Progesterone prevents impairment of cognitive, affective and motor events in a reserpine model of parkinsonism in male rats

Autores
Yunes, Roberto Miguel Federico; Bregonzio Diaz, Claudia; Villegas, Vanina Anabel; Mulle Bernedo, María Belén; Cabrera Kreiker, Ricardo Jorge
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Parkinson’s is a common neurodegenerative disorder, second only to Alzheimer´s disease.It has been the object of growing interest since its frequency tends to augment as life expectancyhas increased globally considered. In this work, we study the eventual neuroprotective effect ofProgesterone (P4) injected a few days before establishing a Reserpine (R) model of Parkinsonism inadult male rats. We focused on cognitive (Novel Object Recognition test; NOR), affective (ForcedSwimming Task; FST) and motor (Catalepsy Test; CT) outputs. We performed the appropriate testsalong with the administration for two weeks of low doses of R. Our results show very clearly thatP4 prevents the impairment of several tasks regarding the deleterious effects of R, without affectingnegatively other areas of the subject behavior. In total accordance with current information, weshow here that P4 -in particular- and neuroactive steroids -in general- are promising molecules todelay diverse manifestations of neurotransmitters depletion.
Fil: Yunes, Roberto Miguel Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Cátedra de Farmacología; Argentina
Fil: Bregonzio Diaz, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
Fil: Villegas, Vanina Anabel. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Mulle Bernedo, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Cátedra de Farmacología; Argentina
Fil: Cabrera Kreiker, Ricardo Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Cátedra de Farmacología; Argentina
Materia
Progesterone
Neuroactive steroids
Parkinsonism
Neuroprotection
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/203818
Acceder
id CONICETDig_7532ced3a3c147554495ebd7812864da
oai_identifier_str oai:ri.conicet.gov.ar:11336/203818
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Progesterone prevents impairment of cognitive, affective and motor events in a reserpine model of parkinsonism in male ratsYunes, Roberto Miguel FedericoBregonzio Diaz, ClaudiaVillegas, Vanina AnabelMulle Bernedo, María BelénCabrera Kreiker, Ricardo JorgeProgesteroneNeuroactive steroidsParkinsonismNeuroprotectionhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Parkinson’s is a common neurodegenerative disorder, second only to Alzheimer´s disease.It has been the object of growing interest since its frequency tends to augment as life expectancyhas increased globally considered. In this work, we study the eventual neuroprotective effect ofProgesterone (P4) injected a few days before establishing a Reserpine (R) model of Parkinsonism inadult male rats. We focused on cognitive (Novel Object Recognition test; NOR), affective (ForcedSwimming Task; FST) and motor (Catalepsy Test; CT) outputs. We performed the appropriate testsalong with the administration for two weeks of low doses of R. Our results show very clearly thatP4 prevents the impairment of several tasks regarding the deleterious effects of R, without affectingnegatively other areas of the subject behavior. In total accordance with current information, weshow here that P4 -in particular- and neuroactive steroids -in general- are promising molecules todelay diverse manifestations of neurotransmitters depletion.Fil: Yunes, Roberto Miguel Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Cátedra de Farmacología; ArgentinaFil: Bregonzio Diaz, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; ArgentinaFil: Villegas, Vanina Anabel. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Mulle Bernedo, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Cátedra de Farmacología; ArgentinaFil: Cabrera Kreiker, Ricardo Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Cátedra de Farmacología; ArgentinaRemedy Publications2022-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/203818Yunes, Roberto Miguel Federico; Bregonzio Diaz, Claudia; Villegas, Vanina Anabel; Mulle Bernedo, María Belén; Cabrera Kreiker, Ricardo Jorge; Progesterone prevents impairment of cognitive, affective and motor events in a reserpine model of parkinsonism in male rats; Remedy Publications; Clinical Case Reports International; 6; 1; 6-2022; 1-62638-4558CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.clinicalcasereportsint.com/abstract.php?aid=8730info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:03:58Zoai:ri.conicet.gov.ar:11336/203818instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:03:58.783CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Progesterone prevents impairment of cognitive, affective and motor events in a reserpine model of parkinsonism in male rats
title Progesterone prevents impairment of cognitive, affective and motor events in a reserpine model of parkinsonism in male rats
spellingShingle Progesterone prevents impairment of cognitive, affective and motor events in a reserpine model of parkinsonism in male rats
Yunes, Roberto Miguel Federico
Progesterone
Neuroactive steroids
Parkinsonism
