Effect of inorganic salts and matrix crosslinking on the dose response of polymer gel dosimeters based on acrylamide

Autores
Chacón Obando, David; Strumia, Miriam Cristina; Valente, Mauro Andres; Mattea, Facundo
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The use of additives in polymer gel dosimeters to enhance their sensitivity or to improve their performance is of great importance for their application in radiomedicine. Inorganic salts have been used as additives with this purpose; however, their presence in the dosimeters induce severe modifications in their mechanical properties and consequently in their capabilities to maintain a stable dose distribution with time. Most studies in this area conclude in the need to use chemical modifications of the species responsible for the mechanical properties of the dosimeters, which in most cases is a gelatin matrix. In this study, a covalent crosslinking of the gelatin matrix of PAGAT dosimeters doped with different inorganic salts, namely MgCl2, CaCl2 and MnCl2 has been carried out. The mechanical properties, X-ray sensitivity and dose distribution stability in these materials were compared to those of PAGAT. The results indicated a compromise between the crosslinking of the gelatin structure and the sensitivity of the dosimetric material. Therefore, the proper selection of the degree of crosslinking and the inorganic salt concentration must be considered. An enhanced dosimeter was obtained by adding MgCl2 with a 1M concentration and by crosslinking the gelatin matrix with glutaraldehyde at a 0.08%w/v concentration. This material presented a 75% enhanced sensitivity relative to PAGAT and similar temporal stability and spatial stability in 2D dose distributions.
Fil: Chacón Obando, David. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina
Fil: Strumia, Miriam Cristina. Universidad Nacional de Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina
Fil: Valente, Mauro Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Universidad de La Frontera; Chile
Fil: Mattea, Facundo. Universidad Nacional de Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina
Materia
ACRYLAMIDE
DOSIMETRY
GELATIN CROSSLINKING
INORGANIC SALTS
POLYMER
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/91579
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/91579
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Effect of inorganic salts and matrix crosslinking on the dose response of polymer gel dosimeters based on acrylamideChacón Obando, DavidStrumia, Miriam CristinaValente, Mauro AndresMattea, FacundoACRYLAMIDEDOSIMETRYGELATIN CROSSLINKINGINORGANIC SALTSPOLYMERhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The use of additives in polymer gel dosimeters to enhance their sensitivity or to improve their performance is of great importance for their application in radiomedicine. Inorganic salts have been used as additives with this purpose; however, their presence in the dosimeters induce severe modifications in their mechanical properties and consequently in their capabilities to maintain a stable dose distribution with time. Most studies in this area conclude in the need to use chemical modifications of the species responsible for the mechanical properties of the dosimeters, which in most cases is a gelatin matrix. In this study, a covalent crosslinking of the gelatin matrix of PAGAT dosimeters doped with different inorganic salts, namely MgCl2, CaCl2 and MnCl2 has been carried out. The mechanical properties, X-ray sensitivity and dose distribution stability in these materials were compared to those of PAGAT. The results indicated a compromise between the crosslinking of the gelatin structure and the sensitivity of the dosimetric material. Therefore, the proper selection of the degree of crosslinking and the inorganic salt concentration must be considered. An enhanced dosimeter was obtained by adding MgCl2 with a 1M concentration and by crosslinking the gelatin matrix with glutaraldehyde at a 0.08%w/v concentration. This material presented a 75% enhanced sensitivity relative to PAGAT and similar temporal stability and spatial stability in 2D dose distributions.Fil: Chacón Obando, David. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; ArgentinaFil: Strumia, Miriam Cristina. Universidad Nacional de Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; ArgentinaFil: Valente, Mauro Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Universidad de La Frontera; ChileFil: Mattea, Facundo. Universidad Nacional de Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; ArgentinaPergamon-Elsevier Science Ltd2018-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/91579Chacón Obando, David; Strumia, Miriam Cristina; Valente, Mauro Andres; Mattea, Facundo; Effect of inorganic salts and matrix crosslinking on the dose response of polymer gel dosimeters based on acrylamide; Pergamon-Elsevier Science Ltd; Radiation Measurements; 117; 10-2018; 7-181350-4487CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1350448718301380info:eu-repo/semantics/altIdentifier/doi/10.1016/j.radmeas.2018.07.004info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:46:04Zoai:ri.conicet.gov.ar:11336/91579instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:46:04.67CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effect of inorganic salts and matrix crosslinking on the dose response of polymer gel dosimeters based on acrylamide
title Effect of inorganic salts and matrix crosslinking on the dose response of polymer gel dosimeters based on acrylamide
spellingShingle Effect of inorganic salts and matrix crosslinking on the dose response of polymer gel dosimeters based on acrylamide
