Gender Differences in Physical, Chemical and Metabolic Factors Involved in Nephrolithiasis

Autores
Moyano, Mario Franco; Orellano, Guillermo Osvaldo; Fuentes, Lucia Beatriz
Año de publicación
2017
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Kidney stones forming require investigations to detect predisposing metabolic abnormalities. A variety of dietary and metabolic factors may contribute or cause stone formation in nephrolithiasis. Some metabolic causes are hypercalciuria, hypocitraturia, gout, hyperoxaluria, and hyperuricosuria. The aim was to investigate physical, chemical and metabolic abnormalities involved in the risk of lithogenesis in both sex. Observational and cross-sectional retrospective study was undertaken. Total metabolic variables were assessed in the data base, including serum and urine chemistries. 421 patients (20-70 years), 57.5% women (W) and 42.5% men (M), Age (years): 44.6 ± 13.8(W) 43.9 ± 13.9 (M), weight (Kg): 64.4 ± 13.1(W) 85.5 ± 14.5 (M), p< 0.0001. BMI: 24.9 ± 4.7(W) 28.2 ± 4.3 (M), p< 0.0001. Serum uric acid, creatinine, urea (mg/dl) increased significantly in M (p<0.0001) and potassium (mEq/l) p<0.01. Urinary excretion 24 h (mg/dl): phosphorus, uric acid, creatinine, magnesium, sodium (mEq/l), potassium (mM/l) increased significantly in M (p< 0.0001). Creatinine clearance: 111.0 ± 28.4 M and 88.1 ± 24.0 W, p<0.001. Calcium/creatinine: 0.20 ± 0.09 W and 0.13 ± 0.06 M, p< 0.001. Citrate/creatinine: 0.51 ± 0.37 W and 0.28 ± 0.16 M, p< 0.001. Uric acid/creatinine: 0.43 ± 0.15 W and 0.39 ± 0.11 M, p< 0.05. Significantly differences in PTH compared W to M, p< 0.001. No significant differences were found in other parameters studied. The risk of renal stone, forming and some metabolic gender differences were found. The results of these investigations can also be used to help guide therapy to prevent future stone formation.
Fil: Moyano, Mario Franco. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; Argentina
Fil: Orellano, Guillermo Osvaldo. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Fuentes, Lucia Beatriz. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
XXXV Reunión Científica Anual de la SBCuyo
San Luis, Villa de Merlo
Argentina
Sociedad de Biologia de Cuyo
Materia
Kidney
Metabolic Factors
Nephhrolithiasis
Stone Formation
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/281618
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Gender Differences in Physical, Chemical and Metabolic Factors Involved in NephrolithiasisMoyano, Mario FrancoOrellano, Guillermo OsvaldoFuentes, Lucia BeatrizKidneyMetabolic FactorsNephhrolithiasisStone Formationhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Kidney stones forming require investigations to detect predisposing metabolic abnormalities. A variety of dietary and metabolic factors may contribute or cause stone formation in nephrolithiasis. Some metabolic causes are hypercalciuria, hypocitraturia, gout, hyperoxaluria, and hyperuricosuria. The aim was to investigate physical, chemical and metabolic abnormalities involved in the risk of lithogenesis in both sex. Observational and cross-sectional retrospective study was undertaken. Total metabolic variables were assessed in the data base, including serum and urine chemistries. 421 patients (20-70 years), 57.5% women (W) and 42.5% men (M), Age (years): 44.6 ± 13.8(W) 43.9 ± 13.9 (M), weight (Kg): 64.4 ± 13.1(W) 85.5 ± 14.5 (M), p< 0.0001. BMI: 24.9 ± 4.7(W) 28.2 ± 4.3 (M), p< 0.0001. Serum uric acid, creatinine, urea (mg/dl) increased significantly in M (p<0.0001) and potassium (mEq/l) p<0.01. Urinary excretion 24 h (mg/dl): phosphorus, uric acid, creatinine, magnesium, sodium (mEq/l), potassium (mM/l) increased significantly in M (p< 0.0001). Creatinine clearance: 111.0 ± 28.4 M and 88.1 ± 24.0 W, p<0.001. Calcium/creatinine: 0.20 ± 0.09 W and 0.13 ± 0.06 M, p< 0.001. Citrate/creatinine: 0.51 ± 0.37 W and 0.28 ± 0.16 M, p< 0.001. Uric acid/creatinine: 0.43 ± 0.15 W and 0.39 ± 0.11 M, p< 0.05. Significantly differences in PTH compared W to M, p< 0.001. No significant differences were found in other parameters studied. The risk of renal stone, forming and some metabolic gender differences were found. The results of these investigations can also be used to help guide therapy to prevent future stone formation.Fil: Moyano, Mario Franco. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; ArgentinaFil: Orellano, Guillermo Osvaldo. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; ArgentinaFil: Fuentes, Lucia Beatriz. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; ArgentinaXXXV Reunión Científica Anual de la SBCuyoSan Luis, Villa de MerloArgentinaSociedad de Biologia de CuyoSociedad de Biologia de Cuyo2017info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/281618Gender Differences in Physical, Chemical and Metabolic Factors Involved in Nephrolithiasis; XXXV Reunión Científica Anual de la SBCuyo; San Luis, Villa de Merlo; Argentina; 2017; 1-41667-5746CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://sbcuyo.org.ar/reuniones-anuales-anteriores/Nacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-04-23T14:13:37Zoai:ri.conicet.gov.ar:11336/281618instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-04-23 14:13:37.532CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Gender Differences in Physical, Chemical and Metabolic Factors Involved in Nephrolithiasis
title Gender Differences in Physical, Chemical and Metabolic Factors Involved in Nephrolithiasis
spellingShingle Gender Differences in Physical, Chemical and Metabolic Factors Involved in Nephrolithiasis
Moyano, Mario Franco
Kidney
Metabolic Factors
Nephhrolithiasis
Stone Formation
title_short Gender Differences in Physical, Chemical and Metabolic Factors Involved in Nephrolithiasis
title_full Gender Differences in Physical, Chemical and Metabolic Factors Involved in Nephrolithiasis
title_fullStr Gender Differences in Physical, Chemical and Metabolic Factors Involved in Nephrolithiasis
title_full_unstemmed Gender Differences in Physical, Chemical and Metabolic Factors Involved in Nephrolithiasis
title_sort Gender Differences in Physical, Chemical and Metabolic Factors Involved in Nephrolithiasis
dc.creator.none.fl_str_mv Moyano, Mario Franco
Orellano, Guillermo Osvaldo
Fuentes, Lucia Beatriz
author Moyano, Mario Franco
author_facet Moyano, Mario Franco
Orellano, Guillermo Osvaldo
Fuentes, Lucia Beatriz
author_role author
author2 Orellano, Guillermo Osvaldo
Fuentes, Lucia Beatriz
author2_role author
author
dc.subject.none.fl_str_mv Kidney
Metabolic Factors
Nephhrolithiasis
Stone Formation
topic Kidney
Metabolic Factors
Nephhrolithiasis
Stone Formation
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Kidney stones forming require investigations to detect predisposing metabolic abnormalities. A variety of dietary and metabolic factors may contribute or cause stone formation in nephrolithiasis. Some metabolic causes are hypercalciuria, hypocitraturia, gout, hyperoxaluria, and hyperuricosuria. The aim was to investigate physical, chemical and metabolic abnormalities involved in the risk of lithogenesis in both sex. Observational and cross-sectional retrospective study was undertaken. Total metabolic variables were assessed in the data base, including serum and urine chemistries. 421 patients (20-70 years), 57.5% women (W) and 42.5% men (M), Age (years): 44.6 ± 13.8(W) 43.9 ± 13.9 (M), weight (Kg): 64.4 ± 13.1(W) 85.5 ± 14.5 (M), p< 0.0001. BMI: 24.9 ± 4.7(W) 28.2 ± 4.3 (M), p< 0.0001. Serum uric acid, creatinine, urea (mg/dl) increased significantly in M (p<0.0001) and potassium (mEq/l) p<0.01. Urinary excretion 24 h (mg/dl): phosphorus, uric acid, creatinine, magnesium, sodium (mEq/l), potassium (mM/l) increased significantly in M (p< 0.0001). Creatinine clearance: 111.0 ± 28.4 M and 88.1 ± 24.0 W, p<0.001. Calcium/creatinine: 0.20 ± 0.09 W and 0.13 ± 0.06 M, p< 0.001. Citrate/creatinine: 0.51 ± 0.37 W and 0.28 ± 0.16 M, p< 0.001. Uric acid/creatinine: 0.43 ± 0.15 W and 0.39 ± 0.11 M, p< 0.05. Significantly differences in PTH compared W to M, p< 0.001. No significant differences were found in other parameters studied. The risk of renal stone, forming and some metabolic gender differences were found. The results of these investigations can also be used to help guide therapy to prevent future stone formation.
