Comparative, Topographically-Based Evaluation of Behavioural Phenotype and Specification of D1-Like:D2 Interactions in a Line of Incipient Congenic Mice with D2 Dopamine Receptor "...
- Autores
- Clifford, Jeremiah J.; Kinsella, Anthony; Tighe, Orna; Rubinstein, Marcelo; Grandy, David K.; Low, Malcolm J.; Croke, David T.; Waddington, John L.
- Año de publicación
- 2001
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Phenotypes were assessed topographically in mice lacking functional D2 dopamine receptors [‘knockouts’], using an ethologically based approach to assess all behaviours in the natural repertoire. D2-null mice evidenced an ethogram characterised initially by modest reductions in locomotion and shifts in rearing topographies. Subsequently, topographies of behaviour habituated similarly for wildtypes and ‘knockouts’. Following challenge with the D2-like agonist RU 24213, both inhibition of rearing at a lower dose and induction of stereotyped sniffing and ponderous locomotion at higher doses were essentially absent in D2-null mice. Following challenge with the D1-like agonist A 68930, vacuous chewing was released in D2-null mice. This topographical approach to phenotypic characterisation implicates: (i) the D2 receptor in these D2-like agonist effects and in oppositional D1-like: D2-like interactions; and (ii) the operation of material compensatory processes consequent to the developmental absence of D2 receptors which are able to maintain ethological function under tonic, ‘naturalistic’ conditions but not under ‘phasic’ challenge.
Fil: Clifford, Jeremiah J.. Royal College of Surgeons; Irlanda. Tralee General Hospital; Irlanda
Fil: Kinsella, Anthony. Dublin Institute of Technology; Irlanda
Fil: Tighe, Orna. Royal College of Surgeons; Irlanda
Fil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Fil: Grandy, David K.. Oregon Health Science University; Estados Unidos
Fil: Low, Malcolm J.. Oregon Health Science University; Estados Unidos
Fil: Croke, David T.. Royal College of Surgeons; Irlanda
Fil: Waddington, John L.. Royal College of Surgeons; Irlanda - Materia
-
Dopamine D2 Receptor
D2 ‘Knockout’
Targeted Gene Deletion
Behavioural Phenotype
Topographical Assessment
Ethogram - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/79323
Ver los metadatos del registro completo
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Comparative, Topographically-Based Evaluation of Behavioural Phenotype and Specification of D1-Like:D2 Interactions in a Line of Incipient Congenic Mice with D2 Dopamine Receptor "Knockout"Clifford, Jeremiah J.Kinsella, AnthonyTighe, OrnaRubinstein, MarceloGrandy, David K.Low, Malcolm J.Croke, David T.Waddington, John L.Dopamine D2 ReceptorD2 ‘Knockout’Targeted Gene DeletionBehavioural PhenotypeTopographical AssessmentEthogramhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Phenotypes were assessed topographically in mice lacking functional D2 dopamine receptors [‘knockouts’], using an ethologically based approach to assess all behaviours in the natural repertoire. D2-null mice evidenced an ethogram characterised initially by modest reductions in locomotion and shifts in rearing topographies. Subsequently, topographies of behaviour habituated similarly for wildtypes and ‘knockouts’. Following challenge with the D2-like agonist RU 24213, both inhibition of rearing at a lower dose and induction of stereotyped sniffing and ponderous locomotion at higher doses were essentially absent in D2-null mice. Following challenge with the D1-like agonist A 68930, vacuous chewing was released in D2-null mice. This topographical approach to phenotypic characterisation implicates: (i) the D2 receptor in these D2-like agonist effects and in oppositional D1-like: D2-like interactions; and (ii) the operation of material compensatory processes consequent to the developmental absence of D2 receptors which are able to maintain ethological function under tonic, ‘naturalistic’ conditions but not under ‘phasic’ challenge.Fil: Clifford, Jeremiah J.. Royal College of Surgeons; Irlanda. Tralee General Hospital; IrlandaFil: Kinsella, Anthony. Dublin Institute of Technology; IrlandaFil: Tighe, Orna. Royal College of Surgeons; IrlandaFil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Grandy, David K.. Oregon Health Science University; Estados UnidosFil: Low, Malcolm J.. Oregon Health Science University; Estados UnidosFil: Croke, David T.. Royal College of Surgeons; IrlandaFil: Waddington, John L.. Royal College of Surgeons; IrlandaElsevier2001-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/79323Clifford, Jeremiah J.; Kinsella, Anthony; Tighe, Orna; Rubinstein, Marcelo; Grandy, David K.; et al.; Comparative, Topographically-Based Evaluation of Behavioural Phenotype and Specification of D1-Like:D2 Interactions in a Line of Incipient Congenic Mice with D2 Dopamine Receptor "Knockout"; Elsevier; Neuropsychopharmacology; 25; 4; 10-2001; 527-5360893-133XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0893133X01002469info:eu-repo/semantics/altIdentifier/doi/10.1016/S0893-133X(01)00246-9info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:35:44Zoai:ri.conicet.gov.ar:11336/79323instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:35:44.788CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Comparative, Topographically-Based Evaluation of Behavioural Phenotype and Specification of D1-Like:D2 Interactions in a Line of Incipient Congenic Mice with D2 Dopamine Receptor "Knockout" |
title |
Comparative, Topographically-Based Evaluation of Behavioural Phenotype and Specification of D1-Like:D2 Interactions in a Line of Incipient Congenic Mice with D2 Dopamine Receptor "Knockout" |
spellingShingle |
Comparative, Topographically-Based Evaluation of Behavioural Phenotype and Specification of D1-Like:D2 Interactions in a Line of Incipient Congenic Mice with D2 Dopamine Receptor "Knockout" Clifford, Jeremiah J. Dopamine D2 Receptor D2 ‘Knockout’ Targeted Gene Deletion Behavioural Phenotype Topographical Assessment Ethogram |
title_short |
Comparative, Topographically-Based Evaluation of Behavioural Phenotype and Specification of D1-Like:D2 Interactions in a Line of Incipient Congenic Mice with D2 Dopamine Receptor "Knockout" |
title_full |
Comparative, Topographically-Based Evaluation of Behavioural Phenotype and Specification of D1-Like:D2 Interactions in a Line of Incipient Congenic Mice with D2 Dopamine Receptor "Knockout" |
title_fullStr |
Comparative, Topographically-Based Evaluation of Behavioural Phenotype and Specification of D1-Like:D2 Interactions in a Line of Incipient Congenic Mice with D2 Dopamine Receptor "Knockout" |
title_full_unstemmed |
Comparative, Topographically-Based Evaluation of Behavioural Phenotype and Specification of D1-Like:D2 Interactions in a Line of Incipient Congenic Mice with D2 Dopamine Receptor "Knockout" |
title_sort |
Comparative, Topographically-Based Evaluation of Behavioural Phenotype and Specification of D1-Like:D2 Interactions in a Line of Incipient Congenic Mice with D2 Dopamine Receptor "Knockout" |
dc.creator.none.fl_str_mv |
Clifford, Jeremiah J. Kinsella, Anthony Tighe, Orna Rubinstein, Marcelo Grandy, David K. Low, Malcolm J. Croke, David T. Waddington, John L. |
author |
Clifford, Jeremiah J. |
author_facet |
Clifford, Jeremiah J. Kinsella, Anthony Tighe, Orna Rubinstein, Marcelo Grandy, David K. Low, Malcolm J. Croke, David T. Waddington, John L. |
author_role |
author |
author2 |
Kinsella, Anthony Tighe, Orna Rubinstein, Marcelo Grandy, David K. Low, Malcolm J. Croke, David T. Waddington, John L. |
author2_role |
author author author author author author author |
dc.subject.none.fl_str_mv |
Dopamine D2 Receptor D2 ‘Knockout’ Targeted Gene Deletion Behavioural Phenotype Topographical Assessment Ethogram |
topic |
