Arterial Stiffness and Endothelial Function in Obese Children and Adolescents and Its Relationship with Cardiovascular Risk Factors

Autores
Joo Turoni, Claudio Martín; Marañón, Rodrigo Oscar; Felipe, Verónica; Bruno, Maria Emilia; Negrete, Alejandro; Salas, Nicolás Martín; Bazan de Casella, María Cristina del Valle; Peral de Bruno, Maria
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Obesity is related to an increase in the rates of cardiovascular disease. Objective: To establish the impact of obesity on vascular function (endothelial function and arterial stiffness) in children and adolescents and its relationship to cardiovascular risk factors. Methods: In obese (OB) children and adolescents, endothelial function and arterial stiffness were evaluated by a pulse plethysmography method (reactive hyperemia and index of digital volume waveforms, respectively). Data were compared with the non-obese (non-OB) group (body mass index >10th to <97th percentile). Anthropometric parameters, body fat percentage, fasting glucose, lipid profile, insulinemia, HOMA-IR and hemodynamic parameters were determined in both groups. Results: Body mass index, weight, waist circumference, body fat, insulinemia and HOMA-IR were significantly higher in the OB group. The OB group showed impaired endothelial function (15.8 ± 0.2%, n = 37) compared to the non-OB group (41.4 ± 5%, n = 20; p < 0.001) and increased arterial stiffness. Endothelial function was only negatively correlated with waist circumference and HOMA-IR in the OB group, whereas a positive correlation was found between insulinemia and HOMA-IR. Conclusions: This study shows that impaired vascular function is already present in OB children and adolescents. The fact that obesity is associated with some markers of cardiovascular risk suggests the importance of early lifestyle interventions in this population to prevent cardiovascular disease.
Fil: Joo Turoni, Claudio Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Fil: Marañón, Rodrigo Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Fil: Felipe, Verónica. Provincia de Tucumán. Hospital del Niño Jesús; Argentina
Fil: Bruno, Maria Emilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Fil: Negrete, Alejandro. Universidad Nacional de Tucumán. Facultad de Medicina. Departamento Biomédico; Argentina
Fil: Salas, Nicolás Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Fil: Bazan de Casella, María Cristina del Valle. Provincia de Tucumán. Hospital del Niño Jesús; Argentina
Fil: Peral de Bruno, Maria. Universidad Nacional de Tucumán. Facultad de Medicina. Departamento Biomédico; Argentina
Materia
Obesity
Children
Endothelial Function
Cardiovascular Risk Factors
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/22835
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/22835
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Arterial Stiffness and Endothelial Function in Obese Children and Adolescents and Its Relationship with Cardiovascular Risk FactorsJoo Turoni, Claudio MartínMarañón, Rodrigo OscarFelipe, VerónicaBruno, Maria EmiliaNegrete, AlejandroSalas, Nicolás MartínBazan de Casella, María Cristina del VallePeral de Bruno, MariaObesityChildrenEndothelial FunctionCardiovascular Risk Factorshttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Background: Obesity is related to an increase in the rates of cardiovascular disease. Objective: To establish the impact of obesity on vascular function (endothelial function and arterial stiffness) in children and adolescents and its relationship to cardiovascular risk factors. Methods: In obese (OB) children and adolescents, endothelial function and arterial stiffness were evaluated by a pulse plethysmography method (reactive hyperemia and index of digital volume waveforms, respectively). Data were compared with the non-obese (non-OB) group (body mass index >10th to <97th percentile). Anthropometric parameters, body fat percentage, fasting glucose, lipid profile, insulinemia, HOMA-IR and hemodynamic parameters were determined in both groups. Results: Body mass index, weight, waist circumference, body fat, insulinemia and HOMA-IR were significantly higher in the OB group. The OB group showed impaired endothelial function (15.8 ± 0.2%, n = 37) compared to the non-OB group (41.4 ± 5%, n = 20; p < 0.001) and increased arterial stiffness. Endothelial function was only negatively correlated with waist circumference and HOMA-IR in the OB group, whereas a positive correlation was found between insulinemia and HOMA-IR. Conclusions: This study shows that impaired vascular function is already present in OB children and adolescents. The fact that obesity is associated with some markers of cardiovascular risk suggests the importance of early lifestyle interventions in this population to prevent cardiovascular disease.Fil: Joo Turoni, Claudio Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; ArgentinaFil: Marañón, Rodrigo Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; ArgentinaFil: Felipe, Verónica. Provincia de Tucumán. Hospital del Niño Jesús; ArgentinaFil: Bruno, Maria Emilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; ArgentinaFil: Negrete, Alejandro. Universidad Nacional de Tucumán. Facultad de Medicina. Departamento Biomédico; ArgentinaFil: Salas, Nicolás Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; ArgentinaFil: Bazan de Casella, María Cristina del Valle. Provincia de Tucumán. Hospital del Niño Jesús; ArgentinaFil: Peral de Bruno, Maria. Universidad Nacional de Tucumán. Facultad de Medicina. Departamento Biomédico; ArgentinaKarger2013-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/22835Joo Turoni, Claudio Martín; Marañón, Rodrigo Oscar; Felipe, Verónica; Bruno, Maria Emilia; Negrete, Alejandro; et al.; Arterial Stiffness and Endothelial Function in Obese Children and Adolescents and Its Relationship with Cardiovascular Risk Factors; Karger; Hormone Research in Paediatrics; 80; 4; 10-2013; 281-2861663-2818CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1159/000354991info:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/Abstract/354991info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-26T09:09:51Zoai:ri.conicet.gov.ar:11336/22835instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-26 09:09:52.094CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Arterial Stiffness and Endothelial Function in Obese Children and Adolescents and Its Relationship with Cardiovascular Risk Factors
title Arterial Stiffness and Endothelial Function in Obese Children and Adolescents and Its Relationship with Cardiovascular Risk Factors
spellingShingle Arterial Stiffness and Endothelial Function in Obese Children and Adolescents and Its Relationship with Cardiovascular Risk Factors
Joo Turoni, Claudio Martín
Obesity
Children
Endothelial Function
Cardiovascular Risk Factors
title_short Arterial Stiffness and Endothelial Function in Obese Children and Adolescents and Its Relationship with Cardiovascular Risk Factors
title_full Arterial Stiffness and Endothelial Function in Obese Children and Adolescents and Its Relationship with Cardiovascular Risk Factors
title_fullStr Arterial Stiffness and Endothelial Function in Obese Children and Adolescents and Its Relationship with Cardiovascular Risk Factors
title_full_unstemmed Arterial Stiffness and Endothelial Function in Obese Children and Adolescents and Its Relationship with Cardiovascular Risk Factors
title_sort Arterial Stiffness and Endothelial Function in Obese Children and Adolescents and Its Relationship with Cardiovascular Risk Factors
dc.creator.none.fl_str_mv Joo Turoni, Claudio Martín
Marañón, Rodrigo Oscar
Felipe, Verónica
Bruno, Maria Emilia
Negrete, Alejandro
Salas, Nicolás Martín
Bazan de Casella, María Cristina del Valle
Peral de Bruno, Maria
author Joo Turoni, Claudio Martín
author_facet Joo Turoni, Claudio Martín
Marañón, Rodrigo Oscar
Felipe, Verónica
Bruno, Maria Emilia
Negrete, Alejandro
Salas, Nicolás Martín
Bazan de Casella, María Cristina del Valle
Peral de Bruno, Maria
author_role author
author2 Marañón, Rodrigo Oscar
Felipe, Verónica
Bruno, Maria Emilia
Negrete, Alejandro
Salas, Nicolás Martín
Bazan de Casella, María Cristina del Valle
Peral de Bruno, Maria
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Obesity
Children
Endothelial Function
Cardiovascular Risk Factors
topic Obesity
Children
Endothelial Function
Cardiovascular Risk Factors
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: Obesity is related to an increase in the rates of cardiovascular disease. Objective: To establish the impact of obesity on vascular function (endothelial function and arterial stiffness) in children and adolescents and its relationship to cardiovascular risk factors. Methods: In obese (OB) children and adolescents, endothelial function and arterial stiffness were evaluated by a pulse plethysmography method (reactive hyperemia and index of digital volume waveforms, respectively). Data were compared with the non-obese (non-OB) group (body mass index >10th to <97th percentile). Anthropometric parameters, body fat percentage, fasting glucose, lipid profile, insulinemia, HOMA-IR and hemodynamic parameters were determined in both groups. Results: Body mass index, weight, waist circumference, body fat, insulinemia and HOMA-IR were significantly higher in the OB group. The OB group showed impaired endothelial function (15.8 ± 0.2%, n = 37) compared to the non-OB group (41.4 ± 5%, n = 20; p < 0.001) and increased arterial stiffness. Endothelial function was only negatively correlated with waist circumference and HOMA-IR in the OB group, whereas a positive correlation was found between insulinemia and HOMA-IR. Conclusions: This study shows that impaired vascular function is already present in OB children and adolescents. The fact that obesity is associated with some markers of cardiovascular risk suggests the importance of early lifestyle interventions in this population to prevent cardiovascular disease.