Fil: Moyano, Mario Franco. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; Argentina
Fil: Orellano, Guillermo Osvaldo. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Fuentes, Lucia Beatriz. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
XXXV Reunión Científica Anual de la SBCuyo
San Luis, Villa de Merlo
Argentina
Sociedad de Biologia de Cuyo
description Kidney stones forming require investigations to detect predisposing metabolic abnormalities. A variety of dietary and metabolic factors may contribute or cause stone formation in nephrolithiasis. Some metabolic causes are hypercalciuria, hypocitraturia, gout, hyperoxaluria, and hyperuricosuria. The aim was to investigate physical, chemical and metabolic abnormalities involved in the risk of lithogenesis in both sex. Observational and cross-sectional retrospective study was undertaken. Total metabolic variables were assessed in the data base, including serum and urine chemistries. 421 patients (20-70 years), 57.5% women (W) and 42.5% men (M), Age (years): 44.6 ± 13.8(W) 43.9 ± 13.9 (M), weight (Kg): 64.4 ± 13.1(W) 85.5 ± 14.5 (M), p< 0.0001. BMI: 24.9 ± 4.7(W) 28.2 ± 4.3 (M), p< 0.0001. Serum uric acid, creatinine, urea (mg/dl) increased significantly in M (p<0.0001) and potassium (mEq/l) p<0.01. Urinary excretion 24 h (mg/dl): phosphorus, uric acid, creatinine, magnesium, sodium (mEq/l), potassium (mM/l) increased significantly in M (p< 0.0001). Creatinine clearance: 111.0 ± 28.4 M and 88.1 ± 24.0 W, p<0.001. Calcium/creatinine: 0.20 ± 0.09 W and 0.13 ± 0.06 M, p< 0.001. Citrate/creatinine: 0.51 ± 0.37 W and 0.28 ± 0.16 M, p< 0.001. Uric acid/creatinine: 0.43 ± 0.15 W and 0.39 ± 0.11 M, p< 0.05. Significantly differences in PTH compared W to M, p< 0.001. No significant differences were found in other parameters studied. The risk of renal stone, forming and some metabolic gender differences were found. The results of these investigations can also be used to help guide therapy to prevent future stone formation.
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Congreso
Book
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/281618
Gender Differences in Physical, Chemical and Metabolic Factors Involved in Nephrolithiasis; XXXV Reunión Científica Anual de la SBCuyo; San Luis, Villa de Merlo; Argentina; 2017; 1-4
1667-5746
CONICET Digital
CONICET
url http://hdl.handle.net/11336/281618
identifier_str_mv Gender Differences in Physical, Chemical and Metabolic Factors Involved in Nephrolithiasis; XXXV Reunión Científica Anual de la SBCuyo; San Luis, Villa de Merlo; Argentina; 2017; 1-4
1667-5746
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://sbcuyo.org.ar/reuniones-anuales-anteriores/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.coverage.none.fl_str_mv Nacional
dc.publisher.none.fl_str_mv Sociedad de Biologia de Cuyo
publisher.none.fl_str_mv Sociedad de Biologia de Cuyo
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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