Adipokines, Cardiovascular Risk, and Therapeutic Management in Obesity and Psoriatic Arthritis

Autores
Porta, Sabrina Valeria; Otero-losada, Matilde Estela; Kolliker Frers, Rodolfo Alberto; Cosentino, Vanesa Laura; Kerzberg, Eduardo Mario; Capani, Francisco
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Psoriatic arthritis is a chronic inflammatory disease with skin and joint pathology as the dominant characteristics. Scientific evidence supports its systemic nature and relevant relationship with obesity, metabolic syndrome, and associated conditions. Metabolic syndrome and obesity share common signaling pathways with joint inflammation, reinforcing the idea that adipose tissue is a major contributor to disease development and severity. The adipose tissue is not a mere energy store but also an endocrine organ participating in the immune response. In the search for the best therapeutic strategy for a patient, we should appraise the adipose tissue as an endocrine and immune organ responsible for mild chronic inflammation. Today, our challenge is not only to achieve disease remission but to control the associated comorbidities as well. In light of the high prevalence of obesity in psoriatic arthritis patients and the importance of the adipose tissue in the development of chronic inflammation, we aimed to identify the most relevant articles in this regard published in English until June 2020 using the PubMed database. Search terms included psoriatic arthritis, in combination with metabolic syndrome, obesity, adipokines, cardiovascular disease, and treatment. This review summarizes the current evidence regarding the role of adipose tissue as an adipokine-secreting endocrine organ, discussing its influence on disease development and severity, and ultimately in meeting successful disease management.
Fil: Porta, Sabrina Valeria. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Otero-losada, Matilde Estela. Universidad Abierta Interamericana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Kolliker Frers, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina. Universidad Abierta Interamericana; Argentina
Fil: Cosentino, Vanesa Laura. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Kerzberg, Eduardo Mario. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Capani, Francisco. Universidad Abierta Interamericana; Argentina. Universidad Argentina "John F. Kennedy"; Argentina. Universidad Autónoma de Chile; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Adipokines
Metabolic syndrome
Cardiovascular risk
Obesity
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/155073
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Adipokines, Cardiovascular Risk, and Therapeutic Management in Obesity and Psoriatic ArthritisPorta, Sabrina ValeriaOtero-losada, Matilde EstelaKolliker Frers, Rodolfo AlbertoCosentino, Vanesa LauraKerzberg, Eduardo MarioCapani, FranciscoAdipokinesMetabolic syndromeCardiovascular riskObesityhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Psoriatic arthritis is a chronic inflammatory disease with skin and joint pathology as the dominant characteristics. Scientific evidence supports its systemic nature and relevant relationship with obesity, metabolic syndrome, and associated conditions. Metabolic syndrome and obesity share common signaling pathways with joint inflammation, reinforcing the idea that adipose tissue is a major contributor to disease development and severity. The adipose tissue is not a mere energy store but also an endocrine organ participating in the immune response. In the search for the best therapeutic strategy for a patient, we should appraise the adipose tissue as an endocrine and immune organ responsible for mild chronic inflammation. Today, our challenge is not only to achieve disease remission but to control the associated comorbidities as well. In light of the high prevalence of obesity in psoriatic arthritis patients and the importance of the adipose tissue in the development of chronic inflammation, we aimed to identify the most relevant articles in this regard published in English until June 2020 using the PubMed database. Search terms included psoriatic arthritis, in combination with metabolic syndrome, obesity, adipokines, cardiovascular disease, and treatment. This review summarizes the current evidence regarding the role of adipose tissue as an adipokine-secreting endocrine organ, discussing its influence on disease development and severity, and ultimately in meeting successful disease management.Fil: Porta, Sabrina Valeria. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; ArgentinaFil: Otero-losada, Matilde Estela. Universidad Abierta Interamericana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Kolliker Frers, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina. Universidad Abierta Interamericana; ArgentinaFil: Cosentino, Vanesa Laura. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; ArgentinaFil: Kerzberg, Eduardo Mario. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; ArgentinaFil: Capani, Francisco. Universidad Abierta Interamericana; Argentina. Universidad Argentina "John F. Kennedy"; Argentina. Universidad Autónoma de Chile; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFrontiers Research Foundation2021-02-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/155073Porta, Sabrina Valeria; Otero-losada, Matilde Estela; Kolliker Frers, Rodolfo Alberto; Cosentino, Vanesa Laura; Kerzberg, Eduardo Mario; et al.; Adipokines, Cardiovascular Risk, and Therapeutic Management in Obesity and Psoriatic Arthritis; Frontiers Research Foundation; Frontiers in Immunology; 11; 10-2-2021; 1-121664-3224CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fimmu.2020.590749/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2020.590749info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:48:46Zoai:ri.conicet.gov.ar:11336/155073instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:48:46.849CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Adipokines, Cardiovascular Risk, and Therapeutic Management in Obesity and Psoriatic Arthritis
title Adipokines, Cardiovascular Risk, and Therapeutic Management in Obesity and Psoriatic Arthritis
spellingShingle Adipokines, Cardiovascular Risk, and Therapeutic Management in Obesity and Psoriatic Arthritis
