Studies on translocation, acute oral toxicity and intestinal colonization of potentially probiotic lactic acid bacteria administered during calf rearing

Autores
Frizzo, Laureano Sebastian; Bertozzi, Ezequiel; Soto, Lorena Paola; Sequeira, Gabriel Jorge; Rodriguez Armesto, Roberto; Rosmini, Marcelo Raul
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In order to test the harmlessness of potentially beneficial bacterial strains when raising young calves, their safety level should be verified before they are included into a probiotic formulation. In the present study, an inoculum composed of three lactic acid bacteria of bovine origin, Lactobacillus casei DSPV 318T, Lactobacillus salivarius DSPV 315T and Pediococcus acidilactici DSPV 006T, was evaluated to define its acute oral toxicity and capacity to colonize, remain in the gastrointestinal tract and translocate to the organs in the internal medium. The inoculum was orally administered to a group of experimental calves in doses of 109 CFU/kg/day suspended in a NaCl 0.15 M solution. A control group received only a NaCl solution as placebo. The results showed that the bacteria of the used probiotic inoculum did not translocate to the internal medium and that there were no adverse effects on the general health state, weight gain and feed consumption in the animals treated with the inoculum. This situation suggests that the strains used are not pathogenic and will be probably safe if used as a food additive in calf diets.
Fil: Frizzo, Laureano Sebastian. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Salud Pública Veterinaria; Argentina
Fil: Bertozzi, Ezequiel. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Salud Pública Veterinaria; Argentina
Fil: Soto, Lorena Paola. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Salud Pública Veterinaria; Argentina
Fil: Sequeira, Gabriel Jorge. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Salud Pública Veterinaria; Argentina
Fil: Rodriguez Armesto, Roberto. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Salud Pública Veterinaria; Argentina
Fil: Rosmini, Marcelo Raul. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Salud Pública Veterinaria; Argentina
Materia
INTESTINAL TRACT
LACTOBACILLUS
PROBIOTIC
TRANSLOCATION
YOUNG CALVES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/97624
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/97624
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Studies on translocation, acute oral toxicity and intestinal colonization of potentially probiotic lactic acid bacteria administered during calf rearingFrizzo, Laureano SebastianBertozzi, EzequielSoto, Lorena PaolaSequeira, Gabriel JorgeRodriguez Armesto, RobertoRosmini, Marcelo RaulINTESTINAL TRACTLACTOBACILLUSPROBIOTICTRANSLOCATIONYOUNG CALVEShttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4In order to test the harmlessness of potentially beneficial bacterial strains when raising young calves, their safety level should be verified before they are included into a probiotic formulation. In the present study, an inoculum composed of three lactic acid bacteria of bovine origin, Lactobacillus casei DSPV 318T, Lactobacillus salivarius DSPV 315T and Pediococcus acidilactici DSPV 006T, was evaluated to define its acute oral toxicity and capacity to colonize, remain in the gastrointestinal tract and translocate to the organs in the internal medium. The inoculum was orally administered to a group of experimental calves in doses of 109 CFU/kg/day suspended in a NaCl 0.15 M solution. A control group received only a NaCl solution as placebo. The results showed that the bacteria of the used probiotic inoculum did not translocate to the internal medium and that there were no adverse effects on the general health state, weight gain and feed consumption in the animals treated with the inoculum. This situation suggests that the strains used are not pathogenic and will be probably safe if used as a food additive in calf diets.Fil: Frizzo, Laureano Sebastian. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Salud Pública Veterinaria; ArgentinaFil: Bertozzi, Ezequiel. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Salud Pública Veterinaria; ArgentinaFil: Soto, Lorena Paola. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Salud Pública Veterinaria; ArgentinaFil: Sequeira, Gabriel Jorge. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Salud Pública Veterinaria; ArgentinaFil: Rodriguez Armesto, Roberto. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Salud Pública Veterinaria; ArgentinaFil: Rosmini, Marcelo Raul. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Salud Pública Veterinaria; ArgentinaElsevier Science2010-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/97624Frizzo, Laureano Sebastian; Bertozzi, Ezequiel; Soto, Lorena Paola; Sequeira, Gabriel Jorge; Rodriguez Armesto, Roberto; et al.; Studies on translocation, acute oral toxicity and intestinal colonization of potentially probiotic lactic acid bacteria administered during calf rearing; Elsevier Science; Livestock Science; 128; 1-3; 3-2010; 28-351871-1413CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.livsci.2009.10.009info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:43:59Zoai:ri.conicet.gov.ar:11336/97624instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:43:59.455CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Studies on translocation, acute oral toxicity and intestinal colonization of potentially probiotic lactic acid bacteria administered during calf rearing
title Studies on translocation, acute oral toxicity and intestinal colonization of potentially probiotic lactic acid bacteria administered during calf rearing
spellingShingle Studies on translocation, acute oral toxicity and intestinal colonization of potentially probiotic lactic acid bacteria administered during calf rearing
