Effect of the trabecular bone microstructure on its thermal conductivity: measurements and a computer modelling-based study

Autores
Fajardo Freites, Jesús Ernesto; Carlevaro, Carlos Manuel; Vericat, Fernando; Berjano, Enrique; Irastorza, Ramiro Miguel
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objective: Computer models have been proposed to evaluate heat transfer in bone tissues resulting from thermal ablation, mechanical drilling, or associated with bone cement in joint prosthesis. The lack of knowledge of the influence of microstructure and marrow on the effective thermal conductivity of trabecular bone makes these modeling less accurate. We conduct experiments and computer simulations in order to quantify it. Approach: Thermal conductivities of twenty bovine trabecular bone samples were measured in two states: non defatted and defatted. A two dimensional realistic computer model was built from microscope images of a typical sample. Main results. Temperature dependence similar to that reported for most tissues (+0.2 % ºC-1) was found. The effects of microstructure, marrow content, and the experimental conditions were explained by computer modeling considering only three media: matrix, marrow (pore), and gap (between probe and sample). The inclusion of the gap filled by PBS has implied an increase of the effective thermal conductivity and generates a systematic error that can be disaffected. Computer results have also shown that the presence of a gap around the energy applicator during hyperthermic procedures is negligible (<0.7ºC) when the gap has been full by PBS and practically does not modify the isotherms location. Significance. Experimental studies where thermal conductivity is measured by inserting a probe in the bone through a drill should take our findings into account. Homogeneous tissue models can be considered for simulations of trabecular bone heat conduction using the temperature depence coefficient found in this work.
Fil: Fajardo Freites, Jesús Ernesto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física de Líquidos y Sistemas Biológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física de Líquidos y Sistemas Biológicos; Argentina
Fil: Carlevaro, Carlos Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física de Líquidos y Sistemas Biológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física de Líquidos y Sistemas Biológicos; Argentina
Fil: Vericat, Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física de Líquidos y Sistemas Biológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física de Líquidos y Sistemas Biológicos; Argentina
Fil: Berjano, Enrique. Universidad Politécnica de Valencia; España
Fil: Irastorza, Ramiro Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física de Líquidos y Sistemas Biológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física de Líquidos y Sistemas Biológicos; Argentina
Materia
COMPUTER MODEL
THERMAL CONDUCTIVITY
TRABECULAR BONE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/91075
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/91075
network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Effect of the trabecular bone microstructure on its thermal conductivity: measurements and a computer modelling-based studyFajardo Freites, Jesús ErnestoCarlevaro, Carlos ManuelVericat, FernandoBerjano, EnriqueIrastorza, Ramiro MiguelCOMPUTER MODELTHERMAL CONDUCTIVITYTRABECULAR BONEhttps://purl.org/becyt/ford/2.6https://purl.org/becyt/ford/2Objective: Computer models have been proposed to evaluate heat transfer in bone tissues resulting from thermal ablation, mechanical drilling, or associated with bone cement in joint prosthesis. The lack of knowledge of the influence of microstructure and marrow on the effective thermal conductivity of trabecular bone makes these modeling less accurate. We conduct experiments and computer simulations in order to quantify it. Approach: Thermal conductivities of twenty bovine trabecular bone samples were measured in two states: non defatted and defatted. A two dimensional realistic computer model was built from microscope images of a typical sample. Main results. Temperature dependence similar to that reported for most tissues (+0.2 % ºC-1) was found. The effects of microstructure, marrow content, and the experimental conditions were explained by computer modeling considering only three media: matrix, marrow (pore), and gap (between probe and sample). The inclusion of the gap filled by PBS has implied an increase of the effective thermal conductivity and generates a systematic error that can be disaffected. Computer results have also shown that the presence of a gap around the energy applicator during hyperthermic procedures is negligible (<0.7ºC) when the gap has been full by PBS and practically does not modify the isotherms location. Significance. Experimental studies where thermal conductivity is measured by inserting a probe in the bone through a drill should take our findings into account. Homogeneous tissue models can be considered for simulations of trabecular bone heat conduction using the temperature depence coefficient found in this work.Fil: Fajardo Freites, Jesús Ernesto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física de Líquidos y Sistemas Biológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física de Líquidos y Sistemas Biológicos; ArgentinaFil: Carlevaro, Carlos Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física de Líquidos y Sistemas Biológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física de Líquidos y Sistemas Biológicos; ArgentinaFil: Vericat, Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física de Líquidos y Sistemas Biológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física de Líquidos y Sistemas Biológicos; ArgentinaFil: Berjano, Enrique. Universidad Politécnica de Valencia; EspañaFil: Irastorza, Ramiro Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física de Líquidos y Sistemas Biológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física de Líquidos y Sistemas Biológicos; ArgentinaPergamon-Elsevier Science Ltd2018-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/91075Fajardo Freites, Jesús Ernesto; Carlevaro, Carlos Manuel; Vericat, Fernando; Berjano, Enrique; Irastorza, Ramiro Miguel; Effect of the trabecular bone microstructure on its thermal conductivity: measurements and a computer modelling-based study; Pergamon-Elsevier Science Ltd; Journal of Thermal Biology; 77; 10-2018; 131-1360306-4565CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0306456518302213info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jtherbio.2018.08.009info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:46:28Zoai:ri.conicet.gov.ar:11336/91075instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:46:28.56CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effect of the trabecular bone microstructure on its thermal conductivity: measurements and a computer modelling-based study
title Effect of the trabecular bone microstructure on its thermal conductivity: measurements and a computer modelling-based study
