Comparative phenotypic resolution of spontaneous, D2-like and D1-like agonist-induced orofacial movement topographies in congenic mutants with dopamine D2 vs. D3 receptor "knockout...

Autores
Tomiyama, Katsunori; Mcnamara, Fergal N.; Clifford, Jeremiah J.; Kinsella, Anthony; Drago, John; Fuchs, Sara; Grandy, David K.; Low, Malcolm J.; Rubinstein, Marcelo; Tighe, Orna; Croke, David T.; Koshikawa, Noriaki; Waddington, John L.
Año de publicación
2004
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Using a novel system, the role of D2-like dopamine receptors in distinct topographies of orofacial movement was assessed in mutant mice with congenic D2 vs. D3 receptor knockout, and compared with findings in D1A mutants. Under spontaneous conditions, D2 mutants evidenced increased vertical jaw movements and unaltered horizontal jaw movements, with reductions in tongue protrusions and incisor chattering; in D3 mutants, only incisor chattering was reduced. Given previous evidence that D1A mutants show reduced horizontal but not vertical jaw movements, this indicates that apparent oppositional D1-like:D2-like interactions in the regulation of composited jaw movements may in fact reflect the independent actions of D2 receptors to inhibit vertical jaw movements and of D1A receptors to facilitate horizontal jaw movements. Effects of the D2-like agonist RU 24213 to exert greater reduction in horizontal than in vertical jaw movements were not altered prominently in either D2 or D3 mutants. The D1-like agonists A 68930 and SK&F 83959 induced vertical jaw movements, tongue protrusions, and incisor chattering; induction of tongue protrusions by A 68930 was reduced in D2 mutants. D2 receptors exert topographically specific regulation of orofacial movements in a manner distinct from their D1A counterparts, while D3 receptors exert only minor regulation of such movements.
Fil: Tomiyama, Katsunori. Royal College of Surgeons in Ireland; Irlanda. Nihon University School of Dentistry; Japón
Fil: Mcnamara, Fergal N.. Royal College of Surgeons in Ireland; Irlanda
Fil: Clifford, Jeremiah J.. Royal College of Surgeons in Ireland; Irlanda
Fil: Kinsella, Anthony. Dublin Institute of Technology; Irlanda
Fil: Drago, John. Monash Medical Centre; Australia
Fil: Fuchs, Sara. Weizmann Institute of Science; Israel
Fil: Grandy, David K.. Oregon Health Sciences University; Estados Unidos
Fil: Low, Malcolm J.. Oregon Health Sciences University; Estados Unidos
Fil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Fil: Tighe, Orna. Royal College of Surgeons in Ireland; Irlanda
Fil: Croke, David T.. Royal College of Surgeons in Ireland; Irlanda
Fil: Koshikawa, Noriaki. Nihon University School of Dentistry; Japón
Fil: Waddington, John L.. Royal College of Surgeons in Ireland; Irlanda
Materia
Profacial Movements
Dopamine Receptors
D2 Knockout
D3 Knockout
Behavioural Phenotype
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/80010
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/80010
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Comparative phenotypic resolution of spontaneous, D2-like and D1-like agonist-induced orofacial movement topographies in congenic mutants with dopamine D2 vs. D3 receptor "knockout"Tomiyama, KatsunoriMcnamara, Fergal N.Clifford, Jeremiah J.Kinsella, AnthonyDrago, JohnFuchs, SaraGrandy, David K.Low, Malcolm J.Rubinstein, MarceloTighe, OrnaCroke, David T.Koshikawa, NoriakiWaddington, John L.Profacial MovementsDopamine ReceptorsD2 KnockoutD3 KnockoutBehavioural Phenotypehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Using a novel system, the role of D2-like dopamine receptors in distinct topographies of orofacial movement was assessed in mutant mice with congenic D2 vs. D3 receptor knockout, and compared with findings in D1A mutants. Under spontaneous conditions, D2 mutants evidenced increased vertical jaw movements and unaltered horizontal jaw movements, with reductions in tongue protrusions and incisor chattering; in D3 mutants, only incisor chattering was reduced. Given previous evidence that D1A mutants show reduced horizontal but not vertical jaw movements, this indicates that apparent oppositional D1-like:D2-like interactions in the regulation of composited jaw movements may in fact reflect the independent actions of D2 receptors to inhibit vertical jaw movements and of D1A receptors to facilitate horizontal jaw movements. Effects of the D2-like agonist RU 24213 to exert greater reduction