Correlation between salivary and serum markers of bone turnover in osteopenic rats

Autores
Pellegrini, Gretel Gisela; Gonzales Chaves, Macarena Maria Sol; Somoza, Julia Isabel; Friedman, Silvia María; Zeni, Susana Noemi
Año de publicación
2008
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Previously, we measured bone alkaline phosphatase (b-ALP) and terminal C-telopeptide of collagen type I (CTX) in saliva. The present longitudinal experimental study sought to determine whether salivary concentrations of b-ALP and CTX have the same response as in serum samples under different conditions: normal, increased, and reduced bone remodeling. Methods: Thirty rats were ovariectomized (OVX) to induce osteopenia 60 days after surgery, and 10 rats were sham operated. Then, the rats were divided into four groups and treated as follows for 45 days: group 1 (G1) = SHAM + vehicle; group 2 (G2) = OVX + 8 μg olpadronate (OPD)/100 g of body weight; group 3 (G3) = OVX + 4 μg OPD/100 g of body weight; and group 4 (G4) = OVX + vehicle. Saliva and serum CTX and b-ALP were determined at 60 days (baseline) and at 75 days (T75). Lumbar spine and proximal tibia bone mineral density (BMD) was determined using dual-energy x-ray absorptiometry at baseline and at 105 days. Results: SHAM baseline and T75 salivary b-ALP and CTX levels correlated with serum concentrations (P <0.01 and P <0.004, respectively). A correlation was observed between saliva and serum concentrations of b-ALP and CTX in OVX at baseline (P<0.0001 and P<0.004, respectively). Baseline salivary b-ALP and CTX levels were lower in SHAM animals compared to OVX groups (P<0.01). After treatment, T75 saliva and serum CTX remained higher in G4 compared to G1 (P<0.05), was lower in G2 than in G1 (P<0.01) and G3 (P<0.01), and was similar in G1 and G3. Changes in BMD were the result of variations in salivary CTX levels due to OPD treatment (P<0.05). Conclusions: Saliva determinations may prove to be practical and reliable for the detection of systemic signs of increased bone remodeling, particularly in cases involving pediatric, obese, and elderly patients, and in screening large populations. Moreover, saliva CTX may be one of the best candidate markers to detect the activity and severity of periodontal disease.
Fil: Pellegrini, Gretel Gisela. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina
Fil: Gonzales Chaves, Macarena Maria Sol. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Somoza, Julia Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Friedman, Silvia María. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Zeni, Susana Noemi. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina
Materia
BISPHOSPHONATES
BONE REMODELING
OSTEOPENIA
PERIODONTITIS
RATS
SALIVA/ANALYSIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/116313
Acceder
id CONICETDig_b79a5a182dbb877b643919c78fd97d39
oai_identifier_str oai:ri.conicet.gov.ar:11336/116313
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Correlation between salivary and serum markers of bone turnover in osteopenic ratsPellegrini, Gretel GiselaGonzales Chaves, Macarena Maria SolSomoza, Julia IsabelFriedman, Silvia MaríaZeni, Susana NoemiBISPHOSPHONATESBONE REMODELINGOSTEOPENIAPERIODONTITISRATSSALIVA/ANALYSIShttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3Background: Previously, we measured bone alkaline phosphatase (b-ALP) and terminal C-telopeptide of collagen type I (CTX) in saliva. The present longitudinal experimental study sought to determine whether salivary concentrations of b-ALP and CTX have the same response as in serum samples under different conditions: normal, increased, and reduced bone remodeling. Methods: Thirty rats were ovariectomized (OVX) to induce osteopenia 60 days after surgery, and 10 rats were sham operated. Then, the rats were divided into four groups and treated as follows for 45 days: group 1 (G1) = SHAM + vehicle; group 2 (G2) = OVX + 8 μg olpadronate (OPD)/100 g of body weight; group 3 (G3) = OVX + 4 μg OPD/100 g of body weight; and group 4 (G4) = OVX + vehicle. Saliva and serum CTX and b-ALP were determined at 60 days (baseline) and at 75 days (T75). Lumbar spine and proximal tibia bone mineral density (BMD) was determined using dual-energy x-ray absorptiometry at baseline and at 105 days. Results: SHAM baseline and T75 salivary b-ALP and CTX levels correlated with serum concentrations (P <0.01 and P <0.004, respectively). A correlation was observed between saliva and serum concentrations of b-ALP and CTX in OVX at baseline (P<0.0001 and P<0.004, respectively). Baseline salivary b-ALP and CTX levels were lower in SHAM animals compared to OVX groups (P<0.01). After treatment, T75 saliva and serum CTX remained higher in G4 compared to G1 (P<0.05), was lower in G2 than in G1 (P<0.01) and G3 (P<0.01), and was similar in G1 and G3. Changes in BMD were the result of variations in salivary CTX levels due to OPD treatment (P<0.05). Conclusions: Saliva determinations may prove to be practical and reliable for the detection of systemic signs of increased bone remodeling, particularly in cases involving pediatric, obese, and elderly patients, and in screening large populations. Moreover, saliva CTX may be one of the best candidate markers to detect the activity and severity of periodontal disease.Fil: Pellegrini, Gretel Gisela. