Role of dopamine D1-like receptors in methamphetamine locomotor responses of D2 receptor knockout mice

Autores
Kelly, M. A.; Low, M. J.; Rubinstein, Marcelo; Phillips, T. J.
Año de publicación
2008
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Behavioral sensitization to psychostimulants manifests as an increased locomotor response with repeated administration. Dopamine systems are accepted to play a fundamental role in sensitization, but the role of specific dopamine receptor subtypes has not been completely defined. This study used the combination of dopamine D2 receptor-deficient mice and a D1-like antagonist to examine dopamine D1 and D2 receptor involvement in acute and sensitized locomotor responses to methamphetamine. Absence of the dopamine D2 receptor resulted in attenuation of the acute stimulant effects of methamphetamine. Mutant and wild-type mice exhibited sensitization that lasted longer within the time period of the challenge test in the mutant animals. Pretreatment with the D1-like receptor antagonist SCH 23390 produced more potent reductions in the acute and sensitized locomotor responses to methamphetamine in D2 receptor-deficient mice than in wild-type mice; however, the expression of locomotor sensitization when challenged with methamphetamine alone was equivalently attenuated by previous treatment with SCH 23390. These data suggest that dopamine D2 receptors play a key role in the acute stimulant and sensitizing effects of methamphetamine and act in concert with D1-like receptors to influence the acquisition of methamphetamine-induced behavioral sensitization, traits that may influence continued methamphetamine use.
Fil: Kelly, M. A.. Oregon Health And Science University; Estados Unidos
Fil: Low, M. J.. Oregon Health And Science University; Estados Unidos
Fil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina
Fil: Phillips, T. J.. Oregon Health And Science University; Estados Unidos
Materia
DOPAMINE RECEPTORS
KNOCKOUT
LOCOMOTOR ACTIVITY
NEUROADAPTATION
NULL MUTANT
PSYCHOSTIMULANT
SENSITIZATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/79641
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Role of dopamine D1-like receptors in methamphetamine locomotor responses of D2 receptor knockout miceKelly, M. A.Low, M. J.Rubinstein, MarceloPhillips, T. J.DOPAMINE RECEPTORSKNOCKOUTLOCOMOTOR ACTIVITYNEUROADAPTATIONNULL MUTANTPSYCHOSTIMULANTSENSITIZATIONhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Behavioral sensitization to psychostimulants manifests as an increased locomotor response with repeated administration. Dopamine systems are accepted to play a fundamental role in sensitization, but the role of specific dopamine receptor subtypes has not been completely defined. This study used the combination of dopamine D2 receptor-deficient mice and a D1-like antagonist to examine dopamine D1 and D2 receptor involvement in acute and sensitized locomotor responses to methamphetamine. Absence of the dopamine D2 receptor resulted in attenuation of the acute stimulant effects of methamphetamine. Mutant and wild-type mice exhibited sensitization that lasted longer within the time period of the challenge test in the mutant animals. Pretreatment with the D1-like receptor antagonist SCH 23390 produced more potent reductions in the acute and sensitized locomotor responses to methamphetamine in D2 receptor-deficient mice than in wild-type mice; however, the expression of locomotor sensitization when challenged with methamphetamine alone was equivalently attenuated by previous treatment with SCH 23390. These data suggest that dopamine D2 receptors play a key role in the acute stimulant and sensitizing effects of methamphetamine and act in concert with D1-like receptors to influence the acquisition of methamphetamine-induced behavioral sensitization, traits that may influence continued methamphetamine use.Fil: Kelly, M. A.. Oregon Health And Science University; Estados UnidosFil: Low, M. J.. Oregon Health And Science University; Estados UnidosFil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; ArgentinaFil: Phillips, T. J.. Oregon Health And Science University; Estados UnidosWiley Blackwell Publishing, Inc2008-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/79641Kelly, M. A.; Low, M. J.; Rubinstein, Marcelo; Phillips, T. J.; Role of dopamine D1-like receptors in methamphetamine locomotor responses of D2 receptor knockout mice; Wiley Blackwell Publishing, Inc; Genes, Brain and Behavior; 7; 5; 7-2008; 568-5771601-1848CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18363855/info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1601-183X.2008.00392.xinfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1111/j.1601-183X.2008.00392.xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:46:43Zoai:ri.conicet.gov.ar:11336/79641instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:46:43.273CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Role of dopamine D1-like receptors in methamphetamine locomotor responses of D2 receptor knockout mice
title Role of dopamine D1-like receptors in methamphetamine locomotor responses of D2 receptor knockout mice
spellingShingle Role of dopamine D1-like receptors in methamphetamine locomotor responses of D2 receptor knockout mice
Kelly, M. A.
