Sun exposure, vitamin D receptor polymorphisms FokI and BsmI and risk of multiple primary melanoma

Autores
Mandelcorn Monson, Rochelle; Marrett, Loraine; Kricker, Anne; Armstrong, Bruce K.; Orlow, Irene; Goumas, Chris; Paine, Susan; Rosso, Stefano; Thomas, Nancy; Millikan, Robert C.; Pole, Jason D.; Cotignola, Javier Hernan; Rosen, Cheryl; Kanetsky, Peter A.; Lee Taylor, Julia; Begg, Colin B.; Berwick, Marianne
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Sunlight exposure increases risk of melanoma. Sunlight also potentiates cutaneous synthesis of vitamin D, which can inhibit melanoma cell growth and promote apoptosis. Vitamin D effects are mediated through the vitamin D receptor (VDR). We hypothesized that genetic variation in VDR affects the relationship of sun exposure to risk of a further melanoma in people who have already had one. Methods: We investigated the interaction between VDR polymorphisms and sun exposure in a population-based multinational study comparing 1138 patients with a multiple (second or subsequent) primary melanoma (cases) to 2151 patients with a first primary melanoma (controls); essentially a case-control study of melanoma in a population of melanoma survivors. Sun exposure was assessed using a questionnaire and interview, and was shown to be associated with multiple primary melanoma. VDR was genotyped at the FokI and BsmI loci and the main effects of variants at these loci and their interactions with sun exposure were analyzed. Results: Only the BsmI variant was associated with multiple primary melanoma (OR = 1.27, 95% CI 0.99-1.62 for the homozygous variant genotype). Joint effects analyses showed highest ORs in the high exposure, homozygous variant BsmI genotype category for each sun exposure variable. Stratified analyses showed somewhat higher ORs for the homozygous BsmI variant genotype in people with high sun exposure than with low sun exposure. P values for interaction, however, were high. Conclusion: These results suggest that risk of multiple primary melanoma is increased in people who have the BsmI variant of VDR. © 2011 Elsevier Ltd.
Fil: Mandelcorn Monson, Rochelle. University of Toronto; Canadá
Fil: Marrett, Loraine. Cancer Care Ontario; Canadá
Fil: Kricker, Anne. The University Of Sydney; Australia
Fil: Armstrong, Bruce K.. The University Of Sydney; Australia
Fil: Orlow, Irene. Memorial Sloan-kettering Cancer Center; Estados Unidos
Fil: Goumas, Chris. The University Of Sydney; Australia
Fil: Paine, Susan. University Of New Mexico Cancer Center; Estados Unidos
Fil: Rosso, Stefano. Piedmont Tumor Registry; Italia
Fil: Thomas, Nancy. Unc Health Care; Estados Unidos
Fil: Millikan, Robert C.. Unc Health Care; Estados Unidos
Fil: Pole, Jason D.. University of Toronto; Canadá
Fil: Cotignola, Javier Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Memorial Sloan-kettering Cancer Center; Estados Unidos
Fil: Rosen, Cheryl. University of Toronto; Canadá
Fil: Kanetsky, Peter A.. The Pennsylvania State University; Estados Unidos
Fil: Lee Taylor, Julia. The Earth And Sun Systems Laboratory; Estados Unidos
Fil: Begg, Colin B.. Memorial Sloan-kettering Cancer Center; Estados Unidos
Fil: Berwick, Marianne. University Of New Mexico Cancer Center; Estados Unidos
Materia
Bsmi
Foki
Melanoma
Sun Exposure
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/66449
Acceder
id CONICETDig_f2b435da7215cfc8575ba029502f675b
oai_identifier_str oai:ri.conicet.gov.ar:11336/66449
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Sun exposure, vitamin D receptor polymorphisms FokI and BsmI and risk of multiple primary melanomaMandelcorn Monson, RochelleMarrett, LoraineKricker, AnneArmstrong, Bruce K.Orlow, IreneGoumas, ChrisPaine, SusanRosso, StefanoThomas, NancyMillikan, Robert C.Pole, Jason D.Cotignola, Javier HernanRosen, CherylKanetsky, Peter A.Lee Taylor, JuliaBegg, Colin B.Berwick, MarianneBsmiFokiMelanomaSun Exposurehttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Background: Sunlight exposure increases risk of melanoma. Sunlight also potentiates cutaneous synthesis of vitamin D, which can inhibit melanoma cell growth and promote apoptosis. Vitamin D effects are mediated through the vitamin D receptor (VDR). We hypothesized that genetic