Multilevel convergence of interoceptive impairments in hypertension: New evidence of disrupted body-brain interactions

Autores
Yoris Magnago, Adrián Ezequiel; Abrevaya, Sofia; Esteves, Sol; Salamone, Paula Celeste; Lori, Nicolás Francisco; Martorell, Miguel; Legaz, Agustina; Alifano, Florencia; Petroni, Agustín; Sánchez, Ramiro; Sedeño, Lucas; García, Adolfo Martín; Ibañez, Agustin Mariano
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Interoception, the sensing of visceral body signals, involves an interplay between neural and autonomic mechanisms. Clinical studies into this domain have focused on patients with neurological and psychiatric disorders, showing that damage to relevant brain mechanisms can variously alter interoceptive functions. However, the association between peripheral cardiac-system alterations and neurocognitive markers of interoception remains poorly understood. To bridge this gap, we examined multidimensional neural markers of interoception in patients with early stage of hypertensive disease (HTD) and healthy controls. Strategically, we recruited only HTD patients without cognitive impairment (as shown by neuropsychological tests), brain atrophy (as assessed with voxel-based morphometry), or white matter abnormalities (as evidenced by diffusion tensor imaging analysis). Interoceptive domains were assessed through (a) a behavioral heartbeat detection task; (b) measures of the heart-evoked potential (HEP), an electrophysiological cortical signature of attention to cardiac signals; and (c) neuroimaging recordings (MRI and fMRI) to evaluate anatomical and functional connectivity properties of key interoceptive regions (namely, the insula and the anterior cingulate cortex). Relative to controls, patients exhibited poorer interoceptive performance and reduced HEP modulations, alongside an abnormal association between interoceptive performance and both the volume and functional connectivity of the above regions. Such results suggest that peripheral cardiac-system impairments can be associated with abnormal behavioral and neurocognitive signatures of interoception. More generally, our findings indicate that interoceptive processes entail bidirectional influences between the cardiovascular and the central nervous systems.
Fil: Yoris Magnago, Adrián Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Universidad Favaloro; Argentina
Fil: Abrevaya, Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Universidad Favaloro; Argentina
Fil: Esteves, Sol. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Universidad Favaloro; Argentina
Fil: Salamone, Paula Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Universidad Favaloro; Argentina
Fil: Lori, Nicolás Francisco. Universidad Favaloro; Argentina. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Universidade do Minho; Portugal
Fil: Martorell, Miguel. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Universidad Favaloro; Argentina
Fil: Legaz, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Universidad Favaloro; Argentina
Fil: Alifano, Florencia. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Universidad Favaloro; Argentina
Fil: Petroni, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Universidad Favaloro; Argentina. Universidad de Buenos Aires; Argentina
Fil: Sánchez, Ramiro. Fundación Favaloro; Argentina
Fil: Sedeño, Lucas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Universidad Favaloro; Argentina
Fil: García, Adolfo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Universidad Favaloro; Argentina. Universidad Nacional de Cuyo; Argentina
Fil: Ibañez, Agustin Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Universidad Autónoma del Caribe; Colombia. Universidad Favaloro; Argentina. Universidad Adolfo Ibañez; Chile
Materia
Embodied Cognition
Heart Evoked Potential
Hypertension
Interoception
Neuroimaging
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/45850
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/45850
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network_name_str CONICET Digital (CONICET)
spelling Multilevel convergence of interoceptive impairments in hypertension: New evidence of disrupted body-brain interactionsYoris Magnago, Adrián EzequielAbrevaya, SofiaEsteves, SolSalamone, Paula CelesteLori, Nicolás FranciscoMartorell, MiguelLegaz, AgustinaAlifano, FlorenciaPetroni, AgustínSánchez, RamiroSedeño, LucasGarcía, Adolfo MartínIbañez, Agustin MarianoEmbodied CognitionHeart Evoked PotentialHypertensionInteroceptionNeuroimaginghttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Interoception, the sensing of visceral body signals, involves an interplay between neural and autonomic mechanisms. Clinical studies into this domain have focused on patients with neurological and psychiatric disorders, showing that damage to relevant brain mechanisms can variously alter interoceptive functions. However, the association between peripheral cardiac-system alterations and neurocognitive markers of interoception remains poorly understood. To bridge this gap, we examined multidimensional neural markers of interoception in patients with early stage of hypertensive disease (HTD) and healthy controls. Strategically, we recruited only HTD patients without cognitive impairment (as shown by neuropsychological tests), brain atrophy (as assessed with voxel-based morphometry), or white matter abnormalities (as evidenced by diffusion tensor imaging analysis). Interoceptive domains were assessed through (a) a behavioral heartbeat detection task; (b) measures of the heart-evoked potential (HEP), an electrophysiological cortical signature of attention to cardiac signals; and (c) neuroimaging recordings (MRI and fMRI) to evaluate anatomical and functional connectivity properties of key interoceptive regions (namely, the insula and the anterior cingulate cortex). Relative to controls, patients exhibited poorer interoceptive performance and reduced HEP modulations, alongside an abnormal association between interoceptive performance and both the volume and functional connectivity of the above regions. Such results suggest that peripheral cardiac-system impairments can be associated with abnormal behavioral and neurocognitive signatures of interoception. More generally, our findings indicate that interoceptive processes entail bidirectional influences between the cardiovascular and the central nervous systems.Fil: Yoris Magnago, Adrián Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Universidad Favaloro; ArgentinaFil: Abrevaya, Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Universidad Favaloro; ArgentinaFil: Esteves, Sol. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Universidad Favaloro; ArgentinaFil: Salamone, Paula Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Universidad Favaloro; ArgentinaFil: Lori, Nicolás Francisco. Universidad Favaloro; Argentina. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Universidade do Minho; PortugalFil: Martorell, Miguel. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Universidad Favaloro; ArgentinaFil: Legaz, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Universidad Favaloro; ArgentinaFil: Alifano, Florencia. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Universidad Favaloro; ArgentinaFil: Petroni, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Universidad Favaloro; Argentina. Universidad de Buenos Aires; ArgentinaFil: Sánchez, Ramiro. Fundación Favaloro; ArgentinaFil: Sedeño, Lucas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Universidad Favaloro; ArgentinaFil: García, Adolfo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Universidad Favaloro; Argentina. Universidad Nacional de Cuyo; ArgentinaFil: Ibañez, Agustin Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Universidad Autónoma del Caribe; Colombia. Universidad Favaloro; Argentina. Universidad Adolfo Ibañez; ChileWiley-liss, Div John Wiley & Sons Inc2018-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/45850Yoris Magnago, Adrián Ezequiel; Abrevaya, Sofia; Esteves, Sol; Salamone, Paula Celeste; Lori, Nicolás Francisco; et al.; Multilevel convergence of interoceptive impairments in hypertension: New evidence of disrupted body-brain interactions; Wiley-liss, Div John Wiley & Sons Inc; Human Brain Mapping; 4-20181065-9471CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/hbm.23933info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/hbm.23933info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:08:17Zoai:ri.conicet.gov.ar:11336/45850instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:08:17.698CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Multilevel convergence of interoceptive impairments in hypertension: New evidence of disrupted body-brain interactions
title Multilevel convergence of interoceptive impairments in hypertension: New evidence of disrupted body-brain interactions
spellingShingle Multilevel convergence of interoceptive impairments in hypertension: New evidence of disrupted body-brain interactions
Yoris Magnago, Adrián Ezequiel
Embodied Cognition
Heart Evoked Potential
Hypertension
Interoception
Neuroimaging
title_short Multilevel convergence of interoceptive impairments in hypertension: New evidence of disrupted body-brain interactions
title_full Multilevel convergence of interoceptive impairments in hypertension: New evidence of disrupted body-brain interactions
title_fullStr Multilevel convergence of interoceptive impairments in hypertension: New evidence of disrupted body-brain interactions
title_full_unstemmed Multilevel convergence of interoceptive impairments in hypertension: New evidence of disrupted body-brain interactions
title_sort Multilevel convergence of interoceptive impairments in hypertension: New evidence of disrupted body-brain interactions
dc.creator.none.fl_str_mv Yoris Magnago, Adrián Ezequiel
Abrevaya, Sofia
Esteves, Sol
Salamone, Paula Celeste
Lori, Nicolás Francisco
Martorell, Miguel
Legaz, Agustina
Alifano, Florencia
Petroni, Agustín
Sánchez, Ramiro
Sedeño, Lucas
García, Adolfo Martín
Ibañez, Agustin Mariano
author Yoris Magnago, Adrián Ezequiel
author_facet Yoris Magnago, Adrián Ezequiel
Abrevaya, Sofia
Esteves, Sol
Salamone, Paula Celeste
Lori, Nicolás Francisco
Martorell, Miguel
Legaz, Agustina
Alifano, Florencia
Petroni, Agustín
Sánchez, Ramiro
Sedeño, Lucas
García, Adolfo Martín
Ibañez, Agustin Mariano
author_role author
author2 Abrevaya, Sofia
Esteves, Sol
Salamone, Paula Celeste
Lori, Nicolás Francisco
Martorell, Miguel
Legaz, Agustina
Alifano, Florencia
Petroni, Agustín
Sánchez, Ramiro
Sedeño, Lucas
García, Adolfo Martín
Ibañez, Agustin Mariano
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Embodied Cognition
Heart Evoked Potential
Hypertension
Interoception
Neuroimaging
topic Embodied Cognition
Heart Evoked Potential
Hypertension
Interoception
Neuroimaging
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Interoception, the sensing of visceral body signals, involves an interplay between neural and autonomic mechanisms. Clinical studies into this domain have focused on patients with neurological and psychiatric disorders, showing that damage to relevant brain mechanisms can variously alter interoceptive functions. However, the association between peripheral cardiac-system alterations and neurocognitive markers of interoception remains poorly understood. To bridge this gap, we examined multidimensional neural markers of interoception in patients with early stage of hypertensive disease (HTD) and healthy controls. Strategically, we recruited only HTD patients without cognitive impairment (as shown by neuropsychological tests), brain atrophy (as assessed with voxel-based morphometry), or white matter abnormalities (as evidenced by diffusion tensor imaging analysis). Interoceptive domains were assessed through (a) a behavioral heartbeat detection task; (b) measures of the heart-evoked potential (HEP), an electrophysiological cortical signature of attention to cardiac signals; and (c) neuroimaging recordings (MRI and fMRI) to evaluate anatomical and functional connectivity properties of key interoceptive regions (namely, the insula and the anterior cingulate cortex). Relative to controls, patients exhibited poorer interoceptive performance and reduced HEP modulations, alongside an abnormal association between interoceptive performance and both the volume and functional connectivity of the above regions. Such results suggest that peripheral cardiac-system impairments can be associated with abnormal behavioral and neurocognitive signatures of interoception. More generally, our findings indicate that interoceptive processes entail bidirectional influences between the cardiovascular and the central nervous systems.
