The INSIDEOUT framework provides precise signatures of the balance of intrinsic and extrinsic dynamics in brain states

Autores
Deco, Gustavo; Sanz Perl Hernandez, Yonatan; Bocaccio, Hernan; Tagliazucchi, Enzo Rodolfo; Kringelbach, Morten L.
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Finding precise signatures of different brain states is a central, unsolved question in neuroscience. We reformulated the problem to quantify the ‘inside out’ balance of intrinsic and extrinsic brain dynamics in brain states. The difference in brain state can be described as differences in the detailed causal interactions found in the underlying intrinsic brain dynamics. We used a thermodynamics framework to quantify the breaking of the detailed balance captured by the level of asymmetry in temporal processing, i.e. the arrow of time. Specifically, the temporal asymmetry was computed by the time-shifted correlation matrices for the forward and reversed time series, reflecting the level of non-reversibility/non-equilibrium. We found precise, distinguishing signatures in terms of the reversibility and hierarchy of large-scale dynamics in three radically different brain states (awake, deep sleep and anaesthesia) in electrocorticography data from non-human primates. Significantly lower levels of reversibility were found in deep sleep and anaesthesia compared to wakefulness. Non-wakeful states also showed a flatter hierarchy, reflecting the diversity of the reversibility across the brain. Overall, this provides signatures of the breaking of detailed balance in different brain states, perhaps reflecting levels of conscious awareness.
Fil: Deco, Gustavo. Universitat Pompeu Fabra; España. Institució Catalana de Recerca i Estudis Avancats; España. Max Planck Institute For Human Cognitive And Brain Sciences; Alemania. Monash University; Australia
Fil: Sanz Perl Hernandez, Yonatan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina. Universitat Pompeu Fabra; España
Fil: Bocaccio, Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina
Fil: Tagliazucchi, Enzo Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina. Universidad Adolfo Ibañez; Chile
Fil: Kringelbach, Morten L.. University Aarhus; Dinamarca. University of Oxford; Reino Unido
Materia
Reversibility
Time
Cognition
Neuroimaging
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/215541
Acceder
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network_name_str CONICET Digital (CONICET)
spelling The INSIDEOUT framework provides precise signatures of the balance of intrinsic and extrinsic dynamics in brain statesDeco, GustavoSanz Perl Hernandez, YonatanBocaccio, HernanTagliazucchi, Enzo RodolfoKringelbach, Morten L.ReversibilityTimeCognitionNeuroimaginghttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1Finding precise signatures of different brain states is a central, unsolved question in neuroscience. We reformulated the problem to quantify the ‘inside out’ balance of intrinsic and extrinsic brain dynamics in brain states. The difference in brain state can be described as differences in the detailed causal interactions found in the underlying intrinsic brain dynamics. We used a thermodynamics framework to quantify the breaking of the detailed balance captured by the level of asymmetry in temporal processing, i.e. the arrow of time. Specifically, the temporal asymmetry was computed by the time-shifted correlation matrices for the forward and reversed time series, reflecting the level of non-reversibility/non-equilibrium. We found precise, distinguishing signatures in terms of the reversibility and hierarchy of large-scale dynamics in three radically different brain states (awake, deep sleep and anaesthesia) in electrocorticography data from non-human primates. Significantly lower levels of reversibility were found in deep sleep and anaesthesia compared to wakefulness. Non-wakeful states also showed a flatter hierarchy, reflecting the diversity of the reversibility across the brain. Overall, this provides signatures of the breaking of detailed balance in different brain states, perhaps reflecting levels of conscious awareness.Fil: Deco, Gustavo. Universitat Pompeu Fabra; España. Institució Catalana de Recerca i Estudis Avancats; España. Max Planck Institute For Human Cognitive And Brain Sciences; Alemania. Monash University; AustraliaFil: Sanz Perl Hernandez, Yonatan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina. Universitat Pompeu Fabra; EspañaFil: Bocaccio, Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; ArgentinaFil: Tagliazucchi, Enzo Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina. Universidad Adolfo Ibañez; ChileFil: Kringelbach, Morten L.. University Aarhus; Dinamarca. University of Oxford; Reino UnidoNature Research2022-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/215541Deco, Gustavo; Sanz Perl Hernandez, Yonatan; Bocaccio, Hernan; Tagliazucchi, Enzo Rodolfo; Kringelbach, Morten L.; The INSIDEOUT framework provides precise signatures of the balance of intrinsic and extrinsic dynamics in brain states; Nature Research; Communications Biology; 5; 1; 6-2022; 1-132399-3642CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s42003-022-03505-7info:eu-repo/semantics/altIdentifier/doi/10.1038/s42003-022-03505-7info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:02:15Zoai:ri.conicet.gov.ar:11336/215541instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:02:16.136CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The INSIDEOUT framework provides precise signatures of the balance of intrinsic and extrinsic dynamics in brain states
title The INSIDEOUT framework provides precise signatures of the balance of intrinsic and extrinsic dynamics in brain states
spellingShingle The INSIDEOUT framework provides precise signatures of the balance of intrinsic and extrinsic dynamics in brain states
Deco, Gustavo
Reversibility
Time
Cognition
Neuroimaging
title_short The INSIDEOUT framework provides precise signatures of the balance of intrinsic and extrinsic dynamics in brain states
title_full The INSIDEOUT framework provides precise signatures of the balance of intrinsic and extrinsic dynamics in brain states
title_fullStr The INSIDEOUT framework provides precise signatures of the balance of intrinsic and extrinsic dynamics in brain states
title_full_unstemmed The INSIDEOUT framework provides precise signatures of the balance of intrinsic and extrinsic dynamics in brain states
title_sort The INSIDEOUT framework provides precise signatures of the balance of intrinsic and extrinsic dynamics in brain states
dc.creator.none.fl_str_mv Deco, Gustavo
Sanz Perl Hernandez, Yonatan
Bocaccio, Hernan
Tagliazucchi, Enzo Rodolfo
Kringelbach, Morten L.
