, Patrick. Centers For Disease Control And Prevention. National Center For Infectious Diseases. Division Of Parasitic Diseases; Estados Unidos de América;Fil: Jacobson, Julie. BILL & MELINDA GATES FOUNDATION;Fil: Gabrielli, Albis-Francesco. WORLD HEALTH ORGANIZATION;Fil: Levecke, Bruno. Ghent University. Faculty of Veterinary Medicine. Parasitology and Immunology. Department of Virology, Bélgica;Fil: Socías, María Guillermina. Fundación Mundo Sano; Argentina;Fil: Arias, Luis María. Ministerio de Salud Pública de la Provincia de Salta; Argentina;Fil: Sosa, Nicanor. Ministerio de Salud Pública de la Provincia de Salta; Argentina;Fil: Abraham, David. Thomas Jefferson University. Department of Microbiology and Immunology. Kimmel Cancer; Argentina;Fil: Cimino, Rubén Oscar. Universidad Nacional de Salta. Sede Regional Oran. Instituto de Investigación de Enfermedades Tropicales; Argentina;Fil: Echazú, Adriana. Universidad Nacional de Salta. Sede Regional Oran. Instituto de Investigación de Enfermedades Tropicales; Argentina;Fil: Crudo, Favio. Municipio de Zárate. Subsecretaría de Salud; Argentina;Fil: Vercruysse, Josef. Department of Control of Neglected Tropical Diseases; Italia;Fil: Albonico, Marco. Ivo de Carneri Foundation; Italia;Public Library Science2013-05-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/636Krolewiecki, Alejandro Javier; Lammie, Patrick; Jacobson, Julie; Gabrielli, Albis-Francesco; Levecke, Bruno; Socías, María Guillermina; Arias, Luis María; Sosa, Nicanor; Abraham, David; Cimino, Rubén Oscar; et al.;A Public Health Response against Strongyloides stercoralis : Time to Look at Soil-Transmitted Helminthiasis in Full; Public Library Science; Plos Neglected Tropical Diseases; 7; 5; 9-5-2013; e2165;1935-2735enginfo:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pntd.0002165info:eu-repo/semantics/altIdentifier/url/http://www.plosntds.org/article/info%3Adoi%2F10.1371%2Fjournal.pntd.0002165info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:49:43Zoai:ri.conicet.gov.ar:11336/636instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:49:43.954CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A Public Health Response against Strongyloides stercoralis : Time to Look at Soil-Transmitted Helminthiasis in Full
title A Public Health Response against Strongyloides stercoralis : Time to Look at Soil-Transmitted Helminthiasis in Full
spellingShingle A Public Health Response against Strongyloides stercoralis : Time to Look at Soil-Transmitted Helminthiasis in Full
Krolewiecki, Alejandro Javier
STRONGYLOIDES STERCORALIS
SOIL TRANSMITTED HELMINTHS
ANTIHELMINTHICS
NEGLECTED TROPICAL DISEASES
title_short A Public Health Response against Strongyloides stercoralis : Time to Look at Soil-Transmitted Helminthiasis in Full
title_full A Public Health Response against Strongyloides stercoralis : Time to Look at Soil-Transmitted Helminthiasis in Full
title_fullStr A Public Health Response against Strongyloides stercoralis : Time to Look at Soil-Transmitted Helminthiasis in Full
title_full_unstemmed A Public Health Response against Strongyloides stercoralis : Time to Look at Soil-Transmitted Helminthiasis in Full
title_sort A Public Health Response against Strongyloides stercoralis : Time to Look at Soil-Transmitted Helminthiasis in Full
dc.creator.none.fl_str_mv Krolewiecki, Alejandro Javier
Lammie, Patrick
Jacobson, Julie
Gabrielli, Albis-Francesco
Levecke, Bruno
Socías, María Guillermina
Arias, Luis María
Sosa, Nicanor
Abraham, David
Cimino, Rubén Oscar
Echazú, Adriana
Crudo, Favio
Vercruysse, Josef
Albonico, Marco
author Krolewiecki, Alejandro Javier
author_facet Krolewiecki, Alejandro Javier
Lammie, Patrick
Jacobson, Julie
Gabrielli, Albis-Francesco
Levecke, Bruno
Socías, María Guillermina
Arias, Luis María
Sosa, Nicanor
Abraham, David
Cimino, Rubén Oscar
Echazú, Adriana
Crudo, Favio
Vercruysse, Josef
Albonico, Marco
author_role author
author2 Lammie, Patrick
Jacobson, Julie
Gabrielli, Albis-Francesco
Levecke, Bruno
Socías, María Guillermina
Arias, Luis María
Sosa, Nicanor
Abraham, David
Cimino, Rubén Oscar
Echazú, Adriana
Crudo, Favio
Vercruysse, Josef
Albonico, Marco
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv STRONGYLOIDES STERCORALIS
SOIL TRANSMITTED HELMINTHS
ANTIHELMINTHICS
NEGLECTED TROPICAL DISEASES
topic STRONGYLOIDES STERCORALIS
SOIL TRANSMITTED HELMINTHS
ANTIHELMINTHICS
NEGLECTED TROPICAL DISEASES
purl_subject.fl_str_mv https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.3
dc.description.none.fl_txt_mv Strongyloides stercoralis infections have a worldwide distribution with a global burden in terms of prevalence and morbidity that is largely ignored. A public health response against soil-transmitted helminth (STH) infections should broaden the strategy to include S. stercoralis and overcome the epidemiological, diagnostic, and therapeutic challenges that this parasite poses in comparison to Ascaris lumbricoides, Trichuris trichiura, and hookworms. The relatively poor sensitivity of single stool evaluations, which is further lowered when quantitative techniques aimed at detecting eggs are used, also complicates morbidity evaluations and adequate drug efficacy measurements, since S. stercoralis is eliminated in stools in a larval stage. Specific stool techniques for the detection of larvae of S. stercoralis, like Baermann?s and Koga?s agar plate, despite superiority over direct techniques are still suboptimal. New serologies using recombinant antigens and molecular-based techniques offer new hopes in those areas. The use of ivermectin rather than benzimidazoles for its treatment and the need to have curative regimens rather than lowering the parasite burden are also unique for S. stercoralis in comparison to the other STH due to its life cycle, which allows reproduction and amplification of the worm burden within the human host. The potential impact on STH of the benzimidazoles/ivermectin combinations, already used for control/elimination of lymphatic filariasis, should be further evaluated in public health settings. While waiting for more effective single-dose drug regimens and new sensitive diagnostics, the evidence and the tools already available warrant the planning of a common platform for STH and S. stercoralis control.
