Combined albendazole-clorsulon treatment to control Fasciola hepatica: integrated pharmacokinetic and efficacy evaluations in sheep

Autores
Chiappetta, Valentina; Cantón, Candela; Pruzzo, Cesar Ivan; Lanusse, Carlos Edmundo; Alvarez, Luis Ignacio; Ceballos, Laura
Año de publicación
2025
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Fasciola hepatica causes fasciolosis, a growing zoonotic disease that affects both livestock and humans worldwide. The WHO has recognized it as a significant emerging neglected disease. Anthelmintic treatments are the main strategy to control fasciolosis in livestock animals, based on drugs such as triclabendazole (TCBZ), albendazole (ABZ), clorsulon (CLOR), nitroxynil, closantel, and rafoxanide. Only TCBZ is available for F. hepatica control in human medicine. However, the intensive use of TCBZ in veterinary medicine has exerted a significant selection pressure, leading to the development of resistant populations of F. hepatica. The use of drug combinations has been proposed as a strategy to preserve efficacy and delay the development of parasite resistance. The goal of the current work was to characterize the pharmacokinetic disposition and flukicidal efficacy for the ABZ+CLOR co-administration in F. hepatica infected sheep. The pharmacokinetic(PK) study included three (3) treated experimental groups: ABZ, CLOR and ABZ+CLOR.An untreated control group was included to perform the controlled efficacy test. Fourteen(14) days after treatment, animals were sacrificed, and adult F. hepatica specimens were removed from bile ducts and counted to evaluate the efficacy. The CLOR disposition kinetics was not affected by its co-administration withABZ. Enhanced systemic exposure of the ABZsulphoxide metabolite was observed after theco-administration ABZ+CLOR compared to theABZ alone treatment. The flukicidal efficacywas 85% (ABZ), 92% (CLOR) and 100% (ABZ+-CLOR). The work described here contributes to the characterization of the disposition kineticsof both flukicidal molecules showing that the combined ABZ and CLOR therapy may enhance flukicidal efficacy in sheep.
Fil: Chiappetta, Valentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Cantón, Candela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Pruzzo, Cesar Ivan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Ceballos, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
30th Conference of the World Association for the Advancements of Veterinary Parasitology
Curitiba
Brasil
World Association for the Advancements of Veterinary Parasitology
Materia
ALBENDAZOLE-CLORSULON
FASCIOLA HEPATICA
SHEEP
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/279424
Acceder
id CONICETDig_bd9137dd3ded2bf8fc5854aef9340eee
oai_identifier_str oai:ri.conicet.gov.ar:11336/279424
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Combined albendazole-clorsulon treatment to control Fasciola hepatica: integrated pharmacokinetic and efficacy evaluations in sheepChiappetta, ValentinaCantón, CandelaPruzzo, Cesar IvanLanusse, Carlos EdmundoAlvarez, Luis IgnacioCeballos, LauraALBENDAZOLE-CLORSULONFASCIOLA HEPATICASHEEPhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Fasciola hepatica causes fasciolosis, a growing zoonotic disease that affects both livestock and humans worldwide. The WHO has recognized it as a significant emerging neglected disease. Anthelmintic treatments are the main strategy to control fasciolosis in livestock animals, based on drugs such as triclabendazole (TCBZ), albendazole (ABZ), clorsulon (CLOR), nitroxynil, closantel, and rafoxanide. Only TCBZ is available for F. hepatica control in human medicine. However, the intensive use of TCBZ in veterinary medicine has exerted a significant selection pressure, leading to the development of resistant populations of F. hepatica. The use of drug combinations has been proposed as a strategy to preserve efficacy and delay the development of parasite resistance. The goal of the current work was to characterize the pharmacokinetic disposition and flukicidal efficacy for the ABZ+CLOR co-administration in F. hepatica infected sheep. The pharmacokinetic(PK) study included three (3) treated experimental groups: ABZ, CLOR and ABZ+CLOR.An untreated control group was included to perform the controlled efficacy test. Fourteen(14) days after treatment, animals were sacrificed, and adult F. hepatica specimens were removed from bile ducts and counted to evaluate the efficacy. The CLOR disposition kinetics was not affected by its co-administration withABZ. Enhanced systemic exposure of the ABZsulphoxide metabolite was observed after theco-administration ABZ+CLOR compared to theABZ alone treatment. The flukicidal efficacywas 85% (ABZ), 92% (CLOR) and 100% (ABZ+-CLOR). The work described here contributes to the characterization of the disposition kineticsof both flukicidal molecules showing that the combined ABZ and CLOR therapy may