A Public Health Response against Strongyloides stercoralis : Time to Look at Soil-Transmitted Helminthiasis in Full
- Autores
- Krolewiecki, Alejandro Javier; Lammie, Patrick; Jacobson, Julie; Gabrielli, Albis-Francesco; Levecke, Bruno; Socías, María Guillermina; Arias, Luis María; Sosa, Nicanor; Abraham, David; Cimino, Rubén Oscar; Echazú, Adriana; Crudo, Favio; Vercruysse, Josef; Albonico, Marco
- Año de publicación
- 2013
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Strongyloides stercoralis infections have a worldwide distribution with a global burden in terms of prevalence and morbidity that is largely ignored. A public health response against soil-transmitted helminth (STH) infections should broaden the strategy to include S. stercoralis and overcome the epidemiological, diagnostic, and therapeutic challenges that this parasite poses in comparison to Ascaris lumbricoides, Trichuris trichiura, and hookworms. The relatively poor sensitivity of single stool evaluations, which is further lowered when quantitative techniques aimed at detecting eggs are used, also complicates morbidity evaluations and adequate drug efficacy measurements, since S. stercoralis is eliminated in stools in a larval stage. Specific stool techniques for the detection of larvae of S. stercoralis, like Baermann?s and Koga?s agar plate, despite superiority over direct techniques are still suboptimal. New serologies using recombinant antigens and molecular-based techniques offer new hopes in those areas. The use of ivermectin rather than benzimidazoles for its treatment and the need to have curative regimens rather than lowering the parasite burden are also unique for S. stercoralis in comparison to the other STH due to its life cycle, which allows reproduction and amplification of the worm burden within the human host. The potential impact on STH of the benzimidazoles/ivermectin combinations, already used for control/elimination of lymphatic filariasis, should be further evaluated in public health settings. While waiting for more effective single-dose drug regimens and new sensitive diagnostics, the evidence and the tools already available warrant the planning of a common platform for STH and S. stercoralis control.
Fil: Krolewiecki, Alejandro Javier. Universidad Nacional de Salta. Sede Regional Oran. Instituto de Investigación de Enfermedades Tropicales; Argentina;
Fil: Lammie, Patrick. Centers For Disease Control And Prevention. National Center For Infectious Diseases. Division Of Parasitic Diseases; Estados Unidos de América;
Fil: Jacobson, Julie. BILL & MELINDA GATES FOUNDATION;
Fil: Gabrielli, Albis-Francesco. WORLD HEALTH ORGANIZATION;
Fil: Levecke, Bruno. Ghent University. Faculty of Veterinary Medicine. Parasitology and Immunology. Department of Virology, Bélgica;
Fil: Socías, María Guillermina. Fundación Mundo Sano; Argentina;
Fil: Arias, Luis María. Ministerio de Salud Pública de la Provincia de Salta; Argentina;
Fil: Sosa, Nicanor. Ministerio de Salud Pública de la Provincia de Salta; Argentina;
Fil: Abraham, David. Thomas Jefferson University. Department of Microbiology and Immunology. Kimmel Cancer; Argentina;
Fil: Cimino, Rubén Oscar. Universidad Nacional de Salta. Sede Regional Oran. Instituto de Investigación de Enfermedades Tropicales; Argentina;
Fil: Echazú, Adriana. Universidad Nacional de Salta. Sede Regional Oran. Instituto de Investigación de Enfermedades Tropicales; Argentina;
Fil: Crudo, Favio. Municipio de Zárate. Subsecretaría de Salud; Argentina;
Fil: Vercruysse, Josef. Department of Control of Neglected Tropical Diseases; Italia;
Fil: Albonico, Marco. Ivo de Carneri Foundation; Italia; - Materia
-
STRONGYLOIDES STERCORALIS
SOIL TRANSMITTED HELMINTHS
ANTIHELMINTHICS
NEGLECTED TROPICAL DISEASES - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/636
