The Metabotropic Glutamate Receptor Mgl-2 Modulates Satiety And Serotonergic Signaling In Caenorhabditis Elegans

Autores
Lacour, Ailin; Blanco, Maria Gabriela; de Rosa, Maria Jose; Rayes, Diego Hernán
Año de publicación
2024
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
The ability to perceive nutritional status is crucial for modulating animal behavior. In this study, we explore the mechanisms by which C. elegans senses its nutritional state. We discovered that mutants in mgl-2, the C. elegans ortholog of mammalian metabotropic glutamate receptors (mGluRs), exhibit hyperphagia and a pronounced reduction in locomotion when exposed to food. While these behaviors are typical of starved animals, these mutants display them even without prior food deprivation. This hyperphagic behavior leads to increased lipid accumulation, indicating that MGL-2 is essential for the perception of satiety in these animals. In starved wild-type animals, encountering food triggers an exacerbated release of serotonin, which allows the animal to increase its feeding rate and slow down locomotion to restore its nutritional status. Through genetic experiments and in vivo neuronal activity measurements, we determined that MGL-2-mediated nutritional state perception is necessary to temper serotonergic signaling in fed animals. We are currently working to identify the specific neurons where MGL-2 exerts these effects. We propose that MGL-2 serves as a key modulator within neural circuits that control appetite and energy homeostasis. Notably, mammalian mGluRs have recently been implicated in hunger and satiety perception. Given the conservation of fundamental processes across the animal kingdom, our study provides potentially universal insights into feeding behaviors.
Fil: Lacour, Ailin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Blanco, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
VI Taller de Biología Celular y del Desarrollo
Argentina
Comité Organizador del V Taller de Biología Celular y del Desarrollo
Materia
Metabotropic Receptor
Nutritional Status
C.elegans
serotonergic signaling
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/278923
Acceder
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network_name_str CONICET Digital (CONICET)
spelling The Metabotropic Glutamate Receptor Mgl-2 Modulates Satiety And Serotonergic Signaling In Caenorhabditis ElegansLacour, AilinBlanco, Maria Gabrielade Rosa, Maria JoseRayes, Diego HernánMetabotropic ReceptorNutritional StatusC.elegansserotonergic signalinghttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The ability to perceive nutritional status is crucial for modulating animal behavior. In this study, we explore the mechanisms by which C. elegans senses its nutritional state. We discovered that mutants in mgl-2, the C. elegans ortholog of mammalian metabotropic glutamate receptors (mGluRs), exhibit hyperphagia and a pronounced reduction in locomotion when exposed to food. While these behaviors are typical of starved animals, these mutants display them even without prior food deprivation. This hyperphagic behavior leads to increased lipid accumulation, indicating that MGL-2 is essential for the perception of satiety in these animals. In starved wild-type animals, encountering food triggers an exacerbated release of serotonin, which allows the animal to increase its feeding rate and slow down locomotion to restore its nutritional status. Through genetic experiments and in vivo neuronal activity measurements, we determined that MGL-2-mediated nutritional state perception is necessary to temper serotonergic signaling in fed animals. We are currently working to identify the specific neurons where MGL-2 exerts these effects. We propose that MGL-2 serves as a key modulator within neural circuits that control appetite and energy homeostasis. Notably, mammalian mGluRs have recently been implicated in hunger and satiety perception. Given the conservation of fundamental processes across the animal kingdom, our study provides potentially universal insights into feeding behaviors.Fil: Lacour, Ailin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Blanco, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaVI Taller de Biología Celular y del DesarrolloArgentinaComité Organizador del V Taller de Biología Celular y del DesarrolloComité Organizador del V Taller de Biología Celular y del Desarrollo2024info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectTallerBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/278923The Metabotropic Glutamate Receptor Mgl-2 Modulates Satiety And Serotonergic Signaling In Caenorhabditis Elegans; VI Taller de Biología Celular y del Desarrollo; Argentina; 2024; 55-56CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://tallerbcd.wixsite.com/tallerbcdNacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-02-06T13:17:14Zoai:ri.conicet.gov.ar:11336/278923instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-02-06 13:17:14.74CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The Metabotropic Glutamate Receptor Mgl-2 Modulates Satiety And Serotonergic Signaling In Caenorhabditis Elegans
title The Metabotropic Glutamate Receptor Mgl-2 Modulates Satiety And Serotonergic Signaling In Caenorhabditis Elegans
spellingShingle The Metabotropic Glutamate Receptor Mgl-2 Modulates Satiety And Serotonergic Signaling In Caenorhabditis Elegans
Lacour, Ailin
Metabotropic Receptor
Nutritional Status
C.elegans
serotonergic signaling
title_short The Metabotropic Glutamate Receptor Mgl-2 Modulates Satiety And Serotonergic Signaling In Caenorhabditis Elegans
