The D2 receptor is critical in mediating opiate motivation only in opiate-dependent and withdrawn mice

Autores
Dockstader, Colleen L.; Rubinstein, Marcelo; Grandy, David K.; Low, Malcolm J.; Van Kooy, Derek Der
Año de publicación
2001
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
According to the dual systems model for opiate reward, dopamine mediates opiate motivation when an animal is in a deprived motivational state (i.e. opiate-dependent and in withdrawal) and not when an animal is in a nondeprived state (i.e. previously drug-naive). To determine the role of the D2 dopamine receptor subtype in mediating opiate motivation, we examined the behaviour of N5 congenic D2 receptor knockout mice and their wild-type siblings in opiate-naive and opiate-dependent and withdrawn place conditioning paradigms. Opiate-naive D2 receptor knockout mice demonstrated acquisition of morphine-conditioned place preference but failed to acquire place preference when conditioned in the deprived state. We propose that D2 receptor function is critical in mediating the motivational effects of opiates only when the animal is in an opiate-dependent and withdrawn motivational state. These findings also underscore the important influence of the genetic background to a given phenotype, as evidenced by the observation that increasing the allelic contribution from the 129/SvJ strain abolishes morphine place preference in C57BL/6 wild-type mice.
Fil: Dockstader, Colleen L.. University of Toronto; Canadá
Fil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Fil: Grandy, David K.. Oregon Health Sciences University; Estados Unidos
Fil: Low, Malcolm J.. Oregon Health Sciences University; Estados Unidos
Fil: Van Kooy, Derek Der. University of Toronto; Canadá
Materia
Backcrossing
D2
Dopamine
Drug Abuse
Knockout Mice
Motivation
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/71810
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling The D2 receptor is critical in mediating opiate motivation only in opiate-dependent and withdrawn miceDockstader, Colleen L.Rubinstein, MarceloGrandy, David K.Low, Malcolm J.Van Kooy, Derek DerBackcrossingD2DopamineDrug AbuseKnockout MiceMotivationhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3According to the dual systems model for opiate reward, dopamine mediates opiate motivation when an animal is in a deprived motivational state (i.e. opiate-dependent and in withdrawal) and not when an animal is in a nondeprived state (i.e. previously drug-naive). To determine the role of the D2 dopamine receptor subtype in mediating opiate motivation, we examined the behaviour of N5 congenic D2 receptor knockout mice and their wild-type siblings in opiate-naive and opiate-dependent and withdrawn place conditioning paradigms. Opiate-naive D2 receptor knockout mice demonstrated acquisition of morphine-conditioned place preference but failed to acquire place preference when conditioned in the deprived state. We propose that D2 receptor function is critical in mediating the motivational effects of opiates only when the animal is in an opiate-dependent and withdrawn motivational state. These findings also underscore the important influence of the genetic background to a given phenotype, as evidenced by the observation that increasing the allelic contribution from the 129/SvJ strain abolishes morphine place preference in C57BL/6 wild-type mice.Fil: Dockstader, Colleen L.. University of Toronto; CanadáFil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Grandy, David K.. Oregon Health Sciences University; Estados UnidosFil: Low, Malcolm J.. Oregon Health Sciences University; Estados UnidosFil: Van Kooy, Derek Der. University of Toronto; CanadáWiley Blackwell Publishing, Inc2001-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/71810Dockstader, Colleen L.; Rubinstein, Marcelo; Grandy, David K.; Low, Malcolm J.; Van Kooy, Derek Der; The D2 receptor is critical in mediating opiate motivation only in opiate-dependent and withdrawn mice; Wiley Blackwell Publishing, Inc; European Journal Of Neuroscience; 13; 5; 3-2001; 995-10010953-816XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1460-9568.2001.01455.xinfo:eu-repo/semantics/altIdentifier/doi/10.1046/j.1460-9568.2001.01455.xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:51:36Zoai:ri.conicet.gov.ar:11336/71810instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:51:36.509CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The D2 receptor is critical in mediating opiate motivation only in opiate-dependent and withdrawn mice
title The D2 receptor is critical in mediating opiate motivation only in opiate-dependent and withdrawn mice
spellingShingle The D2 receptor is critical in mediating opiate motivation only in opiate-dependent and withdrawn mice
Dockstader, Colleen L.
