Comparative, Topographically-Based Evaluation of Behavioural Phenotype and Specification of D1-Like:D2 Interactions in a Line of Incipient Congenic Mice with D2 Dopamine Receptor "...

Autores
Clifford, Jeremiah J.; Kinsella, Anthony; Tighe, Orna; Rubinstein, Marcelo; Grandy, David K.; Low, Malcolm J.; Croke, David T.; Waddington, John L.
Año de publicación
2001
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Phenotypes were assessed topographically in mice lacking functional D2 dopamine receptors [‘knockouts’], using an ethologically based approach to assess all behaviours in the natural repertoire. D2-null mice evidenced an ethogram characterised initially by modest reductions in locomotion and shifts in rearing topographies. Subsequently, topographies of behaviour habituated similarly for wildtypes and ‘knockouts’. Following challenge with the D2-like agonist RU 24213, both inhibition of rearing at a lower dose and induction of stereotyped sniffing and ponderous locomotion at higher doses were essentially absent in D2-null mice. Following challenge with the D1-like agonist A 68930, vacuous chewing was released in D2-null mice. This topographical approach to phenotypic characterisation implicates: (i) the D2 receptor in these D2-like agonist effects and in oppositional D1-like: D2-like interactions; and (ii) the operation of material compensatory processes consequent to the developmental absence of D2 receptors which are able to maintain ethological function under tonic, ‘naturalistic’ conditions but not under ‘phasic’ challenge.
Fil: Clifford, Jeremiah J.. Royal College of Surgeons; Irlanda. Tralee General Hospital; Irlanda
Fil: Kinsella, Anthony. Dublin Institute of Technology; Irlanda
Fil: Tighe, Orna. Royal College of Surgeons; Irlanda
Fil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Fil: Grandy, David K.. Oregon Health Science University; Estados Unidos
Fil: Low, Malcolm J.. Oregon Health Science University; Estados Unidos
Fil: Croke, David T.. Royal College of Surgeons; Irlanda
Fil: Waddington, John L.. Royal College of Surgeons; Irlanda
Materia
Dopamine D2 Receptor
D2 ‘Knockout’
Targeted Gene Deletion
Behavioural Phenotype
Topographical Assessment
Ethogram
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/79323

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oai_identifier_str oai:ri.conicet.gov.ar:11336/79323
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Comparative, Topographically-Based Evaluation of Behavioural Phenotype and Specification of D1-Like:D2 Interactions in a Line of Incipient Congenic Mice with D2 Dopamine Receptor "Knockout"Clifford, Jeremiah J.Kinsella, AnthonyTighe, OrnaRubinstein, MarceloGrandy, David K.Low, Malcolm J.Croke, David T.Waddington, John L.Dopamine D2 ReceptorD2 ‘Knockout’Targeted Gene DeletionBehavioural PhenotypeTopographical AssessmentEthogramhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Phenotypes were assessed topographically in mice lacking functional D2 dopamine receptors [‘knockouts’], using an ethologically based approach to assess all behaviours in the natural repertoire. D2-null mice evidenced an ethogram characterised initially by modest reductions in locomotion and shifts in rearing topographies. Subsequently, topographies of behaviour habituated similarly for wildtypes and ‘knockouts’. Following challenge with the D2-like agonist RU 24213, both inhibition of rearing at a lower dose and induction of stereotyped sniffing and ponderous locomotion at higher doses were essentially absent in D2-null mice. Following challenge with the D1-like agonist A 68930, vacuous chewing was released in D2-null mice. This topographical approach to phenotypic characterisation implicates: (i) the D2 receptor in these D2-like agonist effects and in oppositional