Evaluation of the clonal origin of multiple primary melanomas using molecular profiling

Autores
Orlow, Irene; Tommasi, Diana V.; Bloom, Bradley; Ostrovnaya, Irina; Cotignola, Javier Hernan; Mujumdar, Urvi; Busam, Klaus J.; Jungbluth, Achim A.; Scolyer, Richard A.; Thompson, John F.; Armstrong, Bruce K.; Berwick, Marianne; Thomas, Nancy E.; Begg, Colin B.
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Numerous investigations have been conducted using molecular profiling to evaluate the possible clonal origin of second malignancies in various cancer types. However, to date no study assessing clonality of multiple primaries has been conducted in melanoma. In this investigation using patients treated at a specialist melanoma treatment center, we compared the somatic mutational profiles of pairs of melanomas designated as independent on the basis of thorough assessment of their clinical and pathologic characteristics. We used a set of highly polymorphic genetic markers selected on the basis of their chromosomal positions and the frequencies of reported allelic losses at these genetic loci. Our statistical testing strategy showed no significant evidence of clonal origin of the two primaries in 17 of the 19 patients examined. The results suggest that most second melanomas designated as independent primary tumors on the basis of their clinicopathologic features are indeed independent occurrences of the disease, supporting the validity of the criteria used by experienced pathologists in distinguishing new primaries from metastases. © 2009 The Society for Investigative Dermatology.
Fil: Orlow, Irene. Memorial Sloan-Kettering Cancer Center; Estados Unidos
Fil: Tommasi, Diana V.. Memorial Sloan-Kettering Cancer Center; Estados Unidos
Fil: Bloom, Bradley. Memorial Sloan-Kettering Cancer Center; Estados Unidos
Fil: Ostrovnaya, Irina. Memorial Sloan-Kettering Cancer Center; Estados Unidos
Fil: Cotignola, Javier Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Memorial Sloan-Kettering Cancer Center; Estados Unidos
Fil: Mujumdar, Urvi. Memorial Sloan-Kettering Cancer Center; Estados Unidos
Fil: Busam, Klaus J.. Memorial Sloan-Kettering Cancer Center; Estados Unidos
Fil: Jungbluth, Achim A.. Ludwig Institute for Cancer Research; Estados Unidos
Fil: Scolyer, Richard A.. Royal Prince Alfred Hospital; Australia
Fil: Thompson, John F.. Royal Prince Alfred Hospital; Australia
Fil: Armstrong, Bruce K.. University of Sydney and Cancer Council New South Wale; Australia
Fil: Berwick, Marianne. University of New Mexico; Estados Unidos
Fil: Thomas, Nancy E.. University of North Carolina; Estados Unidos
Fil: Begg, Colin B.. Memorial Sloan-Kettering Cancer Center; Estados Unidos
Materia
Melanoma
Microsatellite
Molecular Profiling
Clonal Origin
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/46221
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Evaluation of the clonal origin of multiple primary melanomas using molecular profilingOrlow, IreneTommasi, Diana V.Bloom, BradleyOstrovnaya, IrinaCotignola, Javier HernanMujumdar, UrviBusam, Klaus J.Jungbluth, Achim A.Scolyer, Richard A.Thompson, John F.Armstrong, Bruce K.Berwick, MarianneThomas, Nancy E.Begg, Colin B.MelanomaMicrosatelliteMolecular ProfilingClonal Originhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Numerous investigations have been conducted using molecular profiling to evaluate the possible clonal origin of second malignancies in various cancer types. However, to date no study assessing clonality of multiple primaries has been conducted in melanoma. In this investigation using patients treated at a specialist melanoma treatment center, we compared the somatic mutational profiles of pairs of melanomas designated as independent on the basis of thorough assessment of their clinical and pathologic characteristics. We used a set of highly polymorphic genetic markers selected on the basis of their chromosomal positions and the frequencies of reported allelic losses at these