Nonalcoholic fatty liver disease in children and adolescents: relationship with Polycystic Ovary Syndrome

Autores
Abruzzese, Giselle Adriana; Motta, Alicia Beatriz
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Nonalcoholic fatty liver disease (NAFLD) is defined as the accumulation of triglycerides (TGs) within hepatocytes exceeding 5 % of liver weight. NAFLD is a spectrum of pathological processes from nonalcoholic fatty liver or simple steatosis to nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and hepatocellular carcinoma. As NAFLD induces metabolic syndrome (MS), then, NAFLD is associated with insulin resistance (IR), type 2 diabetes mellitus (T2DM), hypertension and even Polycystic Ovary Syndrome (PCOS). Because it is well established that patients carrying gene mutations also develop NAFLD in the absence of IR, the genetic predisposition to NAFLD is also discussed. Little is known about the diagnosis and treatment of NAFLD in children and adolescents and the lack of non-invasive diagnostic tools in these populations is a major problem faced by physicians. The present review aims to discuss recent findings of NAFLD in children and adolescents and, considering the features in common with PCOS, we also discuss their relationship.
Fil: Abruzzese, Giselle Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Motta, Alicia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Materia
Nonalcoholic Fatty Liver Disease
Polycystic Ovary Syndrome
Triglycerides
Adolescents
Children
Metabolic Syndrome
Insulin Resistance
Obesity
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/13723
Acceder
id CONICETDig_fcc263741215daa5a63bcb3eedcaf895
oai_identifier_str oai:ri.conicet.gov.ar:11336/13723
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Nonalcoholic fatty liver disease in children and adolescents: relationship with Polycystic Ovary SyndromeAbruzzese, Giselle AdrianaMotta, Alicia BeatrizNonalcoholic Fatty Liver DiseasePolycystic Ovary SyndromeTriglyceridesAdolescentsChildrenMetabolic SyndromeInsulin ResistanceObesityhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Nonalcoholic fatty liver disease (NAFLD) is defined as the accumulation of triglycerides (TGs) within hepatocytes exceeding 5 % of liver weight. NAFLD is a spectrum of pathological processes from nonalcoholic fatty liver or simple steatosis to nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and hepatocellular carcinoma. As NAFLD induces metabolic syndrome (MS), then, NAFLD is associated with insulin resistance (IR), type 2 diabetes mellitus (T2DM), hypertension and even Polycystic Ovary Syndrome (PCOS). Because it is well established that patients carrying gene mutations also develop NAFLD in the absence of IR, the genetic predisposition to NAFLD is also discussed. Little is known about the diagnosis and treatment of NAFLD in children and adolescents and the lack of non-invasive diagnostic tools in these populations is a major problem faced by physicians. The present review aims to discuss recent findings of NAFLD in children and adolescents and, considering the features in common with PCOS, we also discuss their relationship.Fil: Abruzzese, Giselle Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Motta, Alicia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaBentham Science Publishers2015-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/zipapplication/pdfhttp://hdl.handle.net/11336/13723Abruzzese, Giselle Adriana; Motta, Alicia Beatriz; Nonalcoholic fatty liver disease in children and adolescents: relationship with Polycystic Ovary Syndrome; Bentham Science Publishers; Current Pharmaceutical Design.; 21; 35; 8-2015; 5144-51501381-61281873-4286enginfo:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/135208/articleinfo:eu-repo/semantics/altIdentifier/doi/10.2174/1381612821666150928105959info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:58:58Zoai:ri.conicet.gov.ar:11336/13723instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:58:58.572CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Nonalcoholic fatty liver disease in children and adolescents: relationship with Polycystic Ovary Syndrome
title Nonalcoholic fatty liver disease in children and adolescents: relationship with Polycystic Ovary Syndrome
spellingShingle Nonalcoholic fatty liver disease in children and adolescents: relationship with Polycystic Ovary Syndrome
Abruzzese, Giselle Adriana
Nonalcoholic Fatty Liver Disease
Polycystic Ovary Syndrome
Triglycerides
Adolescents
Children
Metabolic Syndrome
Insulin Resistance
