The Metabotropic Glutamate Receptor MGL-2 gates satiety by modulating Serotonergic Signaling in C. elegans

Autores
Lacour, Ailin; Blanco, Maria Gabriela; de Rosa, Maria Jose; Rayes, Diego Hernán
Año de publicación
2025
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
How neural circuits encode internal nutrient states to generate adaptive behaviors is a fundamental question in neuroscience. In this study, we explore the mechanisms through which C. elegans perceives its nutritional state and adjusts feeding and locomotor behaviors. We show that mutants of mgl-2, the C. elegans ortholog of mammalian metabotropic glutamate receptors (mGluRs), exhibit hyperphagia and decreased locomotion—phenotypes reminiscent of hungry animals, even in the absence of food deprivation. This excessive feeding results in elevated lipid accumulation, underscoring the critical role of MGL-2 in promoting satiety. In wild-type animals, food encounter after starvation induces a pronounced serotonin release that facilitates feeding and suppresses locomotion to promote nutrient recovery. Using genetic approaches and in vivo neuronal imaging, we demonstrate that MGL-2 is essential for the perception of nutritional status and for regulating serotonergic signaling in fed animals. Ongoing work aims to identify the specific neuronal circuits in which MGL-2 operates. Our findings support a model in which MGL-2 acts as a key modulator within neural pathways governing appetite and energy balance. Notably, mammalian mGluRs have recently been linked to hunger and satiety perception, suggesting evolutionary conservation in these regulatory mechanisms. This study provides insights into the neurobiological basis of feeding behavior with potential relevance across species.
Fil: Lacour, Ailin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Blanco, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
XL Sociedad Argentina de Neurociencias
Buenos Aires
Argentina
Sociedad Argentina de Neurociencias
Materia
C ELEGANS
SEROTONINERGIC
SACIETY
GLUTAMATE RECEPTORS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/280642
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The Metabotropic Glutamate Receptor MGL-2 gates satiety by modulating Serotonergic Signaling in C. elegansLacour, AilinBlanco, Maria Gabrielade Rosa, Maria JoseRayes, Diego HernánC ELEGANSSEROTONINERGICSACIETYGLUTAMATE RECEPTORShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1How neural circuits encode internal nutrient states to generate adaptive behaviors is a fundamental question in neuroscience. In this study, we explore the mechanisms through which C. elegans perceives its nutritional state and adjusts feeding and locomotor behaviors. We show that mutants of mgl-2, the C. elegans ortholog of mammalian metabotropic glutamate receptors (mGluRs), exhibit hyperphagia and decreased locomotion—phenotypes reminiscent of hungry animals, even in the absence of food deprivation. This excessive feeding results in elevated lipid accumulation, underscoring the critical role of MGL-2 in promoting satiety. In wild-type animals, food encounter after starvation induces a pronounced serotonin release that facilitates feeding and suppresses locomotion to promote nutrient recovery. Using genetic approaches and in vivo neuronal imaging, we demonstrate that MGL-2 is essential for the perception of nutritional status and for regulating serotonergic signaling in fed animals. Ongoing work aims to identify the specific neuronal circuits in which MGL-2 operates. Our findings support a model in which MGL-2 acts as a key modulator within neural pathways governing appetite and energy balance. Notably, mammalian mGluRs have recently been linked to hunger and satiety perception, suggesting evolutionary conservation in these regulatory mechanisms. This study provides insights into the neurobiological basis of feeding behavior with potential relevance across species.Fil: Lacour, Ailin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Blanco, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaXL Sociedad Argentina de NeurocienciasBuenos AiresArgentinaSociedad Argentina de NeurocienciasSociedad Argentina de Investigación en Neurociencias2025info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/280642The Metabotropic Glutamate Receptor MGL-2 gates satiety by modulating Serotonergic Signaling in C. elegans; XL Sociedad Argentina de Neurociencias; Buenos Aires; Argentina; 2025; 289-289CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://csan2025.saneurociencias.org.ar/wp-content/uploads/2025/10/SAN2025-Poster-EBOOK-.pdfInternacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-02-26T10:05:06Zoai:ri.conicet.gov.ar:11336/280642instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-02-26 10:05:06.969CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The Metabotropic Glutamate Receptor MGL-2 gates satiety by modulating Serotonergic Signaling in C. elegans
title The Metabotropic Glutamate Receptor MGL-2 gates satiety by modulating Serotonergic Signaling in C. elegans
spellingShingle The Metabotropic Glutamate Receptor MGL-2 gates satiety by modulating Serotonergic Signaling in C. elegans
Lacour, Ailin
C ELEGANS
SEROTONINERGIC
SACIETY
GLUTAMATE RECEPTORS
title_short The Metabotropic Glutamate Receptor MGL-2 gates satiety by modulating Serotonergic Signaling in C. elegans
