The lack of temporal brain dynamics asymmetry as a signature of impaired consciousness states

Autores
Guzmán, Elvira G.; Sanz Perl Hernandez, Yonatan; Vohryzek, Jakub; Escrichs, Anira; Manasova, Dragana; Türker, Başak; Tagliazucchi, Enzo Rodolfo; Kringelbach, Morten; Sitt, Jacobo Diego; Deco, Gustavo
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Life is a constant battle against equilibrium. From the cellular level to the macroscopic scale, living organisms as dissipative systems require the violation of their detailed balance, i.e. metabolic enzymatic reactions, in order to survive. We present a framework based on temporal asymmetry as a measure of non-equilibrium. By means of statistical physics, it was discovered that temporal asymmetries establish an arrow of time useful for assessing the reversibility in human brain time series. Previous studies in human and non-human primates have shown that decreased consciousness states such as sleep and anaesthesia result in brain dynamics closer to the equilibrium. Furthermore, there is growing interest in the analysis of brain symmetry based on neuroimaging recordings and since it is a non-invasive technique, it can be extended to different brain imaging modalities and applied at different temporo-spatial scales. In the present study, we provide a detailed description of our methodological approach, paying special attention to the theories that motivated this work. We test, for the first time, the reversibility analysis in human functional magnetic resonance imaging data in patients suffering from disorder of consciousness. We verify that the tendency of a decrease in the asymmetry of the brain signal together with the decrease in non-stationarity are key characteristics of impaired consciousness states. We expect that this work will open the way for assessing biomarkers for patients’ improvement and classification, as well as motivating further research on the mechanistic understanding underlying states of impaired consciousness.
Fil: Guzmán, Elvira G.. Universitat Pompeu Fabra; España
Fil: Sanz Perl Hernandez, Yonatan. Université Pierre et Marie Curie; Francia. Universitat Pompeu Fabra; España. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Vohryzek, Jakub. Universitat Pompeu Fabra; España. University of Oxford; Reino Unido
Fil: Escrichs, Anira. Universitat Pompeu Fabra; España
Fil: Manasova, Dragana. Université Pierre et Marie Curie; Francia. Université Paris Cité; Francia
Fil: Türker, Başak. Université Pierre et Marie Curie; Francia
Fil: Tagliazucchi, Enzo Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina. Universidad Adolfo Ibañez; Chile
Fil: Kringelbach, Morten. University Aarhus; Dinamarca. University of Oxford; Reino Unido
Fil: Sitt, Jacobo Diego. Université Pierre et Marie Curie; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Deco, Gustavo. Monash University; Australia. Max Planck Institute For Human Cognitive And Brain Sciences; Alemania. Universitat Pompeu Fabra; España. Institució Catalana de Recerca I Estudis Avançats; España
Materia
ARROW OF TIME
DISORDER OF CONSCIOUSNESS
FUNCTIONAL MAGNETIC RESONANCE IMAGING
NONEQUILIBRIUM
REVERSIBILITY
TEMPORAL ASYMMETRY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/228623
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/228623
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The lack of temporal brain dynamics asymmetry as a signature of impaired consciousness statesGuzmán, Elvira G.Sanz Perl Hernandez, YonatanVohryzek, JakubEscrichs, AniraManasova, DraganaTürker, BaşakTagliazucchi, Enzo RodolfoKringelbach, MortenSitt, Jacobo DiegoDeco, GustavoARROW OF TIMEDISORDER OF CONSCIOUSNESSFUNCTIONAL MAGNETIC RESONANCE IMAGINGNONEQUILIBRIUMREVERSIBILITYTEMPORAL ASYMMETRYhttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1Life is a constant battle against equilibrium. From the cellular level to the macroscopic scale, living organisms as dissipative systems require the violation of their detailed balance, i.e. metabolic enzymatic reactions, in order to survive. We present a framework based on temporal asymmetry as a measure of non-equilibrium. By means of statistical physics, it was discovered that temporal asymmetries establish an arrow of time useful for assessing the reversibility in human brain time series. Previous studies in human and non-human primates have shown that decreased consciousness states such as sleep and anaesthesia result in brain dynamics closer to the equilibrium. Furthermore, there is growing interest in the analysis of brain symmetry based on neuroimaging recordings and since it is a non-invasive technique, it can be extended to different brain imaging modalities and applied at different temporo-spatial scales. In the present study, we provide a detailed description of our methodological approach, paying special attention to the theories that motivated this work. We test, for the first time, the reversibility analysis in human functional magnetic resonance imaging data in patients suffering from disorder of consciousness. We verify that the tendency of a decrease in the asymmetry of the brain signal together with the decrease in non-stationarity are key characteristics of impaired consciousness states. We expect that this work will open the way for assessing biomarkers for patients’ improvement and classification, as well as motivating further research on the mechanistic understanding underlying states of impaired consciousness.Fil: Guzmán, Elvira G.. Universitat Pompeu Fabra; EspañaFil: Sanz Perl Hernandez, Yonatan. Université Pierre et Marie Curie; Francia. Universitat Pompeu Fabra; España. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Vohryzek, Jakub. Universitat Pompeu Fabra; España. University of Oxford; Reino UnidoFil: Escrichs, Anira. Universitat Pompeu Fabra; EspañaFil: Manasova, Dragana. Université Pierre et Marie Curie; Francia. Université Paris Cité; FranciaFil: Türker, Başak. Université Pierre et Marie Curie; FranciaFil: Tagliazucchi, Enzo Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina. Universidad Adolfo Ibañez; ChileFil: Kringelbach, Morten. University Aarhus; Dinamarca. University of Oxford; Reino UnidoFil: Sitt, Jacobo Diego. Université Pierre et Marie Curie; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Deco, Gustavo. Monash University; Australia. Max Planck Institute For Human Cognitive And Brain Sciences; Alemania. Universitat Pompeu Fabra; España. Institució Catalana de Recerca I Estudis Avançats; EspañaThe Royal Society2023-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/228623Guzmán, Elvira G.; Sanz Perl Hernandez, Yonatan; Vohryzek, Jakub; Escrichs, Anira; Manasova, Dragana; et al.; The lack of temporal brain dynamics asymmetry as a signature of impaired consciousness states; The Royal Society; Interface Focus; 13; 3; 4-2023; 1-152042-88982042-8901CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://royalsocietypublishing.org/doi/full/10.1098/rsfs.2022.0086info:eu-repo/semantics/altIdentifier/doi/10.1098/rsfs.2022.0086info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:05:08Zoai:ri.conicet.gov.ar:11336/228623instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:05:08.477CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The lack of temporal brain dynamics asymmetry as a signature of impaired consciousness states
title The lack of temporal brain dynamics asymmetry as a signature of impaired consciousness states
spellingShingle The lack of temporal brain dynamics asymmetry as a signature of impaired consciousness states
Guzmán, Elvira G.
ARROW OF TIME
DISORDER OF CONSCIOUSNESS
FUNCTIONAL MAGNETIC RESONANCE IMAGING
NONEQUILIBRIUM
REVERSIBILITY
TEMPORAL ASYMMETRY
title_short The lack of temporal brain dynamics asymmetry as a signature of impaired consciousness states
title_full The lack of temporal brain dynamics asymmetry as a signature of impaired consciousness states
title_fullStr The lack of temporal brain dynamics asymmetry as a signature of impaired consciousness states
title_full_unstemmed The lack of temporal brain dynamics asymmetry as a signature of impaired consciousness states
title_sort The lack of temporal brain dynamics asymmetry as a signature of impaired consciousness states
dc.creator.none.fl_str_mv Guzmán, Elvira G.
Sanz Perl Hernandez, Yonatan
Vohryzek, Jakub
Escrichs, Anira
Manasova, Dragana
Türker, Başak
Tagliazucchi, Enzo Rodolfo
Kringelbach, Morten
Sitt, Jacobo Diego
Deco, Gustavo
author Guzmán, Elvira G.
author_facet Guzmán, Elvira G.
Sanz Perl Hernandez, Yonatan
Vohryzek, Jakub
Escrichs, Anira
Manasova, Dragana
Türker, Başak
Tagliazucchi, Enzo Rodolfo
Kringelbach, Morten
Sitt, Jacobo Diego
Deco, Gustavo
author_role author
author2 Sanz Perl Hernandez, Yonatan
Vohryzek, Jakub
Escrichs, Anira
Manasova, Dragana
Türker, Başak
Tagliazucchi, Enzo Rodolfo
Kringelbach, Morten
Sitt, Jacobo Diego
Deco, Gustavo
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ARROW OF TIME
DISORDER OF CONSCIOUSNESS
FUNCTIONAL MAGNETIC RESONANCE IMAGING
NONEQUILIBRIUM
REVERSIBILITY
TEMPORAL ASYMMETRY
topic ARROW OF TIME
DISORDER OF CONSCIOUSNESS
FUNCTIONAL MAGNETIC RESONANCE IMAGING
NONEQUILIBRIUM
REVERSIBILITY
TEMPORAL ASYMMETRY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Life is a constant battle against equilibrium. From the cellular level to the macroscopic scale, living organisms as dissipative systems require the violation of their detailed balance, i.e. metabolic enzymatic reactions, in order to survive. We present a framework based on temporal asymmetry as a measure of non-equilibrium. By means of statistical physics, it was discovered that temporal asymmetries establish an arrow of time useful for assessing the reversibility in human brain time series. Previous studies in human and non-human primates have shown that decreased consciousness states such as sleep and anaesthesia result in brain dynamics closer to the equilibrium. Furthermore, there is growing interest in the analysis of brain symmetry based on neuroimaging recordings and since it is a non-invasive technique, it can be extended to different brain imaging modalities and applied at different temporo-spatial scales. In the present study, we provide a detailed description of our methodological approach, paying special attention to the theories that motivated this work. We test, for the first time, the reversibility analysis in human functional magnetic resonance imaging data in patients suffering from disorder of consciousness. We verify that the tendency of a decrease in the asymmetry of the brain signal together with the decrease in non-stationarity are key characteristics of impaired consciousness states. We expect that this work will open the way for assessing biomarkers for patients’ improvement and classification, as well as motivating further research on the mechanistic understanding underlying states of impaired consciousness.
