Influence of the ionic character of a drug on its release rate from hydrogels based on 2-hydroxyethylmethacrylate and acrylamide synthesized by photopolymerization

Autores
Gomez, María Lorena; Williams, Roberto Juan Jose; Montejano, Hernan Alfredo; Previtali, Carlos Mario
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The influence of the ionic character of a specific drug on its release rate from a hydrogel based on 2-hydroxyethylmethacrylate (HEMA) and acrylamide (AAm) is analyzed. The hydrogel was synthesized by photopolymerization employing visible light, safranine O (Saf), as sensitizer, and a silsesquioxane functionalized with amine and methacrylate groups (SFMA), as co-initiator and crosslinker. Safranine O (Saf) was employed as a model of a cationic drug and the anionic form of resorufin (Rf) as a model of an anionic drug.  Saf exhibited a larger affinity with functional groups of the hydrogel than that of Rf. This produced a lower loading and a faster release rate of Rf with respect to Saf. Besides, the release rate of Rf followed a Fickian behavior while that of Saf exhibited a non-Fickian behavior. By hydrolyzing the hydrogel at pH = 13, amide groups supplied by AAm were irreversibly converted into carboxylic acid groups. Higher loadings and slower release rates of Saf from the hydrolyzed hydrogels were observed, making them particularly suitable for the slow drug-delivery of cationic drugs.
Fil: Gomez, María Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina
Fil: Williams, Roberto Juan Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Montejano, Hernan Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina
Fil: Previtali, Carlos Mario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina
Materia
Polymer gels
Hydrogels
Drug release
Hydroxyethylmethacrylate
Acrylamide
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/241669
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/241669
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Influence of the ionic character of a drug on its release rate from hydrogels based on 2-hydroxyethylmethacrylate and acrylamide synthesized by photopolymerizationGomez, María LorenaWilliams, Roberto Juan JoseMontejano, Hernan AlfredoPrevitali, Carlos MarioPolymer gelsHydrogelsDrug releaseHydroxyethylmethacrylateAcrylamidehttps://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/2The influence of the ionic character of a specific drug on its release rate from a hydrogel based on 2-hydroxyethylmethacrylate (HEMA) and acrylamide (AAm) is analyzed. The hydrogel was synthesized by photopolymerization employing visible light, safranine O (Saf), as sensitizer, and a silsesquioxane functionalized with amine and methacrylate groups (SFMA), as co-initiator and crosslinker. Safranine O (Saf) was employed as a model of a cationic drug and the anionic form of resorufin (Rf) as a model of an anionic drug.  Saf exhibited a larger affinity with functional groups of the hydrogel than that of Rf. This produced a lower loading and a faster release rate of Rf with respect to Saf. Besides, the release rate of Rf followed a Fickian behavior while that of Saf exhibited a non-Fickian behavior. By hydrolyzing the hydrogel at pH = 13, amide groups supplied by AAm were irreversibly converted into carboxylic acid groups. Higher loadings and slower release rates of Saf from the hydrolyzed hydrogels were observed, making them particularly suitable for the slow drug-delivery of cationic drugs.Fil: Gomez, María Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; ArgentinaFil: Williams, Roberto Juan Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Montejano, Hernan Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; ArgentinaFil: Previtali, Carlos Mario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; ArgentinaBudapest University of Technology and Economics2012-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/241669Gomez, María Lorena; Williams, Roberto Juan Jose; Montejano, Hernan Alfredo; Previtali, Carlos Mario; Influence of the ionic character of a drug on its release rate from hydrogels based on 2-hydroxyethylmethacrylate and acrylamide synthesized by photopolymerization; Budapest University of Technology and Economics; Express Polymer Letters; 6; 3; 3-2012; 189-1971788-618XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.expresspolymlett.com/letolt.php?file=EPL-0002864&mi=cinfo:eu-repo/semantics/altIdentifier/doi/10.3144/expresspolymlett.2012.21info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:46:47Zoai:ri.conicet.gov.ar:11336/241669instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:46:47.471CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Influence of the ionic character of a drug on its release rate from hydrogels based on 2-hydroxyethylmethacrylate and acrylamide synthesized by photopolymerization
title Influence of the ionic character of a drug on its release rate from hydrogels based on 2-hydroxyethylmethacrylate and acrylamide synthesized by photopolymerization
spellingShingle Influence of the ionic character of a drug on its release rate from hydrogels based on 2-hydroxyethylmethacrylate and acrylamide synthesized by photopolymerization
Gomez, María Lorena
Polymer gels
Hydrogels
Drug release
Hydroxyethylmethacrylate
Acrylamide
title_short Influence of the ionic character of a drug on its release rate from hydrogels based on 2-hydroxyethylmethacrylate and acrylamide synthesized by photopolymerization