variation in VDR affects the relationship of sun exposure to risk of a further melanoma in people who have already had one. Methods: We investigated the interaction between VDR polymorphisms and sun exposure in a population-based multinational study comparing 1138 patients with a multiple (second or subsequent) primary melanoma (cases) to 2151 patients with a first primary melanoma (controls); essentially a case-control study of melanoma in a population of melanoma survivors. Sun exposure was assessed using a questionnaire and interview, and was shown to be associated with multiple primary melanoma. VDR was genotyped at the FokI and BsmI loci and the main effects of variants at these loci and their interactions with sun exposure were analyzed. Results: Only the BsmI variant was associated with multiple primary melanoma (OR = 1.27, 95% CI 0.99-1.62 for the homozygous variant genotype). Joint effects analyses showed highest ORs in the high exposure, homozygous variant BsmI genotype category for each sun exposure variable. Stratified analyses showed somewhat higher ORs for the homozygous BsmI variant genotype in people with high sun exposure than with low sun exposure. P values for interaction, however, were high. Conclusion: These results suggest that risk of multiple primary melanoma is increased in people who have the BsmI variant of VDR. © 2011 Elsevier Ltd.Fil: Mandelcorn Monson, Rochelle. University of Toronto; CanadáFil: Marrett, Loraine. Cancer Care Ontario; CanadáFil: Kricker, Anne. The University Of Sydney; AustraliaFil: Armstrong, Bruce K.. The University Of Sydney; AustraliaFil: Orlow, Irene. Memorial Sloan-kettering Cancer Center; Estados UnidosFil: Goumas, Chris. The University Of Sydney; AustraliaFil: Paine, Susan. University Of New Mexico Cancer Center; Estados UnidosFil: Rosso, Stefano. Piedmont Tumor Registry; ItaliaFil: Thomas, Nancy. Unc Health Care; Estados UnidosFil: Millikan, Robert C.. Unc Health Care; Estados UnidosFil: Pole, Jason D.. University of Toronto; CanadáFil: Cotignola, Javier Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Memorial Sloan-kettering Cancer Center; Estados UnidosFil: Rosen, Cheryl. University of Toronto; CanadáFil: Kanetsky, Peter A.. The Pennsylvania State University; Estados UnidosFil: Lee Taylor, Julia. The Earth And Sun Systems Laboratory; Estados UnidosFil: Begg, Colin B.. Memorial Sloan-kettering Cancer Center; Estados UnidosFil: Berwick, Marianne. University Of New Mexico Cancer Center; Estados UnidosElsevier2011-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/66449Mandelcorn Monson, Rochelle; Marrett, Loraine; Kricker, Anne; Armstrong, Bruce K.; Orlow, Irene; et al.; Sun exposure, vitamin D receptor polymorphisms FokI and BsmI and risk of multiple primary melanoma; Elsevier; Cancer Epidemiology; 35; 6; 12-2011; 105-1101877-7821CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1877782111000580info:eu-repo/semantics/altIdentifier/doi/10.1016/j.canep.2011.03.003info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:37:55Zoai:ri.conicet.gov.ar:11336/66449instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:37:56.168CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Sun exposure, vitamin D receptor polymorphisms FokI and BsmI and risk of multiple primary melanoma
title Sun exposure, vitamin D receptor polymorphisms FokI and BsmI and risk of multiple primary melanoma
spellingShingle Sun exposure, vitamin D receptor polymorphisms FokI and BsmI and risk of multiple primary melanoma
Mandelcorn Monson, Rochelle
Bsmi
Foki
Melanoma
Sun Exposure
title_short Sun exposure, vitamin D receptor polymorphisms FokI and BsmI and risk of multiple primary melanoma
title_full Sun exposure, vitamin D receptor polymorphisms FokI and BsmI and risk of multiple primary melanoma
title_fullStr Sun exposure, vitamin D receptor polymorphisms FokI and BsmI and risk of multiple primary melanoma
title_full_unstemmed Sun exposure, vitamin D receptor polymorphisms FokI and BsmI and risk of multiple primary melanoma
title_sort Sun exposure, vitamin D receptor polymorphisms FokI and BsmI and risk of multiple primary melanoma
dc.creator.none.fl_str_mv Mandelcorn Monson, Rochelle
Marrett, Loraine
Kricker, Anne
Armstrong, Bruce K.