title_full The Metabotropic Glutamate Receptor MGL-2 gates satiety by modulating Serotonergic Signaling in C. elegans
title_fullStr The Metabotropic Glutamate Receptor MGL-2 gates satiety by modulating Serotonergic Signaling in C. elegans
title_full_unstemmed The Metabotropic Glutamate Receptor MGL-2 gates satiety by modulating Serotonergic Signaling in C. elegans
title_sort The Metabotropic Glutamate Receptor MGL-2 gates satiety by modulating Serotonergic Signaling in C. elegans
dc.creator.none.fl_str_mv Lacour, Ailin
Blanco, Maria Gabriela
de Rosa, Maria Jose
Rayes, Diego Hernán
author Lacour, Ailin
author_facet Lacour, Ailin
Blanco, Maria Gabriela
de Rosa, Maria Jose
Rayes, Diego Hernán
author_role author
author2 Blanco, Maria Gabriela
de Rosa, Maria Jose
Rayes, Diego Hernán
author2_role author
author
author
dc.subject.none.fl_str_mv C ELEGANS
SEROTONINERGIC
SACIETY
GLUTAMATE RECEPTORS
topic C ELEGANS
SEROTONINERGIC
SACIETY
GLUTAMATE RECEPTORS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv How neural circuits encode internal nutrient states to generate adaptive behaviors is a fundamental question in neuroscience. In this study, we explore the mechanisms through which C. elegans perceives its nutritional state and adjusts feeding and locomotor behaviors. We show that mutants of mgl-2, the C. elegans ortholog of mammalian metabotropic glutamate receptors (mGluRs), exhibit hyperphagia and decreased locomotion—phenotypes reminiscent of hungry animals, even in the absence of food deprivation. This excessive feeding results in elevated lipid accumulation, underscoring the critical role of MGL-2 in promoting satiety. In wild-type animals, food encounter after starvation induces a pronounced serotonin release that facilitates feeding and suppresses locomotion to promote nutrient recovery. Using genetic approaches and in vivo neuronal imaging, we demonstrate that MGL-2 is essential for the perception of nutritional status and for regulating serotonergic signaling in fed animals. Ongoing work aims to identify the specific neuronal circuits in which MGL-2 operates. Our findings support a model in which MGL-2 acts as a key modulator within neural pathways governing appetite and energy balance. Notably, mammalian mGluRs have recently been linked to hunger and satiety perception, suggesting evolutionary conservation in these regulatory mechanisms. This study provides insights into the neurobiological basis of feeding behavior with potential relevance across species.
Fil: Lacour, Ailin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Blanco, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
XL Sociedad Argentina de Neurociencias
Buenos Aires
Argentina
Sociedad Argentina de Neurociencias
description How neural circuits encode internal nutrient states to generate adaptive behaviors is a fundamental question in neuroscience. In this study, we explore the mechanisms through which C. elegans perceives its nutritional state and adjusts feeding and locomotor behaviors. We show that mutants of mgl-2, the C. elegans ortholog of mammalian metabotropic glutamate receptors (mGluRs), exhibit hyperphagia and decreased locomotion—phenotypes reminiscent of hungry animals, even in the absence of food deprivation. This excessive feeding results in elevated lipid accumulation, underscoring the critical role of MGL-2 in promoting satiety. In wild-type animals, food encounter after starvation induces a pronounced serotonin release that facilitates feeding and suppresses locomotion to promote nutrient recovery. Using genetic approaches and in vivo neuronal imaging, we demonstrate that MGL-2 is essential for the perception of nutritional status and for regulating serotonergic signaling in fed animals. Ongoing work aims to identify the specific neuronal circuits in which MGL-2 operates. Our findings support a model in which MGL-2 acts as a key modulator within neural pathways governing appetite and energy balance. Notably, mammalian mGluRs have recently been linked to hunger and satiety perception, suggesting evolutionary conservation in these regulatory mechanisms. This study provides insights into the neurobiological basis of feeding behavior with potential relevance across species.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Congreso
Book
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/280642
The Metabotropic Glutamate Receptor MGL-2 gates satiety by modulating Serotonergic Signaling in C. elegans; XL Sociedad Argentina de Neurociencias; Buenos Aires; Argentina; 2025; 289-289
CONICET Digital
CONICET
url http://hdl.handle.net/11336/280642
identifier_str_mv The Metabotropic Glutamate Receptor MGL-2 gates satiety by modulating Serotonergic Signaling in C. elegans; XL Sociedad Argentina de Neurociencias; Buenos Aires; Argentina; 2025; 289-289
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://csan2025.saneurociencias.org.ar/wp-content/uploads/2025/10/SAN2025-Poster-EBOOK-.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.coverage.none.fl_str_mv Internacional
dc.publisher.none.fl_str_mv Sociedad Argentina de Investigación en Neurociencias
publisher.none.fl_str_mv Sociedad Argentina de Investigación en Neurociencias
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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