enhance flukicidal efficacy in sheep.Fil: Chiappetta, Valentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Cantón, Candela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Pruzzo, Cesar Ivan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaFil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Ceballos, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina30th Conference of the World Association for the Advancements of Veterinary ParasitologyCuritibaBrasilWorld Association for the Advancements of Veterinary ParasitologyWorld Association for the Advancements of Veterinary Parasitology2025info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectConferenciaBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/279424Combined albendazole-clorsulon treatment to control Fasciola hepatica: integrated pharmacokinetic and efficacy evaluations in sheep; 30th Conference of the World Association for the Advancements of Veterinary Parasitology; Curitiba; Brasil; 2025; 156-157CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://waavp2025.com/Internacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-02-26T10:02:37Zoai:ri.conicet.gov.ar:11336/279424instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-02-26 10:02:37.461CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Combined albendazole-clorsulon treatment to control Fasciola hepatica: integrated pharmacokinetic and efficacy evaluations in sheep
title Combined albendazole-clorsulon treatment to control Fasciola hepatica: integrated pharmacokinetic and efficacy evaluations in sheep
spellingShingle Combined albendazole-clorsulon treatment to control Fasciola hepatica: integrated pharmacokinetic and efficacy evaluations in sheep
Chiappetta, Valentina
ALBENDAZOLE-CLORSULON
FASCIOLA HEPATICA
SHEEP
title_short Combined albendazole-clorsulon treatment to control Fasciola hepatica: integrated pharmacokinetic and efficacy evaluations in sheep
title_full Combined albendazole-clorsulon treatment to control Fasciola hepatica: integrated pharmacokinetic and efficacy evaluations in sheep
title_fullStr Combined albendazole-clorsulon treatment to control Fasciola hepatica: integrated pharmacokinetic and efficacy evaluations in sheep
title_full_unstemmed Combined albendazole-clorsulon treatment to control Fasciola hepatica: integrated pharmacokinetic and efficacy evaluations in sheep
title_sort Combined albendazole-clorsulon treatment to control Fasciola hepatica: integrated pharmacokinetic and efficacy evaluations in sheep
dc.creator.none.fl_str_mv Chiappetta, Valentina
Cantón, Candela
Pruzzo, Cesar Ivan
Lanusse, Carlos Edmundo
Alvarez, Luis Ignacio
Ceballos, Laura
author Chiappetta, Valentina
author_facet Chiappetta, Valentina
Cantón, Candela
Pruzzo, Cesar Ivan
Lanusse, Carlos Edmundo
Alvarez, Luis Ignacio
Ceballos, Laura
author_role author
author2 Cantón, Candela
Pruzzo, Cesar Ivan
Lanusse, Carlos Edmundo
Alvarez, Luis Ignacio
Ceballos, Laura
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv ALBENDAZOLE-CLORSULON
FASCIOLA HEPATICA
SHEEP
topic ALBENDAZOLE-CLORSULON
FASCIOLA HEPATICA
SHEEP
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Fasciola hepatica causes fasciolosis, a growing zoonotic disease that affects both livestock and humans worldwide. The WHO has recognized it as a significant emerging neglected disease. Anthelmintic treatments are the main strategy to control fasciolosis in livestock animals, based on drugs such as triclabendazole (TCBZ), albendazole (ABZ), clorsulon (CLOR), nitroxynil, closantel, and rafoxanide. Only TCBZ is available for F. hepatica control in human medicine. However, the intensive use of TCBZ in veterinary medicine has exerted a significant selection pressure, leading to the development of resistant populations of F. hepatica. The use of drug combinations has been proposed as a strategy to preserve efficacy and delay the development of parasite resistance. The goal of the current work was to characterize the pharmacokinetic disposition and flukicidal efficacy for the ABZ+CLOR co-administration in F. hepatica infected sheep. The pharmacokinetic(PK) study included three (3) treated experimental groups: ABZ, CLOR and ABZ+CLOR.An untreated control group was included to perform the controlled efficacy test. Fourteen(14) days after treatment, animals were sacrificed, and adult F. hepatica specimens were removed from bile ducts and counted to evaluate the efficacy. The CLOR disposition kinetics was not affected by its co-administration withABZ. Enhanced systemic exposure of the ABZsulphoxide metabolite was observed after theco-administration ABZ+CLOR compared to theABZ alone treatment. The flukicidal efficacywas 85% (ABZ), 92% (CLOR) and 100% (ABZ+-CLOR). The work described here contributes to the characterization of the disposition kineticsof both flukicidal molecules showing that the combined ABZ and CLOR therapy may enhance flukicidal efficacy in sheep.