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A Public Health Response against Strongyloides stercoralis : Time to Look at Soil-Transmitted Helminthiasis in FullKrolewiecki, Alejandro JavierLammie, PatrickJacobson, JulieGabrielli, Albis-FrancescoLevecke, BrunoSocías, María GuillerminaArias, Luis MaríaSosa, NicanorAbraham, DavidCimino, Rubén OscarEchazú, AdrianaCrudo, FavioVercruysse, JosefAlbonico, MarcoSTRONGYLOIDES STERCORALISSOIL TRANSMITTED HELMINTHSANTIHELMINTHICSNEGLECTED TROPICAL DISEASEShttps://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.3Strongyloides stercoralis infections have a worldwide distribution with a global burden in terms of prevalence and morbidity that is largely ignored. A public health response against soil-transmitted helminth (STH) infections should broaden the strategy to include S. stercoralis and overcome the epidemiological, diagnostic, and therapeutic challenges that this parasite poses in comparison to Ascaris lumbricoides, Trichuris trichiura, and hookworms. The relatively poor sensitivity of single stool evaluations, which is further lowered when quantitative techniques aimed at detecting eggs are used, also complicates morbidity evaluations and adequate drug efficacy measurements, since S. stercoralis is eliminated in stools in a larval stage. Specific stool techniques for the detection of larvae of S. stercoralis, like Baermann?s and Koga?s agar plate, despite superiority over direct techniques are still suboptimal. New serologies using recombinant antigens and molecular-based techniques offer new hopes in those areas. The use of ivermectin rather than benzimidazoles for its treatment and the need to have curative regimens rather than lowering the parasite burden are also unique for S. stercoralis in comparison to the other STH due to its life cycle, which allows reproduction and amplification of the worm burden within the human host. The potential impact on STH of the benzimidazoles/ivermectin combinations, already used for control/elimination of lymphatic filariasis, should be further evaluated in public health settings. While waiting for more effective single-dose drug regimens and new sensitive diagnostics, the evidence and the tools already available warrant the planning of a common platform for STH and S. stercoralis control.Fil: Krolewiecki, Alejandro Javier. Universidad Nacional de Salta. Sede Regional Oran. Instituto de Investigación de Enfermedades Tropicales; Argentina;Fil: Lammie, Patrick. Centers For Disease Control And Prevention. National Center For Infectious Diseases. Division Of Parasitic Diseases; Estados Unidos de América;Fil: Jacobson, Julie. BILL & MELINDA GATES FOUNDATION;Fil: Gabrielli, Albis-Francesco. WORLD HEALTH ORGANIZATION;Fil: Levecke, Bruno. Ghent University. Faculty of Veterinary Medicine. Parasitology and Immunology. Department of Virology, Bélgica;Fil: Socías, María Guillermina. Fundación Mundo Sano; Argentina;Fil: Arias, Luis María. Ministerio de Salud Pública de la Provincia de Salta; Argentina;Fil: Sosa, Nicanor. Ministerio de Salud Pública de la Provincia de Salta; Argentina;Fil: Abraham, David. Thomas Jefferson University. Department of Microbiology and Immunology. Kimmel Cancer; Argentina;Fil: Cimino, Rubén Oscar. Universidad Nacional de Salta. Sede Regional Oran. Instituto de Investigación de Enfermedades Tropicales; Argentina;Fil: Echazú, Adriana. Universidad Nacional de Salta. Sede Regional Oran. Instituto de Investigación de Enfermedades Tropicales; Argentina;Fil: Crudo, Favio. Municipio de Zárate. Subsecretaría de Salud; Argentina;Fil: Vercruysse, Josef. Department of Control of Neglected Tropical Diseases; Italia;Fil: Albonico, Marco. Ivo de Carneri Foundation; Italia;Public Library Science2013-05-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/636Krolewiecki, Alejandro Javier; Lammie, Patrick; Jacobson, Julie; Gabrielli, Albis-Francesco; Levecke, Bruno; Socías, María Guillermina; Arias, Luis María; Sosa, Nicanor; Abraham, David; Cimino, Rubén Oscar; et al.;A Public Health Response against Strongyloides stercoralis : Time to Look at Soil-Transmitted Helminthiasis in Full; Public Library Science; Plos Neglected Tropical Diseases; 7; 5; 9-5-2013; e2165;1935-2735enginfo:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pntd.0002165info:eu-repo/semantics/altIdentifier/url/http://www.plosntds.org/article/info%3Adoi%2F10.1371%2Fjournal.pntd.0002165info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:49:43Zoai:ri.conicet.gov.ar:11336/636instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:49:43.954CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
A Public Health Response against Strongyloides stercoralis : Time to Look at Soil-Transmitted Helminthiasis in Full |
title |