title_full Influence of the ionic character of a drug on its release rate from hydrogels based on 2-hydroxyethylmethacrylate and acrylamide synthesized by photopolymerization
title_fullStr Influence of the ionic character of a drug on its release rate from hydrogels based on 2-hydroxyethylmethacrylate and acrylamide synthesized by photopolymerization
title_full_unstemmed Influence of the ionic character of a drug on its release rate from hydrogels based on 2-hydroxyethylmethacrylate and acrylamide synthesized by photopolymerization
title_sort Influence of the ionic character of a drug on its release rate from hydrogels based on 2-hydroxyethylmethacrylate and acrylamide synthesized by photopolymerization
dc.creator.none.fl_str_mv Gomez, María Lorena
Williams, Roberto Juan Jose
Montejano, Hernan Alfredo
Previtali, Carlos Mario
author Gomez, María Lorena
author_facet Gomez, María Lorena
Williams, Roberto Juan Jose
Montejano, Hernan Alfredo
Previtali, Carlos Mario
author_role author
author2 Williams, Roberto Juan Jose
Montejano, Hernan Alfredo
Previtali, Carlos Mario
author2_role author
author
author
dc.subject.none.fl_str_mv Polymer gels
Hydrogels
Drug release
Hydroxyethylmethacrylate
Acrylamide
topic Polymer gels
Hydrogels
Drug release
Hydroxyethylmethacrylate
Acrylamide
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.5
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv The influence of the ionic character of a specific drug on its release rate from a hydrogel based on 2-hydroxyethylmethacrylate (HEMA) and acrylamide (AAm) is analyzed. The hydrogel was synthesized by photopolymerization employing visible light, safranine O (Saf), as sensitizer, and a silsesquioxane functionalized with amine and methacrylate groups (SFMA), as co-initiator and crosslinker. Safranine O (Saf) was employed as a model of a cationic drug and the anionic form of resorufin (Rf) as a model of an anionic drug.  Saf exhibited a larger affinity with functional groups of the hydrogel than that of Rf. This produced a lower loading and a faster release rate of Rf with respect to Saf. Besides, the release rate of Rf followed a Fickian behavior while that of Saf exhibited a non-Fickian behavior. By hydrolyzing the hydrogel at pH = 13, amide groups supplied by AAm were irreversibly converted into carboxylic acid groups. Higher loadings and slower release rates of Saf from the hydrolyzed hydrogels were observed, making them particularly suitable for the slow drug-delivery of cationic drugs.
Fil: Gomez, María Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina
Fil: Williams, Roberto Juan Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Montejano, Hernan Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina
Fil: Previtali, Carlos Mario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina
description The influence of the ionic character of a specific drug on its release rate from a hydrogel based on 2-hydroxyethylmethacrylate (HEMA) and acrylamide (AAm) is analyzed. The hydrogel was synthesized by photopolymerization employing visible light, safranine O (Saf), as sensitizer, and a silsesquioxane functionalized with amine and methacrylate groups (SFMA), as co-initiator and crosslinker. Safranine O (Saf) was employed as a model of a cationic drug and the anionic form of resorufin (Rf) as a model of an anionic drug.  Saf exhibited a larger affinity with functional groups of the hydrogel than that of Rf. This produced a lower loading and a faster release rate of Rf with respect to Saf. Besides, the release rate of Rf followed a Fickian behavior while that of Saf exhibited a non-Fickian behavior. By hydrolyzing the hydrogel at pH = 13, amide groups supplied by AAm were irreversibly converted into carboxylic acid groups. Higher loadings and slower release rates of Saf from the hydrolyzed hydrogels were observed, making them particularly suitable for the slow drug-delivery of cationic drugs.
publishDate 2012
dc.date.none.fl_str_mv 2012-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/241669
Gomez, María Lorena; Williams, Roberto Juan Jose; Montejano, Hernan Alfredo; Previtali, Carlos Mario; Influence of the ionic character of a drug on its release rate from hydrogels based on 2-hydroxyethylmethacrylate and acrylamide synthesized by photopolymerization; Budapest University of Technology and Economics; Express Polymer Letters; 6; 3; 3-2012; 189-197
1788-618X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/241669
identifier_str_mv Gomez, María Lorena; Williams, Roberto Juan Jose; Montejano, Hernan Alfredo; Previtali, Carlos Mario; Influence of the ionic character of a drug on its release rate from hydrogels based on 2-hydroxyethylmethacrylate and acrylamide synthesized by photopolymerization; Budapest University of Technology and Economics; Express Polymer Letters; 6; 3; 3-2012; 189-197
1788-618X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.expresspolymlett.com/letolt.php?file=EPL-0002864&mi=c
info:eu-repo/semantics/altIdentifier/doi/10.3144/expresspolymlett.2012.21
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Budapest University of Technology and Economics
publisher.none.fl_str_mv Budapest University of Technology and Economics
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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