DOPAMINE RECEPTORS
KNOCKOUT
LOCOMOTOR ACTIVITY
NEUROADAPTATION
NULL MUTANT
PSYCHOSTIMULANT
SENSITIZATION
title_short Role of dopamine D1-like receptors in methamphetamine locomotor responses of D2 receptor knockout mice
title_full Role of dopamine D1-like receptors in methamphetamine locomotor responses of D2 receptor knockout mice
title_fullStr Role of dopamine D1-like receptors in methamphetamine locomotor responses of D2 receptor knockout mice
title_full_unstemmed Role of dopamine D1-like receptors in methamphetamine locomotor responses of D2 receptor knockout mice
title_sort Role of dopamine D1-like receptors in methamphetamine locomotor responses of D2 receptor knockout mice
dc.creator.none.fl_str_mv Kelly, M. A.
Low, M. J.
Rubinstein, Marcelo
Phillips, T. J.
author Kelly, M. A.
author_facet Kelly, M. A.
Low, M. J.
Rubinstein, Marcelo
Phillips, T. J.
author_role author
author2 Low, M. J.
Rubinstein, Marcelo
Phillips, T. J.
author2_role author
author
author
dc.subject.none.fl_str_mv DOPAMINE RECEPTORS
KNOCKOUT
LOCOMOTOR ACTIVITY
NEUROADAPTATION
NULL MUTANT
PSYCHOSTIMULANT
SENSITIZATION
topic DOPAMINE RECEPTORS
KNOCKOUT
LOCOMOTOR ACTIVITY
NEUROADAPTATION
NULL MUTANT
PSYCHOSTIMULANT
SENSITIZATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Behavioral sensitization to psychostimulants manifests as an increased locomotor response with repeated administration. Dopamine systems are accepted to play a fundamental role in sensitization, but the role of specific dopamine receptor subtypes has not been completely defined. This study used the combination of dopamine D2 receptor-deficient mice and a D1-like antagonist to examine dopamine D1 and D2 receptor involvement in acute and sensitized locomotor responses to methamphetamine. Absence of the dopamine D2 receptor resulted in attenuation of the acute stimulant effects of methamphetamine. Mutant and wild-type mice exhibited sensitization that lasted longer within the time period of the challenge test in the mutant animals. Pretreatment with the D1-like receptor antagonist SCH 23390 produced more potent reductions in the acute and sensitized locomotor responses to methamphetamine in D2 receptor-deficient mice than in wild-type mice; however, the expression of locomotor sensitization when challenged with methamphetamine alone was equivalently attenuated by previous treatment with SCH 23390. These data suggest that dopamine D2 receptors play a key role in the acute stimulant and sensitizing effects of methamphetamine and act in concert with D1-like receptors to influence the acquisition of methamphetamine-induced behavioral sensitization, traits that may influence continued methamphetamine use.
Fil: Kelly, M. A.. Oregon Health And Science University; Estados Unidos
Fil: Low, M. J.. Oregon Health And Science University; Estados Unidos
Fil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina
Fil: Phillips, T. J.. Oregon Health And Science University; Estados Unidos
description Behavioral sensitization to psychostimulants manifests as an increased locomotor response with repeated administration. Dopamine systems are accepted to play a fundamental role in sensitization, but the role of specific dopamine receptor subtypes has not been completely defined. This study used the combination of dopamine D2 receptor-deficient mice and a D1-like antagonist to examine dopamine D1 and D2 receptor involvement in acute and sensitized locomotor responses to methamphetamine. Absence of the dopamine D2 receptor resulted in attenuation of the acute stimulant effects of methamphetamine. Mutant and wild-type mice exhibited sensitization that lasted longer within the time period of the challenge test in the mutant animals. Pretreatment with the D1-like receptor antagonist SCH 23390 produced more potent reductions in the acute and sensitized locomotor responses to methamphetamine in D2 receptor-deficient mice than in wild-type mice; however, the expression of locomotor sensitization when challenged with methamphetamine alone was equivalently attenuated by previous treatment with SCH 23390. These data suggest that dopamine D2 receptors play a key role in the acute stimulant and sensitizing effects of methamphetamine and act in concert with D1-like receptors to influence the acquisition of methamphetamine-induced behavioral sensitization, traits that may influence continued methamphetamine use.
publishDate 2008
dc.date.none.fl_str_mv 2008-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/79641
Kelly, M. A.; Low, M. J.; Rubinstein, Marcelo; Phillips, T. J.; Role of dopamine D1-like receptors in methamphetamine locomotor responses of D2 receptor knockout mice; Wiley Blackwell Publishing, Inc; Genes, Brain and Behavior; 7; 5; 7-2008; 568-577
1601-1848
CONICET Digital
CONICET
url http://hdl.handle.net/11336/79641
identifier_str_mv Kelly, M. A.; Low, M. J.; Rubinstein, Marcelo; Phillips, T. J.; Role of dopamine D1-like receptors in methamphetamine locomotor responses of D2 receptor knockout mice; Wiley Blackwell Publishing, Inc; Genes, Brain and Behavior; 7; 5; 7-2008; 568-577
1601-1848
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18363855/
info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1601-183X.2008.00392.x
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1111/j.1601-183X.2008.00392.x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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