Effect of inorganic salts and matrix crosslinking on the dose response of polymer gel dosimeters based on acrylamide
- Autores
- Chacón Obando, David; Strumia, Miriam Cristina; Valente, Mauro Andres; Mattea, Facundo
- Año de publicación
- 2018
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The use of additives in polymer gel dosimeters to enhance their sensitivity or to improve their performance is of great importance for their application in radiomedicine. Inorganic salts have been used as additives with this purpose; however, their presence in the dosimeters induce severe modifications in their mechanical properties and consequently in their capabilities to maintain a stable dose distribution with time. Most studies in this area conclude in the need to use chemical modifications of the species responsible for the mechanical properties of the dosimeters, which in most cases is a gelatin matrix. In this study, a covalent crosslinking of the gelatin matrix of PAGAT dosimeters doped with different inorganic salts, namely MgCl2, CaCl2 and MnCl2 has been carried out. The mechanical properties, X-ray sensitivity and dose distribution stability in these materials were compared to those of PAGAT. The results indicated a compromise between the crosslinking of the gelatin structure and the sensitivity of the dosimetric material. Therefore, the proper selection of the degree of crosslinking and the inorganic salt concentration must be considered. An enhanced dosimeter was obtained by adding MgCl2 with a 1M concentration and by crosslinking the gelatin matrix with glutaraldehyde at a 0.08%w/v concentration. This material presented a 75% enhanced sensitivity relative to PAGAT and similar temporal stability and spatial stability in 2D dose distributions.
Fil: Chacón Obando, David. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina
Fil: Strumia, Miriam Cristina. Universidad Nacional de Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina
Fil: Valente, Mauro Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Universidad de La Frontera; Chile
Fil: Mattea, Facundo. Universidad Nacional de Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina - Materia
-
ACRYLAMIDE
DOSIMETRY
GELATIN CROSSLINKING
INORGANIC SALTS
POLYMER - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/91579
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Effect of inorganic salts and matrix crosslinking on the dose response of polymer gel dosimeters based on acrylamideChacón Obando, DavidStrumia, Miriam CristinaValente, Mauro AndresMattea, FacundoACRYLAMIDEDOSIMETRYGELATIN CROSSLINKINGINORGANIC SALTSPOLYMERhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The use of additives in polymer gel dosimeters to enhance their sensitivity or to improve their performance is of great importance for their application in radiomedicine. Inorganic salts have been used as additives with this purpose; however, their presence in the dosimeters induce severe modifications in their mechanical properties and consequently in their capabilities to maintain a stable dose distribution with time. Most studies in this area conclude in the need to use chemical modifications of the species responsible for the mechanical properties of the dosimeters, which in most cases is a gelatin matrix. In this study, a covalent crosslinking of the gelatin matrix of PAGAT dosimeters doped with different inorganic salts, namely MgCl2, CaCl2 and MnCl2 has been carried out. The mechanical properties, X-ray sensitivity and dose distribution stability in these materials were compared to those of PAGAT. The results indicated a compromise between the crosslinking of the gelatin structure and the sensitivity of the dosimetric material. Therefore, the proper selection of the degree of crosslinking and the inorganic salt concentration must be considered. An enhanced dosimeter was obtained by adding MgCl2 with a 1M concentration and by crosslinking the gelatin matrix with glutaraldehyde at a 0.08%w/v concentration. This material presented a 75% enhanced sensitivity relative to PAGAT and similar temporal stability and spatial stability in 2D dose distributions.Fil: Chacón Obando, David. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; ArgentinaFil: Strumia, Miriam Cristina. Universidad Nacional de Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; ArgentinaFil: Valente, Mauro Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Universidad de La Frontera; ChileFil: Mattea, Facundo. Universidad Nacional de Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; ArgentinaPergamon-Elsevier Science Ltd2018-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/91579Chacón Obando, David; Strumia, Miriam Cristina; Valente, Mauro Andres; Mattea, Facundo; Effect of inorganic salts and matrix crosslinking on the dose response of polymer gel dosimeters based on acrylamide; Pergamon-Elsevier Science Ltd; Radiation Measurements; 117; 10-2018; 7-181350-4487CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1350448718301380info:eu-repo/semantics/altIdentifier/doi/10.1016/j.radmeas.2018.07.004info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:50:43Zoai:ri.conicet.gov.ar:11336/91579instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:50:43.594CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Effect of inorganic salts and matrix crosslinking on the dose response of polymer gel dosimeters based on acrylamide |
title |
Effect of inorganic salts and matrix crosslinking on the dose response of polymer gel dosimeters based on acrylamide |
spellingShingle |
Effect of inorganic salts and matrix crosslinking on the dose response of polymer gel dosimeters based on acrylamide Chacón Obando, David ACRYLAMIDE DOSIMETRY GELATIN CROSSLINKING INORGANIC SALTS POLYMER |