Neuroprotection
title_short Progesterone prevents impairment of cognitive, affective and motor events in a reserpine model of parkinsonism in male rats
title_full Progesterone prevents impairment of cognitive, affective and motor events in a reserpine model of parkinsonism in male rats
title_fullStr Progesterone prevents impairment of cognitive, affective and motor events in a reserpine model of parkinsonism in male rats
title_full_unstemmed Progesterone prevents impairment of cognitive, affective and motor events in a reserpine model of parkinsonism in male rats
title_sort Progesterone prevents impairment of cognitive, affective and motor events in a reserpine model of parkinsonism in male rats
dc.creator.none.fl_str_mv Yunes, Roberto Miguel Federico
Bregonzio Diaz, Claudia
Villegas, Vanina Anabel
Mulle Bernedo, María Belén
Cabrera Kreiker, Ricardo Jorge
author Yunes, Roberto Miguel Federico
author_facet Yunes, Roberto Miguel Federico
Bregonzio Diaz, Claudia
Villegas, Vanina Anabel
Mulle Bernedo, María Belén
Cabrera Kreiker, Ricardo Jorge
author_role author
author2 Bregonzio Diaz, Claudia
Villegas, Vanina Anabel
Mulle Bernedo, María Belén
Cabrera Kreiker, Ricardo Jorge
author2_role author
author
author
author
dc.subject.none.fl_str_mv Progesterone
Neuroactive steroids
Parkinsonism
Neuroprotection
topic Progesterone
Neuroactive steroids
Parkinsonism
Neuroprotection
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Parkinson’s is a common neurodegenerative disorder, second only to Alzheimer´s disease.It has been the object of growing interest since its frequency tends to augment as life expectancyhas increased globally considered. In this work, we study the eventual neuroprotective effect ofProgesterone (P4) injected a few days before establishing a Reserpine (R) model of Parkinsonism inadult male rats. We focused on cognitive (Novel Object Recognition test; NOR), affective (ForcedSwimming Task; FST) and motor (Catalepsy Test; CT) outputs. We performed the appropriate testsalong with the administration for two weeks of low doses of R. Our results show very clearly thatP4 prevents the impairment of several tasks regarding the deleterious effects of R, without affectingnegatively other areas of the subject behavior. In total accordance with current information, weshow here that P4 -in particular- and neuroactive steroids -in general- are promising molecules todelay diverse manifestations of neurotransmitters depletion.
Fil: Yunes, Roberto Miguel Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Cátedra de Farmacología; Argentina
Fil: Bregonzio Diaz, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
Fil: Villegas, Vanina Anabel. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Mulle Bernedo, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Cátedra de Farmacología; Argentina
Fil: Cabrera Kreiker, Ricardo Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Cátedra de Farmacología; Argentina
description Parkinson’s is a common neurodegenerative disorder, second only to Alzheimer´s disease.It has been the object of growing interest since its frequency tends to augment as life expectancyhas increased globally considered. In this work, we study the eventual neuroprotective effect ofProgesterone (P4) injected a few days before establishing a Reserpine (R) model of Parkinsonism inadult male rats. We focused on cognitive (Novel Object Recognition test; NOR), affective (ForcedSwimming Task; FST) and motor (Catalepsy Test; CT) outputs. We performed the appropriate testsalong with the administration for two weeks of low doses of R. Our results show very clearly thatP4 prevents the impairment of several tasks regarding the deleterious effects of R, without affectingnegatively other areas of the subject behavior. In total accordance with current information, weshow here that P4 -in particular- and neuroactive steroids -in general- are promising molecules todelay diverse manifestations of neurotransmitters depletion.
publishDate 2022
dc.date.none.fl_str_mv 2022-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/203818
Yunes, Roberto Miguel Federico; Bregonzio Diaz, Claudia; Villegas, Vanina Anabel; Mulle Bernedo, María Belén; Cabrera Kreiker, Ricardo Jorge; Progesterone prevents impairment of cognitive, affective and motor events in a reserpine model of parkinsonism in male rats; Remedy Publications; Clinical Case Reports International; 6; 1; 6-2022; 1-6
2638-4558
CONICET Digital
CONICET
url http://hdl.handle.net/11336/203818
identifier_str_mv Yunes, Roberto Miguel Federico; Bregonzio Diaz, Claudia; Villegas, Vanina Anabel; Mulle Bernedo, María Belén; Cabrera Kreiker, Ricardo Jorge; Progesterone prevents impairment of cognitive, affective and motor events in a reserpine model of parkinsonism in male rats; Remedy Publications; Clinical Case Reports International; 6; 1; 6-2022; 1-6
2638-4558
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.clinicalcasereportsint.com/abstract.php?aid=8730
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Remedy Publications
publisher.none.fl_str_mv Remedy Publications
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083182909194240
score 13.22299

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