D1-like: D2-like interactions; and (ii) the operation of material compensatory processes consequent to the developmental absence of D2 receptors which are able to maintain ethological function under tonic, ‘naturalistic’ conditions but not under ‘phasic’ challenge.Fil: Clifford, Jeremiah J.. Royal College of Surgeons; Irlanda. Tralee General Hospital; IrlandaFil: Kinsella, Anthony. Dublin Institute of Technology; IrlandaFil: Tighe, Orna. Royal College of Surgeons; IrlandaFil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Grandy, David K.. Oregon Health Science University; Estados UnidosFil: Low, Malcolm J.. Oregon Health Science University; Estados UnidosFil: Croke, David T.. Royal College of Surgeons; IrlandaFil: Waddington, John L.. Royal College of Surgeons; IrlandaElsevier2001-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/79323Clifford, Jeremiah J.; Kinsella, Anthony; Tighe, Orna; Rubinstein, Marcelo; Grandy, David K.; et al.; Comparative, Topographically-Based Evaluation of Behavioural Phenotype and Specification of D1-Like:D2 Interactions in a Line of Incipient Congenic Mice with D2 Dopamine Receptor "Knockout"; Elsevier; Neuropsychopharmacology; 25; 4; 10-2001; 527-5360893-133XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0893133X01002469info:eu-repo/semantics/altIdentifier/doi/10.1016/S0893-133X(01)00246-9info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:35:44Zoai:ri.conicet.gov.ar:11336/79323instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:35:44.788CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Comparative, Topographically-Based Evaluation of Behavioural Phenotype and Specification of D1-Like:D2 Interactions in a Line of Incipient Congenic Mice with D2 Dopamine Receptor "Knockout"
title Comparative, Topographically-Based Evaluation of Behavioural Phenotype and Specification of D1-Like:D2 Interactions in a Line of Incipient Congenic Mice with D2 Dopamine Receptor "Knockout"
spellingShingle Comparative, Topographically-Based Evaluation of Behavioural Phenotype and Specification of D1-Like:D2 Interactions in a Line of Incipient Congenic Mice with D2 Dopamine Receptor "Knockout"
Clifford, Jeremiah J.
Dopamine D2 Receptor
D2 ‘Knockout’
Targeted Gene Deletion
Behavioural Phenotype
Topographical Assessment
Ethogram
title_short Comparative, Topographically-Based Evaluation of Behavioural Phenotype and Specification of D1-Like:D2 Interactions in a Line of Incipient Congenic Mice with D2 Dopamine Receptor "Knockout"
title_full Comparative, Topographically-Based Evaluation of Behavioural Phenotype and Specification of D1-Like:D2 Interactions in a Line of Incipient Congenic Mice with D2 Dopamine Receptor "Knockout"
title_fullStr Comparative, Topographically-Based Evaluation of Behavioural Phenotype and Specification of D1-Like:D2 Interactions in a Line of Incipient Congenic Mice with D2 Dopamine Receptor "Knockout"
title_full_unstemmed Comparative, Topographically-Based Evaluation of Behavioural Phenotype and Specification of D1-Like:D2 Interactions in a Line of Incipient Congenic Mice with D2 Dopamine Receptor "Knockout"
title_sort Comparative, Topographically-Based Evaluation of Behavioural Phenotype and Specification of D1-Like:D2 Interactions in a Line of Incipient Congenic Mice with D2 Dopamine Receptor "Knockout"
dc.creator.none.fl_str_mv Clifford, Jeremiah J.
Kinsella, Anthony
Tighe, Orna
Rubinstein, Marcelo
Grandy, David K.
Low, Malcolm J.
Croke, David T.
Waddington, John L.
author Clifford, Jeremiah J.
author_facet Clifford, Jeremiah J.
Kinsella, Anthony
Tighe, Orna
Rubinstein, Marcelo
Grandy, David K.
Low, Malcolm J.
Croke, David T.
Waddington, John L.
author_role author
author2 Kinsella, Anthony
Tighe, Orna
Rubinstein, Marcelo
Grandy, David K.
Low, Malcolm J.
Croke, David T.