Orlow, Irene
Goumas, Chris
Paine, Susan
Rosso, Stefano
Thomas, Nancy
Millikan, Robert C.
Pole, Jason D.
Cotignola, Javier Hernan
Rosen, Cheryl
Kanetsky, Peter A.
Lee Taylor, Julia
Begg, Colin B.
Berwick, Marianne
author Mandelcorn Monson, Rochelle
author_facet Mandelcorn Monson, Rochelle
Marrett, Loraine
Kricker, Anne
Armstrong, Bruce K.
Orlow, Irene
Goumas, Chris
Paine, Susan
Rosso, Stefano
Thomas, Nancy
Millikan, Robert C.
Pole, Jason D.
Cotignola, Javier Hernan
Rosen, Cheryl
Kanetsky, Peter A.
Lee Taylor, Julia
Begg, Colin B.
Berwick, Marianne
author_role author
author2 Marrett, Loraine
Kricker, Anne
Armstrong, Bruce K.
Orlow, Irene
Goumas, Chris
Paine, Susan
Rosso, Stefano
Thomas, Nancy
Millikan, Robert C.
Pole, Jason D.
Cotignola, Javier Hernan
Rosen, Cheryl
Kanetsky, Peter A.
Lee Taylor, Julia
Begg, Colin B.
Berwick, Marianne
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Bsmi
Foki
Melanoma
Sun Exposure
topic Bsmi
Foki
Melanoma
Sun Exposure
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Background: Sunlight exposure increases risk of melanoma. Sunlight also potentiates cutaneous synthesis of vitamin D, which can inhibit melanoma cell growth and promote apoptosis. Vitamin D effects are mediated through the vitamin D receptor (VDR). We hypothesized that genetic variation in VDR affects the relationship of sun exposure to risk of a further melanoma in people who have already had one. Methods: We investigated the interaction between VDR polymorphisms and sun exposure in a population-based multinational study comparing 1138 patients with a multiple (second or subsequent) primary melanoma (cases) to 2151 patients with a first primary melanoma (controls); essentially a case-control study of melanoma in a population of melanoma survivors. Sun exposure was assessed using a questionnaire and interview, and was shown to be associated with multiple primary melanoma. VDR was genotyped at the FokI and BsmI loci and the main effects of variants at these loci and their interactions with sun exposure were analyzed. Results: Only the BsmI variant was associated with multiple primary melanoma (OR = 1.27, 95% CI 0.99-1.62 for the homozygous variant genotype). Joint effects analyses showed highest ORs in the high exposure, homozygous variant BsmI genotype category for each sun exposure variable. Stratified analyses showed somewhat higher ORs for the homozygous BsmI variant genotype in people with high sun exposure than with low sun exposure. P values for interaction, however, were high. Conclusion: These results suggest that risk of multiple primary melanoma is increased in people who have the BsmI variant of VDR. © 2011 Elsevier Ltd.