Fil: Krolewiecki, Alejandro Javier. Universidad Nacional de Salta. Sede Regional Oran. Instituto de Investigación de Enfermedades Tropicales; Argentina;
Fil: Lammie, Patrick. Centers For Disease Control And Prevention. National Center For Infectious Diseases. Division Of Parasitic Diseases; Estados Unidos de América;
Fil: Jacobson, Julie. BILL & MELINDA GATES FOUNDATION;
Fil: Gabrielli, Albis-Francesco. WORLD HEALTH ORGANIZATION;
Fil: Levecke, Bruno. Ghent University. Faculty of Veterinary Medicine. Parasitology and Immunology. Department of Virology, Bélgica;
Fil: Socías, María Guillermina. Fundación Mundo Sano; Argentina;
Fil: Arias, Luis María. Ministerio de Salud Pública de la Provincia de Salta; Argentina;
Fil: Sosa, Nicanor. Ministerio de Salud Pública de la Provincia de Salta; Argentina;
Fil: Abraham, David. Thomas Jefferson University. Department of Microbiology and Immunology. Kimmel Cancer; Argentina;
Fil: Cimino, Rubén Oscar. Universidad Nacional de Salta. Sede Regional Oran. Instituto de Investigación de Enfermedades Tropicales; Argentina;
Fil: Echazú, Adriana. Universidad Nacional de Salta. Sede Regional Oran. Instituto de Investigación de Enfermedades Tropicales; Argentina;
Fil: Crudo, Favio. Municipio de Zárate. Subsecretaría de Salud; Argentina;
Fil: Vercruysse, Josef. Department of Control of Neglected Tropical Diseases; Italia;
Fil: Albonico, Marco. Ivo de Carneri Foundation; Italia;
description Strongyloides stercoralis infections have a worldwide distribution with a global burden in terms of prevalence and morbidity that is largely ignored. A public health response against soil-transmitted helminth (STH) infections should broaden the strategy to include S. stercoralis and overcome the epidemiological, diagnostic, and therapeutic challenges that this parasite poses in comparison to Ascaris lumbricoides, Trichuris trichiura, and hookworms. The relatively poor sensitivity of single stool evaluations, which is further lowered when quantitative techniques aimed at detecting eggs are used, also complicates morbidity evaluations and adequate drug efficacy measurements, since S. stercoralis is eliminated in stools in a larval stage. Specific stool techniques for the detection of larvae of S. stercoralis, like Baermann?s and Koga?s agar plate, despite superiority over direct techniques are still suboptimal. New serologies using recombinant antigens and molecular-based techniques offer new hopes in those areas. The use of ivermectin rather than benzimidazoles for its treatment and the need to have curative regimens rather than lowering the parasite burden are also unique for S. stercoralis in comparison to the other STH due to its life cycle, which allows reproduction and amplification of the worm burden within the human host. The potential impact on STH of the benzimidazoles/ivermectin combinations, already used for control/elimination of lymphatic filariasis, should be further evaluated in public health settings. While waiting for more effective single-dose drug regimens and new sensitive diagnostics, the evidence and the tools already available warrant the planning of a common platform for STH and S. stercoralis control.
publishDate 2013
dc.date.none.fl_str_mv 2013-05-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/636
Krolewiecki, Alejandro Javier; Lammie, Patrick; Jacobson, Julie; Gabrielli, Albis-Francesco; Levecke, Bruno; Socías, María Guillermina; Arias, Luis María; Sosa, Nicanor; Abraham, David; Cimino, Rubén Oscar; et al.;A Public Health Response against Strongyloides stercoralis : Time to Look at Soil-Transmitted Helminthiasis in Full; Public Library Science; Plos Neglected Tropical Diseases; 7; 5; 9-5-2013; e2165;
1935-2735
url http://hdl.handle.net/11336/636
identifier_str_mv Krolewiecki, Alejandro Javier; Lammie, Patrick; Jacobson, Julie; Gabrielli, Albis-Francesco; Levecke, Bruno; Socías, María Guillermina; Arias, Luis María; Sosa, Nicanor; Abraham, David; Cimino, Rubén Oscar; et al.;A Public Health Response against Strongyloides stercoralis : Time to Look at Soil-Transmitted Helminthiasis in Full; Public Library Science; Plos Neglected Tropical Diseases; 7; 5; 9-5-2013; e2165;
1935-2735
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/url/http://www.plosntds.org/article/info%3Adoi%2F10.1371%2Fjournal.pntd.0002165
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library Science
publisher.none.fl_str_mv Public Library Science
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reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
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repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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