Fil: Joo Turoni, Claudio Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Fil: Marañón, Rodrigo Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Fil: Felipe, Verónica. Provincia de Tucumán. Hospital del Niño Jesús; Argentina
Fil: Bruno, Maria Emilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Fil: Negrete, Alejandro. Universidad Nacional de Tucumán. Facultad de Medicina. Departamento Biomédico; Argentina
Fil: Salas, Nicolás Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Fil: Bazan de Casella, María Cristina del Valle. Provincia de Tucumán. Hospital del Niño Jesús; Argentina
Fil: Peral de Bruno, Maria. Universidad Nacional de Tucumán. Facultad de Medicina. Departamento Biomédico; Argentina
description Background: Obesity is related to an increase in the rates of cardiovascular disease. Objective: To establish the impact of obesity on vascular function (endothelial function and arterial stiffness) in children and adolescents and its relationship to cardiovascular risk factors. Methods: In obese (OB) children and adolescents, endothelial function and arterial stiffness were evaluated by a pulse plethysmography method (reactive hyperemia and index of digital volume waveforms, respectively). Data were compared with the non-obese (non-OB) group (body mass index >10th to <97th percentile). Anthropometric parameters, body fat percentage, fasting glucose, lipid profile, insulinemia, HOMA-IR and hemodynamic parameters were determined in both groups. Results: Body mass index, weight, waist circumference, body fat, insulinemia and HOMA-IR were significantly higher in the OB group. The OB group showed impaired endothelial function (15.8 ± 0.2%, n = 37) compared to the non-OB group (41.4 ± 5%, n = 20; p < 0.001) and increased arterial stiffness. Endothelial function was only negatively correlated with waist circumference and HOMA-IR in the OB group, whereas a positive correlation was found between insulinemia and HOMA-IR. Conclusions: This study shows that impaired vascular function is already present in OB children and adolescents. The fact that obesity is associated with some markers of cardiovascular risk suggests the importance of early lifestyle interventions in this population to prevent cardiovascular disease.
publishDate 2013
dc.date.none.fl_str_mv 2013-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/22835
Joo Turoni, Claudio Martín; Marañón, Rodrigo Oscar; Felipe, Verónica; Bruno, Maria Emilia; Negrete, Alejandro; et al.; Arterial Stiffness and Endothelial Function in Obese Children and Adolescents and Its Relationship with Cardiovascular Risk Factors; Karger; Hormone Research in Paediatrics; 80; 4; 10-2013; 281-286
1663-2818
CONICET Digital
CONICET
url http://hdl.handle.net/11336/22835
identifier_str_mv Joo Turoni, Claudio Martín; Marañón, Rodrigo Oscar; Felipe, Verónica; Bruno, Maria Emilia; Negrete, Alejandro; et al.; Arterial Stiffness and Endothelial Function in Obese Children and Adolescents and Its Relationship with Cardiovascular Risk Factors; Karger; Hormone Research in Paediatrics; 80; 4; 10-2013; 281-286
1663-2818
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1159/000354991
info:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/Abstract/354991
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Karger
publisher.none.fl_str_mv Karger
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.011256

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