A Public Health Response against Strongyloides stercoralis : Time to Look at Soil-Transmitted Helminthiasis in Full |
spellingShingle |
A Public Health Response against Strongyloides stercoralis : Time to Look at Soil-Transmitted Helminthiasis in Full Krolewiecki, Alejandro Javier STRONGYLOIDES STERCORALIS SOIL TRANSMITTED HELMINTHS ANTIHELMINTHICS NEGLECTED TROPICAL DISEASES |
title_short |
A Public Health Response against Strongyloides stercoralis : Time to Look at Soil-Transmitted Helminthiasis in Full |
title_full |
A Public Health Response against Strongyloides stercoralis : Time to Look at Soil-Transmitted Helminthiasis in Full |
title_fullStr |
A Public Health Response against Strongyloides stercoralis : Time to Look at Soil-Transmitted Helminthiasis in Full |
title_full_unstemmed |
A Public Health Response against Strongyloides stercoralis : Time to Look at Soil-Transmitted Helminthiasis in Full |
title_sort |
A Public Health Response against Strongyloides stercoralis : Time to Look at Soil-Transmitted Helminthiasis in Full |
dc.creator.none.fl_str_mv |
Krolewiecki, Alejandro Javier Lammie, Patrick Jacobson, Julie Gabrielli, Albis-Francesco Levecke, Bruno Socías, María Guillermina Arias, Luis María Sosa, Nicanor Abraham, David Cimino, Rubén Oscar Echazú, Adriana Crudo, Favio Vercruysse, Josef Albonico, Marco |
author |
Krolewiecki, Alejandro Javier |
author_facet |
Krolewiecki, Alejandro Javier Lammie, Patrick Jacobson, Julie Gabrielli, Albis-Francesco Levecke, Bruno Socías, María Guillermina Arias, Luis María Sosa, Nicanor Abraham, David Cimino, Rubén Oscar Echazú, Adriana Crudo, Favio Vercruysse, Josef Albonico, Marco |
author_role |
author |
author2 |
Lammie, Patrick Jacobson, Julie Gabrielli, Albis-Francesco Levecke, Bruno Socías, María Guillermina Arias, Luis María Sosa, Nicanor Abraham, David Cimino, Rubén Oscar Echazú, Adriana Crudo, Favio Vercruysse, Josef Albonico, Marco |
author2_role |
author author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
STRONGYLOIDES STERCORALIS SOIL TRANSMITTED HELMINTHS ANTIHELMINTHICS NEGLECTED TROPICAL DISEASES |
topic |
STRONGYLOIDES STERCORALIS SOIL TRANSMITTED HELMINTHS ANTIHELMINTHICS NEGLECTED TROPICAL DISEASES |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3 https://purl.org/becyt/ford/3.3 |
dc.description.none.fl_txt_mv |
Strongyloides stercoralis infections have a worldwide distribution with a global burden in terms of prevalence and morbidity that is largely ignored. A public health response against soil-transmitted helminth (STH) infections should broaden the strategy to include S. stercoralis and overcome the epidemiological, diagnostic, and therapeutic challenges that this parasite poses in comparison to Ascaris lumbricoides, Trichuris trichiura, and hookworms. The relatively poor sensitivity of single stool evaluations, which is further lowered when quantitative techniques aimed at detecting eggs are used, also complicates morbidity evaluations and adequate drug efficacy measurements, since S. stercoralis is eliminated in stools in a larval stage. Specific stool techniques for the detection of larvae of S. stercoralis, like Baermann?s and Koga?s agar plate, despite superiority over direct techniques are still suboptimal. New serologies using recombinant antigens and molecular-based techniques offer new hopes in those areas. The use of ivermectin rather than benzimidazoles for its treatment and the need to have curative regimens rather than lowering the parasite burden are also unique for S. stercoralis in comparison to the other STH due to its life cycle, which allows reproduction and amplification of the worm burden within the human host. The potential impact on STH of the benzimidazoles/ivermectin combinations, already used for control/elimination of lymphatic filariasis, should be further evaluated in public health settings. While waiting for more effective single-dose drug regimens and new sensitive diagnostics, the evidence and the tools already available warrant the planning of a common platform for STH and S. stercoralis control. Fil: Krolewiecki, Alejandro Javier. Universidad Nacional de Salta. Sede Regional Oran. Instituto de Investigación de Enfermedades Tropicales; Argentina; Fil: Lammie, Patrick. Centers For Disease Control And Prevention. National Center For Infectious Diseases. Division Of Parasitic Diseases; Estados