title_short |
Effect of inorganic salts and matrix crosslinking on the dose response of polymer gel dosimeters based on acrylamide |
title_full |
Effect of inorganic salts and matrix crosslinking on the dose response of polymer gel dosimeters based on acrylamide |
title_fullStr |
Effect of inorganic salts and matrix crosslinking on the dose response of polymer gel dosimeters based on acrylamide |
title_full_unstemmed |
Effect of inorganic salts and matrix crosslinking on the dose response of polymer gel dosimeters based on acrylamide |
title_sort |
Effect of inorganic salts and matrix crosslinking on the dose response of polymer gel dosimeters based on acrylamide |
dc.creator.none.fl_str_mv |
Chacón Obando, David Strumia, Miriam Cristina Valente, Mauro Andres Mattea, Facundo |
author |
Chacón Obando, David |
author_facet |
Chacón Obando, David Strumia, Miriam Cristina Valente, Mauro Andres Mattea, Facundo |
author_role |
author |
author2 |
Strumia, Miriam Cristina Valente, Mauro Andres Mattea, Facundo |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
ACRYLAMIDE DOSIMETRY GELATIN CROSSLINKING INORGANIC SALTS POLYMER |
topic |
ACRYLAMIDE DOSIMETRY GELATIN CROSSLINKING INORGANIC SALTS POLYMER |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
The use of additives in polymer gel dosimeters to enhance their sensitivity or to improve their performance is of great importance for their application in radiomedicine. Inorganic salts have been used as additives with this purpose; however, their presence in the dosimeters induce severe modifications in their mechanical properties and consequently in their capabilities to maintain a stable dose distribution with time. Most studies in this area conclude in the need to use chemical modifications of the species responsible for the mechanical properties of the dosimeters, which in most cases is a gelatin matrix. In this study, a covalent crosslinking of the gelatin matrix of PAGAT dosimeters doped with different inorganic salts, namely MgCl2, CaCl2 and MnCl2 has been carried out. The mechanical properties, X-ray sensitivity and dose distribution stability in these materials were compared to those of PAGAT. The results indicated a compromise between the crosslinking of the gelatin structure and the sensitivity of the dosimetric material. Therefore, the proper selection of the degree of crosslinking and the inorganic salt concentration must be considered. An enhanced dosimeter was obtained by adding MgCl2 with a 1M concentration and by crosslinking the gelatin matrix with glutaraldehyde at a 0.08%w/v concentration. This material presented a 75% enhanced sensitivity relative to PAGAT and similar temporal stability and spatial stability in 2D dose distributions. Fil: Chacón Obando, David. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina Fil: Strumia, Miriam Cristina. Universidad Nacional de Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina Fil: Valente, Mauro Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Universidad de La Frontera; Chile Fil: Mattea, Facundo. Universidad Nacional de Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina |
description |
The use of additives in polymer gel dosimeters to enhance their sensitivity or to improve their performance is of great importance for their application in radiomedicine. Inorganic salts have been used as additives with this purpose; however, their presence in the dosimeters induce severe modifications in their mechanical properties and consequently in their capabilities to maintain a stable dose distribution with time. Most studies in this area conclude in the need to use chemical modifications of the species responsible for the mechanical properties of the dosimeters, which in most cases is a gelatin matrix. In this study, a covalent crosslinking of the gelatin matrix of PAGAT dosimeters doped with different inorganic salts, namely MgCl2, CaCl2 and MnCl2 has been carried out. The mechanical properties, X-ray sensitivity and dose distribution stability in these materials were compared to those of PAGAT. The results indicated a compromise between the crosslinking of the gelatin structure and the sensitivity of the dosimetric material. Therefore, the proper selection of the degree of crosslinking and the inorganic salt concentration must be considered. An enhanced dosimeter was obtained by adding MgCl2 with a 1M concentration and by crosslinking the gelatin matrix with glutaraldehyde at a 0.08%w/v concentration. This material presented a 75% enhanced sensitivity relative to PAGAT and similar temporal stability and spatial stability in 2D dose distributions. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-10 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/91579 Chacón Obando, David; Strumia, Miriam Cristina; Valente, Mauro Andres; Mattea, Facundo; Effect of inorganic salts and matrix crosslinking on the dose response of polymer gel dosimeters based on acrylamide; Pergamon-Elsevier Science Ltd; Radiation Measurements; 117; 10-2018; 7-18 1350-4487 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/91579 |
identifier_str_mv |
Chacón Obando, David; Strumia, Miriam Cristina; Valente, Mauro Andres; Mattea, Facundo; Effect of inorganic salts and matrix crosslinking on the dose response of polymer gel dosimeters based on acrylamide; Pergamon-Elsevier Science Ltd; Radiation Measurements; 117; 10-2018; 7-18 1350-4487 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1350448718301380 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.radmeas.2018.07.004 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Pergamon-Elsevier Science Ltd |
publisher.none.fl_str_mv |
Pergamon-Elsevier Science Ltd |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842269049235439616 |
score |
13.13397 |