Porta, Sabrina Valeria
Adipokines
Metabolic syndrome
Cardiovascular risk
Obesity
title_short Adipokines, Cardiovascular Risk, and Therapeutic Management in Obesity and Psoriatic Arthritis
title_full Adipokines, Cardiovascular Risk, and Therapeutic Management in Obesity and Psoriatic Arthritis
title_fullStr Adipokines, Cardiovascular Risk, and Therapeutic Management in Obesity and Psoriatic Arthritis
title_full_unstemmed Adipokines, Cardiovascular Risk, and Therapeutic Management in Obesity and Psoriatic Arthritis
title_sort Adipokines, Cardiovascular Risk, and Therapeutic Management in Obesity and Psoriatic Arthritis
dc.creator.none.fl_str_mv Porta, Sabrina Valeria
Otero-losada, Matilde Estela
Kolliker Frers, Rodolfo Alberto
Cosentino, Vanesa Laura
Kerzberg, Eduardo Mario
Capani, Francisco
author Porta, Sabrina Valeria
author_facet Porta, Sabrina Valeria
Otero-losada, Matilde Estela
Kolliker Frers, Rodolfo Alberto
Cosentino, Vanesa Laura
Kerzberg, Eduardo Mario
Capani, Francisco
author_role author
author2 Otero-losada, Matilde Estela
Kolliker Frers, Rodolfo Alberto
Cosentino, Vanesa Laura
Kerzberg, Eduardo Mario
Capani, Francisco
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Adipokines
Metabolic syndrome
Cardiovascular risk
Obesity
topic Adipokines
Metabolic syndrome
Cardiovascular risk
Obesity
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Psoriatic arthritis is a chronic inflammatory disease with skin and joint pathology as the dominant characteristics. Scientific evidence supports its systemic nature and relevant relationship with obesity, metabolic syndrome, and associated conditions. Metabolic syndrome and obesity share common signaling pathways with joint inflammation, reinforcing the idea that adipose tissue is a major contributor to disease development and severity. The adipose tissue is not a mere energy store but also an endocrine organ participating in the immune response. In the search for the best therapeutic strategy for a patient, we should appraise the adipose tissue as an endocrine and immune organ responsible for mild chronic inflammation. Today, our challenge is not only to achieve disease remission but to control the associated comorbidities as well. In light of the high prevalence of obesity in psoriatic arthritis patients and the importance of the adipose tissue in the development of chronic inflammation, we aimed to identify the most relevant articles in this regard published in English until June 2020 using the PubMed database. Search terms included psoriatic arthritis, in combination with metabolic syndrome, obesity, adipokines, cardiovascular disease, and treatment. This review summarizes the current evidence regarding the role of adipose tissue as an adipokine-secreting endocrine organ, discussing its influence on disease development and severity, and ultimately in meeting successful disease management.
Fil: Porta, Sabrina Valeria. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Otero-losada, Matilde Estela. Universidad Abierta Interamericana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Kolliker Frers, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina. Universidad Abierta Interamericana; Argentina
Fil: Cosentino, Vanesa Laura. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Kerzberg, Eduardo Mario. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Capani, Francisco. Universidad Abierta Interamericana; Argentina. Universidad Argentina "John F. Kennedy"; Argentina. Universidad Autónoma de Chile; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Psoriatic arthritis is a chronic inflammatory disease with skin and joint pathology as the dominant characteristics. Scientific evidence supports its systemic nature and relevant relationship with obesity, metabolic syndrome, and associated conditions. Metabolic syndrome and obesity share common signaling pathways with joint inflammation, reinforcing the idea that adipose tissue is a major contributor to disease development and severity. The adipose tissue is not a mere energy store but also an endocrine organ participating in the immune response. In the search for the best therapeutic strategy for a patient, we should appraise the adipose tissue as an endocrine and immune organ responsible for mild chronic inflammation. Today, our challenge is not only to achieve disease remission but to control the associated comorbidities as well. In light of the high prevalence of obesity in psoriatic arthritis patients and the importance of the adipose tissue in the development of chronic inflammation, we aimed to identify the most relevant articles in this regard published in English until June 2020 using the PubMed database. Search terms included psoriatic arthritis, in combination with metabolic syndrome, obesity, adipokines, cardiovascular disease, and treatment. This review summarizes the current evidence regarding the role of adipose tissue as an adipokine-secreting endocrine organ, discussing its influence on disease development and severity, and ultimately in meeting successful disease management.
publishDate 2021
dc.date.none.fl_str_mv 2021-02-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/155073
Porta, Sabrina Valeria; Otero-losada, Matilde Estela; Kolliker Frers, Rodolfo Alberto; Cosentino, Vanesa Laura; Kerzberg, Eduardo Mario; et al.; Adipokines, Cardiovascular Risk, and Therapeutic Management in Obesity and Psoriatic Arthritis; Frontiers Research Foundation; Frontiers in Immunology; 11; 10-2-2021; 1-12
1664-3224
CONICET Digital
CONICET
url http://hdl.handle.net/11336/155073
identifier_str_mv Porta, Sabrina Valeria; Otero-losada, Matilde Estela; Kolliker Frers, Rodolfo Alberto; Cosentino, Vanesa Laura; Kerzberg, Eduardo Mario; et al.; Adipokines, Cardiovascular Risk, and Therapeutic Management in Obesity and Psoriatic Arthritis; Frontiers Research Foundation; Frontiers in Immunology; 11; 10-2-2021; 1-12
1664-3224
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fimmu.2020.590749/full
info:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2020.590749
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Research Foundation
publisher.none.fl_str_mv Frontiers Research Foundation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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