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; ArgentinaFil: Gonzales Chaves, Macarena Maria Sol. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Odontología; ArgentinaFil: Somoza, Julia Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Friedman, Silvia María. Universidad de Buenos Aires. Facultad de Odontología; ArgentinaFil: Zeni, Susana Noemi. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; ArgentinaAmerican Academy of Periodontology2008-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/116313Pellegrini, Gretel Gisela; Gonzales Chaves, Macarena Maria Sol; Somoza, Julia Isabel; Friedman, Silvia María; Zeni, Susana Noemi; Correlation between salivary and serum markers of bone turnover in osteopenic rats; American Academy of Periodontology; Journal of Periodontology; 79; 1; 1-2008; 158-1650022-3492CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://aap.onlinelibrary.wiley.com/doi/abs/10.1902/jop.2008.070168info:eu-repo/semantics/altIdentifier/doi/10.1902/jop.2008.070168info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:57:19Zoai:ri.conicet.gov.ar:11336/116313instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:57:19.277CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Correlation between salivary and serum markers of bone turnover in osteopenic rats
title Correlation between salivary and serum markers of bone turnover in osteopenic rats
spellingShingle Correlation between salivary and serum markers of bone turnover in osteopenic rats
Pellegrini, Gretel Gisela
BISPHOSPHONATES
BONE REMODELING
OSTEOPENIA
PERIODONTITIS
RATS
SALIVA/ANALYSIS
title_short Correlation between salivary and serum markers of bone turnover in osteopenic rats
title_full Correlation between salivary and serum markers of bone turnover in osteopenic rats
title_fullStr Correlation between salivary and serum markers of bone turnover in osteopenic rats
title_full_unstemmed Correlation between salivary and serum markers of bone turnover in osteopenic rats
title_sort Correlation between salivary and serum markers of bone turnover in osteopenic rats
dc.creator.none.fl_str_mv Pellegrini, Gretel Gisela
Gonzales Chaves, Macarena Maria Sol
Somoza, Julia Isabel
Friedman, Silvia María
Zeni, Susana Noemi
author Pellegrini, Gretel Gisela
author_facet Pellegrini, Gretel Gisela
Gonzales Chaves, Macarena Maria Sol
Somoza, Julia Isabel
Friedman, Silvia María
Zeni, Susana Noemi
author_role author
author2 Gonzales Chaves, Macarena Maria Sol
Somoza, Julia Isabel
Friedman, Silvia María
Zeni, Susana Noemi
author2_role author
author
author
author
dc.subject.none.fl_str_mv BISPHOSPHONATES
BONE REMODELING
OSTEOPENIA
PERIODONTITIS
RATS
SALIVA/ANALYSIS
topic BISPHOSPHONATES
BONE REMODELING
OSTEOPENIA
PERIODONTITIS
RATS
SALIVA/ANALYSIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: Previously, we measured bone alkaline phosphatase (b-ALP) and terminal C-telopeptide of collagen type I (CTX) in saliva. The present longitudinal experimental study sought to determine whether salivary concentrations of b-ALP and CTX have the same response as in serum samples under different conditions: normal, increased, and reduced bone remodeling. Methods: Thirty rats were ovariectomized (OVX) to induce osteopenia 60 days after surgery, and 10 rats were sham operated. Then, the rats were divided into four groups and treated as follows for 45 days: group 1 (G1) = SHAM + vehicle; group 2 (G2) = OVX + 8 μg olpadronate (OPD)/100 g of body weight; group 3 (G3) = OVX + 4 μg OPD/100 g of body weight; and group 4 (G4) = OVX + vehicle. Saliva and serum CTX and b-ALP were determined at 60 days (baseline) and at 75 days (T75). Lumbar spine and proximal tibia bone mineral density (BMD) was determined using dual-energy x-ray absorptiometry at baseline and at 105 days. Results: SHAM baseline and T75 salivary b-ALP and CTX levels correlated with serum concentrations (P <0.01 and P <0.004, respectively). A correlation was observed between saliva and serum concentrations of b-ALP and CTX in OVX at baseline (P<0.0001 and P<0.004, respectively). Baseline salivary b-ALP and CTX levels were lower in SHAM animals compared to OVX groups (P<0.01). After treatment, T75 saliva and serum CTX remained higher in G4 compared to G1 (P<0.05), was lower in G2 than in G1 (P<0.01) and G3 (P<0.01), and was similar in G1 and G3. Changes in BMD were the result of variations in salivary CTX levels due to OPD treatment (P<0.05). Conclusions: Saliva determinations may prove to be practical and reliable for the detection of systemic signs of increased bone remodeling, particularly in cases involving pediatric, obese, and elderly patients, and in screening large populations. Moreover, saliva CTX may be one of the best candidate markers to detect the activity and severity of periodontal disease.