Fil: Yoris Magnago, Adrián Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Universidad Favaloro; Argentina
Fil: Abrevaya, Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Universidad Favaloro; Argentina
Fil: Esteves, Sol. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Universidad Favaloro; Argentina
Fil: Salamone, Paula Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Universidad Favaloro; Argentina
Fil: Lori, Nicolás Francisco. Universidad Favaloro; Argentina. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Universidade do Minho; Portugal
Fil: Martorell, Miguel. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Universidad Favaloro; Argentina
Fil: Legaz, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Universidad Favaloro; Argentina
Fil: Alifano, Florencia. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Universidad Favaloro; Argentina
Fil: Petroni, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Universidad Favaloro; Argentina. Universidad de Buenos Aires; Argentina
Fil: Sánchez, Ramiro. Fundación Favaloro; Argentina
Fil: Sedeño, Lucas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Universidad Favaloro; Argentina
Fil: García, Adolfo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Universidad Favaloro; Argentina. Universidad Nacional de Cuyo; Argentina
Fil: Ibañez, Agustin Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Universidad Autónoma del Caribe; Colombia. Universidad Favaloro; Argentina. Universidad Adolfo Ibañez; Chile
description Interoception, the sensing of visceral body signals, involves an interplay between neural and autonomic mechanisms. Clinical studies into this domain have focused on patients with neurological and psychiatric disorders, showing that damage to relevant brain mechanisms can variously alter interoceptive functions. However, the association between peripheral cardiac-system alterations and neurocognitive markers of interoception remains poorly understood. To bridge this gap, we examined multidimensional neural markers of interoception in patients with early stage of hypertensive disease (HTD) and healthy controls. Strategically, we recruited only HTD patients without cognitive impairment (as shown by neuropsychological tests), brain atrophy (as assessed with voxel-based morphometry), or white matter abnormalities (as evidenced by diffusion tensor imaging analysis). Interoceptive domains were assessed through (a) a behavioral heartbeat detection task; (b) measures of the heart-evoked potential (HEP), an electrophysiological cortical signature of attention to cardiac signals; and (c) neuroimaging recordings (MRI and fMRI) to evaluate anatomical and functional connectivity properties of key interoceptive regions (namely, the insula and the anterior cingulate cortex). Relative to controls, patients exhibited poorer interoceptive performance and reduced HEP modulations, alongside an abnormal association between interoceptive performance and both the volume and functional connectivity of the above regions. Such results suggest that peripheral cardiac-system impairments can be associated with abnormal behavioral and neurocognitive signatures of interoception. More generally, our findings indicate that interoceptive processes entail bidirectional influences between the cardiovascular and the central nervous systems.
publishDate 2018
dc.date.none.fl_str_mv 2018-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/45850
Yoris Magnago, Adrián Ezequiel; Abrevaya, Sofia; Esteves, Sol; Salamone, Paula Celeste; Lori, Nicolás Francisco; et al.; Multilevel convergence of interoceptive impairments in hypertension: New evidence of disrupted body-brain interactions; Wiley-liss, Div John Wiley & Sons Inc; Human Brain Mapping; 4-2018
1065-9471
CONICET Digital
CONICET
url http://hdl.handle.net/11336/45850
identifier_str_mv Yoris Magnago, Adrián Ezequiel; Abrevaya, Sofia; Esteves, Sol; Salamone, Paula Celeste; Lori, Nicolás Francisco; et al.; Multilevel convergence of interoceptive impairments in hypertension: New evidence of disrupted body-brain interactions; Wiley-liss, Div John Wiley & Sons Inc; Human Brain Mapping; 4-2018
1065-9471
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Wiley-liss, Div John Wiley & Sons Inc
publisher.none.fl_str_mv Wiley-liss, Div John Wiley & Sons Inc
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