title_full The Metabotropic Glutamate Receptor Mgl-2 Modulates Satiety And Serotonergic Signaling In Caenorhabditis Elegans
title_fullStr The Metabotropic Glutamate Receptor Mgl-2 Modulates Satiety And Serotonergic Signaling In Caenorhabditis Elegans
title_full_unstemmed The Metabotropic Glutamate Receptor Mgl-2 Modulates Satiety And Serotonergic Signaling In Caenorhabditis Elegans
title_sort The Metabotropic Glutamate Receptor Mgl-2 Modulates Satiety And Serotonergic Signaling In Caenorhabditis Elegans
dc.creator.none.fl_str_mv Lacour, Ailin
Blanco, Maria Gabriela
de Rosa, Maria Jose
Rayes, Diego Hernán
author Lacour, Ailin
author_facet Lacour, Ailin
Blanco, Maria Gabriela
de Rosa, Maria Jose
Rayes, Diego Hernán
author_role author
author2 Blanco, Maria Gabriela
de Rosa, Maria Jose
Rayes, Diego Hernán
author2_role author
author
author
dc.subject.none.fl_str_mv Metabotropic Receptor
Nutritional Status
C.elegans
serotonergic signaling
topic Metabotropic Receptor
Nutritional Status
C.elegans
serotonergic signaling
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The ability to perceive nutritional status is crucial for modulating animal behavior. In this study, we explore the mechanisms by which C. elegans senses its nutritional state. We discovered that mutants in mgl-2, the C. elegans ortholog of mammalian metabotropic glutamate receptors (mGluRs), exhibit hyperphagia and a pronounced reduction in locomotion when exposed to food. While these behaviors are typical of starved animals, these mutants display them even without prior food deprivation. This hyperphagic behavior leads to increased lipid accumulation, indicating that MGL-2 is essential for the perception of satiety in these animals. In starved wild-type animals, encountering food triggers an exacerbated release of serotonin, which allows the animal to increase its feeding rate and slow down locomotion to restore its nutritional status. Through genetic experiments and in vivo neuronal activity measurements, we determined that MGL-2-mediated nutritional state perception is necessary to temper serotonergic signaling in fed animals. We are currently working to identify the specific neurons where MGL-2 exerts these effects. We propose that MGL-2 serves as a key modulator within neural circuits that control appetite and energy homeostasis. Notably, mammalian mGluRs have recently been implicated in hunger and satiety perception. Given the conservation of fundamental processes across the animal kingdom, our study provides potentially universal insights into feeding behaviors.
Fil: Lacour, Ailin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Blanco, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
VI Taller de Biología Celular y del Desarrollo
Argentina
Comité Organizador del V Taller de Biología Celular y del Desarrollo
description The ability to perceive nutritional status is crucial for modulating animal behavior. In this study, we explore the mechanisms by which C. elegans senses its nutritional state. We discovered that mutants in mgl-2, the C. elegans ortholog of mammalian metabotropic glutamate receptors (mGluRs), exhibit hyperphagia and a pronounced reduction in locomotion when exposed to food. While these behaviors are typical of starved animals, these mutants display them even without prior food deprivation. This hyperphagic behavior leads to increased lipid accumulation, indicating that MGL-2 is essential for the perception of satiety in these animals. In starved wild-type animals, encountering food triggers an exacerbated release of serotonin, which allows the animal to increase its feeding rate and slow down locomotion to restore its nutritional status. Through genetic experiments and in vivo neuronal activity measurements, we determined that MGL-2-mediated nutritional state perception is necessary to temper serotonergic signaling in fed animals. We are currently working to identify the specific neurons where MGL-2 exerts these effects. We propose that MGL-2 serves as a key modulator within neural circuits that control appetite and energy homeostasis. Notably, mammalian mGluRs have recently been implicated in hunger and satiety perception. Given the conservation of fundamental processes across the animal kingdom, our study provides potentially universal insights into feeding behaviors.
publishDate 2024
dc.date.none.fl_str_mv 2024
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info:eu-repo/semantics/conferenceObject
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Book
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info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/278923
The Metabotropic Glutamate Receptor Mgl-2 Modulates Satiety And Serotonergic Signaling In Caenorhabditis Elegans; VI Taller de Biología Celular y del Desarrollo; Argentina; 2024; 55-56
CONICET Digital
CONICET
url http://hdl.handle.net/11336/278923
identifier_str_mv The Metabotropic Glutamate Receptor Mgl-2 Modulates Satiety And Serotonergic Signaling In Caenorhabditis Elegans; VI Taller de Biología Celular y del Desarrollo; Argentina; 2024; 55-56
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
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dc.publisher.none.fl_str_mv Comité Organizador del V Taller de Biología Celular y del Desarrollo
publisher.none.fl_str_mv Comité Organizador del V Taller de Biología Celular y del Desarrollo
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repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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