Effect of melatonin on bone metabolism in ovariectomized rats

Autores
Ladizesky, Marta Graciela; Cutrera, Rodolfo Angel; Boggio, Veronica Ines; Somoza, Julia Isabel; Centrella, J. M.; Mautalen, Carlos Alfredo; Cardinali, Daniel Pedro
Año de publicación
2001
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
To asses the effect of pharmacological dose of melatonin on bone metabolism in ovariectomized rats, urinary deoxypyridinoline (a marker of bone resorption) and calcium excretion, circulating levels of calcium, phosphorus and bone alkaline phosphatase  activitity (a marker of bone formation), and bone mineral density (BMD), mineral content (BMC) and bone area (BA) of total body, were measured in adult rats for up to 60 days after surgery. Rats received melatonin in the drinkling water (25ug/ml water) or drinking water alone. Urinary deoxypyridinoline increased significantly after ovariectomy by 51% (30 days after surgery) and by 47% (60 days after surgerery). The increase in urinary deoxypyridinoline found 30 days after ovariectomy was not observedin melatonin-treated rats. Urinary calcium concentration was similar in the 4 experimental groups studied, as was the circulating calcium concentration was similar in the 4 experimental groups studied, as  was the circulating calcium concentration at every time interval examined. Fifteen days after surgery, a significant increase in serum phosphorus and bone alkaline phosphatase levels occurred in ovariectomized rats receiving melatonin as compared to their controls. Sixty days after surgery BMD, BMC and BA decreased significantly in ovariectomized rats, an effect not modified by melatonin. Serum estradiol decreased significantly by 30 days after ovariectomy to attain values close to the limit of detection of the assay by 60 days after ovariectomy. The results support the conclusion that a pharmacological amount of melatonin modifies bone remodeling after ovariectomy and that the effect may need adecuate concentrations of estradiol. Keywords: Melatonin, Bone remodeling, Bone mineral content, Ovariectomy, Estradiol.
Fil: Ladizesky, Marta Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Cutrera, Rodolfo Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Boggio, Veronica Ines. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Somoza, Julia Isabel. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina
Fil: Centrella, J. M.. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Mautalen, Carlos Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Cardinali, Daniel Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
Materia
BONE MINERAL CONTENT
BONE REMODELING
ESTRADIOL
MELATONIN
OVARIECTOMY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/123807
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/123807
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Effect of melatonin on bone metabolism in ovariectomized ratsLadizesky, Marta GracielaCutrera, Rodolfo AngelBoggio, Veronica InesSomoza, Julia IsabelCentrella, J. M.Mautalen, Carlos AlfredoCardinali, Daniel PedroBONE MINERAL CONTENTBONE REMODELINGESTRADIOLMELATONINOVARIECTOMYhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3To asses the effect of pharmacological dose of melatonin on bone metabolism in ovariectomized rats, urinary deoxypyridinoline (a marker of bone resorption) and calcium excretion, circulating levels of calcium, phosphorus and bone alkaline phosphatase  activitity (a marker of bone formation), and bone mineral density (BMD), mineral content (BMC) and bone area (BA) of total body, were measured in adult rats for up to 60 days after surgery. Rats received melatonin in the drinkling water (25ug/ml water) or drinking water alone. Urinary deoxypyridinoline increased significantly after ovariectomy by 51% (30 days after surgery) and by 47% (60 days after surgerery). The increase in urinary deoxypyridinoline found 30 days after ovariectomy was not observedin melatonin-treated rats. Urinary calcium concentration was similar in the 4 experimental groups studied, as was the circulating calcium concentration was similar in the 4 experimental groups studied, as  was the circulating calcium concentration at every time interval examined. Fifteen days after surgery, a significant increase in serum phosphorus and bone alkaline phosphatase levels occurred in ovariectomized rats receiving melatonin as compared to their controls. Sixty days after surgery BMD, BMC and BA decreased significantly in ovariectomized rats, an effect not modified by melatonin. Serum estradiol decreased significantly by 30 days after ovariectomy to attain values close to the limit of detection of the assay by 60 days after ovariectomy. The results support the conclusion that a pharmacological amount of melatonin modifies bone remodeling after ovariectomy and that the effect may need adecuate concentrations of estradiol. Keywords: Melatonin, Bone remodeling, Bone mineral content, Ovariectomy, Estradiol.Fil: Ladizesky, Marta Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Cutrera, Rodolfo Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Boggio, Veronica Ines. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Somoza, Julia Isabel. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; ArgentinaFil: Centrella, J. M.. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Mautalen, Carlos Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Cardinali, Daniel Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; ArgentinaPergamon-Elsevier Science Ltd2001-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/123807Ladizesky, Marta Graciela; Cutrera, Rodolfo Angel; Boggio, Veronica Ines; Somoza, Julia Isabel; Centrella, J. M.; et al.; Effect of melatonin on bone metabolism in ovariectomized rats; Pergamon-Elsevier Science Ltd; Life Sciences; 70; 5; 7-2001; 557-5650024-3205CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/s0024-3205(01)01431-xinfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S002432050101431Xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:02:03Zoai:ri.conicet.gov.ar:11336/123807instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:02:03.778CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effect of melatonin on bone metabolism in ovariectomized rats
title Effect of melatonin on bone metabolism in ovariectomized rats
spellingShingle Effect of melatonin on bone metabolism in ovariectomized rats
Ladizesky, Marta Graciela
BONE MINERAL CONTENT
BONE REMODELING
ESTRADIOL
MELATONIN
OVARIECTOMY
title_short Effect of melatonin on bone metabolism in ovariectomized rats
title_full Effect of melatonin on bone metabolism in ovariectomized rats
title_fullStr Effect of melatonin on bone metabolism in ovariectomized rats
title_full_unstemmed Effect of melatonin on bone metabolism in ovariectomized rats
title_sort Effect of melatonin on bone metabolism in ovariectomized rats
dc.creator.none.fl_str_mv Ladizesky, Marta Graciela
Cutrera, Rodolfo Angel
Boggio, Veronica Ines
Somoza, Julia Isabel
Centrella, J. M.
