Combined albendazole-clorsulon treatment as strategy to control fasciola hepatica. Pharmacokinetic and efficacy evaluation in ovine

Autores
Chiappetta, Valentina; Cantón, Candela; Pruzzo, Cesar Ivan; Moriones, Lucila; Lanusse, Carlos Edmundo; Alvarez, Luis Ignacio; Ceballos, Laura
Año de publicación
2024
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Introduction: Fasciola hepatica causes fasciolosis, a growing zoonotic disease affecting livestock and humans worldwide. The WHO has recognized it as a significant emerging neglected disease. Anthelmintic treatments are the main strategy to control fasciolosis in livestock, based in drugs such as triclabendazole (TCBZ), albendazole (ABZ), clorsulon (CLOR), nitroxinil, closantel, and rafoxanide. Only TCBZ is available for human treatment. The intensive use of TCBZ in veterinary medicine has exerted significant selection pressure, leading to the development of resistant populations of F. hepatica. The combined use of drugs has been proposed as a strategy to preserve efficacy and delay the development of resistance. The goal of the work was to evaluate the potential pharmacokinetic interaction and efficacy of ABZ-CLOR co-administration in F. hepatica infected sheep. Methods: PK study: includes three groups of healthy sheep (n=6): Group ABZ, (7.5 mg/kg bw orally); Group CLOR (2 mg/kg bw subcutaneous); and Group ABZ+ CLOR, (same doses). Blood samples were taken previously and between 1 to 48 h post-treatment. Plasma was analyzed by HPLC. Efficacy controlled test: 16 sheep artificially infected with F. hepatica, were allocated into four (4) experimental groups: Control Group (without treatment) and treated groups, which received the same treatment mentioned in the PK study. Fifteen days after treatment animals were sacrificed and adult F. hepatica specimens were counted to evaluate the efficacy. Results: higher plasma availability was observed for ABZ-sulfoxide in the co-administered group compared to those in Group ABZ. CLOR PK behavior was not affected by co-administration with ABZ. The clinical efficacy was 85%, 92% and 100% for groups ABZ, CLOR and ABZ+CLOR, respectively. Conclusion: this study shows a PK interaction and improved efficacy after ABZ+CLOR co-administration, which can help to effectively control F. hepatica in sheep.
Fil: Chiappetta, Valentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Cantón, Candela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Pruzzo, Cesar Ivan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Clínica. Centro de Diagnóstico e Investigaciones Veterinarias; Argentina
Fil: Moriones, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Ceballos, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
LVI Reunión Anual de la Asociación Argentina de Farmacología Experimental
Bahía Blanca
Argentina
Asociación Argentina de Farmacología Experimental
Materia
ALBENDAZOLE-CLORSULON
FASCIOLA HEPATICA
PHARMACOKINETIC
OVINE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/257744
Acceder
id CONICETDig_b5661eed51895476023d57cf002d5e64
oai_identifier_str oai:ri.conicet.gov.ar:11336/257744
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Combined albendazole-clorsulon treatment as strategy to control fasciola hepatica. Pharmacokinetic and efficacy evaluation in ovineChiappetta, ValentinaCantón, CandelaPruzzo, Cesar IvanMoriones, LucilaLanusse, Carlos EdmundoAlvarez, Luis IgnacioCeballos, LauraALBENDAZOLE-CLORSULONFASCIOLA HEPATICAPHARMACOKINETICOVINEhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Introduction: Fasciola hepatica causes fasciolosis, a growing zoonotic disease affecting livestock and humans worldwide. The WHO has recognized it as a significant emerging neglected disease. Anthelmintic treatments are the main strategy to control fasciolosis in livestock, based in drugs such as triclabendazole (TCBZ), albendazole (ABZ), clorsulon (CLOR), nitroxinil, closantel, and rafoxanide. Only TCBZ is available for human treatment. The intensive use of TCBZ in veterinary medicine has exerted significant selection pressure, leading to the development of resistant populations of F. hepatica. The combined use of drugs has been proposed as a strategy to preserve efficacy and delay the development of resistance. The goal of the work was to evaluate the potential pharmacokinetic interaction and efficacy of ABZ-CLOR co-administration in F. hepatica infected sheep. Methods: PK study: includes three groups of healthy sheep (n=6): Group ABZ, (7.5 mg/kg bw orally); Group CLOR (2 mg/kg bw subcutaneous); and Group ABZ+ CLOR, (same doses). Blood samples were taken previously and between 1 to 48 h post-treatment. Plasma was analyzed by HPLC. Efficacy controlled test: 16 sheep artificially infected with F. hepatica, were allocated into four (4) experimental groups: Control Group (without treatment) and treated groups, which received the same treatment mentioned in the PK study. Fifteen days after treatment animals were sacrificed and adult F. hepatica specimens were counted to evaluate the efficacy. Results: higher plasma availability was observed for ABZ-sulfoxide in the co-administered group compared to those in Group ABZ. CLOR PK behavior was not affected by co-administration with ABZ. The clinical efficacy was 85%, 92% and 100% for groups ABZ, CLOR and ABZ+CLOR, respectively. Conclusion: this study shows