in horizontal than in vertical jaw movements were not altered prominently in either D2 or D3 mutants. The D1-like agonists A 68930 and SK&F 83959 induced vertical jaw movements, tongue protrusions, and incisor chattering; induction of tongue protrusions by A 68930 was reduced in D2 mutants. D2 receptors exert topographically specific regulation of orofacial movements in a manner distinct from their D1A counterparts, while D3 receptors exert only minor regulation of such movements.Fil: Tomiyama, Katsunori. Royal College of Surgeons in Ireland; Irlanda. Nihon University School of Dentistry; JapónFil: Mcnamara, Fergal N.. Royal College of Surgeons in Ireland; IrlandaFil: Clifford, Jeremiah J.. Royal College of Surgeons in Ireland; IrlandaFil: Kinsella, Anthony. Dublin Institute of Technology; IrlandaFil: Drago, John. Monash Medical Centre; AustraliaFil: Fuchs, Sara. Weizmann Institute of Science; IsraelFil: Grandy, David K.. Oregon Health Sciences University; Estados UnidosFil: Low, Malcolm J.. Oregon Health Sciences University; Estados UnidosFil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Tighe, Orna. Royal College of Surgeons in Ireland; IrlandaFil: Croke, David T.. Royal College of Surgeons in Ireland; IrlandaFil: Koshikawa, Noriaki. Nihon University School of Dentistry; JapónFil: Waddington, John L.. Royal College of Surgeons in Ireland; IrlandaWiley2004-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/80010Tomiyama, Katsunori; Mcnamara, Fergal N.; Clifford, Jeremiah J.; Kinsella, Anthony; Drago, John; et al.; Comparative phenotypic resolution of spontaneous, D2-like and D1-like agonist-induced orofacial movement topographies in congenic mutants with dopamine D2 vs. D3 receptor "knockout"; Wiley; Synapse; 51; 1; 1-2004; 71-810887-4476CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/syn.10284info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/syn.10284info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:09:41Zoai:ri.conicet.gov.ar:11336/80010instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:09:41.722CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Comparative phenotypic resolution of spontaneous, D2-like and D1-like agonist-induced orofacial movement topographies in congenic mutants with dopamine D2 vs. D3 receptor "knockout"
title Comparative phenotypic resolution of spontaneous, D2-like and D1-like agonist-induced orofacial movement topographies in congenic mutants with dopamine D2 vs. D3 receptor "knockout"
spellingShingle Comparative phenotypic resolution of spontaneous, D2-like and D1-like agonist-induced orofacial movement topographies in congenic mutants with dopamine D2 vs. D3 receptor "knockout"
Tomiyama, Katsunori
Profacial Movements
Dopamine Receptors
D2 Knockout
D3 Knockout
Behavioural Phenotype
title_short Comparative phenotypic resolution of spontaneous, D2-like and D1-like agonist-induced orofacial movement topographies in congenic mutants with dopamine D2 vs. D3 receptor "knockout"
title_full Comparative phenotypic resolution of spontaneous, D2-like and D1-like agonist-induced orofacial movement topographies in congenic mutants with dopamine D2 vs. D3 receptor "knockout"
title_fullStr Comparative phenotypic resolution of spontaneous, D2-like and D1-like agonist-induced orofacial movement topographies in congenic mutants with dopamine D2 vs. D3 receptor "knockout"
title_full_unstemmed Comparative phenotypic resolution of spontaneous, D2-like and D1-like agonist-induced orofacial movement topographies in congenic mutants with dopamine D2 vs. D3 receptor "knockout"
title_sort Comparative phenotypic resolution of spontaneous, D2-like and D1-like agonist-induced orofacial movement topographies in congenic mutants with dopamine D2 vs. D3 receptor "knockout"
dc.creator.none.fl_str_mv Tomiyama, Katsunori
Mcnamara, Fergal N.
Clifford, Jeremiah J.
Kinsella, Anthony
Drago, John
Fuchs, Sara
Grandy, David K.
Low, Malcolm J.
Rubinstein, Marcelo
Tighe, Orna
Croke, David T.
Koshikawa, Noriaki
Waddington, John L.
author Tomiyama, Katsunori
author_facet Tomiyama, Katsunori
Mcnamara, Fergal N.
Clifford, Jeremiah J.
Kinsella, Anthony
Drago, John
Fuchs, Sara
Grandy, David K.
Low, Malcolm J.
Rubinstein, Marcelo
Tighe, Orna
Croke, David T.
Koshikawa, Noriaki
Waddington, John L.
author_role author
author2 Mcnamara, Fergal N.
Clifford, Jeremiah J.
Kinsella, Anthony
Drago, John
Fuchs, Sara
Grandy, David K.
Low, Malcolm J.
Rubinstein, Marcelo
Tighe, Orna
Croke, David T.