spellingShingle Effect of the trabecular bone microstructure on its thermal conductivity: measurements and a computer modelling-based study
Fajardo Freites, Jesús Ernesto
COMPUTER MODEL
THERMAL CONDUCTIVITY
TRABECULAR BONE
title_short Effect of the trabecular bone microstructure on its thermal conductivity: measurements and a computer modelling-based study
title_full Effect of the trabecular bone microstructure on its thermal conductivity: measurements and a computer modelling-based study
title_fullStr Effect of the trabecular bone microstructure on its thermal conductivity: measurements and a computer modelling-based study
title_full_unstemmed Effect of the trabecular bone microstructure on its thermal conductivity: measurements and a computer modelling-based study
title_sort Effect of the trabecular bone microstructure on its thermal conductivity: measurements and a computer modelling-based study
dc.creator.none.fl_str_mv Fajardo Freites, Jesús Ernesto
Carlevaro, Carlos Manuel
Vericat, Fernando
Berjano, Enrique
Irastorza, Ramiro Miguel
author Fajardo Freites, Jesús Ernesto
author_facet Fajardo Freites, Jesús Ernesto
Carlevaro, Carlos Manuel
Vericat, Fernando
Berjano, Enrique
Irastorza, Ramiro Miguel
author_role author
author2 Carlevaro, Carlos Manuel
Vericat, Fernando
Berjano, Enrique
Irastorza, Ramiro Miguel
author2_role author
author
author
author
dc.subject.none.fl_str_mv COMPUTER MODEL
THERMAL CONDUCTIVITY
TRABECULAR BONE
topic COMPUTER MODEL
THERMAL CONDUCTIVITY
TRABECULAR BONE
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.6
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Objective: Computer models have been proposed to evaluate heat transfer in bone tissues resulting from thermal ablation, mechanical drilling, or associated with bone cement in joint prosthesis. The lack of knowledge of the influence of microstructure and marrow on the effective thermal conductivity of trabecular bone makes these modeling less accurate. We conduct experiments and computer simulations in order to quantify it. Approach: Thermal conductivities of twenty bovine trabecular bone samples were measured in two states: non defatted and defatted. A two dimensional realistic computer model was built from microscope images of a typical sample. Main results. Temperature dependence similar to that reported for most tissues (+0.2 % ºC-1) was found. The effects of microstructure, marrow content, and the experimental conditions were explained by computer modeling considering only three media: matrix, marrow (pore), and gap (between probe and sample). The inclusion of the gap filled by PBS has implied an increase of the effective thermal conductivity and generates a systematic error that can be disaffected. Computer results have also shown that the presence of a gap around the energy applicator during hyperthermic procedures is negligible (<0.7ºC) when the gap has been full by PBS and practically does not modify the isotherms location. Significance. Experimental studies where thermal conductivity is measured by inserting a probe in the bone through a drill should take our findings into account. Homogeneous tissue models can be considered for simulations of trabecular bone heat conduction using the temperature depence coefficient found in this work.
Fil: Fajardo Freites, Jesús Ernesto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física de Líquidos y Sistemas Biológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física de Líquidos y Sistemas Biológicos; Argentina
Fil: Carlevaro, Carlos Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física de Líquidos y Sistemas Biológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física de Líquidos y Sistemas Biológicos; Argentina
Fil: Vericat, Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física de Líquidos y Sistemas Biológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física de Líquidos y Sistemas Biológicos; Argentina
Fil: Berjano, Enrique. Universidad Politécnica de Valencia; España
Fil: Irastorza, Ramiro Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física de Líquidos y Sistemas Biológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física de Líquidos y Sistemas Biológicos; Argentina
description Objective: Computer models have been proposed to evaluate heat transfer in bone tissues resulting from thermal ablation, mechanical drilling, or associated with bone cement in joint prosthesis. The lack of knowledge of the influence of microstructure and marrow on the effective thermal conductivity of trabecular bone makes these modeling less accurate. We conduct experiments and computer simulations in order to quantify it. Approach: Thermal conductivities of twenty bovine trabecular bone samples were measured in two states: non defatted and defatted. A two dimensional realistic computer model was built from microscope images of a typical sample. Main results. Temperature dependence similar to that reported for most tissues (+0.2 % ºC-1) was found. The effects of microstructure, marrow content, and the experimental conditions were explained by computer modeling considering only three media: matrix, marrow (pore), and gap (between probe and sample). The inclusion of the gap filled by PBS has implied an increase of the effective thermal conductivity and generates a systematic error that can be disaffected. Computer results have also shown that the presence of a gap around the energy applicator during hyperthermic procedures is negligible (<0.7ºC) when the gap has been full by PBS and practically does not modify the isotherms location. Significance. Experimental studies where thermal conductivity is measured by inserting a probe in the bone through a drill should take our findings into account. Homogeneous tissue models can be considered for simulations of trabecular bone heat conduction using the temperature depence coefficient found in this work.
publishDate 2018
dc.date.none.fl_str_mv 2018-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/91075
Fajardo Freites, Jesús Ernesto; Carlevaro, Carlos Manuel; Vericat, Fernando; Berjano, Enrique; Irastorza, Ramiro Miguel; Effect of the trabecular bone microstructure on its thermal conductivity: measurements and a computer modelling-based study; Pergamon-Elsevier Science Ltd; Journal of Thermal Biology; 77; 10-2018; 131-136
0306-4565
CONICET Digital
CONICET
url http://hdl.handle.net/11336/91075
identifier_str_mv Fajardo Freites, Jesús Ernesto; Carlevaro, Carlos Manuel; Vericat, Fernando; Berjano, Enrique; Irastorza, Ramiro Miguel; Effect of the trabecular bone microstructure on its thermal conductivity: measurements and a computer modelling-based study; Pergamon-Elsevier Science Ltd; Journal of Thermal Biology; 77; 10-2018; 131-136
0306-4565
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0306456518302213
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jtherbio.2018.08.009
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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