Neuroactive Steroids in Hypoxic–Ischemic Brain Injury: Overview and Future Directions

Autores
Toro Urrego, Nicolas; Avila Rodriguez, Marco; Herrera, María Inés; Aguilar, Andrea; Udovin, Lucas; Luaces, Juan Pablo
Año de publicación
2020
Idioma
español castellano
Tipo de recurso
parte de libro
Estado
versión publicada
Descripción
Hypoxic?ischemic brain injury is a number one cause of long-term neurologic dis- ability and death worldwide. This public health burden is mainly characterized by a decrease in oxygen concentration and blood flow to the tissues, which lead to an inef- ficient supply of nutrients to the brain. This condition induces cell death by energy depletion and increases free radical generation and inflammation. Hypoxic ischemic brain injury may occur in ischemic-stroke and over perinatal asphyxia, being both leading causes of morbidity in adults and children, respectively. Currently, there are no effective pharmaceutical strategies to prevent the triggering of secondary injury cascades, including oxidative stress and metabolic dysfunction. Neuroactive steroids like selective estrogen receptor modulators, SERMs, and selective tissue estrogenic activity regulators, STEARs, exert several neuroprotective effects. These encompass mitochondrial survival, a decrease in reactive oxygen species, and maintenance of cell viability, among others. In this context, these neurosteroids constitute promising molecules, which could modify brain response to injury. Here we show an updated overview of the underlying mechanisms of hypoxic ischemic brain injury. We also highlight the neuroprotective effects of neurosteroids and their future directions.
Fil: Toro Urrego, Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Avila Rodriguez, Marco. No especifíca;
Fil: Herrera, María Inés. No especifíca;
Fil: Aguilar, Andrea. No especifíca;
Fil: Udovin, Lucas. No especifíca;
Fil: Luaces, Juan Pablo. Universidad Abierta Interamericana. Secretaría de Investigación. Centro de Altos Estudios En Ciencias Humanas y de la Salud - Sede Buenos Aires.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
neuroactive steroids
hypoxia-ischemia
brain injury
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/129690
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Neuroactive Steroids in Hypoxic–Ischemic Brain Injury: Overview and Future DirectionsToro Urrego, NicolasAvila Rodriguez, MarcoHerrera, María InésAguilar, AndreaUdovin, LucasLuaces, Juan Pabloneuroactive steroidshypoxia-ischemiabrain injuryhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Hypoxic?ischemic brain injury is a number one cause of long-term neurologic dis- ability and death worldwide. This public health burden is mainly characterized by a decrease in oxygen concentration and blood flow to the tissues, which lead to an inef- ficient supply of nutrients to the brain. This condition induces cell death by energy depletion and increases free radical generation and inflammation. Hypoxic ischemic brain injury may occur in ischemic-stroke and over perinatal asphyxia, being both leading causes of morbidity in adults and children, respectively. Currently, there are no effective pharmaceutical strategies to prevent the triggering of secondary injury cascades, including oxidative stress and metabolic dysfunction. Neuroactive steroids like selective estrogen receptor modulators, SERMs, and selective tissue estrogenic activity regulators, STEARs, exert several neuroprotective effects. These encompass mitochondrial survival, a decrease in reactive oxygen species, and maintenance of cell viability, among others. In this context, these neurosteroids constitute promising molecules, which could modify brain response to injury. Here we show an updated overview of the underlying mechanisms of hypoxic ischemic brain injury. We also highlight the neuroprotective effects of neurosteroids and their future directions.Fil: Toro Urrego, Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Avila Rodriguez, Marco. No especifíca;Fil: Herrera, María Inés. No especifíca;Fil: Aguilar, Andrea. No especifíca;Fil: Udovin, Lucas. No especifíca;Fil: Luaces, Juan Pablo. Universidad Abierta Interamericana. Secretaría de Investigación. Centro de Altos Estudios En Ciencias Humanas y de la Salud - Sede Buenos Aires.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaIntechOpenOtero-losada, Matilde Estela2020info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bookParthttp://purl.org/coar/resource_type/c_3248info:ar-repo/semantics/parteDeLibroapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/129690Toro Urrego, Nicolas; Avila Rodriguez, Marco; Herrera, María Inés; Aguilar, Andrea; Udovin, Lucas; et al.; Neuroactive Steroids in Hypoxic–Ischemic Brain Injury: Overview and Future Directions; IntechOpen; 2020; 1-42978-1-83880-440-4CONICET DigitalCONICETspainfo:eu-repo/semantics/altIdentifier/url/https://www.intechopen.com/chapters/73869info:eu-repo/semantics/altIdentifier/doi/10.5772/intechopen.93956info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:14:31Zoai:ri.conicet.gov.ar:11336/129690instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:14:31.595CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Neuroactive Steroids in Hypoxic–Ischemic Brain Injury: Overview and Future Directions
title Neuroactive Steroids in Hypoxic–Ischemic Brain Injury: Overview and Future Directions
spellingShingle Neuroactive Steroids in Hypoxic–Ischemic Brain Injury: Overview and Future Directions
Toro Urrego, Nicolas
