Synthesis, characterization and slow drug delivery of hydrogels based in N-acryloyl-tris-(hydroxymethyl) aminomethane and N-isopropyl acrylamide
- Autores
- Cuggino, Julio César; Strumia, Miriam Cristina; Alvarez Igarzabal, Cecilia Ines
- Año de publicación
- 2011
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- In this study, new hydrogels in rod shape were prepared from N-isopropyl acrylamide (NIPA), N-acryloyl-tris-(hydroxymethyl) aminomethane (NAT) and N,N´-methylenebisacrylamide (BIS). The effect of the incorporation of NAT into poly(N-isopropyl acrylamide) (PNIPA) structures for which the monomer composition was varied from NIPA 100% to NAT 100% was explored. The rheological studies were used to test their viscoelastic properties. Swelling experiments were used to test the capacity of water absorption, the modification of the network parameters, the swelling kinetics, the temperature and pH swelling response and n (number that determines the type of diffusion of water). NAT-containing hydrogels showed values of n between 0.5 and 1, therefore the diffusion of water into the hydrogels was found to have a non-Fickian character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at high temperature that maintains the drug and hinders the release was controlled by the introduction of NAT into the network, to allow a slow drug release of ibuprofen at 37 ºC and pH 7.4.
Fil: Cuggino, Julio César. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina
Fil: Strumia, Miriam Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina
Fil: Alvarez Igarzabal, Cecilia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina - Materia
-
Hydrogel Synthesis
Thermo-Sensitive Hydrogels
Drug Controlled Release
Corsslinked Strucutres - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/12934
Ver los metadatos del registro completo
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Synthesis, characterization and slow drug delivery of hydrogels based in N-acryloyl-tris-(hydroxymethyl) aminomethane and N-isopropyl acrylamideCuggino, Julio CésarStrumia, Miriam CristinaAlvarez Igarzabal, Cecilia InesHydrogel SynthesisThermo-Sensitive HydrogelsDrug Controlled ReleaseCorsslinked Strucutreshttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1https://purl.org/becyt/ford/2.9https://purl.org/becyt/ford/2In this study, new hydrogels in rod shape were prepared from N-isopropyl acrylamide (NIPA), N-acryloyl-tris-(hydroxymethyl) aminomethane (NAT) and N,N´-methylenebisacrylamide (BIS). The effect of the incorporation of NAT into poly(N-isopropyl acrylamide) (PNIPA) structures for which the monomer composition was varied from NIPA 100% to NAT 100% was explored. The rheological studies were used to test their viscoelastic properties. Swelling experiments were used to test the capacity of water absorption, the modification of the network parameters, the swelling kinetics, the temperature and pH swelling response and n (number that determines the type of diffusion of water). NAT-containing hydrogels showed values of n between 0.5 and 1, therefore the diffusion of water into the hydrogels was found to have a non-Fickian character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at high temperature that maintains the drug and hinders the release was controlled by the introduction of NAT into the network, to allow a slow drug release of ibuprofen at 37 ºC and pH 7.4.Fil: Cuggino, Julio César. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); ArgentinaFil: Strumia, Miriam Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); ArgentinaFil: Alvarez Igarzabal, Cecilia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); ArgentinaElsevier Science2011-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/12934Cuggino, Julio César; Strumia, Miriam Cristina; Alvarez Igarzabal, Cecilia Ines; Synthesis, characterization and slow drug delivery of hydrogels based in N-acryloyl-tris-(hydroxymethyl) aminomethane and N-isopropyl acrylamide; Elsevier Science; Reactive & Functional Polymers; 71; 4; 4-2011; 440-4461381-5148enginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.reactfunctpolym.2011.01.002info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1381514811000083info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:09:29Zoai:ri.conicet.gov.ar:11336/12934instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:09:29.726CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Synthesis, characterization and slow drug delivery of hydrogels based in N-acryloyl-tris-(hydroxymethyl) aminomethane and N-isopropyl acrylamide |
title |
Synthesis, characterization and slow drug delivery of hydrogels based in N-acryloyl-tris-(hydroxymethyl) aminomethane and N-isopropyl acrylamide |
spellingShingle |
Synthesis, characterization and slow drug delivery of hydrogels based in N-acryloyl-tris-(hydroxymethyl) aminomethane and N-isopropyl acrylamide Cuggino, Julio César Hydrogel Synthesis Thermo-Sensitive Hydrogels Drug Controlled Release Corsslinked Strucutres |
title_short |