Koshikawa, Noriaki
Waddington, John L.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Profacial Movements
Dopamine Receptors
D2 Knockout
D3 Knockout
Behavioural Phenotype
topic Profacial Movements
Dopamine Receptors
D2 Knockout
D3 Knockout
Behavioural Phenotype
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Using a novel system, the role of D2-like dopamine receptors in distinct topographies of orofacial movement was assessed in mutant mice with congenic D2 vs. D3 receptor knockout, and compared with findings in D1A mutants. Under spontaneous conditions, D2 mutants evidenced increased vertical jaw movements and unaltered horizontal jaw movements, with reductions in tongue protrusions and incisor chattering; in D3 mutants, only incisor chattering was reduced. Given previous evidence that D1A mutants show reduced horizontal but not vertical jaw movements, this indicates that apparent oppositional D1-like:D2-like interactions in the regulation of composited jaw movements may in fact reflect the independent actions of D2 receptors to inhibit vertical jaw movements and of D1A receptors to facilitate horizontal jaw movements. Effects of the D2-like agonist RU 24213 to exert greater reduction in horizontal than in vertical jaw movements were not altered prominently in either D2 or D3 mutants. The D1-like agonists A 68930 and SK&F 83959 induced vertical jaw movements, tongue protrusions, and incisor chattering; induction of tongue protrusions by A 68930 was reduced in D2 mutants. D2 receptors exert topographically specific regulation of orofacial movements in a manner distinct from their D1A counterparts, while D3 receptors exert only minor regulation of such movements.
Fil: Tomiyama, Katsunori. Royal College of Surgeons in Ireland; Irlanda. Nihon University School of Dentistry; Japón
Fil: Mcnamara, Fergal N.. Royal College of Surgeons in Ireland; Irlanda
Fil: Clifford, Jeremiah J.. Royal College of Surgeons in Ireland; Irlanda
Fil: Kinsella, Anthony. Dublin Institute of Technology; Irlanda
Fil: Drago, John. Monash Medical Centre; Australia
Fil: Fuchs, Sara. Weizmann Institute of Science; Israel
Fil: Grandy, David K.. Oregon Health Sciences University; Estados Unidos
Fil: Low, Malcolm J.. Oregon Health Sciences University; Estados Unidos
Fil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Fil: Tighe, Orna. Royal College of Surgeons in Ireland; Irlanda
Fil: Croke, David T.. Royal College of Surgeons in Ireland; Irlanda
Fil: Koshikawa, Noriaki. Nihon University School of Dentistry; Japón
Fil: Waddington, John L.. Royal College of Surgeons in Ireland; Irlanda
description Using a novel system, the role of D2-like dopamine receptors in distinct topographies of orofacial movement was assessed in mutant mice with congenic D2 vs. D3 receptor knockout, and compared with findings in D1A mutants. Under spontaneous conditions, D2 mutants evidenced increased vertical jaw movements and unaltered horizontal jaw movements, with reductions in tongue protrusions and incisor chattering; in D3 mutants, only incisor chattering was reduced. Given previous evidence that D1A mutants show reduced horizontal but not vertical jaw movements, this indicates that apparent oppositional D1-like:D2-like interactions in the regulation of composited jaw movements may in fact reflect the independent actions of D2 receptors to inhibit vertical jaw movements and of D1A receptors to facilitate horizontal jaw movements. Effects of the D2-like agonist RU 24213 to exert greater reduction in horizontal than in vertical jaw movements were not altered prominently in either D2 or D3 mutants. The D1-like agonists A 68930 and SK&F 83959 induced vertical jaw movements, tongue protrusions, and incisor chattering; induction of tongue protrusions by A 68930 was reduced in D2 mutants. D2 receptors exert topographically specific regulation of orofacial movements in a manner distinct from their D1A counterparts, while D3 receptors exert only minor regulation of such movements.
publishDate 2004
dc.date.none.fl_str_mv 2004-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/80010
Tomiyama, Katsunori; Mcnamara, Fergal N.; Clifford, Jeremiah J.; Kinsella, Anthony; Drago, John; et al.; Comparative phenotypic resolution of spontaneous, D2-like and D1-like agonist-induced orofacial movement topographies in congenic mutants with dopamine D2 vs. D3 receptor "knockout"; Wiley; Synapse; 51; 1; 1-2004; 71-81
0887-4476
CONICET Digital
CONICET
url http://hdl.handle.net/11336/80010
identifier_str_mv Tomiyama, Katsunori; Mcnamara, Fergal N.; Clifford, Jeremiah J.; Kinsella, Anthony; Drago, John; et al.; Comparative phenotypic resolution of spontaneous, D2-like and D1-like agonist-induced orofacial movement topographies in congenic mutants with dopamine D2 vs. D3 receptor "knockout"; Wiley; Synapse; 51; 1; 1-2004; 71-81
0887-4476
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1002/syn.10284
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/syn.10284
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842270091453923328
score 13.13397

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