genetic loci. Our statistical testing strategy showed no significant evidence of clonal origin of the two primaries in 17 of the 19 patients examined. The results suggest that most second melanomas designated as independent primary tumors on the basis of their clinicopathologic features are indeed independent occurrences of the disease, supporting the validity of the criteria used by experienced pathologists in distinguishing new primaries from metastases. © 2009 The Society for Investigative Dermatology.Fil: Orlow, Irene. Memorial Sloan-Kettering Cancer Center; Estados UnidosFil: Tommasi, Diana V.. Memorial Sloan-Kettering Cancer Center; Estados UnidosFil: Bloom, Bradley. Memorial Sloan-Kettering Cancer Center; Estados UnidosFil: Ostrovnaya, Irina. Memorial Sloan-Kettering Cancer Center; Estados UnidosFil: Cotignola, Javier Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Memorial Sloan-Kettering Cancer Center; Estados UnidosFil: Mujumdar, Urvi. Memorial Sloan-Kettering Cancer Center; Estados UnidosFil: Busam, Klaus J.. Memorial Sloan-Kettering Cancer Center; Estados UnidosFil: Jungbluth, Achim A.. Ludwig Institute for Cancer Research; Estados UnidosFil: Scolyer, Richard A.. Royal Prince Alfred Hospital; AustraliaFil: Thompson, John F.. Royal Prince Alfred Hospital; AustraliaFil: Armstrong, Bruce K.. University of Sydney and Cancer Council New South Wale; AustraliaFil: Berwick, Marianne. University of New Mexico; Estados UnidosFil: Thomas, Nancy E.. University of North Carolina; Estados UnidosFil: Begg, Colin B.. Memorial Sloan-Kettering Cancer Center; Estados UnidosNature Publishing Group2009-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/46221Orlow, Irene; Tommasi, Diana V.; Bloom, Bradley; Ostrovnaya, Irina; Cotignola, Javier Hernan; et al.; Evaluation of the clonal origin of multiple primary melanomas using molecular profiling; Nature Publishing Group; Journal Of Investigative Dermatology; 129; 8; 8-2009; 1972-19820022-202XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1038/jid.2009.4info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0022202X15344584info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:10:26Zoai:ri.conicet.gov.ar:11336/46221instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:10:27.276CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Evaluation of the clonal origin of multiple primary melanomas using molecular profiling
title Evaluation of the clonal origin of multiple primary melanomas using molecular profiling
spellingShingle Evaluation of the clonal origin of multiple primary melanomas using molecular profiling
Orlow, Irene
Melanoma
Microsatellite
Molecular Profiling
Clonal Origin
title_short Evaluation of the clonal origin of multiple primary melanomas using molecular profiling
title_full Evaluation of the clonal origin of multiple primary melanomas using molecular profiling
title_fullStr Evaluation of the clonal origin of multiple primary melanomas using molecular profiling
title_full_unstemmed Evaluation of the clonal origin of multiple primary melanomas using molecular profiling
title_sort Evaluation of the clonal origin of multiple primary melanomas using molecular profiling
dc.creator.none.fl_str_mv Orlow, Irene
Tommasi, Diana V.
Bloom, Bradley
Ostrovnaya, Irina
Cotignola, Javier Hernan
Mujumdar, Urvi
Busam, Klaus J.
Jungbluth, Achim A.
Scolyer, Richard A.
Thompson, John F.
Armstrong, Bruce K.
Berwick, Marianne
Thomas, Nancy E.
Begg, Colin B.
author Orlow, Irene
author_facet Orlow, Irene
Tommasi, Diana V.
Bloom, Bradley
Ostrovnaya, Irina
Cotignola, Javier Hernan
Mujumdar, Urvi
Busam, Klaus J.
Jungbluth, Achim A.
Scolyer, Richard A.
Thompson, John F.
Armstrong, Bruce K.
Berwick, Marianne
Thomas, Nancy E.
Begg, Colin B.
author_role author
author2 Tommasi, Diana V.
Bloom, Bradley
Ostrovnaya, Irina
Cotignola, Javier Hernan
Mujumdar, Urvi
Busam, Klaus J.
Jungbluth, Achim A.
Scolyer, Richard A.
Thompson, John F.
Armstrong, Bruce K.
Berwick, Marianne
Thomas, Nancy E.
