Effect of melatonin on bone metabolism in ovariectomized rats
- Autores
- Ladizesky, Marta Graciela; Cutrera, Rodolfo Angel; Boggio, Veronica Ines; Somoza, Julia Isabel; Centrella, J. M.; Mautalen, Carlos Alfredo; Cardinali, Daniel Pedro
- Año de publicación
- 2001
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- To asses the effect of pharmacological dose of melatonin on bone metabolism in ovariectomized rats, urinary deoxypyridinoline (a marker of bone resorption) and calcium excretion, circulating levels of calcium, phosphorus and bone alkaline phosphatase activitity (a marker of bone formation), and bone mineral density (BMD), mineral content (BMC) and bone area (BA) of total body, were measured in adult rats for up to 60 days after surgery. Rats received melatonin in the drinkling water (25ug/ml water) or drinking water alone. Urinary deoxypyridinoline increased significantly after ovariectomy by 51% (30 days after surgery) and by 47% (60 days after surgerery). The increase in urinary deoxypyridinoline found 30 days after ovariectomy was not observedin melatonin-treated rats. Urinary calcium concentration was similar in the 4 experimental groups studied, as was the circulating calcium concentration was similar in the 4 experimental groups studied, as was the circulating calcium concentration at every time interval examined. Fifteen days after surgery, a significant increase in serum phosphorus and bone alkaline phosphatase levels occurred in ovariectomized rats receiving melatonin as compared to their controls. Sixty days after surgery BMD, BMC and BA decreased significantly in ovariectomized rats, an effect not modified by melatonin. Serum estradiol decreased significantly by 30 days after ovariectomy to attain values close to the limit of detection of the assay by 60 days after ovariectomy. The results support the conclusion that a pharmacological amount of melatonin modifies bone remodeling after ovariectomy and that the effect may need adecuate concentrations of estradiol. Keywords: Melatonin, Bone remodeling, Bone mineral content, Ovariectomy, Estradiol.
Fil: Ladizesky, Marta Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Cutrera, Rodolfo Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Boggio, Veronica Ines. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Somoza, Julia Isabel. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina
Fil: Centrella, J. M.. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Mautalen, Carlos Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Cardinali, Daniel Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina - Materia
-
BONE MINERAL CONTENT
BONE REMODELING
ESTRADIOL
MELATONIN
OVARIECTOMY - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/123807
Ver los metadatos del registro completo
id |
CONICETDig_4fedf3a811f7af68692dd0ce47d3914d |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/123807 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Effect of melatonin on bone metabolism in ovariectomized ratsLadizesky, Marta GracielaCutrera, Rodolfo AngelBoggio, Veronica InesSomoza, Julia IsabelCentrella, J. M.Mautalen, Carlos AlfredoCardinali, Daniel PedroBONE MINERAL CONTENTBONE REMODELINGESTRADIOLMELATONINOVARIECTOMYhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3To asses the effect of pharmacological dose of melatonin on bone metabolism in ovariectomized rats, urinary deoxypyridinoline (a marker of bone resorption) and calcium excretion, circulating levels of calcium, phosphorus and bone alkaline phosphatase activitity (a marker of bone formation), and bone mineral density (BMD), mineral content (BMC) and bone area (BA) of total body, were measured in adult rats for up to 60 days after surgery. Rats received melatonin in the drinkling water (25ug/ml water) or drinking water alone. Urinary deoxypyridinoline increased significantly after ovariectomy by 51% (30 days after surgery) and by 47% (60 days after surgerery). The increase in urinary deoxypyridinoline found 30 days after ovariectomy was not observedin melatonin-treated rats. Urinary calcium concentration was similar in the 4 experimental groups studied, as was the circulating calcium concentration was similar in the 4 experimental groups studied, as was the circulating calcium concentration at every time interval examined. Fifteen days after surgery, a significant