Obesity
title_short Nonalcoholic fatty liver disease in children and adolescents: relationship with Polycystic Ovary Syndrome
title_full Nonalcoholic fatty liver disease in children and adolescents: relationship with Polycystic Ovary Syndrome
title_fullStr Nonalcoholic fatty liver disease in children and adolescents: relationship with Polycystic Ovary Syndrome
title_full_unstemmed Nonalcoholic fatty liver disease in children and adolescents: relationship with Polycystic Ovary Syndrome
title_sort Nonalcoholic fatty liver disease in children and adolescents: relationship with Polycystic Ovary Syndrome
dc.creator.none.fl_str_mv Abruzzese, Giselle Adriana
Motta, Alicia Beatriz
author Abruzzese, Giselle Adriana
author_facet Abruzzese, Giselle Adriana
Motta, Alicia Beatriz
author_role author
author2 Motta, Alicia Beatriz
author2_role author
dc.subject.none.fl_str_mv Nonalcoholic Fatty Liver Disease
Polycystic Ovary Syndrome
Triglycerides
Adolescents
Children
Metabolic Syndrome
Insulin Resistance
Obesity
topic Nonalcoholic Fatty Liver Disease
Polycystic Ovary Syndrome
Triglycerides
Adolescents
Children
Metabolic Syndrome
Insulin Resistance
Obesity
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Nonalcoholic fatty liver disease (NAFLD) is defined as the accumulation of triglycerides (TGs) within hepatocytes exceeding 5 % of liver weight. NAFLD is a spectrum of pathological processes from nonalcoholic fatty liver or simple steatosis to nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and hepatocellular carcinoma. As NAFLD induces metabolic syndrome (MS), then, NAFLD is associated with insulin resistance (IR), type 2 diabetes mellitus (T2DM), hypertension and even Polycystic Ovary Syndrome (PCOS). Because it is well established that patients carrying gene mutations also develop NAFLD in the absence of IR, the genetic predisposition to NAFLD is also discussed. Little is known about the diagnosis and treatment of NAFLD in children and adolescents and the lack of non-invasive diagnostic tools in these populations is a major problem faced by physicians. The present review aims to discuss recent findings of NAFLD in children and adolescents and, considering the features in common with PCOS, we also discuss their relationship.
Fil: Abruzzese, Giselle Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Motta, Alicia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
description Nonalcoholic fatty liver disease (NAFLD) is defined as the accumulation of triglycerides (TGs) within hepatocytes exceeding 5 % of liver weight. NAFLD is a spectrum of pathological processes from nonalcoholic fatty liver or simple steatosis to nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and hepatocellular carcinoma. As NAFLD induces metabolic syndrome (MS), then, NAFLD is associated with insulin resistance (IR), type 2 diabetes mellitus (T2DM), hypertension and even Polycystic Ovary Syndrome (PCOS). Because it is well established that patients carrying gene mutations also develop NAFLD in the absence of IR, the genetic predisposition to NAFLD is also discussed. Little is known about the diagnosis and treatment of NAFLD in children and adolescents and the lack of non-invasive diagnostic tools in these populations is a major problem faced by physicians. The present review aims to discuss recent findings of NAFLD in children and adolescents and, considering the features in common with PCOS, we also discuss their relationship.
publishDate 2015
dc.date.none.fl_str_mv 2015-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/13723
Abruzzese, Giselle Adriana; Motta, Alicia Beatriz; Nonalcoholic fatty liver disease in children and adolescents: relationship with Polycystic Ovary Syndrome; Bentham Science Publishers; Current Pharmaceutical Design.; 21; 35; 8-2015; 5144-5150
1381-6128
1873-4286
url http://hdl.handle.net/11336/13723
identifier_str_mv Abruzzese, Giselle Adriana; Motta, Alicia Beatriz; Nonalcoholic fatty liver disease in children and adolescents: relationship with Polycystic Ovary Syndrome; Bentham Science Publishers; Current Pharmaceutical Design.; 21; 35; 8-2015; 5144-5150
1381-6128
1873-4286
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/135208/article
info:eu-repo/semantics/altIdentifier/doi/10.2174/1381612821666150928105959
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/vnd.openxmlformats-officedocument.wordprocessingml.document
application/zip
application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613753691176960
score 13.070432

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