Toxina botulínica para uso terapéutico

Autores
Fernandez, Rafael Alfredo; Lopez Laur, J.D.; Ciccarelli, A.S.; de Jong, L.I.T.; Caballero, Patricia Alejandra; Bianco, María Isabel
Año de publicación
2006
Idioma
español castellano
Tipo de recurso
artículo
Estado
versión publicada
Descripción
From the year 1980 the intramuscular inoculation of botulinal neurotoxin (BoNT) is realized for treatment of disorders of the muscular tone. The simplicity of the treatment does an excellent alternative to the surgery. The p rincipal action is a flaccid muscular palsy that needs between 2 and 6 months for its rec overy. As for the therapeutic rank, the BoNT would overcome in safety to the majority o f the drugs. In the latter decade the use of the therapy with BoNT has experimented an am azing growth, with new and mul- tiple indications, especially neurological, and has turned into the treatment of aesthetic medicine with more rapid growth into his demand. It would be ideal to obtain prepara- tions that: during the making and storage the toxic ity does not diminish significantly, could be stored to ambient temperature, support maj or time the activity and with dimin- ished capacity of diffusion and of formation of ant ibodies. The effect is not instantane- ous, but progressive in the first days and ideally between 1 and 2 weeks later. Between 3 and 4 months later, the effect starts diminishing and the muscles contract again. The result is not the definitive remedy, and repeated d oses being needed. Its use is limited by economic reasons.
Fil: Fernandez, Rafael Alfredo. Universidad Nacional de Cuyo; Argentina
Fil: Lopez Laur, J.D.. Universidad Nacional de Cuyo; Argentina
Fil: Ciccarelli, A.S.. Universidad Nacional de Cuyo; Argentina
Fil: de Jong, L.I.T.. Universidad Nacional de Cuyo; Argentina
Fil: Caballero, Patricia Alejandra. Universidad Nacional de Cuyo; Argentina
Fil: Bianco, María Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología ; Argentina
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/40939
Acceder
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spelling Toxina botulínica para uso terapéuticoFernandez, Rafael AlfredoLopez Laur, J.D.Ciccarelli, A.S.de Jong, L.I.T.Caballero, Patricia AlejandraBianco, María Isabelhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1From the year 1980 the intramuscular inoculation of botulinal neurotoxin (BoNT) is realized for treatment of disorders of the muscular tone. The simplicity of the treatment does an excellent alternative to the surgery. The p rincipal action is a flaccid muscular palsy that needs between 2 and 6 months for its rec overy. As for the therapeutic rank, the BoNT would overcome in safety to the majority o f the drugs. In the latter decade the use of the therapy with BoNT has experimented an am azing growth, with new and mul- tiple indications, especially neurological, and has turned into the treatment of aesthetic medicine with more rapid growth into his demand. It would be ideal to obtain prepara- tions that: during the making and storage the toxic ity does not diminish significantly, could be stored to ambient temperature, support maj or time the activity and with dimin- ished capacity of diffusion and of formation of ant ibodies. The effect is not instantane- ous, but progressive in the first days and ideally between 1 and 2 weeks later. Between 3 and 4 months later, the effect starts diminishing and the muscles contract again. The result is not the definitive remedy, and repeated d oses being needed. Its use is limited by economic reasons.Fil: Fernandez, Rafael Alfredo. Universidad Nacional de Cuyo; ArgentinaFil: Lopez Laur, J.D.. Universidad Nacional de Cuyo; ArgentinaFil: Ciccarelli, A.S.. Universidad Nacional de Cuyo; ArgentinaFil: de Jong, L.I.T.. Universidad Nacional de Cuyo; ArgentinaFil: Caballero, Patricia Alejandra. Universidad Nacional de Cuyo; ArgentinaFil: Bianco, María Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología ; ArgentinaFacultad de Ciencias Médicas. Universidad Nacional de Cuyo2006-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/40939Fernandez, Rafael Alfredo; Lopez Laur, J.D.; Ciccarelli, A.S.; de Jong, L.I.T.; Caballero, Patricia Alejandra; et al.; Toxina botulínica para uso terapéutico; Facultad de Ciencias Médicas. Universidad Nacional de Cuyo; Revista Médica Universitaria; 2; 1; 12-2006; 1-71669-8991CONICET DigitalCONICETspainfo:eu-repo/semantics/altIdentifier/url/http://revista.medicina.edu.ar/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:06:57Zoai:ri.conicet.gov.ar:11336/40939instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:06:58.191CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Toxina botulínica para uso terapéutico
title Toxina botulínica para uso terapéutico
spellingShingle Toxina botulínica para uso terapéutico
Fernandez, Rafael Alfredo
title_short Toxina botulínica para uso terapéutico
title_full Toxina botulínica para uso terapéutico
title_fullStr Toxina botulínica para uso terapéutico
title_full_unstemmed Toxina botulínica para uso terapéutico
title_sort Toxina botulínica para uso terapéutico
dc.creator.none.fl_str_mv Fernandez, Rafael Alfredo
Lopez Laur, J.D.
