A controlled trial comparing one-year biochemical bone metabolism outcome in postmenopausal frail osteopenic women under weekly alendronate treatment, with or without whole-body vi...

Autores
Capiglioni, Ricardo; Gómez Acotto, Claudia; Marino, Alicia; Muntaabski, María Georgina; Montangero, Victor; D`Alessio, Luciana; Roldán, Emilio José Antonio
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Purpose: The influence of regular exercise on bone properties is not well defined. Frail subjects have limitations to perform exercise with skeletal impact. This study aims to analyze whole-bone vibration treatment (WBV) as an enhancer of bisphosphonate effects in postmenopausal frail women with osteopenia/osteoporosis. Methods: Fiftythree postmenopausal sedentary osteopenic women were treated during 12 months with a drinkable alendronate (ALN) formulation. By randomization, 21 of them underwent a WBV (15-min sessions, 3 days per week) as an additional treatment. The serum C-terminal telopeptide of type I collagen (CTx) and total alkaline phosphatase (TAP) were determined at 0, 6 and 12 months of ALN therapy. In subgroups of 19/13 women, peripheral quantitative computerized tomography (pQCT) was applied at the tibia mid shaft to determine the volumetric BMD of cortical bone (CtBMDv) and the polar strain-strength index (SSIp). Results: CTx levels fell significantly deeper in the WBV subgroup (-39.3% and -30.3%, respectively, p<0.01), suggesting that in these women WBV promotes a greater effect of ALN on bone resorption inhibition. Basal CtBMDv and SSIp values were similar in both groups and were weakly (negatively) associated with basal CTx values. After treatment, the correlation between CtBMDv or SSIp values with CTx values were also weak and negative in the Sedentary subgroup but become positive and closer in the WBV subgroup. Conclusions: Vibration treatment enhanced the ALN-induced inhibition of bone resorption and may affect positively bone properties. Protracted treatments should show whether this trend is maintained as to effectively reduce the incidence of falls and skeletal fractures in frail subjects.
Fil: Capiglioni, Ricardo.
Fil: Gómez Acotto, Claudia.
Fil: Marino, Alicia.
Fil: Muntaabski, María Georgina.
Fil: Montangero, Victor.
Fil: D`Alessio, Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina. Universidad de Buenos Aires; Argentina
Fil: Roldán, Emilio José Antonio.
Materia
Bone biochemical markers
Drinkable alendronate
Osteopeni
Osteoporosis
Peripheral quantitative computerized tomography
Whole-Body-Vibration
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/17822
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/17822
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A controlled trial comparing one-year biochemical bone metabolism outcome in postmenopausal frail osteopenic women under weekly alendronate treatment, with or without whole-body vibration interventionCapiglioni, RicardoGómez Acotto, ClaudiaMarino, AliciaMuntaabski, María GeorginaMontangero, VictorD`Alessio, LucianaRoldán, Emilio José AntonioBone biochemical markersDrinkable alendronateOsteopeniOsteoporosisPeripheral quantitative computerized tomographyWhole-Body-Vibrationhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Purpose: The influence of regular exercise on bone properties is not well defined. Frail subjects have limitations to perform exercise with skeletal impact. This study aims to analyze whole-bone vibration treatment (WBV) as an enhancer of bisphosphonate effects in postmenopausal frail women with osteopenia/osteoporosis. Methods: Fiftythree postmenopausal sedentary osteopenic women were treated during 12 months with a drinkable alendronate (ALN) formulation. By randomization, 21 of them underwent a WBV (15-min sessions, 3 days per week) as an additional treatment. The serum C-terminal telopeptide of type I collagen (CTx) and total alkaline phosphatase (TAP) were determined at 0, 6 and 12 months of ALN therapy. In subgroups of 19/13 women, peripheral quantitative computerized tomography (pQCT) was applied at the tibia mid shaft to determine the volumetric BMD of cortical bone (CtBMDv) and the polar strain-strength index (SSIp). Results: CTx levels fell significantly deeper in the WBV subgroup (-39.3% and -30.3%, respectively, p<0.01), suggesting that in these women WBV promotes a greater effect of ALN on bone resorption inhibition. Basal CtBMDv and SSIp values were similar in both groups and were weakly (negatively) associated with basal CTx values. After treatment, the correlation between CtBMDv or SSIp values with CTx values were also weak and negative in the Sedentary subgroup but become positive and closer in the WBV subgroup. Conclusions: Vibration treatment enhanced the ALN-induced inhibition of bone resorption and may affect positively bone properties. Protracted treatments should show whether this trend is maintained as to effectively reduce the incidence of falls and skeletal fractures in frail subjects.Fil: Capiglioni, Ricardo.Fil: Gómez Acotto, Claudia.Fil: Marino, Alicia.Fil: Muntaabski, María Georgina.Fil: Montangero, Victor.Fil: D`Alessio, Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina. Universidad de Buenos Aires; ArgentinaFil: Roldán, Emilio José Antonio.Hylonome