Fil: Mandelcorn Monson, Rochelle. University of Toronto; Canadá
Fil: Marrett, Loraine. Cancer Care Ontario; Canadá
Fil: Kricker, Anne. The University Of Sydney; Australia
Fil: Armstrong, Bruce K.. The University Of Sydney; Australia
Fil: Orlow, Irene. Memorial Sloan-kettering Cancer Center; Estados Unidos
Fil: Goumas, Chris. The University Of Sydney; Australia
Fil: Paine, Susan. University Of New Mexico Cancer Center; Estados Unidos
Fil: Rosso, Stefano. Piedmont Tumor Registry; Italia
Fil: Thomas, Nancy. Unc Health Care; Estados Unidos
Fil: Millikan, Robert C.. Unc Health Care; Estados Unidos
Fil: Pole, Jason D.. University of Toronto; Canadá
Fil: Cotignola, Javier Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Memorial Sloan-kettering Cancer Center; Estados Unidos
Fil: Rosen, Cheryl. University of Toronto; Canadá
Fil: Kanetsky, Peter A.. The Pennsylvania State University; Estados Unidos
Fil: Lee Taylor, Julia. The Earth And Sun Systems Laboratory; Estados Unidos
Fil: Begg, Colin B.. Memorial Sloan-kettering Cancer Center; Estados Unidos
Fil: Berwick, Marianne. University Of New Mexico Cancer Center; Estados Unidos
description Background: Sunlight exposure increases risk of melanoma. Sunlight also potentiates cutaneous synthesis of vitamin D, which can inhibit melanoma cell growth and promote apoptosis. Vitamin D effects are mediated through the vitamin D receptor (VDR). We hypothesized that genetic variation in VDR affects the relationship of sun exposure to risk of a further melanoma in people who have already had one. Methods: We investigated the interaction between VDR polymorphisms and sun exposure in a population-based multinational study comparing 1138 patients with a multiple (second or subsequent) primary melanoma (cases) to 2151 patients with a first primary melanoma (controls); essentially a case-control study of melanoma in a population of melanoma survivors. Sun exposure was assessed using a questionnaire and interview, and was shown to be associated with multiple primary melanoma. VDR was genotyped at the FokI and BsmI loci and the main effects of variants at these loci and their interactions with sun exposure were analyzed. Results: Only the BsmI variant was associated with multiple primary melanoma (OR = 1.27, 95% CI 0.99-1.62 for the homozygous variant genotype). Joint effects analyses showed highest ORs in the high exposure, homozygous variant BsmI genotype category for each sun exposure variable. Stratified analyses showed somewhat higher ORs for the homozygous BsmI variant genotype in people with high sun exposure than with low sun exposure. P values for interaction, however, were high. Conclusion: These results suggest that risk of multiple primary melanoma is increased in people who have the BsmI variant of VDR. © 2011 Elsevier Ltd.
publishDate 2011
dc.date.none.fl_str_mv 2011-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/66449
Mandelcorn Monson, Rochelle; Marrett, Loraine; Kricker, Anne; Armstrong, Bruce K.; Orlow, Irene; et al.; Sun exposure, vitamin D receptor polymorphisms FokI and BsmI and risk of multiple primary melanoma; Elsevier; Cancer Epidemiology; 35; 6; 12-2011; 105-110
1877-7821
CONICET Digital
CONICET
url http://hdl.handle.net/11336/66449
identifier_str_mv Mandelcorn Monson, Rochelle; Marrett, Loraine; Kricker, Anne; Armstrong, Bruce K.; Orlow, Irene; et al.; Sun exposure, vitamin D receptor polymorphisms FokI and BsmI and risk of multiple primary melanoma; Elsevier; Cancer Epidemiology; 35; 6; 12-2011; 105-110
1877-7821
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1877782111000580
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.canep.2011.03.003
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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