neuroactive steroids
hypoxia-ischemia
brain injury
title_short Neuroactive Steroids in Hypoxic–Ischemic Brain Injury: Overview and Future Directions
title_full Neuroactive Steroids in Hypoxic–Ischemic Brain Injury: Overview and Future Directions
title_fullStr Neuroactive Steroids in Hypoxic–Ischemic Brain Injury: Overview and Future Directions
title_full_unstemmed Neuroactive Steroids in Hypoxic–Ischemic Brain Injury: Overview and Future Directions
title_sort Neuroactive Steroids in Hypoxic–Ischemic Brain Injury: Overview and Future Directions
dc.creator.none.fl_str_mv Toro Urrego, Nicolas
Avila Rodriguez, Marco
Herrera, María Inés
Aguilar, Andrea
Udovin, Lucas
Luaces, Juan Pablo
author Toro Urrego, Nicolas
author_facet Toro Urrego, Nicolas
Avila Rodriguez, Marco
Herrera, María Inés
Aguilar, Andrea
Udovin, Lucas
Luaces, Juan Pablo
author_role author
author2 Avila Rodriguez, Marco
Herrera, María Inés
Aguilar, Andrea
Udovin, Lucas
Luaces, Juan Pablo
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Otero-losada, Matilde Estela
dc.subject.none.fl_str_mv neuroactive steroids
hypoxia-ischemia
brain injury
topic neuroactive steroids
hypoxia-ischemia
brain injury
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Hypoxic?ischemic brain injury is a number one cause of long-term neurologic dis- ability and death worldwide. This public health burden is mainly characterized by a decrease in oxygen concentration and blood flow to the tissues, which lead to an inef- ficient supply of nutrients to the brain. This condition induces cell death by energy depletion and increases free radical generation and inflammation. Hypoxic ischemic brain injury may occur in ischemic-stroke and over perinatal asphyxia, being both leading causes of morbidity in adults and children, respectively. Currently, there are no effective pharmaceutical strategies to prevent the triggering of secondary injury cascades, including oxidative stress and metabolic dysfunction. Neuroactive steroids like selective estrogen receptor modulators, SERMs, and selective tissue estrogenic activity regulators, STEARs, exert several neuroprotective effects. These encompass mitochondrial survival, a decrease in reactive oxygen species, and maintenance of cell viability, among others. In this context, these neurosteroids constitute promising molecules, which could modify brain response to injury. Here we show an updated overview of the underlying mechanisms of hypoxic ischemic brain injury. We also highlight the neuroprotective effects of neurosteroids and their future directions.
Fil: Toro Urrego, Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Avila Rodriguez, Marco. No especifíca;
Fil: Herrera, María Inés. No especifíca;
Fil: Aguilar, Andrea. No especifíca;
Fil: Udovin, Lucas. No especifíca;
Fil: Luaces, Juan Pablo. Universidad Abierta Interamericana. Secretaría de Investigación. Centro de Altos Estudios En Ciencias Humanas y de la Salud - Sede Buenos Aires.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Hypoxic?ischemic brain injury is a number one cause of long-term neurologic dis- ability and death worldwide. This public health burden is mainly characterized by a decrease in oxygen concentration and blood flow to the tissues, which lead to an inef- ficient supply of nutrients to the brain. This condition induces cell death by energy depletion and increases free radical generation and inflammation. Hypoxic ischemic brain injury may occur in ischemic-stroke and over perinatal asphyxia, being both leading causes of morbidity in adults and children, respectively. Currently, there are no effective pharmaceutical strategies to prevent the triggering of secondary injury cascades, including oxidative stress and metabolic dysfunction. Neuroactive steroids like selective estrogen receptor modulators, SERMs, and selective tissue estrogenic activity regulators, STEARs, exert several neuroprotective effects. These encompass mitochondrial survival, a decrease in reactive oxygen species, and maintenance of cell viability, among others. In this context, these neurosteroids constitute promising molecules, which could modify brain response to injury. Here we show an updated overview of the underlying mechanisms of hypoxic ischemic brain injury. We also highlight the neuroprotective effects of neurosteroids and their future directions.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/bookPart
http://purl.org/coar/resource_type/c_3248
info:ar-repo/semantics/parteDeLibro
status_str publishedVersion
format bookPart
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/129690
Toro Urrego, Nicolas; Avila Rodriguez, Marco; Herrera, María Inés; Aguilar, Andrea; Udovin, Lucas; et al.; Neuroactive Steroids in Hypoxic–Ischemic Brain Injury: Overview and Future Directions; IntechOpen; 2020; 1-42
978-1-83880-440-4
CONICET Digital
CONICET
url http://hdl.handle.net/11336/129690
identifier_str_mv Toro Urrego, Nicolas; Avila Rodriguez, Marco; Herrera, María Inés; Aguilar, Andrea; Udovin, Lucas; et al.; Neuroactive Steroids in Hypoxic–Ischemic Brain Injury: Overview and Future Directions; IntechOpen; 2020; 1-42
978-1-83880-440-4
CONICET Digital
CONICET
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.intechopen.com/chapters/73869
info:eu-repo/semantics/altIdentifier/doi/10.5772/intechopen.93956
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv IntechOpen
publisher.none.fl_str_mv IntechOpen
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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