Mautalen, Carlos Alfredo
Cardinali, Daniel Pedro
author Ladizesky, Marta Graciela
author_facet Ladizesky, Marta Graciela
Cutrera, Rodolfo Angel
Boggio, Veronica Ines
Somoza, Julia Isabel
Centrella, J. M.
Mautalen, Carlos Alfredo
Cardinali, Daniel Pedro
author_role author
author2 Cutrera, Rodolfo Angel
Boggio, Veronica Ines
Somoza, Julia Isabel
Centrella, J. M.
Mautalen, Carlos Alfredo
Cardinali, Daniel Pedro
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv BONE MINERAL CONTENT
BONE REMODELING
ESTRADIOL
MELATONIN
OVARIECTOMY
topic BONE MINERAL CONTENT
BONE REMODELING
ESTRADIOL
MELATONIN
OVARIECTOMY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv To asses the effect of pharmacological dose of melatonin on bone metabolism in ovariectomized rats, urinary deoxypyridinoline (a marker of bone resorption) and calcium excretion, circulating levels of calcium, phosphorus and bone alkaline phosphatase  activitity (a marker of bone formation), and bone mineral density (BMD), mineral content (BMC) and bone area (BA) of total body, were measured in adult rats for up to 60 days after surgery. Rats received melatonin in the drinkling water (25ug/ml water) or drinking water alone. Urinary deoxypyridinoline increased significantly after ovariectomy by 51% (30 days after surgery) and by 47% (60 days after surgerery). The increase in urinary deoxypyridinoline found 30 days after ovariectomy was not observedin melatonin-treated rats. Urinary calcium concentration was similar in the 4 experimental groups studied, as was the circulating calcium concentration was similar in the 4 experimental groups studied, as  was the circulating calcium concentration at every time interval examined. Fifteen days after surgery, a significant increase in serum phosphorus and bone alkaline phosphatase levels occurred in ovariectomized rats receiving melatonin as compared to their controls. Sixty days after surgery BMD, BMC and BA decreased significantly in ovariectomized rats, an effect not modified by melatonin. Serum estradiol decreased significantly by 30 days after ovariectomy to attain values close to the limit of detection of the assay by 60 days after ovariectomy. The results support the conclusion that a pharmacological amount of melatonin modifies bone remodeling after ovariectomy and that the effect may need adecuate concentrations of estradiol. Keywords: Melatonin, Bone remodeling, Bone mineral content, Ovariectomy, Estradiol.
Fil: Ladizesky, Marta Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Cutrera, Rodolfo Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Boggio, Veronica Ines. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Somoza, Julia Isabel. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina
Fil: Centrella, J. M.. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Mautalen, Carlos Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Cardinali, Daniel Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
description To asses the effect of pharmacological dose of melatonin on bone metabolism in ovariectomized rats, urinary deoxypyridinoline (a marker of bone resorption) and calcium excretion, circulating levels of calcium, phosphorus and bone alkaline phosphatase  activitity (a marker of bone formation), and bone mineral density (BMD), mineral content (BMC) and bone area (BA) of total body, were measured in adult rats for up to 60 days after surgery. Rats received melatonin in the drinkling water (25ug/ml water) or drinking water alone. Urinary deoxypyridinoline increased significantly after ovariectomy by 51% (30 days after surgery) and by 47% (60 days after surgerery). The increase in urinary deoxypyridinoline found 30 days after ovariectomy was not observedin melatonin-treated rats. Urinary calcium concentration was similar in the 4 experimental groups studied, as was the circulating calcium concentration was similar in the 4 experimental groups studied, as  was the circulating calcium concentration at every time interval examined. Fifteen days after surgery, a significant increase in serum phosphorus and bone alkaline phosphatase levels occurred in ovariectomized rats receiving melatonin as compared to their controls. Sixty days after surgery BMD, BMC and BA decreased significantly in ovariectomized rats, an effect not modified by melatonin. Serum estradiol decreased significantly by 30 days after ovariectomy to attain values close to the limit of detection of the assay by 60 days after ovariectomy. The results support the conclusion that a pharmacological amount of melatonin modifies bone remodeling after ovariectomy and that the effect may need adecuate concentrations of estradiol. Keywords: Melatonin, Bone remodeling, Bone mineral content, Ovariectomy, Estradiol.
publishDate 2001
dc.date.none.fl_str_mv 2001-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/123807
Ladizesky, Marta Graciela; Cutrera, Rodolfo Angel; Boggio, Veronica Ines; Somoza, Julia Isabel; Centrella, J. M.; et al.; Effect of melatonin on bone metabolism in ovariectomized rats; Pergamon-Elsevier Science Ltd; Life Sciences; 70; 5; 7-2001; 557-565
0024-3205
CONICET Digital
CONICET
url http://hdl.handle.net/11336/123807
identifier_str_mv Ladizesky, Marta Graciela; Cutrera, Rodolfo Angel; Boggio, Veronica Ines; Somoza, Julia Isabel; Centrella, J. M.; et al.; Effect of melatonin on bone metabolism in ovariectomized rats; Pergamon-Elsevier Science Ltd; Life Sciences; 70; 5; 7-2001; 557-565
0024-3205
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/s0024-3205(01)01431-x
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S002432050101431X
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.069144

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