Synthesis, characterization and slow drug delivery of hydrogels based in N-acryloyl-tris-(hydroxymethyl) aminomethane and N-isopropyl acrylamide |
title_full |
Synthesis, characterization and slow drug delivery of hydrogels based in N-acryloyl-tris-(hydroxymethyl) aminomethane and N-isopropyl acrylamide |
title_fullStr |
Synthesis, characterization and slow drug delivery of hydrogels based in N-acryloyl-tris-(hydroxymethyl) aminomethane and N-isopropyl acrylamide |
title_full_unstemmed |
Synthesis, characterization and slow drug delivery of hydrogels based in N-acryloyl-tris-(hydroxymethyl) aminomethane and N-isopropyl acrylamide |
title_sort |
Synthesis, characterization and slow drug delivery of hydrogels based in N-acryloyl-tris-(hydroxymethyl) aminomethane and N-isopropyl acrylamide |
dc.creator.none.fl_str_mv |
Cuggino, Julio César Strumia, Miriam Cristina Alvarez Igarzabal, Cecilia Ines |
author |
Cuggino, Julio César |
author_facet |
Cuggino, Julio César Strumia, Miriam Cristina Alvarez Igarzabal, Cecilia Ines |
author_role |
author |
author2 |
Strumia, Miriam Cristina Alvarez Igarzabal, Cecilia Ines |
author2_role |
author author |
dc.subject.none.fl_str_mv |
Hydrogel Synthesis Thermo-Sensitive Hydrogels Drug Controlled Release Corsslinked Strucutres |
topic |
Hydrogel Synthesis Thermo-Sensitive Hydrogels Drug Controlled Release Corsslinked Strucutres |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 https://purl.org/becyt/ford/2.9 https://purl.org/becyt/ford/2 |
dc.description.none.fl_txt_mv |
In this study, new hydrogels in rod shape were prepared from N-isopropyl acrylamide (NIPA), N-acryloyl-tris-(hydroxymethyl) aminomethane (NAT) and N,N´-methylenebisacrylamide (BIS). The effect of the incorporation of NAT into poly(N-isopropyl acrylamide) (PNIPA) structures for which the monomer composition was varied from NIPA 100% to NAT 100% was explored. The rheological studies were used to test their viscoelastic properties. Swelling experiments were used to test the capacity of water absorption, the modification of the network parameters, the swelling kinetics, the temperature and pH swelling response and n (number that determines the type of diffusion of water). NAT-containing hydrogels showed values of n between 0.5 and 1, therefore the diffusion of water into the hydrogels was found to have a non-Fickian character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at high temperature that maintains the drug and hinders the release was controlled by the introduction of NAT into the network, to allow a slow drug release of ibuprofen at 37 ºC and pH 7.4. Fil: Cuggino, Julio César. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina Fil: Strumia, Miriam Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina Fil: Alvarez Igarzabal, Cecilia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina |
description |
In this study, new hydrogels in rod shape were prepared from N-isopropyl acrylamide (NIPA), N-acryloyl-tris-(hydroxymethyl) aminomethane (NAT) and N,N´-methylenebisacrylamide (BIS). The effect of the incorporation of NAT into poly(N-isopropyl acrylamide) (PNIPA) structures for which the monomer composition was varied from NIPA 100% to NAT 100% was explored. The rheological studies were used to test their viscoelastic properties. Swelling experiments were used to test the capacity of water absorption, the modification of the network parameters, the swelling kinetics, the temperature and pH swelling response and n (number that determines the type of diffusion of water). NAT-containing hydrogels showed values of n between 0.5 and 1, therefore the diffusion of water into the hydrogels was found to have a non-Fickian character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at high temperature that maintains the drug and hinders the release was controlled by the introduction of NAT into the network, to allow a slow drug release of ibuprofen at 37 ºC and pH 7.4. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-04 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/12934 Cuggino, Julio César; Strumia, Miriam Cristina; Alvarez Igarzabal, Cecilia Ines; Synthesis, characterization and slow drug delivery of hydrogels based in N-acryloyl-tris-(hydroxymethyl) aminomethane and N-isopropyl acrylamide; Elsevier Science; Reactive & Functional Polymers; 71; 4; 4-2011; 440-446 1381-5148 |
url |
http://hdl.handle.net/11336/12934 |
identifier_str_mv |
Cuggino, Julio César; Strumia, Miriam Cristina; Alvarez Igarzabal, Cecilia Ines; Synthesis, characterization and slow drug delivery of hydrogels based in N-acryloyl-tris-(hydroxymethyl) aminomethane and N-isopropyl acrylamide; Elsevier Science; Reactive & Functional Polymers; 71; 4; 4-2011; 440-446 1381-5148 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.reactfunctpolym.2011.01.002 info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1381514811000083 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Science |
publisher.none.fl_str_mv |
Elsevier Science |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613974546448384 |
score |
13.070432 |