author Deco, Gustavo
author_facet Deco, Gustavo
Sanz Perl Hernandez, Yonatan
Bocaccio, Hernan
Tagliazucchi, Enzo Rodolfo
Kringelbach, Morten L.
author_role author
author2 Sanz Perl Hernandez, Yonatan
Bocaccio, Hernan
Tagliazucchi, Enzo Rodolfo
Kringelbach, Morten L.
author2_role author
author
author
author
dc.subject.none.fl_str_mv Reversibility
Time
Cognition
Neuroimaging
topic Reversibility
Time
Cognition
Neuroimaging
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Finding precise signatures of different brain states is a central, unsolved question in neuroscience. We reformulated the problem to quantify the ‘inside out’ balance of intrinsic and extrinsic brain dynamics in brain states. The difference in brain state can be described as differences in the detailed causal interactions found in the underlying intrinsic brain dynamics. We used a thermodynamics framework to quantify the breaking of the detailed balance captured by the level of asymmetry in temporal processing, i.e. the arrow of time. Specifically, the temporal asymmetry was computed by the time-shifted correlation matrices for the forward and reversed time series, reflecting the level of non-reversibility/non-equilibrium. We found precise, distinguishing signatures in terms of the reversibility and hierarchy of large-scale dynamics in three radically different brain states (awake, deep sleep and anaesthesia) in electrocorticography data from non-human primates. Significantly lower levels of reversibility were found in deep sleep and anaesthesia compared to wakefulness. Non-wakeful states also showed a flatter hierarchy, reflecting the diversity of the reversibility across the brain. Overall, this provides signatures of the breaking of detailed balance in different brain states, perhaps reflecting levels of conscious awareness.
Fil: Deco, Gustavo. Universitat Pompeu Fabra; España. Institució Catalana de Recerca i Estudis Avancats; España. Max Planck Institute For Human Cognitive And Brain Sciences; Alemania. Monash University; Australia
Fil: Sanz Perl Hernandez, Yonatan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina. Universitat Pompeu Fabra; España
Fil: Bocaccio, Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina
Fil: Tagliazucchi, Enzo Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina. Universidad Adolfo Ibañez; Chile
Fil: Kringelbach, Morten L.. University Aarhus; Dinamarca. University of Oxford; Reino Unido
description Finding precise signatures of different brain states is a central, unsolved question in neuroscience. We reformulated the problem to quantify the ‘inside out’ balance of intrinsic and extrinsic brain dynamics in brain states. The difference in brain state can be described as differences in the detailed causal interactions found in the underlying intrinsic brain dynamics. We used a thermodynamics framework to quantify the breaking of the detailed balance captured by the level of asymmetry in temporal processing, i.e. the arrow of time. Specifically, the temporal asymmetry was computed by the time-shifted correlation matrices for the forward and reversed time series, reflecting the level of non-reversibility/non-equilibrium. We found precise, distinguishing signatures in terms of the reversibility and hierarchy of large-scale dynamics in three radically different brain states (awake, deep sleep and anaesthesia) in electrocorticography data from non-human primates. Significantly lower levels of reversibility were found in deep sleep and anaesthesia compared to wakefulness. Non-wakeful states also showed a flatter hierarchy, reflecting the diversity of the reversibility across the brain. Overall, this provides signatures of the breaking of detailed balance in different brain states, perhaps reflecting levels of conscious awareness.
publishDate 2022
dc.date.none.fl_str_mv 2022-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/215541
Deco, Gustavo; Sanz Perl Hernandez, Yonatan; Bocaccio, Hernan; Tagliazucchi, Enzo Rodolfo; Kringelbach, Morten L.; The INSIDEOUT framework provides precise signatures of the balance of intrinsic and extrinsic dynamics in brain states; Nature Research; Communications Biology; 5; 1; 6-2022; 1-13
2399-3642
CONICET Digital
CONICET
url http://hdl.handle.net/11336/215541
identifier_str_mv Deco, Gustavo; Sanz Perl Hernandez, Yonatan; Bocaccio, Hernan; Tagliazucchi, Enzo Rodolfo; Kringelbach, Morten L.; The INSIDEOUT framework provides precise signatures of the balance of intrinsic and extrinsic dynamics in brain states; Nature Research; Communications Biology; 5; 1; 6-2022; 1-13
2399-3642
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s42003-022-03505-7
info:eu-repo/semantics/altIdentifier/doi/10.1038/s42003-022-03505-7
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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