Unidos de América; Fil: Jacobson, Julie. BILL & MELINDA GATES FOUNDATION; Fil: Gabrielli, Albis-Francesco. WORLD HEALTH ORGANIZATION; Fil: Levecke, Bruno. Ghent University. Faculty of Veterinary Medicine. Parasitology and Immunology. Department of Virology, Bélgica; Fil: Socías, María Guillermina. Fundación Mundo Sano; Argentina; Fil: Arias, Luis María. Ministerio de Salud Pública de la Provincia de Salta; Argentina; Fil: Sosa, Nicanor. Ministerio de Salud Pública de la Provincia de Salta; Argentina; Fil: Abraham, David. Thomas Jefferson University. Department of Microbiology and Immunology. Kimmel Cancer; Argentina; Fil: Cimino, Rubén Oscar. Universidad Nacional de Salta. Sede Regional Oran. Instituto de Investigación de Enfermedades Tropicales; Argentina; Fil: Echazú, Adriana. Universidad Nacional de Salta. Sede Regional Oran. Instituto de Investigación de Enfermedades Tropicales; Argentina; Fil: Crudo, Favio. Municipio de Zárate. Subsecretaría de Salud; Argentina; Fil: Vercruysse, Josef. Department of Control of Neglected Tropical Diseases; Italia; Fil: Albonico, Marco. Ivo de Carneri Foundation; Italia; |
description |
Strongyloides stercoralis infections have a worldwide distribution with a global burden in terms of prevalence and morbidity that is largely ignored. A public health response against soil-transmitted helminth (STH) infections should broaden the strategy to include S. stercoralis and overcome the epidemiological, diagnostic, and therapeutic challenges that this parasite poses in comparison to Ascaris lumbricoides, Trichuris trichiura, and hookworms. The relatively poor sensitivity of single stool evaluations, which is further lowered when quantitative techniques aimed at detecting eggs are used, also complicates morbidity evaluations and adequate drug efficacy measurements, since S. stercoralis is eliminated in stools in a larval stage. Specific stool techniques for the detection of larvae of S. stercoralis, like Baermann?s and Koga?s agar plate, despite superiority over direct techniques are still suboptimal. New serologies using recombinant antigens and molecular-based techniques offer new hopes in those areas. The use of ivermectin rather than benzimidazoles for its treatment and the need to have curative regimens rather than lowering the parasite burden are also unique for S. stercoralis in comparison to the other STH due to its life cycle, which allows reproduction and amplification of the worm burden within the human host. The potential impact on STH of the benzimidazoles/ivermectin combinations, already used for control/elimination of lymphatic filariasis, should be further evaluated in public health settings. While waiting for more effective single-dose drug regimens and new sensitive diagnostics, the evidence and the tools already available warrant the planning of a common platform for STH and S. stercoralis control. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-05-09 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/636 Krolewiecki, Alejandro Javier; Lammie, Patrick; Jacobson, Julie; Gabrielli, Albis-Francesco; Levecke, Bruno; Socías, María Guillermina; Arias, Luis María; Sosa, Nicanor; Abraham, David; Cimino, Rubén Oscar; et al.;A Public Health Response against Strongyloides stercoralis : Time to Look at Soil-Transmitted Helminthiasis in Full; Public Library Science; Plos Neglected Tropical Diseases; 7; 5; 9-5-2013; e2165; 1935-2735 |
url |
http://hdl.handle.net/11336/636 |
identifier_str_mv |
Krolewiecki, Alejandro Javier; Lammie, Patrick; Jacobson, Julie; Gabrielli, Albis-Francesco; Levecke, Bruno; Socías, María Guillermina; Arias, Luis María; Sosa, Nicanor; Abraham, David; Cimino, Rubén Oscar; et al.;A Public Health Response against Strongyloides stercoralis : Time to Look at Soil-Transmitted Helminthiasis in Full; Public Library Science; Plos Neglected Tropical Diseases; 7; 5; 9-5-2013; e2165; 1935-2735 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pntd.0002165 info:eu-repo/semantics/altIdentifier/url/http://www.plosntds.org/article/info%3Adoi%2F10.1371%2Fjournal.pntd.0002165 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Public Library Science |
publisher.none.fl_str_mv |
Public Library Science |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842268990782570496 |
score |
13.13397 |