N,N-Dimethylacrylamide Hydrogels for Controlled Drug Delivery. Influence of Network Structure and Drug Solubility on the Load and Release Mechanisms

Autores
Garcia, Valeria Soledad; González, Verónica Doris Guadalupe; Gugliotta, Luis Marcelino
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of the present work was to synthesize sustained-release hydrogels based on N,N-dimethylacrylamide (DMA) to study the effect of the polymer matrix structure and the solubility of drugs on the load and release mechanisms. A series of cross-linked DMA hydrogels were synthesized with different monomer concentration and crosslinker to monomer ratio by free radical aqueous solution polymerization at 37ºC using N,N-methylen-bis-acrylamide as crosslinking agent. The effect of total monomer concentration and degree of crosslinking on the water absorption, glass transition temperature values, mechanical properties, and load/release of different drugs was studied. Main results showed that: a) the structure of the network, obtained by varying the monomer and crosslinking agent concentration, is a factor that governs the chemical and physical properties of the hydrogel (water absorption, glass transition temperature, storage and loss moduli, network parameters), b) the rate and amount of drug released from swellable hydrogels depend on both the degree of hydrogel crosslinking and the water solubility of the drug. In all cases, as the concentration of the crosslinker agent increased, the swelling capacity of the hydrogels was reduced and drugs with high solubility in water were more easily released, probably due to their greater affinity for the medium.
Fil: Garcia, Valeria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: González, Verónica Doris Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Gugliotta, Luis Marcelino. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Materia
N,N-DIMETHYLACRYLAMIDE HYDROGELS
SWELLING KINETICS
MECHANICAL PROPERTIES
DRUG RELEASE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/106803
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/106803
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling N,N-Dimethylacrylamide Hydrogels for Controlled Drug Delivery. Influence of Network Structure and Drug Solubility on the Load and Release MechanismsGarcia, Valeria SoledadGonzález, Verónica Doris GuadalupeGugliotta, Luis MarcelinoN,N-DIMETHYLACRYLAMIDE HYDROGELSSWELLING KINETICSMECHANICAL PROPERTIESDRUG RELEASEhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The aim of the present work was to synthesize sustained-release hydrogels based on N,N-dimethylacrylamide (DMA) to study the effect of the polymer matrix structure and the solubility of drugs on the load and release mechanisms. A series of cross-linked DMA hydrogels were synthesized with different monomer concentration and crosslinker to monomer ratio by free radical aqueous solution polymerization at 37ºC using N,N-methylen-bis-acrylamide as crosslinking agent. The effect of total monomer concentration and degree of crosslinking on the water absorption, glass transition temperature values, mechanical properties, and load/release of different drugs was studied. Main results showed that: a) the structure of the network, obtained by varying the monomer and crosslinking agent concentration, is a factor that governs the chemical and physical properties of the hydrogel (water absorption, glass transition temperature, storage and loss moduli, network parameters), b) the rate and amount of drug released from swellable hydrogels depend on both the degree of hydrogel crosslinking and the water solubility of the drug. In all cases, as the concentration of the crosslinker agent increased, the swelling capacity of the hydrogels was reduced and drugs with high solubility in water were more easily released, probably due to their greater affinity for the medium.Fil: Garcia, Valeria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: González, Verónica Doris Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Gugliotta, Luis Marcelino. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaPlanta Piloto de Ingeniería Química2019-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/106803Garcia, Valeria Soledad; González, Verónica Doris Guadalupe; Gugliotta, Luis Marcelino; N,N-Dimethylacrylamide Hydrogels for Controlled Drug Delivery. Influence of Network Structure and Drug Solubility on the Load and Release Mechanisms; Planta Piloto de Ingeniería Química; Latin American Applied Research; 49; 2; 8-2019; 83-910327-07931851-8796CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://laar.plapiqui.edu.ar/OJS/index.php/laar/article/view/365info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:24:37Zoai:ri.conicet.gov.ar:11336/106803instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:24:37.514CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv N,N-Dimethylacrylamide Hydrogels for Controlled Drug Delivery. Influence of Network Structure and Drug Solubility on the Load and Release Mechanisms
title N,N-Dimethylacrylamide Hydrogels for Controlled Drug Delivery. Influence of Network Structure and Drug Solubility on the Load and Release Mechanisms
spellingShingle N,N-Dimethylacrylamide Hydrogels for Controlled Drug Delivery. Influence of Network Structure and Drug Solubility on the Load and Release Mechanisms
Garcia, Valeria Soledad
N,N-DIMETHYLACRYLAMIDE HYDROGELS
SWELLING KINETICS
MECHANICAL PROPERTIES
DRUG RELEASE
title_short N,N-Dimethylacrylamide Hydrogels for Controlled Drug Delivery. Influence of Network Structure and Drug Solubility on the Load and Release Mechanisms