Fil: Guzmán, Elvira G.. Universitat Pompeu Fabra; España
Fil: Sanz Perl Hernandez, Yonatan. Université Pierre et Marie Curie; Francia. Universitat Pompeu Fabra; España. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Vohryzek, Jakub. Universitat Pompeu Fabra; España. University of Oxford; Reino Unido
Fil: Escrichs, Anira. Universitat Pompeu Fabra; España
Fil: Manasova, Dragana. Université Pierre et Marie Curie; Francia. Université Paris Cité; Francia
Fil: Türker, Başak. Université Pierre et Marie Curie; Francia
Fil: Tagliazucchi, Enzo Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina. Universidad Adolfo Ibañez; Chile
Fil: Kringelbach, Morten. University Aarhus; Dinamarca. University of Oxford; Reino Unido
Fil: Sitt, Jacobo Diego. Université Pierre et Marie Curie; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Deco, Gustavo. Monash University; Australia. Max Planck Institute For Human Cognitive And Brain Sciences; Alemania. Universitat Pompeu Fabra; España. Institució Catalana de Recerca I Estudis Avançats; España
description Life is a constant battle against equilibrium. From the cellular level to the macroscopic scale, living organisms as dissipative systems require the violation of their detailed balance, i.e. metabolic enzymatic reactions, in order to survive. We present a framework based on temporal asymmetry as a measure of non-equilibrium. By means of statistical physics, it was discovered that temporal asymmetries establish an arrow of time useful for assessing the reversibility in human brain time series. Previous studies in human and non-human primates have shown that decreased consciousness states such as sleep and anaesthesia result in brain dynamics closer to the equilibrium. Furthermore, there is growing interest in the analysis of brain symmetry based on neuroimaging recordings and since it is a non-invasive technique, it can be extended to different brain imaging modalities and applied at different temporo-spatial scales. In the present study, we provide a detailed description of our methodological approach, paying special attention to the theories that motivated this work. We test, for the first time, the reversibility analysis in human functional magnetic resonance imaging data in patients suffering from disorder of consciousness. We verify that the tendency of a decrease in the asymmetry of the brain signal together with the decrease in non-stationarity are key characteristics of impaired consciousness states. We expect that this work will open the way for assessing biomarkers for patients’ improvement and classification, as well as motivating further research on the mechanistic understanding underlying states of impaired consciousness.
publishDate 2023
dc.date.none.fl_str_mv 2023-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/228623
Guzmán, Elvira G.; Sanz Perl Hernandez, Yonatan; Vohryzek, Jakub; Escrichs, Anira; Manasova, Dragana; et al.; The lack of temporal brain dynamics asymmetry as a signature of impaired consciousness states; The Royal Society; Interface Focus; 13; 3; 4-2023; 1-15
2042-8898
2042-8901
CONICET Digital
CONICET
url http://hdl.handle.net/11336/228623
identifier_str_mv Guzmán, Elvira G.; Sanz Perl Hernandez, Yonatan; Vohryzek, Jakub; Escrichs, Anira; Manasova, Dragana; et al.; The lack of temporal brain dynamics asymmetry as a signature of impaired consciousness states; The Royal Society; Interface Focus; 13; 3; 4-2023; 1-15
2042-8898
2042-8901
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://royalsocietypublishing.org/doi/full/10.1098/rsfs.2022.0086
info:eu-repo/semantics/altIdentifier/doi/10.1098/rsfs.2022.0086
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv The Royal Society
publisher.none.fl_str_mv The Royal Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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