Fil: Pellegrini, Gretel Gisela. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina
Fil: Gonzales Chaves, Macarena Maria Sol. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Somoza, Julia Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Friedman, Silvia María. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Zeni, Susana Noemi. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina
description Background: Previously, we measured bone alkaline phosphatase (b-ALP) and terminal C-telopeptide of collagen type I (CTX) in saliva. The present longitudinal experimental study sought to determine whether salivary concentrations of b-ALP and CTX have the same response as in serum samples under different conditions: normal, increased, and reduced bone remodeling. Methods: Thirty rats were ovariectomized (OVX) to induce osteopenia 60 days after surgery, and 10 rats were sham operated. Then, the rats were divided into four groups and treated as follows for 45 days: group 1 (G1) = SHAM + vehicle; group 2 (G2) = OVX + 8 μg olpadronate (OPD)/100 g of body weight; group 3 (G3) = OVX + 4 μg OPD/100 g of body weight; and group 4 (G4) = OVX + vehicle. Saliva and serum CTX and b-ALP were determined at 60 days (baseline) and at 75 days (T75). Lumbar spine and proximal tibia bone mineral density (BMD) was determined using dual-energy x-ray absorptiometry at baseline and at 105 days. Results: SHAM baseline and T75 salivary b-ALP and CTX levels correlated with serum concentrations (P <0.01 and P <0.004, respectively). A correlation was observed between saliva and serum concentrations of b-ALP and CTX in OVX at baseline (P<0.0001 and P<0.004, respectively). Baseline salivary b-ALP and CTX levels were lower in SHAM animals compared to OVX groups (P<0.01). After treatment, T75 saliva and serum CTX remained higher in G4 compared to G1 (P<0.05), was lower in G2 than in G1 (P<0.01) and G3 (P<0.01), and was similar in G1 and G3. Changes in BMD were the result of variations in salivary CTX levels due to OPD treatment (P<0.05). Conclusions: Saliva determinations may prove to be practical and reliable for the detection of systemic signs of increased bone remodeling, particularly in cases involving pediatric, obese, and elderly patients, and in screening large populations. Moreover, saliva CTX may be one of the best candidate markers to detect the activity and severity of periodontal disease.
publishDate 2008
dc.date.none.fl_str_mv 2008-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/116313
Pellegrini, Gretel Gisela; Gonzales Chaves, Macarena Maria Sol; Somoza, Julia Isabel; Friedman, Silvia María; Zeni, Susana Noemi; Correlation between salivary and serum markers of bone turnover in osteopenic rats; American Academy of Periodontology; Journal of Periodontology; 79; 1; 1-2008; 158-165
0022-3492
CONICET Digital
CONICET
url http://hdl.handle.net/11336/116313
identifier_str_mv Pellegrini, Gretel Gisela; Gonzales Chaves, Macarena Maria Sol; Somoza, Julia Isabel; Friedman, Silvia María; Zeni, Susana Noemi; Correlation between salivary and serum markers of bone turnover in osteopenic rats; American Academy of Periodontology; Journal of Periodontology; 79; 1; 1-2008; 158-165
0022-3492
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://aap.onlinelibrary.wiley.com/doi/abs/10.1902/jop.2008.070168
info:eu-repo/semantics/altIdentifier/doi/10.1902/jop.2008.070168
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Academy of Periodontology
publisher.none.fl_str_mv American Academy of Periodontology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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