a PK interaction and improved efficacy after ABZ+CLOR co-administration, which can help to effectively control F. hepatica in sheep.Fil: Chiappetta, Valentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Cantón, Candela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Pruzzo, Cesar Ivan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Clínica. Centro de Diagnóstico e Investigaciones Veterinarias; ArgentinaFil: Moriones, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Ceballos, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaLVI Reunión Anual de la Asociación Argentina de Farmacología ExperimentalBahía BlancaArgentinaAsociación Argentina de Farmacología ExperimentalAsociación Argentina de Farmacología Experimental2024info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/257744Combined albendazole-clorsulon treatment as strategy to control fasciola hepatica. Pharmacokinetic and efficacy evaluation in ovine; LVI Reunión Anual de la Asociación Argentina de Farmacología Experimental; Bahía Blanca; Argentina; 2024; 26-26978-631-90806-0-5CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://aafeargentina.org/congreso-aafe-2024-2/info:eu-repo/semantics/altIdentifier/url/https://aafeargentina.org/congresos-aafe/Nacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:44:24Zoai:ri.conicet.gov.ar:11336/257744instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:44:24.996CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Combined albendazole-clorsulon treatment as strategy to control fasciola hepatica. Pharmacokinetic and efficacy evaluation in ovine
title Combined albendazole-clorsulon treatment as strategy to control fasciola hepatica. Pharmacokinetic and efficacy evaluation in ovine
spellingShingle Combined albendazole-clorsulon treatment as strategy to control fasciola hepatica. Pharmacokinetic and efficacy evaluation in ovine
Chiappetta, Valentina
ALBENDAZOLE-CLORSULON
FASCIOLA HEPATICA
PHARMACOKINETIC
OVINE
title_short Combined albendazole-clorsulon treatment as strategy to control fasciola hepatica. Pharmacokinetic and efficacy evaluation in ovine
title_full Combined albendazole-clorsulon treatment as strategy to control fasciola hepatica. Pharmacokinetic and efficacy evaluation in ovine
title_fullStr Combined albendazole-clorsulon treatment as strategy to control fasciola hepatica. Pharmacokinetic and efficacy evaluation in ovine
title_full_unstemmed Combined albendazole-clorsulon treatment as strategy to control fasciola hepatica. Pharmacokinetic and efficacy evaluation in ovine
title_sort Combined albendazole-clorsulon treatment as strategy to control fasciola hepatica. Pharmacokinetic and efficacy evaluation in ovine
dc.creator.none.fl_str_mv Chiappetta, Valentina
Cantón, Candela
Pruzzo, Cesar Ivan
Moriones, Lucila
Lanusse, Carlos Edmundo
Alvarez, Luis Ignacio
Ceballos, Laura
author Chiappetta, Valentina
author_facet Chiappetta, Valentina
Cantón, Candela
Pruzzo, Cesar Ivan
Moriones, Lucila
Lanusse, Carlos Edmundo
Alvarez, Luis Ignacio
Ceballos, Laura
author_role author
author2 Cantón, Candela
Pruzzo, Cesar Ivan
Moriones, Lucila
Lanusse, Carlos Edmundo
Alvarez, Luis Ignacio
Ceballos, Laura
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv ALBENDAZOLE-CLORSULON
FASCIOLA HEPATICA
PHARMACOKINETIC
OVINE
topic ALBENDAZOLE-CLORSULON
FASCIOLA HEPATICA
PHARMACOKINETIC
OVINE
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Introduction: Fasciola hepatica causes fasciolosis, a growing zoonotic disease affecting livestock and humans worldwide. The WHO has recognized it as a significant emerging neglected disease. Anthelmintic treatments are the main strategy to control fasciolosis in livestock, based in drugs such as triclabendazole (TCBZ), albendazole (ABZ), clorsulon (CLOR), nitroxinil, closantel, and rafoxanide. Only TCBZ is available for human treatment. The intensive use of TCBZ in veterinary medicine has exerted significant selection pressure, leading to the development of resistant populations of F. hepatica. The combined use of drugs has been proposed as a strategy to preserve efficacy and delay the development of resistance. The goal of the work was to evaluate the potential pharmacokinetic interaction and efficacy of ABZ-CLOR co-administration in F. hepatica infected sheep. Methods: PK study: includes three groups of healthy sheep (n=6): Group ABZ, (7.5 mg/kg bw orally); Group CLOR (2 mg/kg bw subcutaneous); and Group ABZ+ CLOR, (same doses). Blood samples were taken previously and between 1 to 48 h post-treatment. Plasma was analyzed by HPLC. Efficacy controlled test: 16 sheep artificially infected with F. hepatica, were allocated into four (4) experimental groups: Control Group (without treatment) and treated groups, which received the same treatment mentioned in the PK study. Fifteen days after treatment animals were sacrificed and adult F. hepatica specimens were counted to evaluate the efficacy. Results: higher plasma availability was observed for ABZ-sulfoxide in the co-administered group compared to those in Group ABZ. CLOR PK behavior was not affected by co-administration with ABZ. The clinical efficacy was 85%, 92% and 100% for groups ABZ, CLOR and ABZ+CLOR, respectively. Conclusion: this study shows a PK interaction and improved efficacy after ABZ+CLOR co-administration, which can help to effectively control F. hepatica in sheep.