Fil: Chiappetta, Valentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Cantón, Candela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Pruzzo, Cesar Ivan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Ceballos, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
30th Conference of the World Association for the Advancements of Veterinary Parasitology
Curitiba
Brasil
World Association for the Advancements of Veterinary Parasitology
description Fasciola hepatica causes fasciolosis, a growing zoonotic disease that affects both livestock and humans worldwide. The WHO has recognized it as a significant emerging neglected disease. Anthelmintic treatments are the main strategy to control fasciolosis in livestock animals, based on drugs such as triclabendazole (TCBZ), albendazole (ABZ), clorsulon (CLOR), nitroxynil, closantel, and rafoxanide. Only TCBZ is available for F. hepatica control in human medicine. However, the intensive use of TCBZ in veterinary medicine has exerted a significant selection pressure, leading to the development of resistant populations of F. hepatica. The use of drug combinations has been proposed as a strategy to preserve efficacy and delay the development of parasite resistance. The goal of the current work was to characterize the pharmacokinetic disposition and flukicidal efficacy for the ABZ+CLOR co-administration in F. hepatica infected sheep. The pharmacokinetic(PK) study included three (3) treated experimental groups: ABZ, CLOR and ABZ+CLOR.An untreated control group was included to perform the controlled efficacy test. Fourteen(14) days after treatment, animals were sacrificed, and adult F. hepatica specimens were removed from bile ducts and counted to evaluate the efficacy. The CLOR disposition kinetics was not affected by its co-administration withABZ. Enhanced systemic exposure of the ABZsulphoxide metabolite was observed after theco-administration ABZ+CLOR compared to theABZ alone treatment. The flukicidal efficacywas 85% (ABZ), 92% (CLOR) and 100% (ABZ+-CLOR). The work described here contributes to the characterization of the disposition kineticsof both flukicidal molecules showing that the combined ABZ and CLOR therapy may enhance flukicidal efficacy in sheep.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Conferencia
Book
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/279424
Combined albendazole-clorsulon treatment to control Fasciola hepatica: integrated pharmacokinetic and efficacy evaluations in sheep; 30th Conference of the World Association for the Advancements of Veterinary Parasitology; Curitiba; Brasil; 2025; 156-157
CONICET Digital
CONICET
url http://hdl.handle.net/11336/279424
identifier_str_mv Combined albendazole-clorsulon treatment to control Fasciola hepatica: integrated pharmacokinetic and efficacy evaluations in sheep; 30th Conference of the World Association for the Advancements of Veterinary Parasitology; Curitiba; Brasil; 2025; 156-157
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://waavp2025.com/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.coverage.none.fl_str_mv Internacional
dc.publisher.none.fl_str_mv World Association for the Advancements of Veterinary Parasitology
publisher.none.fl_str_mv World Association for the Advancements of Veterinary Parasitology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.176822

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