Chacón Obando, David
ACRYLAMIDE
DOSIMETRY
GELATIN CROSSLINKING
INORGANIC SALTS
POLYMER
title_short Effect of inorganic salts and matrix crosslinking on the dose response of polymer gel dosimeters based on acrylamide
title_full Effect of inorganic salts and matrix crosslinking on the dose response of polymer gel dosimeters based on acrylamide
title_fullStr Effect of inorganic salts and matrix crosslinking on the dose response of polymer gel dosimeters based on acrylamide
title_full_unstemmed Effect of inorganic salts and matrix crosslinking on the dose response of polymer gel dosimeters based on acrylamide
title_sort Effect of inorganic salts and matrix crosslinking on the dose response of polymer gel dosimeters based on acrylamide
dc.creator.none.fl_str_mv Chacón Obando, David
Strumia, Miriam Cristina
Valente, Mauro Andres
Mattea, Facundo
author Chacón Obando, David
author_facet Chacón Obando, David
Strumia, Miriam Cristina
Valente, Mauro Andres
Mattea, Facundo
author_role author
author2 Strumia, Miriam Cristina
Valente, Mauro Andres
Mattea, Facundo
author2_role author
author
author
dc.subject.none.fl_str_mv ACRYLAMIDE
DOSIMETRY
GELATIN CROSSLINKING
INORGANIC SALTS
POLYMER
topic ACRYLAMIDE
DOSIMETRY
GELATIN CROSSLINKING
INORGANIC SALTS
POLYMER
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The use of additives in polymer gel dosimeters to enhance their sensitivity or to improve their performance is of great importance for their application in radiomedicine. Inorganic salts have been used as additives with this purpose; however, their presence in the dosimeters induce severe modifications in their mechanical properties and consequently in their capabilities to maintain a stable dose distribution with time. Most studies in this area conclude in the need to use chemical modifications of the species responsible for the mechanical properties of the dosimeters, which in most cases is a gelatin matrix. In this study, a covalent crosslinking of the gelatin matrix of PAGAT dosimeters doped with different inorganic salts, namely MgCl2, CaCl2 and MnCl2 has been carried out. The mechanical properties, X-ray sensitivity and dose distribution stability in these materials were compared to those of PAGAT. The results indicated a compromise between the crosslinking of the gelatin structure and the sensitivity of the dosimetric material. Therefore, the proper selection of the degree of crosslinking and the inorganic salt concentration must be considered. An enhanced dosimeter was obtained by adding MgCl2 with a 1M concentration and by crosslinking the gelatin matrix with glutaraldehyde at a 0.08%w/v concentration. This material presented a 75% enhanced sensitivity relative to PAGAT and similar temporal stability and spatial stability in 2D dose distributions.
Fil: Chacón Obando, David. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina
Fil: Strumia, Miriam Cristina. Universidad Nacional de Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina
Fil: Valente, Mauro Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Universidad de La Frontera; Chile
Fil: Mattea, Facundo. Universidad Nacional de Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina
description The use of additives in polymer gel dosimeters to enhance their sensitivity or to improve their performance is of great importance for their application in radiomedicine. Inorganic salts have been used as additives with this purpose; however, their presence in the dosimeters induce severe modifications in their mechanical properties and consequently in their capabilities to maintain a stable dose distribution with time. Most studies in this area conclude in the need to use chemical modifications of the species responsible for the mechanical properties of the dosimeters, which in most cases is a gelatin matrix. In this study, a covalent crosslinking of the gelatin matrix of PAGAT dosimeters doped with different inorganic salts, namely MgCl2, CaCl2 and MnCl2 has been carried out. The mechanical properties, X-ray sensitivity and dose distribution stability in these materials were compared to those of PAGAT. The results indicated a compromise between the crosslinking of the gelatin structure and the sensitivity of the dosimetric material. Therefore, the proper selection of the degree of crosslinking and the inorganic salt concentration must be considered. An enhanced dosimeter was obtained by adding MgCl2 with a 1M concentration and by crosslinking the gelatin matrix with glutaraldehyde at a 0.08%w/v concentration. This material presented a 75% enhanced sensitivity relative to PAGAT and similar temporal stability and spatial stability in 2D dose distributions.
publishDate 2018
dc.date.none.fl_str_mv 2018-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/91579
Chacón Obando, David; Strumia, Miriam Cristina; Valente, Mauro Andres; Mattea, Facundo; Effect of inorganic salts and matrix crosslinking on the dose response of polymer gel dosimeters based on acrylamide; Pergamon-Elsevier Science Ltd; Radiation Measurements; 117; 10-2018; 7-18
1350-4487
CONICET Digital
CONICET
url http://hdl.handle.net/11336/91579
identifier_str_mv Chacón Obando, David; Strumia, Miriam Cristina; Valente, Mauro Andres; Mattea, Facundo; Effect of inorganic salts and matrix crosslinking on the dose response of polymer gel dosimeters based on acrylamide; Pergamon-Elsevier Science Ltd; Radiation Measurements; 117; 10-2018; 7-18
1350-4487
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1350448718301380
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.radmeas.2018.07.004
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.069144

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