Waddington, John L.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Dopamine D2 Receptor
D2 ‘Knockout’
Targeted Gene Deletion
Behavioural Phenotype
Topographical Assessment
Ethogram
topic Dopamine D2 Receptor
D2 ‘Knockout’
Targeted Gene Deletion
Behavioural Phenotype
Topographical Assessment
Ethogram
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Phenotypes were assessed topographically in mice lacking functional D2 dopamine receptors [‘knockouts’], using an ethologically based approach to assess all behaviours in the natural repertoire. D2-null mice evidenced an ethogram characterised initially by modest reductions in locomotion and shifts in rearing topographies. Subsequently, topographies of behaviour habituated similarly for wildtypes and ‘knockouts’. Following challenge with the D2-like agonist RU 24213, both inhibition of rearing at a lower dose and induction of stereotyped sniffing and ponderous locomotion at higher doses were essentially absent in D2-null mice. Following challenge with the D1-like agonist A 68930, vacuous chewing was released in D2-null mice. This topographical approach to phenotypic characterisation implicates: (i) the D2 receptor in these D2-like agonist effects and in oppositional D1-like: D2-like interactions; and (ii) the operation of material compensatory processes consequent to the developmental absence of D2 receptors which are able to maintain ethological function under tonic, ‘naturalistic’ conditions but not under ‘phasic’ challenge.
Fil: Clifford, Jeremiah J.. Royal College of Surgeons; Irlanda. Tralee General Hospital; Irlanda
Fil: Kinsella, Anthony. Dublin Institute of Technology; Irlanda
Fil: Tighe, Orna. Royal College of Surgeons; Irlanda
Fil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Fil: Grandy, David K.. Oregon Health Science University; Estados Unidos
Fil: Low, Malcolm J.. Oregon Health Science University; Estados Unidos
Fil: Croke, David T.. Royal College of Surgeons; Irlanda
Fil: Waddington, John L.. Royal College of Surgeons; Irlanda
description Phenotypes were assessed topographically in mice lacking functional D2 dopamine receptors [‘knockouts’], using an ethologically based approach to assess all behaviours in the natural repertoire. D2-null mice evidenced an ethogram characterised initially by modest reductions in locomotion and shifts in rearing topographies. Subsequently, topographies of behaviour habituated similarly for wildtypes and ‘knockouts’. Following challenge with the D2-like agonist RU 24213, both inhibition of rearing at a lower dose and induction of stereotyped sniffing and ponderous locomotion at higher doses were essentially absent in D2-null mice. Following challenge with the D1-like agonist A 68930, vacuous chewing was released in D2-null mice. This topographical approach to phenotypic characterisation implicates: (i) the D2 receptor in these D2-like agonist effects and in oppositional D1-like: D2-like interactions; and (ii) the operation of material compensatory processes consequent to the developmental absence of D2 receptors which are able to maintain ethological function under tonic, ‘naturalistic’ conditions but not under ‘phasic’ challenge.
publishDate 2001
dc.date.none.fl_str_mv 2001-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/79323
Clifford, Jeremiah J.; Kinsella, Anthony; Tighe, Orna; Rubinstein, Marcelo; Grandy, David K.; et al.; Comparative, Topographically-Based Evaluation of Behavioural Phenotype and Specification of D1-Like:D2 Interactions in a Line of Incipient Congenic Mice with D2 Dopamine Receptor "Knockout"; Elsevier; Neuropsychopharmacology; 25; 4; 10-2001; 527-536
0893-133X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/79323
identifier_str_mv Clifford, Jeremiah J.; Kinsella, Anthony; Tighe, Orna; Rubinstein, Marcelo; Grandy, David K.; et al.; Comparative, Topographically-Based Evaluation of Behavioural Phenotype and Specification of D1-Like:D2 Interactions in a Line of Incipient Congenic Mice with D2 Dopamine Receptor "Knockout"; Elsevier; Neuropsychopharmacology; 25; 4; 10-2001; 527-536
0893-133X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0893133X01002469
info:eu-repo/semantics/altIdentifier/doi/10.1016/S0893-133X(01)00246-9
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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