increase in serum phosphorus and bone alkaline phosphatase levels occurred in ovariectomized rats receiving melatonin as compared to their controls. Sixty days after surgery BMD, BMC and BA decreased significantly in ovariectomized rats, an effect not modified by melatonin. Serum estradiol decreased significantly by 30 days after ovariectomy to attain values close to the limit of detection of the assay by 60 days after ovariectomy. The results support the conclusion that a pharmacological amount of melatonin modifies bone remodeling after ovariectomy and that the effect may need adecuate concentrations of estradiol. Keywords: Melatonin, Bone remodeling, Bone mineral content, Ovariectomy, Estradiol.Fil: Ladizesky, Marta Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Cutrera, Rodolfo Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Boggio, Veronica Ines. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Somoza, Julia Isabel. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; ArgentinaFil: Centrella, J. M.. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Mautalen, Carlos Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Cardinali, Daniel Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; ArgentinaPergamon-Elsevier Science Ltd2001-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/123807Ladizesky, Marta Graciela; Cutrera, Rodolfo Angel; Boggio, Veronica Ines; Somoza, Julia Isabel; Centrella, J. M.; et al.; Effect of melatonin on bone metabolism in ovariectomized rats; Pergamon-Elsevier Science Ltd; Life Sciences; 70; 5; 7-2001; 557-5650024-3205CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/s0024-3205(01)01431-xinfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S002432050101431Xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:56:58Zoai:ri.conicet.gov.ar:11336/123807instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:56:58.94CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Effect of melatonin on bone metabolism in ovariectomized rats |
title |
Effect of melatonin on bone metabolism in ovariectomized rats |
spellingShingle |
Effect of melatonin on bone metabolism in ovariectomized rats Ladizesky, Marta Graciela BONE MINERAL CONTENT BONE REMODELING ESTRADIOL MELATONIN OVARIECTOMY |
title_short |
Effect of melatonin on bone metabolism in ovariectomized rats |
title_full |
Effect of melatonin on bone metabolism in ovariectomized rats |
title_fullStr |
Effect of melatonin on bone metabolism in ovariectomized rats |
title_full_unstemmed |
Effect of melatonin on bone metabolism in ovariectomized rats |
title_sort |
Effect of melatonin on bone metabolism in ovariectomized rats |
dc.creator.none.fl_str_mv |
Ladizesky, Marta Graciela Cutrera, Rodolfo Angel Boggio, Veronica Ines Somoza, Julia Isabel Centrella, J. M. Mautalen, Carlos Alfredo Cardinali, Daniel Pedro |
author |
Ladizesky, Marta Graciela |
author_facet |
Ladizesky, Marta Graciela Cutrera, Rodolfo Angel Boggio, Veronica Ines Somoza, Julia Isabel Centrella, J. M. Mautalen, Carlos Alfredo Cardinali, Daniel Pedro |
author_role |
author |
author2 |
Cutrera, Rodolfo Angel Boggio, Veronica Ines Somoza, Julia Isabel Centrella, J. M. Mautalen, Carlos Alfredo Cardinali, Daniel Pedro |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
BONE MINERAL CONTENT BONE REMODELING ESTRADIOL MELATONIN OVARIECTOMY |
topic |
BONE MINERAL CONTENT BONE REMODELING ESTRADIOL MELATONIN OVARIECTOMY |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
To asses the effect of pharmacological dose of melatonin on bone metabolism in ovariectomized rats, urinary deoxypyridinoline (a marker of bone resorption) and calcium excretion, circulating levels of calcium, phosphorus and bone alkaline phosphatase activitity (a marker of bone formation), and bone mineral density (BMD), mineral content (BMC) and bone area (BA) of total body, were measured in adult rats for up to 60 days after surgery. Rats received melatonin in the drinkling water (25ug/ml water) or drinking water alone. Urinary deoxypyridinoline increased significantly after ovariectomy by 51% (30 days after surgery) and by 47% (60 days after surgerery). The increase in urinary deoxypyridinoline found 30 days after ovariectomy was not observedin melatonin-treated rats. Urinary calcium concentration was similar in the 4 experimental groups studied, as was the circulating calcium