Backcrossing
D2
Dopamine
Drug Abuse
Knockout Mice
Motivation
title_short The D2 receptor is critical in mediating opiate motivation only in opiate-dependent and withdrawn mice
title_full The D2 receptor is critical in mediating opiate motivation only in opiate-dependent and withdrawn mice
title_fullStr The D2 receptor is critical in mediating opiate motivation only in opiate-dependent and withdrawn mice
title_full_unstemmed The D2 receptor is critical in mediating opiate motivation only in opiate-dependent and withdrawn mice
title_sort The D2 receptor is critical in mediating opiate motivation only in opiate-dependent and withdrawn mice
dc.creator.none.fl_str_mv Dockstader, Colleen L.
Rubinstein, Marcelo
Grandy, David K.
Low, Malcolm J.
Van Kooy, Derek Der
author Dockstader, Colleen L.
author_facet Dockstader, Colleen L.
Rubinstein, Marcelo
Grandy, David K.
Low, Malcolm J.
Van Kooy, Derek Der
author_role author
author2 Rubinstein, Marcelo
Grandy, David K.
Low, Malcolm J.
Van Kooy, Derek Der
author2_role author
author
author
author
dc.subject.none.fl_str_mv Backcrossing
D2
Dopamine
Drug Abuse
Knockout Mice
Motivation
topic Backcrossing
D2
Dopamine
Drug Abuse
Knockout Mice
Motivation
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv According to the dual systems model for opiate reward, dopamine mediates opiate motivation when an animal is in a deprived motivational state (i.e. opiate-dependent and in withdrawal) and not when an animal is in a nondeprived state (i.e. previously drug-naive). To determine the role of the D2 dopamine receptor subtype in mediating opiate motivation, we examined the behaviour of N5 congenic D2 receptor knockout mice and their wild-type siblings in opiate-naive and opiate-dependent and withdrawn place conditioning paradigms. Opiate-naive D2 receptor knockout mice demonstrated acquisition of morphine-conditioned place preference but failed to acquire place preference when conditioned in the deprived state. We propose that D2 receptor function is critical in mediating the motivational effects of opiates only when the animal is in an opiate-dependent and withdrawn motivational state. These findings also underscore the important influence of the genetic background to a given phenotype, as evidenced by the observation that increasing the allelic contribution from the 129/SvJ strain abolishes morphine place preference in C57BL/6 wild-type mice.
Fil: Dockstader, Colleen L.. University of Toronto; Canadá
Fil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Fil: Grandy, David K.. Oregon Health Sciences University; Estados Unidos
Fil: Low, Malcolm J.. Oregon Health Sciences University; Estados Unidos
Fil: Van Kooy, Derek Der. University of Toronto; Canadá
description According to the dual systems model for opiate reward, dopamine mediates opiate motivation when an animal is in a deprived motivational state (i.e. opiate-dependent and in withdrawal) and not when an animal is in a nondeprived state (i.e. previously drug-naive). To determine the role of the D2 dopamine receptor subtype in mediating opiate motivation, we examined the behaviour of N5 congenic D2 receptor knockout mice and their wild-type siblings in opiate-naive and opiate-dependent and withdrawn place conditioning paradigms. Opiate-naive D2 receptor knockout mice demonstrated acquisition of morphine-conditioned place preference but failed to acquire place preference when conditioned in the deprived state. We propose that D2 receptor function is critical in mediating the motivational effects of opiates only when the animal is in an opiate-dependent and withdrawn motivational state. These findings also underscore the important influence of the genetic background to a given phenotype, as evidenced by the observation that increasing the allelic contribution from the 129/SvJ strain abolishes morphine place preference in C57BL/6 wild-type mice.
publishDate 2001
dc.date.none.fl_str_mv 2001-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/71810
Dockstader, Colleen L.; Rubinstein, Marcelo; Grandy, David K.; Low, Malcolm J.; Van Kooy, Derek Der; The D2 receptor is critical in mediating opiate motivation only in opiate-dependent and withdrawn mice; Wiley Blackwell Publishing, Inc; European Journal Of Neuroscience; 13; 5; 3-2001; 995-1001
0953-816X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/71810
identifier_str_mv Dockstader, Colleen L.; Rubinstein, Marcelo; Grandy, David K.; Low, Malcolm J.; Van Kooy, Derek Der; The D2 receptor is critical in mediating opiate motivation only in opiate-dependent and withdrawn mice; Wiley Blackwell Publishing, Inc; European Journal Of Neuroscience; 13; 5; 3-2001; 995-1001
0953-816X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1460-9568.2001.01455.x
info:eu-repo/semantics/altIdentifier/doi/10.1046/j.1460-9568.2001.01455.x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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