Nucleoredoxin Plays a Key Role in the Maintenance of Retinal Pigmented Epithelium Differentiation
- Autores
- Holubiec, Mariana Ines; Romero, Juan Ignacio; Urbainsky, Claudia; Gellert, Manuela; Galeano, Pablo; Capani, Francisco; Lillig, Christopher Horst; Hanschmann, Eva Maria
- Año de publicación
- 2022
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Nucleoredoxin (Nrx) belongs to the Thioredoxin protein family and functions in redox-mediated signal transduction. It contains the dithiol active site motif Cys-Pro-Pro-Cys and interacts and regulates different proteins in distinct cellular pathways. Nrx was shown to be catalytically active in the insulin assay and recent findings indicate that Nrx functions, in fact, as oxidase. Here, we have analyzed Nrx in the mammalian retina exposed to (perinatal) hypoxia-ischemia/reoxygenation, combining ex vivo and in vitro models. Our data show that Nrx regulates cell differentiation, which is important to (i) increase the number of glial cells and (ii) replenish neurons that are lost following the hypoxic insult. Nrx is essential to maintain cell morphology. These regulatory changes are related to VEGF but do not seem to be linked to the Wnt/β-catenin pathway, which is not affected by Nrx knock-down. In conclusion, our results strongly suggest that hypoxia-ischemia could lead to alterations in the organization of the retina, related to changes in RPE cell differentiation. Nrx may play an essential role in the maintenance of the RPE cell differentiation state via the regulation of VEGF release.
Fil: Holubiec, Mariana Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina
Fil: Romero, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Urbainsky, Claudia. Ernst Moritz Arndt Universität Greifswald. Institut fur Geographie und Geologie; Alemania
Fil: Gellert, Manuela. Ernst Moritz Arndt Universität Greifswald. Institut fur Geographie und Geologie; Alemania
Fil: Galeano, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Capani, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina. Universidad Autonoma de Chile; Chile. Universidad Abierta Interamericana. Secretaría de Investigación. Centro de Altos Estudios En Ciencias Humanas y de la Salud - Sede Buenos Aires; Argentina
Fil: Lillig, Christopher Horst. Ernst Moritz Arndt Universität Greifswald. Institut fur Geographie und Geologie; Alemania
Fil: Hanschmann, Eva Maria. Ernst Moritz Arndt Universität Greifswald. Institut fur Geographie und Geologie; Alemania. Heinrich-Heine University; Alemania - Materia
-
DIFFERENTIATION
GLIA
HYPOXIA-ISCHEMIA
MORPHOLOGY
NEURONS
NUCLEOREDOXIN
REDOX REGULATION
REOXYGENATION
RETINA
RPE - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/214766
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Nucleoredoxin Plays a Key Role in the Maintenance of Retinal Pigmented Epithelium DifferentiationHolubiec, Mariana InesRomero, Juan IgnacioUrbainsky, ClaudiaGellert, ManuelaGaleano, PabloCapani, FranciscoLillig, Christopher HorstHanschmann, Eva MariaDIFFERENTIATIONGLIAHYPOXIA-ISCHEMIAMORPHOLOGYNEURONSNUCLEOREDOXINREDOX REGULATIONREOXYGENATIONRETINARPEhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Nucleoredoxin (Nrx) belongs to the Thioredoxin protein family and functions in redox-mediated signal transduction. It contains the dithiol active site motif Cys-Pro-Pro-Cys and interacts and regulates different proteins in distinct cellular pathways. Nrx was shown to be catalytically active in the insulin assay and recent findings indicate that Nrx functions, in fact, as oxidase. Here, we have analyzed Nrx in the mammalian retina exposed to (perinatal) hypoxia-ischemia/reoxygenation, combining ex vivo and in vitro models. Our data show that Nrx regulates cell differentiation, which is important to (i) increase the number of glial cells and (ii) replenish neurons that are lost following the hypoxic insult. Nrx is essential to maintain cell morphology. These regulatory changes are related to VEGF but do not seem to be linked to the Wnt/β-catenin pathway, which is not affected by Nrx knock-down. In conclusion, our results strongly suggest that hypoxia-ischemia could lead to alterations in the organization of the retina, related to changes in RPE cell differentiation. Nrx may play an essential role in the