title_full N,N-Dimethylacrylamide Hydrogels for Controlled Drug Delivery. Influence of Network Structure and Drug Solubility on the Load and Release Mechanisms
title_fullStr N,N-Dimethylacrylamide Hydrogels for Controlled Drug Delivery. Influence of Network Structure and Drug Solubility on the Load and Release Mechanisms
title_full_unstemmed N,N-Dimethylacrylamide Hydrogels for Controlled Drug Delivery. Influence of Network Structure and Drug Solubility on the Load and Release Mechanisms
title_sort N,N-Dimethylacrylamide Hydrogels for Controlled Drug Delivery. Influence of Network Structure and Drug Solubility on the Load and Release Mechanisms
dc.creator.none.fl_str_mv Garcia, Valeria Soledad
González, Verónica Doris Guadalupe
Gugliotta, Luis Marcelino
author Garcia, Valeria Soledad
author_facet Garcia, Valeria Soledad
González, Verónica Doris Guadalupe
Gugliotta, Luis Marcelino
author_role author
author2 González, Verónica Doris Guadalupe
Gugliotta, Luis Marcelino
author2_role author
author
dc.subject.none.fl_str_mv N,N-DIMETHYLACRYLAMIDE HYDROGELS
SWELLING KINETICS
MECHANICAL PROPERTIES
DRUG RELEASE
topic N,N-DIMETHYLACRYLAMIDE HYDROGELS
SWELLING KINETICS
MECHANICAL PROPERTIES
DRUG RELEASE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The aim of the present work was to synthesize sustained-release hydrogels based on N,N-dimethylacrylamide (DMA) to study the effect of the polymer matrix structure and the solubility of drugs on the load and release mechanisms. A series of cross-linked DMA hydrogels were synthesized with different monomer concentration and crosslinker to monomer ratio by free radical aqueous solution polymerization at 37ºC using N,N-methylen-bis-acrylamide as crosslinking agent. The effect of total monomer concentration and degree of crosslinking on the water absorption, glass transition temperature values, mechanical properties, and load/release of different drugs was studied. Main results showed that: a) the structure of the network, obtained by varying the monomer and crosslinking agent concentration, is a factor that governs the chemical and physical properties of the hydrogel (water absorption, glass transition temperature, storage and loss moduli, network parameters), b) the rate and amount of drug released from swellable hydrogels depend on both the degree of hydrogel crosslinking and the water solubility of the drug. In all cases, as the concentration of the crosslinker agent increased, the swelling capacity of the hydrogels was reduced and drugs with high solubility in water were more easily released, probably due to their greater affinity for the medium.
Fil: Garcia, Valeria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: González, Verónica Doris Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Gugliotta, Luis Marcelino. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
description The aim of the present work was to synthesize sustained-release hydrogels based on N,N-dimethylacrylamide (DMA) to study the effect of the polymer matrix structure and the solubility of drugs on the load and release mechanisms. A series of cross-linked DMA hydrogels were synthesized with different monomer concentration and crosslinker to monomer ratio by free radical aqueous solution polymerization at 37ºC using N,N-methylen-bis-acrylamide as crosslinking agent. The effect of total monomer concentration and degree of crosslinking on the water absorption, glass transition temperature values, mechanical properties, and load/release of different drugs was studied. Main results showed that: a) the structure of the network, obtained by varying the monomer and crosslinking agent concentration, is a factor that governs the chemical and physical properties of the hydrogel (water absorption, glass transition temperature, storage and loss moduli, network parameters), b) the rate and amount of drug released from swellable hydrogels depend on both the degree of hydrogel crosslinking and the water solubility of the drug. In all cases, as the concentration of the crosslinker agent increased, the swelling capacity of the hydrogels was reduced and drugs with high solubility in water were more easily released, probably due to their greater affinity for the medium.
publishDate 2019
dc.date.none.fl_str_mv 2019-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/106803
Garcia, Valeria Soledad; González, Verónica Doris Guadalupe; Gugliotta, Luis Marcelino; N,N-Dimethylacrylamide Hydrogels for Controlled Drug Delivery. Influence of Network Structure and Drug Solubility on the Load and Release Mechanisms; Planta Piloto de Ingeniería Química; Latin American Applied Research; 49; 2; 8-2019; 83-91
0327-0793
1851-8796
CONICET Digital
CONICET
url http://hdl.handle.net/11336/106803
identifier_str_mv Garcia, Valeria Soledad; González, Verónica Doris Guadalupe; Gugliotta, Luis Marcelino; N,N-Dimethylacrylamide Hydrogels for Controlled Drug Delivery. Influence of Network Structure and Drug Solubility on the Load and Release Mechanisms; Planta Piloto de Ingeniería Química; Latin American Applied Research; 49; 2; 8-2019; 83-91
0327-0793
1851-8796
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://laar.plapiqui.edu.ar/OJS/index.php/laar/article/view/365
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Planta Piloto de Ingeniería Química
publisher.none.fl_str_mv Planta Piloto de Ingeniería Química
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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