The Metabotropic Glutamate Receptor MGL-2 Modulates Satiety and Serotonergic Signaling in C. elegans

Autores
Lacour, Ailin; Blanco, Maria Gabriela; de Rosa, Maria Jose; Rayes, Diego Hernán
Año de publicación
2024
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
The ability to perceive nutritional status is crucial for modulating animal behavior. In this study, we explore the mechanisms by which C. elegans senses its nutritional state. We discovered that mutants in mgl-2, the C. elegans ortholog of mammalian metabotropic glutamate receptors (mGluRs), exhibit hyperphagia and a pronounced reduction in locomotion when exposed to food. While these behaviors are typical of starved animals, these mutants display them even without prior food deprivation. This hyperphagic behavior leads to increased lipid accumulation, indicating that MGL-2 is essential for the perception of satiety in these animals. In starved wild-type animals, encountering food triggers an exacerbated release of serotonin, which allows the animal to increase its feeding rate and slow down locomotion to restore its nutritional status. Through genetic experiments and in vivo neuronal activity measurements, we determined that MGL-2-mediated nutritional state perception is necessary to temper serotonergic signaling in fed animals. We are currently working to identify the specific neurons where MGL-2 exerts these effects. We propose that MGL-2 serves as a key modulator within neural circuits that control appetite and energy homeostasis. Notably, mammalian mGluRs have recently been implicated in hunger and satiety perception. Given the conservation of fundamental processes across the animal kingdom, our study provides potentially universal insights into feeding behaviors.
Fil: Lacour, Ailin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Blanco, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
XXXIX Annual Meeting
Buenos Aires
Argentina
Sociedad Argentina de Investigación en Neurociencias
Materia
C. ELEGANS
MGL-2
NUTRITION
NEURAL CIRCUIT
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/278847
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/278847
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The Metabotropic Glutamate Receptor MGL-2 Modulates Satiety and Serotonergic Signaling in C. elegansLacour, AilinBlanco, Maria Gabrielade Rosa, Maria JoseRayes, Diego HernánC. ELEGANSMGL-2NUTRITIONNEURAL CIRCUIThttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The ability to perceive nutritional status is crucial for modulating animal behavior. In this study, we explore the mechanisms by which C. elegans senses its nutritional state. We discovered that mutants in mgl-2, the C. elegans ortholog of mammalian metabotropic glutamate receptors (mGluRs), exhibit hyperphagia and a pronounced reduction in locomotion when exposed to food. While these behaviors are typical of starved animals, these mutants display them even without prior food deprivation. This hyperphagic behavior leads to increased lipid accumulation, indicating that MGL-2 is essential for the perception of satiety in these animals. In starved wild-type animals, encountering food triggers an exacerbated release of serotonin, which allows the animal to increase its feeding rate and slow down locomotion to restore its nutritional status. Through genetic experiments and in vivo neuronal activity measurements, we determined that MGL-2-mediated nutritional state perception is necessary to temper serotonergic signaling in fed animals. We are currently working to identify the specific neurons where MGL-2 exerts these effects. We propose that MGL-2 serves as a key modulator within neural circuits that control appetite and energy homeostasis. Notably, mammalian mGluRs have recently been implicated in hunger and satiety perception. Given the conservation of fundamental processes across the animal kingdom, our study provides potentially universal insights into feeding behaviors.Fil: Lacour, Ailin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Blanco, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaXXXIX Annual MeetingBuenos AiresArgentinaSociedad Argentina de Investigación en NeurocienciasSociedad Argentina de Investigación en Neurociencias2024info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/278847The Metabotropic Glutamate Receptor MGL-2 Modulates Satiety and Serotonergic Signaling in C. elegans; XXXIX Annual Meeting; Buenos Aires; Argentina; 2024; 333-333CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://csan2024.saneurociencias.org.ar/ebook-san2024/Nacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-02-26T10:07:02Zoai:ri.conicet.gov.ar:11336/278847instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-02-26 10:07:02.508CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The Metabotropic Glutamate Receptor MGL-2 Modulates Satiety and Serotonergic Signaling in C. elegans
title The Metabotropic Glutamate Receptor MGL-2 Modulates Satiety and Serotonergic Signaling in C. elegans
spellingShingle The Metabotropic Glutamate Receptor MGL-2 Modulates Satiety and Serotonergic Signaling in C. elegans
Lacour, Ailin
C. ELEGANS
MGL-2
NUTRITION
NEURAL CIRCUIT