Begg, Colin B.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Melanoma
Microsatellite
Molecular Profiling
Clonal Origin
topic Melanoma
Microsatellite
Molecular Profiling
Clonal Origin
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Numerous investigations have been conducted using molecular profiling to evaluate the possible clonal origin of second malignancies in various cancer types. However, to date no study assessing clonality of multiple primaries has been conducted in melanoma. In this investigation using patients treated at a specialist melanoma treatment center, we compared the somatic mutational profiles of pairs of melanomas designated as independent on the basis of thorough assessment of their clinical and pathologic characteristics. We used a set of highly polymorphic genetic markers selected on the basis of their chromosomal positions and the frequencies of reported allelic losses at these genetic loci. Our statistical testing strategy showed no significant evidence of clonal origin of the two primaries in 17 of the 19 patients examined. The results suggest that most second melanomas designated as independent primary tumors on the basis of their clinicopathologic features are indeed independent occurrences of the disease, supporting the validity of the criteria used by experienced pathologists in distinguishing new primaries from metastases. © 2009 The Society for Investigative Dermatology.
Fil: Orlow, Irene. Memorial Sloan-Kettering Cancer Center; Estados Unidos
Fil: Tommasi, Diana V.. Memorial Sloan-Kettering Cancer Center; Estados Unidos
Fil: Bloom, Bradley. Memorial Sloan-Kettering Cancer Center; Estados Unidos
Fil: Ostrovnaya, Irina. Memorial Sloan-Kettering Cancer Center; Estados Unidos
Fil: Cotignola, Javier Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Memorial Sloan-Kettering Cancer Center; Estados Unidos
Fil: Mujumdar, Urvi. Memorial Sloan-Kettering Cancer Center; Estados Unidos
Fil: Busam, Klaus J.. Memorial Sloan-Kettering Cancer Center; Estados Unidos
Fil: Jungbluth, Achim A.. Ludwig Institute for Cancer Research; Estados Unidos
Fil: Scolyer, Richard A.. Royal Prince Alfred Hospital; Australia
Fil: Thompson, John F.. Royal Prince Alfred Hospital; Australia
Fil: Armstrong, Bruce K.. University of Sydney and Cancer Council New South Wale; Australia
Fil: Berwick, Marianne. University of New Mexico; Estados Unidos
Fil: Thomas, Nancy E.. University of North Carolina; Estados Unidos
Fil: Begg, Colin B.. Memorial Sloan-Kettering Cancer Center; Estados Unidos
description Numerous investigations have been conducted using molecular profiling to evaluate the possible clonal origin of second malignancies in various cancer types. However, to date no study assessing clonality of multiple primaries has been conducted in melanoma. In this investigation using patients treated at a specialist melanoma treatment center, we compared the somatic mutational profiles of pairs of melanomas designated as independent on the basis of thorough assessment of their clinical and pathologic characteristics. We used a set of highly polymorphic genetic markers selected on the basis of their chromosomal positions and the frequencies of reported allelic losses at these genetic loci. Our statistical testing strategy showed no significant evidence of clonal origin of the two primaries in 17 of the 19 patients examined. The results suggest that most second melanomas designated as independent primary tumors on the basis of their clinicopathologic features are indeed independent occurrences of the disease, supporting the validity of the criteria used by experienced pathologists in distinguishing new primaries from metastases. © 2009 The Society for Investigative Dermatology.
publishDate 2009
dc.date.none.fl_str_mv 2009-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/46221
Orlow, Irene; Tommasi, Diana V.; Bloom, Bradley; Ostrovnaya, Irina; Cotignola, Javier Hernan; et al.; Evaluation of the clonal origin of multiple primary melanomas using molecular profiling; Nature Publishing Group; Journal Of Investigative Dermatology; 129; 8; 8-2009; 1972-1982
0022-202X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/46221
identifier_str_mv Orlow, Irene; Tommasi, Diana V.; Bloom, Bradley; Ostrovnaya, Irina; Cotignola, Javier Hernan; et al.; Evaluation of the clonal origin of multiple primary melanomas using molecular profiling; Nature Publishing Group; Journal Of Investigative Dermatology; 129; 8; 8-2009; 1972-1982
0022-202X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1038/jid.2009.4
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0022202X15344584
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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