Frizzo, Laureano Sebastian
INTESTINAL TRACT
LACTOBACILLUS
PROBIOTIC
TRANSLOCATION
YOUNG CALVES
title_short Studies on translocation, acute oral toxicity and intestinal colonization of potentially probiotic lactic acid bacteria administered during calf rearing
title_full Studies on translocation, acute oral toxicity and intestinal colonization of potentially probiotic lactic acid bacteria administered during calf rearing
title_fullStr Studies on translocation, acute oral toxicity and intestinal colonization of potentially probiotic lactic acid bacteria administered during calf rearing
title_full_unstemmed Studies on translocation, acute oral toxicity and intestinal colonization of potentially probiotic lactic acid bacteria administered during calf rearing
title_sort Studies on translocation, acute oral toxicity and intestinal colonization of potentially probiotic lactic acid bacteria administered during calf rearing
dc.creator.none.fl_str_mv Frizzo, Laureano Sebastian
Bertozzi, Ezequiel
Soto, Lorena Paola
Sequeira, Gabriel Jorge
Rodriguez Armesto, Roberto
Rosmini, Marcelo Raul
author Frizzo, Laureano Sebastian
author_facet Frizzo, Laureano Sebastian
Bertozzi, Ezequiel
Soto, Lorena Paola
Sequeira, Gabriel Jorge
Rodriguez Armesto, Roberto
Rosmini, Marcelo Raul
author_role author
author2 Bertozzi, Ezequiel
Soto, Lorena Paola
Sequeira, Gabriel Jorge
Rodriguez Armesto, Roberto
Rosmini, Marcelo Raul
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv INTESTINAL TRACT
LACTOBACILLUS
PROBIOTIC
TRANSLOCATION
YOUNG CALVES
topic INTESTINAL TRACT
LACTOBACILLUS
PROBIOTIC
TRANSLOCATION
YOUNG CALVES
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv In order to test the harmlessness of potentially beneficial bacterial strains when raising young calves, their safety level should be verified before they are included into a probiotic formulation. In the present study, an inoculum composed of three lactic acid bacteria of bovine origin, Lactobacillus casei DSPV 318T, Lactobacillus salivarius DSPV 315T and Pediococcus acidilactici DSPV 006T, was evaluated to define its acute oral toxicity and capacity to colonize, remain in the gastrointestinal tract and translocate to the organs in the internal medium. The inoculum was orally administered to a group of experimental calves in doses of 109 CFU/kg/day suspended in a NaCl 0.15 M solution. A control group received only a NaCl solution as placebo. The results showed that the bacteria of the used probiotic inoculum did not translocate to the internal medium and that there were no adverse effects on the general health state, weight gain and feed consumption in the animals treated with the inoculum. This situation suggests that the strains used are not pathogenic and will be probably safe if used as a food additive in calf diets.
Fil: Frizzo, Laureano Sebastian. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Salud Pública Veterinaria; Argentina
Fil: Bertozzi, Ezequiel. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Salud Pública Veterinaria; Argentina
Fil: Soto, Lorena Paola. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Salud Pública Veterinaria; Argentina
Fil: Sequeira, Gabriel Jorge. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Salud Pública Veterinaria; Argentina
Fil: Rodriguez Armesto, Roberto. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Salud Pública Veterinaria; Argentina
Fil: Rosmini, Marcelo Raul. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Salud Pública Veterinaria; Argentina
description In order to test the harmlessness of potentially beneficial bacterial strains when raising young calves, their safety level should be verified before they are included into a probiotic formulation. In the present study, an inoculum composed of three lactic acid bacteria of bovine origin, Lactobacillus casei DSPV 318T, Lactobacillus salivarius DSPV 315T and Pediococcus acidilactici DSPV 006T, was evaluated to define its acute oral toxicity and capacity to colonize, remain in the gastrointestinal tract and translocate to the organs in the internal medium. The inoculum was orally administered to a group of experimental calves in doses of 109 CFU/kg/day suspended in a NaCl 0.15 M solution. A control group received only a NaCl solution as placebo. The results showed that the bacteria of the used probiotic inoculum did not translocate to the internal medium and that there were no adverse effects on the general health state, weight gain and feed consumption in the animals treated with the inoculum. This situation suggests that the strains used are not pathogenic and will be probably safe if used as a food additive in calf diets.
publishDate 2010
dc.date.none.fl_str_mv 2010-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/97624
Frizzo, Laureano Sebastian; Bertozzi, Ezequiel; Soto, Lorena Paola; Sequeira, Gabriel Jorge; Rodriguez Armesto, Roberto; et al.; Studies on translocation, acute oral toxicity and intestinal colonization of potentially probiotic lactic acid bacteria administered during calf rearing; Elsevier Science; Livestock Science; 128; 1-3; 3-2010; 28-35
1871-1413
CONICET Digital
CONICET
url http://hdl.handle.net/11336/97624
identifier_str_mv Frizzo, Laureano Sebastian; Bertozzi, Ezequiel; Soto, Lorena Paola; Sequeira, Gabriel Jorge; Rodriguez Armesto, Roberto; et al.; Studies on translocation, acute oral toxicity and intestinal colonization of potentially probiotic lactic acid bacteria administered during calf rearing; Elsevier Science; Livestock Science; 128; 1-3; 3-2010; 28-35
1871-1413
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.livsci.2009.10.009
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614476228198400
score 13.070432

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