Ciccarelli, A.S.
de Jong, L.I.T.
Caballero, Patricia Alejandra
Bianco, María Isabel
author Fernandez, Rafael Alfredo
author_facet Fernandez, Rafael Alfredo
Lopez Laur, J.D.
Ciccarelli, A.S.
de Jong, L.I.T.
Caballero, Patricia Alejandra
Bianco, María Isabel
author_role author
author2 Lopez Laur, J.D.
Ciccarelli, A.S.
de Jong, L.I.T.
Caballero, Patricia Alejandra
Bianco, María Isabel
author2_role author
author
author
author
author
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv From the year 1980 the intramuscular inoculation of botulinal neurotoxin (BoNT) is realized for treatment of disorders of the muscular tone. The simplicity of the treatment does an excellent alternative to the surgery. The p rincipal action is a flaccid muscular palsy that needs between 2 and 6 months for its rec overy. As for the therapeutic rank, the BoNT would overcome in safety to the majority o f the drugs. In the latter decade the use of the therapy with BoNT has experimented an am azing growth, with new and mul- tiple indications, especially neurological, and has turned into the treatment of aesthetic medicine with more rapid growth into his demand. It would be ideal to obtain prepara- tions that: during the making and storage the toxic ity does not diminish significantly, could be stored to ambient temperature, support maj or time the activity and with dimin- ished capacity of diffusion and of formation of ant ibodies. The effect is not instantane- ous, but progressive in the first days and ideally between 1 and 2 weeks later. Between 3 and 4 months later, the effect starts diminishing and the muscles contract again. The result is not the definitive remedy, and repeated d oses being needed. Its use is limited by economic reasons.
Fil: Fernandez, Rafael Alfredo. Universidad Nacional de Cuyo; Argentina
Fil: Lopez Laur, J.D.. Universidad Nacional de Cuyo; Argentina
Fil: Ciccarelli, A.S.. Universidad Nacional de Cuyo; Argentina
Fil: de Jong, L.I.T.. Universidad Nacional de Cuyo; Argentina
Fil: Caballero, Patricia Alejandra. Universidad Nacional de Cuyo; Argentina
Fil: Bianco, María Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología ; Argentina
description From the year 1980 the intramuscular inoculation of botulinal neurotoxin (BoNT) is realized for treatment of disorders of the muscular tone. The simplicity of the treatment does an excellent alternative to the surgery. The p rincipal action is a flaccid muscular palsy that needs between 2 and 6 months for its rec overy. As for the therapeutic rank, the BoNT would overcome in safety to the majority o f the drugs. In the latter decade the use of the therapy with BoNT has experimented an am azing growth, with new and mul- tiple indications, especially neurological, and has turned into the treatment of aesthetic medicine with more rapid growth into his demand. It would be ideal to obtain prepara- tions that: during the making and storage the toxic ity does not diminish significantly, could be stored to ambient temperature, support maj or time the activity and with dimin- ished capacity of diffusion and of formation of ant ibodies. The effect is not instantane- ous, but progressive in the first days and ideally between 1 and 2 weeks later. Between 3 and 4 months later, the effect starts diminishing and the muscles contract again. The result is not the definitive remedy, and repeated d oses being needed. Its use is limited by economic reasons.
publishDate 2006
dc.date.none.fl_str_mv 2006-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/40939
Fernandez, Rafael Alfredo; Lopez Laur, J.D.; Ciccarelli, A.S.; de Jong, L.I.T.; Caballero, Patricia Alejandra; et al.; Toxina botulínica para uso terapéutico; Facultad de Ciencias Médicas. Universidad Nacional de Cuyo; Revista Médica Universitaria; 2; 1; 12-2006; 1-7
1669-8991
CONICET Digital
CONICET
url http://hdl.handle.net/11336/40939
identifier_str_mv Fernandez, Rafael Alfredo; Lopez Laur, J.D.; Ciccarelli, A.S.; de Jong, L.I.T.; Caballero, Patricia Alejandra; et al.; Toxina botulínica para uso terapéutico; Facultad de Ciencias Médicas. Universidad Nacional de Cuyo; Revista Médica Universitaria; 2; 1; 12-2006; 1-7
1669-8991
CONICET Digital
CONICET
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://revista.medicina.edu.ar/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Facultad de Ciencias Médicas. Universidad Nacional de Cuyo
publisher.none.fl_str_mv Facultad de Ciencias Médicas. Universidad Nacional de Cuyo
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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