maintenance of the RPE cell differentiation state via the regulation of VEGF release.Fil: Holubiec, Mariana Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; ArgentinaFil: Romero, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Urbainsky, Claudia. Ernst Moritz Arndt Universität Greifswald. Institut fur Geographie und Geologie; AlemaniaFil: Gellert, Manuela. Ernst Moritz Arndt Universität Greifswald. Institut fur Geographie und Geologie; AlemaniaFil: Galeano, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Capani, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina. Universidad Autonoma de Chile; Chile. Universidad Abierta Interamericana. Secretaría de Investigación. Centro de Altos Estudios En Ciencias Humanas y de la Salud - Sede Buenos Aires; ArgentinaFil: Lillig, Christopher Horst. Ernst Moritz Arndt Universität Greifswald. Institut fur Geographie und Geologie; AlemaniaFil: Hanschmann, Eva Maria. Ernst Moritz Arndt Universität Greifswald. Institut fur Geographie und Geologie; Alemania. Heinrich-Heine University; AlemaniaMultidisciplinary Digital Publishing Institute2022-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/214766Holubiec, Mariana Ines; Romero, Juan Ignacio; Urbainsky, Claudia; Gellert, Manuela ; Galeano, Pablo; et al.; Nucleoredoxin Plays a Key Role in the Maintenance of Retinal Pigmented Epithelium Differentiation; Multidisciplinary Digital Publishing Institute; Antioxidants; 11; 6; 6-2022; 1-172076-3921CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2076-3921/11/6/1106info:eu-repo/semantics/altIdentifier/doi/10.3390/antiox11061106info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:28:14Zoai:ri.conicet.gov.ar:11336/214766instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:28:14.842CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Nucleoredoxin Plays a Key Role in the Maintenance of Retinal Pigmented Epithelium Differentiation |
title |
Nucleoredoxin Plays a Key Role in the Maintenance of Retinal Pigmented Epithelium Differentiation |
spellingShingle |
Nucleoredoxin Plays a Key Role in the Maintenance of Retinal Pigmented Epithelium Differentiation Holubiec, Mariana Ines DIFFERENTIATION GLIA HYPOXIA-ISCHEMIA MORPHOLOGY NEURONS NUCLEOREDOXIN REDOX REGULATION REOXYGENATION RETINA RPE |
title_short |
Nucleoredoxin Plays a Key Role in the Maintenance of Retinal Pigmented Epithelium Differentiation |
title_full |
Nucleoredoxin Plays a Key Role in the Maintenance of Retinal Pigmented Epithelium Differentiation |
title_fullStr |
Nucleoredoxin Plays a Key Role in the Maintenance of Retinal Pigmented Epithelium Differentiation |
title_full_unstemmed |
Nucleoredoxin Plays a Key Role in the Maintenance of Retinal Pigmented Epithelium Differentiation |
title_sort |
Nucleoredoxin Plays a Key Role in the Maintenance of Retinal Pigmented Epithelium Differentiation |
dc.creator.none.fl_str_mv |
Holubiec, Mariana Ines Romero, Juan Ignacio Urbainsky, Claudia Gellert, Manuela Galeano, Pablo Capani, Francisco Lillig, Christopher Horst Hanschmann, Eva Maria |
author |
Holubiec, Mariana Ines |
author_facet |
Holubiec, Mariana Ines Romero, Juan Ignacio Urbainsky, Claudia Gellert, Manuela Galeano, Pablo Capani, Francisco Lillig, Christopher Horst Hanschmann, Eva Maria |
author_role |
author |
author2 |
Romero, Juan Ignacio Urbainsky, Claudia Gellert, Manuela Galeano, Pablo Capani, Francisco Lillig, Christopher Horst Hanschmann, Eva Maria |
author2_role |
author author author author author author author |
dc.subject.none.fl_str_mv |
DIFFERENTIATION GLIA HYPOXIA-ISCHEMIA MORPHOLOGY NEURONS NUCLEOREDOXIN REDOX REGULATION REOXYGENATION RETINA RPE |
topic |
DIFFERENTIATION GLIA HYPOXIA-ISCHEMIA MORPHOLOGY NEURONS NUCLEOREDOXIN REDOX REGULATION REOXYGENATION RETINA RPE |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Nucleoredoxin (Nrx) belongs to the Thioredoxin protein family and functions in redox-mediated signal transduction. It contains the dithiol active site motif Cys-Pro-Pro-Cys and interacts and regulates different proteins in distinct cellular pathways. Nrx was shown to be catalytically active in the insulin assay and recent findings indicate that Nrx functions, in fact, as oxidase. Here, we have analyzed Nrx in the mammalian retina exposed to (perinatal) hypoxia-ischemia/reoxygenation, combining