Dopamine D2 Receptor D2 ‘Knockout’ Targeted Gene Deletion Behavioural Phenotype Topographical Assessment Ethogram |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Phenotypes were assessed topographically in mice lacking functional D2 dopamine receptors [‘knockouts’], using an ethologically based approach to assess all behaviours in the natural repertoire. D2-null mice evidenced an ethogram characterised initially by modest reductions in locomotion and shifts in rearing topographies. Subsequently, topographies of behaviour habituated similarly for wildtypes and ‘knockouts’. Following challenge with the D2-like agonist RU 24213, both inhibition of rearing at a lower dose and induction of stereotyped sniffing and ponderous locomotion at higher doses were essentially absent in D2-null mice. Following challenge with the D1-like agonist A 68930, vacuous chewing was released in D2-null mice. This topographical approach to phenotypic characterisation implicates: (i) the D2 receptor in these D2-like agonist effects and in oppositional D1-like: D2-like interactions; and (ii) the operation of material compensatory processes consequent to the developmental absence of D2 receptors which are able to maintain ethological function under tonic, ‘naturalistic’ conditions but not under ‘phasic’ challenge. Fil: Clifford, Jeremiah J.. Royal College of Surgeons; Irlanda. Tralee General Hospital; Irlanda Fil: Kinsella, Anthony. Dublin Institute of Technology; Irlanda Fil: Tighe, Orna. Royal College of Surgeons; Irlanda Fil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina Fil: Grandy, David K.. Oregon Health Science University; Estados Unidos Fil: Low, Malcolm J.. Oregon Health Science University; Estados Unidos Fil: Croke, David T.. Royal College of Surgeons; Irlanda Fil: Waddington, John L.. Royal College of Surgeons; Irlanda |
description |
Phenotypes were assessed topographically in mice lacking functional D2 dopamine receptors [‘knockouts’], using an ethologically based approach to assess all behaviours in the natural repertoire. D2-null mice evidenced an ethogram characterised initially by modest reductions in locomotion and shifts in rearing topographies. Subsequently, topographies of behaviour habituated similarly for wildtypes and ‘knockouts’. Following challenge with the D2-like agonist RU 24213, both inhibition of rearing at a lower dose and induction of stereotyped sniffing and ponderous locomotion at higher doses were essentially absent in D2-null mice. Following challenge with the D1-like agonist A 68930, vacuous chewing was released in D2-null mice. This topographical approach to phenotypic characterisation implicates: (i) the D2 receptor in these D2-like agonist effects and in oppositional D1-like: D2-like interactions; and (ii) the operation of material compensatory processes consequent to the developmental absence of D2 receptors which are able to maintain ethological function under tonic, ‘naturalistic’ conditions but not under ‘phasic’ challenge. |
publishDate |
2001 |
dc.date.none.fl_str_mv |
2001-10 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/79323 Clifford, Jeremiah J.; Kinsella, Anthony; Tighe, Orna; Rubinstein, Marcelo; Grandy, David K.; et al.; Comparative, Topographically-Based Evaluation of Behavioural Phenotype and Specification of D1-Like:D2 Interactions in a Line of Incipient Congenic Mice with D2 Dopamine Receptor "Knockout"; Elsevier; Neuropsychopharmacology; 25; 4; 10-2001; 527-536 0893-133X CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/79323 |
identifier_str_mv |
Clifford, Jeremiah J.; Kinsella, Anthony; Tighe, Orna; Rubinstein, Marcelo; Grandy, David K.; et al.; Comparative, Topographically-Based Evaluation of Behavioural Phenotype and Specification of D1-Like:D2 Interactions in a Line of Incipient Congenic Mice with D2 Dopamine Receptor "Knockout"; Elsevier; Neuropsychopharmacology; 25; 4; 10-2001; 527-536 0893-133X CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0893133X01002469 info:eu-repo/semantics/altIdentifier/doi/10.1016/S0893-133X(01)00246-9 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613115516289024 |
score |
13.070432 |