title_short The Metabotropic Glutamate Receptor MGL-2 Modulates Satiety and Serotonergic Signaling in C. elegans
title_full The Metabotropic Glutamate Receptor MGL-2 Modulates Satiety and Serotonergic Signaling in C. elegans
title_fullStr The Metabotropic Glutamate Receptor MGL-2 Modulates Satiety and Serotonergic Signaling in C. elegans
title_full_unstemmed The Metabotropic Glutamate Receptor MGL-2 Modulates Satiety and Serotonergic Signaling in C. elegans
title_sort The Metabotropic Glutamate Receptor MGL-2 Modulates Satiety and Serotonergic Signaling in C. elegans
dc.creator.none.fl_str_mv Lacour, Ailin
Blanco, Maria Gabriela
de Rosa, Maria Jose
Rayes, Diego Hernán
author Lacour, Ailin
author_facet Lacour, Ailin
Blanco, Maria Gabriela
de Rosa, Maria Jose
Rayes, Diego Hernán
author_role author
author2 Blanco, Maria Gabriela
de Rosa, Maria Jose
Rayes, Diego Hernán
author2_role author
author
author
dc.subject.none.fl_str_mv C. ELEGANS
MGL-2
NUTRITION
NEURAL CIRCUIT
topic C. ELEGANS
MGL-2
NUTRITION
NEURAL CIRCUIT
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The ability to perceive nutritional status is crucial for modulating animal behavior. In this study, we explore the mechanisms by which C. elegans senses its nutritional state. We discovered that mutants in mgl-2, the C. elegans ortholog of mammalian metabotropic glutamate receptors (mGluRs), exhibit hyperphagia and a pronounced reduction in locomotion when exposed to food. While these behaviors are typical of starved animals, these mutants display them even without prior food deprivation. This hyperphagic behavior leads to increased lipid accumulation, indicating that MGL-2 is essential for the perception of satiety in these animals. In starved wild-type animals, encountering food triggers an exacerbated release of serotonin, which allows the animal to increase its feeding rate and slow down locomotion to restore its nutritional status. Through genetic experiments and in vivo neuronal activity measurements, we determined that MGL-2-mediated nutritional state perception is necessary to temper serotonergic signaling in fed animals. We are currently working to identify the specific neurons where MGL-2 exerts these effects. We propose that MGL-2 serves as a key modulator within neural circuits that control appetite and energy homeostasis. Notably, mammalian mGluRs have recently been implicated in hunger and satiety perception. Given the conservation of fundamental processes across the animal kingdom, our study provides potentially universal insights into feeding behaviors.
Fil: Lacour, Ailin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Blanco, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
XXXIX Annual Meeting
Buenos Aires
Argentina
Sociedad Argentina de Investigación en Neurociencias
description The ability to perceive nutritional status is crucial for modulating animal behavior. In this study, we explore the mechanisms by which C. elegans senses its nutritional state. We discovered that mutants in mgl-2, the C. elegans ortholog of mammalian metabotropic glutamate receptors (mGluRs), exhibit hyperphagia and a pronounced reduction in locomotion when exposed to food. While these behaviors are typical of starved animals, these mutants display them even without prior food deprivation. This hyperphagic behavior leads to increased lipid accumulation, indicating that MGL-2 is essential for the perception of satiety in these animals. In starved wild-type animals, encountering food triggers an exacerbated release of serotonin, which allows the animal to increase its feeding rate and slow down locomotion to restore its nutritional status. Through genetic experiments and in vivo neuronal activity measurements, we determined that MGL-2-mediated nutritional state perception is necessary to temper serotonergic signaling in fed animals. We are currently working to identify the specific neurons where MGL-2 exerts these effects. We propose that MGL-2 serves as a key modulator within neural circuits that control appetite and energy homeostasis. Notably, mammalian mGluRs have recently been implicated in hunger and satiety perception. Given the conservation of fundamental processes across the animal kingdom, our study provides potentially universal insights into feeding behaviors.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Reunión
Book
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/278847
The Metabotropic Glutamate Receptor MGL-2 Modulates Satiety and Serotonergic Signaling in C. elegans; XXXIX Annual Meeting; Buenos Aires; Argentina; 2024; 333-333
CONICET Digital
CONICET
url http://hdl.handle.net/11336/278847
identifier_str_mv The Metabotropic Glutamate Receptor MGL-2 Modulates Satiety and Serotonergic Signaling in C. elegans; XXXIX Annual Meeting; Buenos Aires; Argentina; 2024; 333-333
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://csan2024.saneurociencias.org.ar/ebook-san2024/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.coverage.none.fl_str_mv Nacional
dc.publisher.none.fl_str_mv Sociedad Argentina de Investigación en Neurociencias
publisher.none.fl_str_mv Sociedad Argentina de Investigación en Neurociencias
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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