ex vivo and in vitro models. Our data show that Nrx regulates cell differentiation, which is important to (i) increase the number of glial cells and (ii) replenish neurons that are lost following the hypoxic insult. Nrx is essential to maintain cell morphology. These regulatory changes are related to VEGF but do not seem to be linked to the Wnt/β-catenin pathway, which is not affected by Nrx knock-down. In conclusion, our results strongly suggest that hypoxia-ischemia could lead to alterations in the organization of the retina, related to changes in RPE cell differentiation. Nrx may play an essential role in the maintenance of the RPE cell differentiation state via the regulation of VEGF release. Fil: Holubiec, Mariana Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina Fil: Romero, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina Fil: Urbainsky, Claudia. Ernst Moritz Arndt Universität Greifswald. Institut fur Geographie und Geologie; Alemania Fil: Gellert, Manuela. Ernst Moritz Arndt Universität Greifswald. Institut fur Geographie und Geologie; Alemania Fil: Galeano, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina Fil: Capani, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina. Universidad Autonoma de Chile; Chile. Universidad Abierta Interamericana. Secretaría de Investigación. Centro de Altos Estudios En Ciencias Humanas y de la Salud - Sede Buenos Aires; Argentina Fil: Lillig, Christopher Horst. Ernst Moritz Arndt Universität Greifswald. Institut fur Geographie und Geologie; Alemania Fil: Hanschmann, Eva Maria. Ernst Moritz Arndt Universität Greifswald. Institut fur Geographie und Geologie; Alemania. Heinrich-Heine University; Alemania |
description |
Nucleoredoxin (Nrx) belongs to the Thioredoxin protein family and functions in redox-mediated signal transduction. It contains the dithiol active site motif Cys-Pro-Pro-Cys and interacts and regulates different proteins in distinct cellular pathways. Nrx was shown to be catalytically active in the insulin assay and recent findings indicate that Nrx functions, in fact, as oxidase. Here, we have analyzed Nrx in the mammalian retina exposed to (perinatal) hypoxia-ischemia/reoxygenation, combining ex vivo and in vitro models. Our data show that Nrx regulates cell differentiation, which is important to (i) increase the number of glial cells and (ii) replenish neurons that are lost following the hypoxic insult. Nrx is essential to maintain cell morphology. These regulatory changes are related to VEGF but do not seem to be linked to the Wnt/β-catenin pathway, which is not affected by Nrx knock-down. In conclusion, our results strongly suggest that hypoxia-ischemia could lead to alterations in the organization of the retina, related to changes in RPE cell differentiation. Nrx may play an essential role in the maintenance of the RPE cell differentiation state via the regulation of VEGF release. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-06 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/214766 Holubiec, Mariana Ines; Romero, Juan Ignacio; Urbainsky, Claudia; Gellert, Manuela ; Galeano, Pablo; et al.; Nucleoredoxin Plays a Key Role in the Maintenance of Retinal Pigmented Epithelium Differentiation; Multidisciplinary Digital Publishing Institute; Antioxidants; 11; 6; 6-2022; 1-17 2076-3921 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/214766 |
identifier_str_mv |
Holubiec, Mariana Ines; Romero, Juan Ignacio; Urbainsky, Claudia; Gellert, Manuela ; Galeano, Pablo; et al.; Nucleoredoxin Plays a Key Role in the Maintenance of Retinal Pigmented Epithelium Differentiation; Multidisciplinary Digital Publishing Institute; Antioxidants; 11; 6; 6-2022; 1-17 2076-3921 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2076-3921/11/6/1106 info:eu-repo/semantics/altIdentifier/doi/10.3390/antiox11061106 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
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openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
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application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute |
publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614286137098240 |
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13.070432 |