Editions2016-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/17822Capiglioni, Ricardo; Gómez Acotto, Claudia; Marino, Alicia; Muntaabski, María Georgina; Montangero, Victor; et al.; A controlled trial comparing one-year biochemical bone metabolism outcome in postmenopausal frail osteopenic women under weekly alendronate treatment, with or without whole-body vibration intervention; Hylonome Editions; Journal of Frailty, Sarcopenia and Falls; 1; 3; 9-2016; 29-2459-4148enginfo:eu-repo/semantics/altIdentifier/url/http://www.jfsf.eu/Archive.php?year=2016info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:02:06Zoai:ri.conicet.gov.ar:11336/17822instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:02:06.583CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A controlled trial comparing one-year biochemical bone metabolism outcome in postmenopausal frail osteopenic women under weekly alendronate treatment, with or without whole-body vibration intervention
title A controlled trial comparing one-year biochemical bone metabolism outcome in postmenopausal frail osteopenic women under weekly alendronate treatment, with or without whole-body vibration intervention
spellingShingle A controlled trial comparing one-year biochemical bone metabolism outcome in postmenopausal frail osteopenic women under weekly alendronate treatment, with or without whole-body vibration intervention
Capiglioni, Ricardo
Bone biochemical markers
Drinkable alendronate
Osteopeni
Osteoporosis
Peripheral quantitative computerized tomography
Whole-Body-Vibration
title_short A controlled trial comparing one-year biochemical bone metabolism outcome in postmenopausal frail osteopenic women under weekly alendronate treatment, with or without whole-body vibration intervention
title_full A controlled trial comparing one-year biochemical bone metabolism outcome in postmenopausal frail osteopenic women under weekly alendronate treatment, with or without whole-body vibration intervention
title_fullStr A controlled trial comparing one-year biochemical bone metabolism outcome in postmenopausal frail osteopenic women under weekly alendronate treatment, with or without whole-body vibration intervention
title_full_unstemmed A controlled trial comparing one-year biochemical bone metabolism outcome in postmenopausal frail osteopenic women under weekly alendronate treatment, with or without whole-body vibration intervention
title_sort A controlled trial comparing one-year biochemical bone metabolism outcome in postmenopausal frail osteopenic women under weekly alendronate treatment, with or without whole-body vibration intervention
dc.creator.none.fl_str_mv Capiglioni, Ricardo
Gómez Acotto, Claudia
Marino, Alicia
Muntaabski, María Georgina
Montangero, Victor
D`Alessio, Luciana
Roldán, Emilio José Antonio
author Capiglioni, Ricardo
author_facet Capiglioni, Ricardo
Gómez Acotto, Claudia
Marino, Alicia
Muntaabski, María Georgina
Montangero, Victor
D`Alessio, Luciana
Roldán, Emilio José Antonio
author_role author
author2 Gómez Acotto, Claudia
Marino, Alicia
Muntaabski, María Georgina
Montangero, Victor
D`Alessio, Luciana
Roldán, Emilio José Antonio
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Bone biochemical markers
Drinkable alendronate
Osteopeni
Osteoporosis
Peripheral quantitative computerized tomography
Whole-Body-Vibration
topic Bone biochemical markers
Drinkable alendronate
Osteopeni
Osteoporosis
Peripheral quantitative computerized tomography
Whole-Body-Vibration
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Purpose: The influence of regular exercise on bone properties is not well defined. Frail subjects have limitations to perform exercise with skeletal impact. This study aims to analyze whole-bone vibration treatment (WBV) as an enhancer of bisphosphonate effects in postmenopausal frail women with osteopenia/osteoporosis. Methods: Fiftythree postmenopausal sedentary osteopenic women were treated during 12 months with a drinkable alendronate (ALN) formulation. By randomization, 21 of them underwent a WBV (15-min sessions, 3 days per week) as an additional treatment. The serum C-terminal telopeptide of type I collagen (CTx) and total alkaline phosphatase (TAP) were determined at 0, 6 and 12 months of ALN therapy. In subgroups of 19/13 women, peripheral quantitative computerized tomography (pQCT) was applied at the tibia mid shaft to determine the volumetric BMD of cortical bone (CtBMDv) and the polar strain-strength index (SSIp). Results: CTx levels fell significantly deeper in the WBV subgroup (-39.3% and -30.3%, respectively, p<0.01), suggesting that in these women WBV promotes a greater effect of ALN on bone resorption inhibition. Basal CtBMDv and SSIp values were similar in both groups and were weakly (negatively) associated with basal CTx values. After treatment, the correlation between CtBMDv or SSIp values with CTx values were also weak and negative in the Sedentary subgroup but become positive and closer in the WBV subgroup. Conclusions: Vibration treatment enhanced the ALN-induced inhibition of bone resorption and may affect positively bone properties. Protracted treatments should show whether this trend is maintained as to effectively reduce the incidence of falls and skeletal fractures in frail subjects.