concentration was similar in the 4 experimental groups studied, as was the circulating calcium concentration at every time interval examined. Fifteen days after surgery, a significant increase in serum phosphorus and bone alkaline phosphatase levels occurred in ovariectomized rats receiving melatonin as compared to their controls. Sixty days after surgery BMD, BMC and BA decreased significantly in ovariectomized rats, an effect not modified by melatonin. Serum estradiol decreased significantly by 30 days after ovariectomy to attain values close to the limit of detection of the assay by 60 days after ovariectomy. The results support the conclusion that a pharmacological amount of melatonin modifies bone remodeling after ovariectomy and that the effect may need adecuate concentrations of estradiol. Keywords: Melatonin, Bone remodeling, Bone mineral content, Ovariectomy, Estradiol. Fil: Ladizesky, Marta Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina Fil: Cutrera, Rodolfo Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina Fil: Boggio, Veronica Ines. Universidad de Buenos Aires. Facultad de Medicina; Argentina Fil: Somoza, Julia Isabel. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina Fil: Centrella, J. M.. Universidad de Buenos Aires. Facultad de Medicina; Argentina Fil: Mautalen, Carlos Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina Fil: Cardinali, Daniel Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina |
description |
To asses the effect of pharmacological dose of melatonin on bone metabolism in ovariectomized rats, urinary deoxypyridinoline (a marker of bone resorption) and calcium excretion, circulating levels of calcium, phosphorus and bone alkaline phosphatase activitity (a marker of bone formation), and bone mineral density (BMD), mineral content (BMC) and bone area (BA) of total body, were measured in adult rats for up to 60 days after surgery. Rats received melatonin in the drinkling water (25ug/ml water) or drinking water alone. Urinary deoxypyridinoline increased significantly after ovariectomy by 51% (30 days after surgery) and by 47% (60 days after surgerery). The increase in urinary deoxypyridinoline found 30 days after ovariectomy was not observedin melatonin-treated rats. Urinary calcium concentration was similar in the 4 experimental groups studied, as was the circulating calcium concentration was similar in the 4 experimental groups studied, as was the circulating calcium concentration at every time interval examined. Fifteen days after surgery, a significant increase in serum phosphorus and bone alkaline phosphatase levels occurred in ovariectomized rats receiving melatonin as compared to their controls. Sixty days after surgery BMD, BMC and BA decreased significantly in ovariectomized rats, an effect not modified by melatonin. Serum estradiol decreased significantly by 30 days after ovariectomy to attain values close to the limit of detection of the assay by 60 days after ovariectomy. The results support the conclusion that a pharmacological amount of melatonin modifies bone remodeling after ovariectomy and that the effect may need adecuate concentrations of estradiol. Keywords: Melatonin, Bone remodeling, Bone mineral content, Ovariectomy, Estradiol. |
publishDate |
2001 |
dc.date.none.fl_str_mv |
2001-07 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/123807 Ladizesky, Marta Graciela; Cutrera, Rodolfo Angel; Boggio, Veronica Ines; Somoza, Julia Isabel; Centrella, J. M.; et al.; Effect of melatonin on bone metabolism in ovariectomized rats; Pergamon-Elsevier Science Ltd; Life Sciences; 70; 5; 7-2001; 557-565 0024-3205 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/123807 |
identifier_str_mv |
Ladizesky, Marta Graciela; Cutrera, Rodolfo Angel; Boggio, Veronica Ines; Somoza, Julia Isabel; Centrella, J. M.; et al.; Effect of melatonin on bone metabolism in ovariectomized rats; Pergamon-Elsevier Science Ltd; Life Sciences; 70; 5; 7-2001; 557-565 0024-3205 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1016/s0024-3205(01)01431-x info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S002432050101431X |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Pergamon-Elsevier Science Ltd |
publisher.none.fl_str_mv |
Pergamon-Elsevier Science Ltd |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1842269431976165376 |
score |
13.13397 |