Fil: Chiappetta, Valentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Cantón, Candela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Pruzzo, Cesar Ivan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Clínica. Centro de Diagnóstico e Investigaciones Veterinarias; Argentina
Fil: Moriones, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Ceballos, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
LVI Reunión Anual de la Asociación Argentina de Farmacología Experimental
Bahía Blanca
Argentina
Asociación Argentina de Farmacología Experimental
description Introduction: Fasciola hepatica causes fasciolosis, a growing zoonotic disease affecting livestock and humans worldwide. The WHO has recognized it as a significant emerging neglected disease. Anthelmintic treatments are the main strategy to control fasciolosis in livestock, based in drugs such as triclabendazole (TCBZ), albendazole (ABZ), clorsulon (CLOR), nitroxinil, closantel, and rafoxanide. Only TCBZ is available for human treatment. The intensive use of TCBZ in veterinary medicine has exerted significant selection pressure, leading to the development of resistant populations of F. hepatica. The combined use of drugs has been proposed as a strategy to preserve efficacy and delay the development of resistance. The goal of the work was to evaluate the potential pharmacokinetic interaction and efficacy of ABZ-CLOR co-administration in F. hepatica infected sheep. Methods: PK study: includes three groups of healthy sheep (n=6): Group ABZ, (7.5 mg/kg bw orally); Group CLOR (2 mg/kg bw subcutaneous); and Group ABZ+ CLOR, (same doses). Blood samples were taken previously and between 1 to 48 h post-treatment. Plasma was analyzed by HPLC. Efficacy controlled test: 16 sheep artificially infected with F. hepatica, were allocated into four (4) experimental groups: Control Group (without treatment) and treated groups, which received the same treatment mentioned in the PK study. Fifteen days after treatment animals were sacrificed and adult F. hepatica specimens were counted to evaluate the efficacy. Results: higher plasma availability was observed for ABZ-sulfoxide in the co-administered group compared to those in Group ABZ. CLOR PK behavior was not affected by co-administration with ABZ. The clinical efficacy was 85%, 92% and 100% for groups ABZ, CLOR and ABZ+CLOR, respectively. Conclusion: this study shows a PK interaction and improved efficacy after ABZ+CLOR co-administration, which can help to effectively control F. hepatica in sheep.
publishDate 2024
dc.date.none.fl_str_mv 2024
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info:eu-repo/semantics/conferenceObject
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info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/257744
Combined albendazole-clorsulon treatment as strategy to control fasciola hepatica. Pharmacokinetic and efficacy evaluation in ovine; LVI Reunión Anual de la Asociación Argentina de Farmacología Experimental; Bahía Blanca; Argentina; 2024; 26-26
978-631-90806-0-5
CONICET Digital
CONICET
url http://hdl.handle.net/11336/257744
identifier_str_mv Combined albendazole-clorsulon treatment as strategy to control fasciola hepatica. Pharmacokinetic and efficacy evaluation in ovine; LVI Reunión Anual de la Asociación Argentina de Farmacología Experimental; Bahía Blanca; Argentina; 2024; 26-26
978-631-90806-0-5
CONICET Digital
CONICET
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language eng
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publisher.none.fl_str_mv Asociación Argentina de Farmacología Experimental
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repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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