Fil: Capiglioni, Ricardo.
Fil: Gómez Acotto, Claudia.
Fil: Marino, Alicia.
Fil: Muntaabski, María Georgina.
Fil: Montangero, Victor.
Fil: D`Alessio, Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina. Universidad de Buenos Aires; Argentina
Fil: Roldán, Emilio José Antonio.
description Purpose: The influence of regular exercise on bone properties is not well defined. Frail subjects have limitations to perform exercise with skeletal impact. This study aims to analyze whole-bone vibration treatment (WBV) as an enhancer of bisphosphonate effects in postmenopausal frail women with osteopenia/osteoporosis. Methods: Fiftythree postmenopausal sedentary osteopenic women were treated during 12 months with a drinkable alendronate (ALN) formulation. By randomization, 21 of them underwent a WBV (15-min sessions, 3 days per week) as an additional treatment. The serum C-terminal telopeptide of type I collagen (CTx) and total alkaline phosphatase (TAP) were determined at 0, 6 and 12 months of ALN therapy. In subgroups of 19/13 women, peripheral quantitative computerized tomography (pQCT) was applied at the tibia mid shaft to determine the volumetric BMD of cortical bone (CtBMDv) and the polar strain-strength index (SSIp). Results: CTx levels fell significantly deeper in the WBV subgroup (-39.3% and -30.3%, respectively, p<0.01), suggesting that in these women WBV promotes a greater effect of ALN on bone resorption inhibition. Basal CtBMDv and SSIp values were similar in both groups and were weakly (negatively) associated with basal CTx values. After treatment, the correlation between CtBMDv or SSIp values with CTx values were also weak and negative in the Sedentary subgroup but become positive and closer in the WBV subgroup. Conclusions: Vibration treatment enhanced the ALN-induced inhibition of bone resorption and may affect positively bone properties. Protracted treatments should show whether this trend is maintained as to effectively reduce the incidence of falls and skeletal fractures in frail subjects.
publishDate 2016
dc.date.none.fl_str_mv 2016-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/17822
Capiglioni, Ricardo; Gómez Acotto, Claudia; Marino, Alicia; Muntaabski, María Georgina; Montangero, Victor; et al.; A controlled trial comparing one-year biochemical bone metabolism outcome in postmenopausal frail osteopenic women under weekly alendronate treatment, with or without whole-body vibration intervention; Hylonome Editions; Journal of Frailty, Sarcopenia and Falls; 1; 3; 9-2016; 29-
2459-4148
url http://hdl.handle.net/11336/17822
identifier_str_mv Capiglioni, Ricardo; Gómez Acotto, Claudia; Marino, Alicia; Muntaabski, María Georgina; Montangero, Victor; et al.; A controlled trial comparing one-year biochemical bone metabolism outcome in postmenopausal frail osteopenic women under weekly alendronate treatment, with or without whole-body vibration intervention; Hylonome Editions; Journal of Frailty, Sarcopenia and Falls; 1; 3; 9-2016; 29-
2459-4148
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.jfsf.eu/Archive.php?year=2016
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Hylonome Editions
publisher.none.fl_str_mv Hylonome Editions
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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